Disability and inclusion: swimming to overcome social barriers

Nowadays all people can and must practice physical activity and engage themselves in various sports specialties. Among the various sports, swimming is ideal in all situations where the weight of the body is a problem, such as in cases of lower limbs disability (amputations, paralysis, etc.). The objective of this study is to investigate if disabled and not-disabled athletes can derive performance benefits and if it is possible to reduce the gap between the competition times between athletes, through a single, performance and training activity. The sample is made up of 12 athletes, including 6 disabled, belonging to the S2 category, and 6 not-disabled athletes skilled in the back. After an anamnesis and a careful initial valuation, it was proposed to all the athletes to do the HIIT method (for 4 weeks), Tabata method (for 4 weeks), and Pilates one (for 8 weeks). Moreover, to the disabled athletes were given physiotherapy sessions to increase joint ROM for 8 weeks. The aim is to promote social inclusion for disabled athletes, often marginalized by the group, to break down those who are the pillars of difference

Tropical and temperate differences in the trophic structure and aquatic prey use of riparian predators

The influence of aquatic resource-inputs on terrestrial communities is poorly understood, particularly in the tropics. We used stable isotope analysis of carbon and nitrogen to trace aquatic prey use and quantify the impact on trophic structure in 240 riparian arthropod communities in tropical and temperate forests. Riparian predators consumed more aquatic prey and were more trophically diverse in the tropics than temperate regions, indicating tropical riparian communities are both more reliant on and impacted by aquatic resources than temperate communities. This suggests they are more vulnerable to disruption of aquatic–terrestrial linkages. Although aquatic resource use declined strongly with distance from water, we observed no correlated change in trophic structure, suggesting trophic flexibility to changing resource availability within riparian predator communities in both tropical and temperate regions. Our findings highlight the importance of aquatic resources for riparian communities, especially in the tropics, but suggest distance from water is less important than resource diversity in maintaining terrestrial trophic structure

ROSAT data analysis with EXSAS

For the x-ray observatory ROSAT, data from survey and pointed mission phases taken with different focal plane instruments and according to a complex mission timeline have to be handled. Data analysis therefore puts high demands on appropriate software tools. With EXSAS - the Extended Scientific Analysis System developed with an effort of 20 man years by the German ROSAT Scientific Data Center - a comfortable system for the reduction of data from the ROSAT x-ray and XUV instruments has been made available. EXSAS comprises a large collection of application modules as typically required in analyzing data of this wavelength regime and runs as a specific context in the wide-spread ESO-MIDAS environment. EXSAS, completely written in FORTRAN 77, takes full advantage of all the standards used in MIDAS and therefore, reflects the same portability (different UNIX installations and VMS). If required, the FORTRAN code also enables users to adapt the software in an easy way to their specific needs. To maintain independence from the specifics of different operating systems also on the data input side, all ROSAT data redistributed in the widely accepted FITS format. Although EXSAS has been developed specifically for data analysis of the ROSAT instruments, its structural design is sufficiently general to serve equally well also data from other X-ray and XUV instruments. EXSAS analysis modules are grouped into 4 application packages dealing with Data Preparation and Instrument Correction, Spatial Analysis, Spectral Analysis and Timing Analysis. A special EXSAS header, read and updated by each application, maintains the general information transfer on the origin, the history and the parameter space of the data stored in tables and images. About 100 genuine commands (most of which offer several additional options) allow to interactively explore the functionality of the system. Up to now 40 institutes all over the world have requested the EXSAS software. Maintenance and regular updates of the software and the comprehensive documentation are provided by the ROSAT Scientific Data Center at Garching

Triple positive breast cancer. A distinct subtype?

Breast cancer is a heterogeneous disease, and within the HER-2 positive subtype this is highly exemplified by the presence of substantial phenotypical and clinical heterogeneity, mostly related to hormonal receptor (HR) expression. It is well known how HER-2 positivity is commonly associated with a more aggressive tumor phenotype and decreased overall survival and, moreover, with a reduced benefit from endocrine treatment. Preclinical studies corroborate the role played by functional crosstalks between HER-2 and estrogen receptor (ER) signaling in endocrine resistance and, more recently, the activation of ER signaling is emerging as a possible mechanism of resistance to HER-2 blocking agents. Indeed, HER-2 positive breast cancer heterogeneity has been suggested to underlie the variability of response not only to endocrine treatments, but also to HER-2 blocking agents. Among HER-2 positive tumors, HR status probably defines two distinct subtypes, with dissimilar clinical behavior and different sensitivity to anticancer agents. The triple positive subtype, namely, ER/PgR/Her-2 positive tumors, could be considered the subset which most closely resembles the HER-2 negative/HR positive tumors, with substantial differences in biology and clinical outcome. We argue on whether in this subgroup the "standard" treatment may be considered, in selected cases, i.e., small tumors, low tumor burden, high expression of both hormonal receptors, an overtreatment. This article review the existing literature on biologic and clinical data concerning the HER-2/ER/PgR positive tumors, in an attempt to better define the HER-2 subtypes and to optimize the use of HER-2 targeted agents, chemotherapy and endocrine treatments in the various subsets

GAME: Grb and All-sky Monitor Experiment

We describe the GRB and All-sky Monitor Experiment (GAME) mission submitted by a large international collaboration (Italy, Germany, Czech Repubblic, Slovenia, Brazil) in response to the 2012 ESA call for a small mission opportunity for a launch in 2017 and presently under further investigation for subsequent opportunities. The general scientific objective is to perform measurements of key importance for GRB science and to provide the wide astrophysical community of an advanced X-ray all-sky monitoring system. The proposed payload was based on silicon drift detectors (~1-50 keV), CdZnTe (CZT) detectors (~15-200 keV) and crystal scintillators in phoswich (NaI/CsI) configuration (~20 keV-20 MeV), three well established technologies, for a total weight of ~250 kg and a required power of ~240 W. Such instrumentation allows a unique, unprecedented and very powerful combination of large field of view (3-4 sr), a broad energy energy band extending from ~1 keV up to ~20 MeV, an energy resolution as good as ~300 eV in the 1-30 keV energy range, a source location accuracy of ~1 arcmin. The mission profile included a launch (e.g., by Vega) into a low Earth orbit, a baseline sky scanning mode plus pointed observations of regions of particular interest, data transmission to ground via X-band (4.8 Gb/orbit, Alcantara and Malindi ground stations), and prompt transmission of GRB / transient triggers.Comment: 13 pages, 8 figures, published in International Journal of Modern Physics

A wide angle view of the Sagittarius dwarf Spheroidal Galaxy. I: VIMOS photometry and radial velocities across Sgr dSph major and minor axis

The Sagittarius dwarf Spheroidal Galaxy (Sgr dSph) provides us with a unique possibility of studying a dwarf galaxy merging event while still in progress. Due to its low distance (25 kpc), the main body of Sgr dSph covers a vast area in the sky (roughly 15 x 7 degrees). Available photometric and spectroscopic studies have concentrated either on the central part of the galaxy or on the stellar stream, but the overwhelming majority of the galaxy body has never been probed. The aim of the present study is twofold. On the one hand, to produce color magnitude diagrams across the extension of Sgr dSph to study its stellar populations, searching for age and/or composition gradients (or lack thereof). On the other hand, to derive spectroscopic low-resolution radial velocities for a subsample of stars to determine membership to Sgr dSph for the purpose of high resolution spectroscopic follow-up. We used VIMOS-VLT to produce V and I photometry and spectroscopy on 7 fields across the Sgr dSph minor and major axis, plus 3 more centered on the associated globular clusters Terzan 7, Terzan 8 and Arp 2. A last field has been centered on M 54, lying in the center of Sgr dSph. We present photometry for 320,000 stars across the main body of Sgr dSph, one of the richest, and safely the most wide-angle sampling ever produced for this fundamental object. We also provide robust memberships for more than one hundred stars, whose high resolution spectroscopic analysis will be the object of forthcoming papers. Sgr dSph appears remarkably uniform among the observed fields. We confirm the presence of a main Sgr dSph population characterized roughly by the same metallicity of 47 Tuc, but we also found the presence of multiple populations on the peripheral fields of the galaxy, with a metallicity spanning from [Fe/H]=-2.3 to a nearly solar value.Comment: 10 pages, 12 figures, accepted for publication in A&

Body mass index in HER2-negative metastatic breast cancer treated with first-line paclitaxel and bevacizumab

The evidence emerged from the TOURANDOT trial encourages evaluating the role of anthropometric determinants on treatment outcomes in HER2-negative metastatic breast cancer patients treated with bevacizumab-including regimens. We thus analyzed data from a subgroup of these patients from a larger cohort previously assessed for treatment outcomes. Patients were included in the present analysis if body mass index values had been recorded at baseline. Clinical benefit rates, progression free survival and overall survival were assessed for the overall study population and subgroups defined upon molecular subtype. One hundred ninety six patients were included (N:196). Body mass index showed no impact on clinical benefit rates in the overall study sample and in the luminal cancer subset (p = 0.12 and p = 0.79, respectively), but did so in the triple negative subgroup, with higher rates in patients with body mass index ≥25 (p = 0.03). In the overall study sample, body mass index did no impact progression free or overall survival (p = 0.33 and p = 0.67, respectively). Conversely, in triple negative patients, progression free survival was significantly longer with body mass index ≥25 (6 vs 14 months, p = 0.04). In this subset, overall survival was more favorable (25 vs 19 months, p = 0.02). The impact of the molecular subtype was confirmed in multivariate models including the length of progression free survival, and number of metastatic sites (p < 0.0001). Further studies are warranted to confirm our findings in more adequately sized, ad hoc, prospective studies

Coxiella burnetii dormancy in a fatal tenyear multisystem dysfunctional illness: case report

In a previous study of a Q fever outbreak in Birmingham, our group identified a non-infective complex of Coxiella burnetii (C.b.) antigens able to survive in the host and provoked aberrant humoral and cell-mediated immunity responses. The study led to recognition of a possible pathogenic link between C.b. infection and subsequent long-term post Q fever fatigue syndrome (QFS). This report presents an unusually severe case of C.b. antigen and DNA detection in post-mortem specimens from a patient with QFS.We report a 19-year old female patient who became ill with an acute unexplained febrile encephalitis-like illness, followed by increasingly severe multisystem dysfunction and death 10 years later. During life, extensive clinical and laboratory investigations from different disciplinary stand points failed to deliver a definitive identification of a cause. Given the history of susceptibility to infection from birth, acute fever and the diagnosis of "post viral syndrome", tests for infective agents were done starting with C.b. and Legionella pneumophila. The patient had previously visited farms a number of times. Comprehensive neuropathological assessment at the time of autopsy had not revealed gross or microscopic abnormalities. The aim was to extend detailed studies with the post-mortem samples and identify possible factors driving severe disturbance of homeostasis and organ dysfunction exhibited by the course of the patient's ten-year illness. Immunohistochemistry for C.b. antigen and PCR for DNA were tested on paraffin embedded blocks of autopsy tissues from brain, spleen, liver, lymph nodes (LN), bone marrow (BM), heart and lung. Standard H&E staining of brain sections was unrevealing. Immuno-staining analysis for astrocyte cytoskeleton proteins using glial fibrillary acidic protein (GFAP) antibodies showed a reactive morphology. Coxiella antigens were demonstrated in GFAP immuno-positive grey and white matter astrocytes, spleen, liver, heart, BM and LN. PCR analysis (COM1/IS1111 genes) confirmed the presence of C.b. DNA in heart, lung, spleen, liver & LN, but not in brain or BM.The study revealed the persistence of C. b. cell components in various organs, including astrocytes of the brain, in a post-infection QFS. The possible mechanisms and molecular adaptations for this alternative C.b. life style are discussed.Olga A. Sukocheva, Jim Manavis, Tuck-Weng Kok, Mark Turra, Angelo Izzo, Peter Blumbergs and Barrie P. Marmio

Fundamental Physics with the Laser Astrometric Test Of Relativity

The Laser Astrometric Test Of Relativity (LATOR) is a joint European-U.S. Michelson-Morley-type experiment designed to test the pure tensor metric nature of gravitation - a fundamental postulate of Einstein's theory of general relativity. By using a combination of independent time-series of highly accurate gravitational deflection of light in the immediate proximity to the Sun, along with measurements of the Shapiro time delay on interplanetary scales (to a precision respectively better than 0.1 picoradians and 1 cm), LATOR will significantly improve our knowledge of relativistic gravity. The primary mission objective is to i) measure the key post-Newtonian Eddington parameter \gamma with accuracy of a part in 10^9. (1-\gamma) is a direct measure for presence of a new interaction in gravitational theory, and, in its search, LATOR goes a factor 30,000 beyond the present best result, Cassini's 2003 test. The mission will also provide: ii) first measurement of gravity's non-linear effects on light to ~0.01% accuracy; including both the Eddington \beta parameter and also the spatial metric's 2nd order potential contribution (never measured before); iii) direct measurement of the solar quadrupole moment J2 (currently unavailable) to accuracy of a part in 200 of its expected size; iv) direct measurement of the "frame-dragging" effect on light by the Sun's gravitomagnetic field, to 1% accuracy. LATOR's primary measurement pushes to unprecedented accuracy the search for cosmologically relevant scalar-tensor theories of gravity by looking for a remnant scalar field in today's solar system. We discuss the mission design of this proposed experiment.Comment: 8 pages, 9 figures; invited talk given at the 2005 ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020," 19-21 April 2005, ESTEC, Noodrwijk, The Netherland