DODEX – Geoscience Documents and Data for Exploration in Greenland

In the following we describe the project Geoscience Documents and Data for Exploration in Greenland, in short DODEX. A central part of DODEX is an interactive web application (http://www.geus.dk/dodex/) that provides easy access to all non-confidential company geoscience reports received by the authorities in Greenland and Denmark in accordance with the Mineral Resources Act of Greenland (1 January 2010) and associated regulations. From the web application it is possible to search in the DODEX report database using alphanumeric and geographic search criteria and to access report metadata. It is also possible to download the actual report as a PDF file. In addition to the open DODEX web application, the project also includes the development of a closed web application where authorised users can access confidential reports. The DODEX project was carried out at the Geological Survey of Denmark and Greenland (GEUS) in cooperation with the Bureau of Minerals and Petroleum (BMP) under the Government of Greenland as part of the promotion of the mineral resources of Greenland

Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

Glucagon is secreted from pancreatic a cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity in hyperglucagonemia is poorly investigated. By screening human plasma using high-resolution-proteomics, we identified several glucagon variants, among which proglucagon 1-61 (PG 1-61) appears to be the most abundant form. PG 1-61 is secreted in subjects with obesity, both before and after gastric bypass surgery, with protein and fat as the main drivers for secretion before surgery, but glucose after. Studies in hepatocytes and in b cells demonstrated that PG 1-61 dose-dependently increases levels of cAMP, through the glucagon receptor, and increases insulin secretion and protein levels of enzymes regulating glycogenolysis and gluconeogenesis. In rats, PG 1-61 increases blood glucose and plasma insulin and decreases plasma levels of amino acids in vivo. We conclude that glucagon variants, such as PG 1-61, may contribute to glucose regulation by stimulating hepatic glucose production and insulin secretion