Studies on morphometry and hydrology of Gandhisagar Reservoir with special reference to its fisheries

Gandhisagar, the second largest reservoir of India is located in Mandsaur district of Madhya Pradesh at latitude 24°44'N and longitude 75°33'E at an altitude of 403.56m MSL in orientation from NE to SE. It has an extensive water spread area of 66000 ha at full reservoir level with a maximum and mean depth of 49.52 and 11.73 m respectively. The maximum length and width of the reservoir are 112 and 16km having a total shore line of 442km. Details of catchment area, bathymetry, standard hydrological data giving water level relation of the basin to water spread area, volume and fish production and the bottom topographical details of 11 experimental fishing stations and 6 fish landing centres are discussed

Higher dimensional radiation collapse and cosmic censorship

We study the occurrence of naked singularities in the spherically symmetric collapse of radiation shells in a higher dimensional spacetime. The necessary conditions for the formation of a naked singularity or a black hole are obtained. The naked singularities are found to be strong in the Tipler's sense and thus violating cosmic censorship conjecture.Comment: 4 pages, ReVTeX, Phys Rev D Vol 62 107502 (2000

Asymptotic symmetries on Killing horizons

We investigate asymptotic symmetries regularly defined on spherically symmetric Killing horizons in the Einstein theory with or without the cosmological constant. Those asymptotic symmetries are described by asymptotic Killing vectors, along which the Lie derivatives of perturbed metrics vanish on a Killing horizon. We derive the general form of asymptotic Killing vectors and find that the group of the asymptotic symmetries consists of rigid O(3) rotations of a horizon two-sphere and supertranslations along the null direction on the horizon, which depend arbitrarily on the null coordinate as well as the angular coordinates. By introducing the notion of asymptotic Killing horizons, we also show that local properties of Killing horizons are preserved under not only diffeomorphisms but also non-trivial transformations generated by the asymptotic symmetry group. Although the asymptotic symmetry group contains the $\mathit{Diff}(S^1)$ subgroup, which results from the supertranslations dependent only on the null coordinate, it is shown that the Poisson bracket algebra of the conserved charges conjugate to asymptotic Killing vectors does not acquire non-trivial central charges. Finally, by considering extended symmetries, we discuss that unnatural reduction of the symmetry group is necessary in order to obtain the Virasoro algebra with non-trivial central charges, which will not be justified when we respect the spherical symmetry of Killing horizons.Comment: 28 page

Higher dimensional dust collapse with a cosmological constant

The general solution of the Einstein equation for higher dimensional (HD) spherically symmetric collapse of inhomogeneous dust in presence of a cosmological term, i.e., exact interior solutions of the Einstein field equations is presented for the HD Tolman-Bondi metrics imbedded in a de Sitter background. The solution is then matched to exterior HD Scwarschild-de Sitter. A brief discussion on the causal structure singularities and horizons is provided. It turns out that the collapse proceed in the same way as in the Minkowski background, i.e., the strong curvature naked singularities form and that the higher dimensions seem to favor black holes rather than naked singularities.Comment: 7 Pages, no figure

Stability of Black Holes and Black Branes

We establish a new criterion for the dynamical stability of black holes in $D \geq 4$ spacetime dimensions in general relativity with respect to axisymmetric perturbations: Dynamical stability is equivalent to the positivity of the canonical energy, \E, on a subspace, $\mathcal T$, of linearized solutions that have vanishing linearized ADM mass, momentum, and angular momentum at infinity and satisfy certain gauge conditions at the horizon. This is shown by proving that---apart from pure gauge perturbations and perturbations towards other stationary black holes---\E is nondegenerate on $\mathcal T$ and that, for axisymmetric perturbations, \E has positive flux properties at both infinity and the horizon. We further show that \E is related to the second order variations of mass, angular momentum, and horizon area by \E = \delta^2 M - \sum_A \Omega_A \delta^2 J_A - \frac{\kappa}{8\pi} \delta^2 A, thereby establishing a close connection between dynamical stability and thermodynamic stability. Thermodynamic instability of a family of black holes need not imply dynamical instability because the perturbations towards other members of the family will not, in general, have vanishing linearized ADM mass and/or angular momentum. However, we prove that for any black brane corresponding to a thermodynamically unstable black hole, sufficiently long wavelength perturbations can be found with \E < 0 and vanishing linearized ADM quantities. Thus, all black branes corresponding to thermodynmically unstable black holes are dynamically unstable, as conjectured by Gubser and Mitra. We also prove that positivity of \E on $\mathcal T$ is equivalent to the satisfaction of a "local Penrose inequality," thus showing that satisfaction of this local Penrose inequality is necessary and sufficient for dynamical stability.Comment: 54 pages, Latex, 2 figures, v2: Anzatz for momentum in proof of Gubser-Mitra conjecture corrected; factor of 2 in symplectic form corrected; several typos in formulas corrected; v3: revised argument concerning horizon gauge condition on p. 10; typos corrected and several minor changes; reference added; v4: formula (86) for \E corrected, footnote adde

Deep analysis of CD4 T cells in the rhesus CNS during SIV infection

Virologic suppression with antiretroviral therapy (ART) has significantly improved health outcomes for people living with HIV, yet challenges related to chronic inflammation in the central nervous system (CNS)—known as Neuro-HIV- persist. As primary targets for HIV-1 with the ability to survey and populate the CNS and interact with myeloid cells to co-ordinate neuroinflammation, CD4 T cells are pivotal in Neuro-HIV. Despite their importance, our understanding of CD4 T cell distribution in virus-targeted CNS tissues, their response to infection, and potential recovery following initiation of ART remain limited. To address these gaps, we studied ten SIVmac251-infected rhesus macaques using an ART regimen simulating suboptimal adherence. We evaluated four macaques during the acute phase pre-ART and six during the chronic phase. Our data revealed that HIV target CCR5+ CD4 T cells inhabit both the brain parenchyma and adjacent CNS tissues, encompassing choroid plexus stroma, dura mater, and the skull bone marrow. Aligning with the known susceptibility of CCR5+ CD4 T cells to viral infection and their presence within the CNS, high levels of viral RNA were detected in the brain parenchyma and its border tissues during acute SIV infection. Single-cell RNA sequencing of CD45+ cells from the brain revealed colocalization of viral transcripts within CD4 clusters and significant activation of antiviral molecules and specific effector programs within T cells, indicating CNS CD4 T cell engagement during infection. Acute infection led to marked imbalance in the CNS CD4/CD8 ratio which persisted into the chronic phase. These observations underscore the functional involvement of CD4 T cells within the CNS during SIV infection, enhancing our understanding of their role in establishing CNS viral presence. Our findings offer insights for potential T cell-focused interventions while underscoring the challenges in eradicating HIV from the CNS, particularly in the context of sub-optimal ART

Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program

The Environmental Influences on Child Health Outcomes (ECHO) Program will evaluate environmental factors affecting children’s health (perinatal, neurodevelopmental, obesity, respiratory, and positive health outcomes) by pooling cohorts composed of >50,000 children in the largest US study of its kind. Our objective was to identify opportunities for studying chemicals and child health using existing or future ECHO chemical exposure data. We described chemical-related information collected by ECHO cohorts and reviewed ECHO-relevant literature on exposure routes, sources, and environmental and human monitoring. Fifty-six ECHO cohorts have existing or planned chemical biomonitoring data for mothers or children. Environmental phenols/parabens, phthalates, metals/metalloids, and tobacco biomarkers are each being measured by ≥15 cohorts, predominantly during pregnancy and childhood, indicating ample opportunities to study child health outcomes. Cohorts are collecting questionnaire data on multiple exposure sources and conducting environmental monitoring including air, dust, and water sample collection that could be used for exposure assessment studies. To supplement existing chemical data, we recommend biomonitoring of emerging chemicals, nontargeted analysis to identify novel chemicals, and expanded measurement of chemicals in alternative biological matrices and dust samples. ECHO’s rich data and samples represent an unprecedented opportunity to accelerate environmental chemical research to improve the health of US children

DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

To address the increasing need for detecting and validating protein biomarkers in clinical specimens, mass spectrometry (MS)-based targeted proteomic techniques, including the selected reaction monitoring (SRM), parallel reaction monitoring (PRM), and massively parallel data-independent acquisition (DIA), have been developed. For optimal performance, they require the fragment ion spectra of targeted peptides as prior knowledge. In this report, we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue samples. To build the spectral resource, we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on Docker. We then applied the workflow to generate DPHL, a comprehensive DIA pan-human library, from 1096 data-dependent acquisition (DDA) MS raw files for 16 types of cancer samples. This extensive spectral resource was then applied to a proteomic study of 17 prostate cancer (PCa) patients. Thereafter, PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was validated. As a second application, the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma (DLBCL) patients and 18 healthy control subjects. Differentially expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by PRM. These data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker discovery. DPHL is freely accessible at https://www.iprox.org/page/project.html?id=IPX0001400000

All-sky search for long-duration gravitational wave transients with initial LIGO

We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society