THE MANAGEMENT OF A PORTFOLIO IN THE CONDITIONS OF ECONOMIC CRISIS

The need for money is one of the main financial goals of any company. Such needs have led to specific segments of demand and supply that demand for money and the money supply, in particular capital. Were created following specific markets: financial markets, with specialized division of labour in money markets and capital markets. Capital market is to supply and demand for medium and long term capital, with the same role as the financial market in general, having featured the long duration of maturity. From the viewpoint of the agents involved two types of markets that is the primary market, which are negotiated in the presence of primary and secondary securities issuer, that and his participation, and market secondary market investors, financial flows are directed to a investor to another. Institution typical secondary capital market is the stock market. Coverage of financial instruments, according to EU directives in force, is broad, including both tradable capital market instruments and money market instruments. Investment is defined in national accounts as gross fixed capital formation is the value of durable goods purchased by the production units to be used at least one year in production processes. The investment flow is therefore measured over a period, often a year, noted that the yield from an investment is proportional to the risk assumed. Investing in shares of the opportunity to diversify revenue and achieving consistent earnings, earnings from sales and purchases of shares may be significantly higher earnings from a bank

The burden of chronic obstructive pulmonary disease associated with maintenance monotherapy in the UK

Susan C Edwards,1 Sian E Fairbrother,2 Anna Scowcroft,3 Gavin Chiu,4 Andrew Ternouth,3 Brian J Lipworth5 1Department of Market Access Pricing & Outcomes Research, 2Department of Medical Affairs - Respiratory, 3Department of Market Access, 4Department of Prescription Medicine - Respiratory, Boehringer Ingelheim, Bracknell, UK; 5Asthma and Allergy Research Group, Division of Cardiovascular and Diabetes Medicine, Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK Background: This study characterized a cohort of chronic obstructive pulmonary disease (COPD) patients on maintenance bronchodilator monotherapy for ≥6 months to establish their disease burden, measured by health care utilization.Methods: Data were extracted from the UK Clinical Practice Research Datalink and linked to Hospital Episode Statistics. The monotherapy period spanned the first prescription of a long-acting β2-adrenergic agonist or a long-acting muscarinic antagonist until the end of the study (December 31, 2013) or until step up to dual/triple therapy, for example, addition of another long-acting bronchodilator, an inhaled corticosteroid, or both. A minimum of four consecutive prescriptions and 6 months on continuous monotherapy were required. Patients <50 years old at first COPD diagnosis or with another significant respiratory disease before starting monotherapy were excluded. Disease burden was evaluated by measuring patients’ rate of face-to-face interactions with a health care professional (HCP), COPD-related exacerbations, hospitalizations, and referrals.Results: A cohort of 8,811 COPD patients (95% Global initiative for chronic Obstructive Lung Disease stage A/B) on maintenance monotherapy was identified between 2002 and 2013; 45% of these patients were still on monotherapy by the end of the study. Median time from first COPD diagnosis to first monotherapy prescription was 56 days, while the median time on maintenance bronchodilator monotherapy was 2 years. The median number of prescriptions was 14. On average, patients had 15 HCP interactions per year, and one in ten patients experienced a COPD exacerbation (N=8,811). One in 50 patients were hospitalized for COPD per year (n=4,848).Conclusion: The average monotherapy-treated patient had a higher than average HCP interaction rate. We also identified a large cohort of patients who were stepped up to triple therapy despite a low rate of exacerbations. The use of the new class of long-acting muscarinic antagonist/long-acting β2-adrenergic agonist fixed-dose combinations may provide a useful step-up treatment option in such monotherapy patients, before the use of inhaled corticosteroids. Keywords: COPD, UK primary care setting, bronchodilators, prescribing patterns, monotherap

The 2010 Pakistan floods: high-resolution simulations with the WRF model

Abstract HKT-ISTP 2013 B

Sobre o "património rural": contributos para a clarificação de um conceito

É objectivo central deste texto discutir, num plano essencialmente teórico, o conceito de «património rural». Para tal, parte-se de uma abordagem genérica sobre o património num sentido mais amplo, para depois, gradualmente, identificar e analisar as dimensões e indicadores, com tradução empírica, subjacentes àquele conceito. Termina-se esta reflexão tentando perceber e discutir o lugar que o património rural – de acordo com a amplitude conceptual que tentamos aqui demonstrar – ocupa no âmbito de processos de desenvolvimento local, em particular naqueles que tendem a operacionaliza-lo enquanto recurso turístico, favorável às economias rurai

Studies of lignin and polysaccharides recovery from kraft liquor for biotechnological applications

According to the biorefinery concept, this study has the objective of evaluating alternatives for the valorization of all the kraft liquor fractions. This liquor consists mainly in lignin, cellulose and hemicellulose. Currently, cellulose pulp industries recover the cooking chemicals by burning and energy is introduced into the process. Sustainable development guidelines, regarding the costs and wastes reduction and biotechnology principles may present new solutions for the production of valuable products. In this study, two methods for the polysaccharides extraction, in three different pH conditions, are presented. The only difference between these methods is the solvent applied: ethanol and 1,4‐dioxane. All the samples were maintained 24 h at 298 K. After a filtration step, the solid fraction resultant from the ethanol treatment had a carbohydrate content of 40.51%, 44.64% and 49.53%, for pH values of 3, 4 and 6, respectively. The treatment with 1,4‐dioxane, reached the following values: 21.17%, 18.41% and 29.73% for the same pH values. These results were obtained with HPLC analysis after polysaccharides hydrolysis. Three unknown peaks were detected that we considered to be sugar derivative compounds. Thus, the polysaccharides contents, for both treatments, might actually be superior. Concerning to the product purity, the ethanol extraction revealed to be the less efficient. The lignin content in the solid fraction, ranged between 28% and 31%, with 1,4‐dioxane extraction, and between 40% and 50%, with ethanol. The lignin molecular weight was determined with GPC, after and before liquor pH lowering. Thereby, for pH 6, pH 4 and pH 3 the obtained MWs were: 2376 Da, 1477 Da and 3705 Da, respectively. The molecular weight increase may be due to the lignin repolymerization. These results suggest that the polysaccharides recovery and lignin molecular weight may be related. As the molecular weight increases or decreases, the polysaccharides percentage presents the same behavior, regardless of the product purity. The data obtained after FT‐IR analysis suggested that there was no significant modifications on lignin structure. Summarizing, these preliminary results indicate that there is a possibility of recovering the kraft liquor´s polysaccharide while the residual lignin can still be used for burning to energy recovery.Erasmus Mundus ‐ ISAC ProgramFundação para a Ciência e a Tecnologia (FCT)Millipore BrazilConselho Nacional de Desenvolvimento Científico e Tecnológico Brazil - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CNPq‐CAPES

Influence of pH on cellular growth of Pichia pastoris KM71H by fed-batch process

Pichia pastoris is a methylotrophic yeast that can be genetically engineered to express proteins for industrial use. One of the most important advantages of protein expression in P. pastoris is its capability of growing on minimal medium and efficiently secreting heterologous proteins with low secretion levels of endogenous proteins. Operational variables such as pH, temperature, stirring rate, among others, usually affect the microorganism’s growth during the fermentation processes. Therefore, the present work aimed to evaluate the influence of pH on cellular growth of P. pastoris KM71H by fed‐batch process. The fermentation run was carried out in a 1.6 L (total volume) bioreactor, being performed in two phases: In the first stage (24 h), the yeast was batchcultured in BMGH medium; while in the second stage (72 h), it was cultivated by feed‐batch operation with a feeding medium containing 50% glycerol and 12ml/l of trace metal solution. During the overall process, which lasted after 96 h, the aeration and temperature conditions were fixed at 10 ml\L.h, 1.5 vvm and 30°C, respectively. Different pH values were evaluated: 5.0, 5.5 and 6.0. Cellular growth was determined by measuring the fermentation broth UVspectrophotometric absorbance at 600 nm, which was correlated to a calibration curve (dry weight ´ optical density). Glycerol consumption was detected by HPLC analysis. P. pastoris KM71H successfully grew in all the evaluated pH values; but the highest biomass production was observed at pH 5.0 (98.79 g/L). Although P. pastoris is reported as being a microorganism able to grow over a wide pH range (from 3 to 7); it was not observed high cell density of P. pastoris KM71H strain when cultivated at pHs 5.5 and 6.0. High cellular growth is especially important for proteins secretion, as the concentration of product in the medium is roughly proportional to the concentration of cells in culture. Finally, these results reveal the possibility of obtaining high cell density of P. pastoris KM71H by fed‐bach cultivation at pH 5.0, which can be a suitable condition for the yeast application in heterologous proteins production.Conselho Nacional de Desenvolvimento Científico e Tecnológico Brazil (CNPq)Improving Skills Across Continents (ISAC ) - Erasmus Mundus External Cooperation Window (ERASMUS

State of Iowa Cybersecurity Strategy, July 2016

On December 21, 2015, Governor Branstad issued Executive Order 87 (EO87); a cybersecurity initiative for the State of Iowa. The executive order establishes a multi-agency partnership, the EO87 Leadership Team, with the Office of the Chief Information Officer, Iowa National Guard, Department of Public Safety, Iowa Communications Network, and the Iowa Homeland Security and Emergency Management Department. The order directs these agencies to develop a comprehensive cybersecurity strategy which addresses lifeline critical infrastructure, risk assessments, best practices, awareness training, public education and communication, collaboration, K-12 and higher education, data breach notifications, and incident response planning to protect the citizens of Iowa and Iowa businesses. The EO87 Leadership Team, along with several key partners, worked diligently over the last six months to prepare recommendations that will have a direct and sustainable impact on protecting lifeline critical infra-structure, reducing risk to government operations, and creating sustainable partnerships in cybersecurity