Análise de contido, tratamento estético e de linguaxe dos informativos audiovisuais en Galicia

No marco dun proxecto de investigación do Grupo de Estudos Audiovisuais do Departamento de Ciencias da Comunicación da USC deseñouse un sistema de xestión da información audiovisual co obxectivo de realizar un seguemento periódico dos informativos das emisoras de radio e de televisión en Galicia con maiores índices de audiencia e de cobertura autonómica (TVG, TVE-Galicia, RG, RNE-1, COPE, SER, Onda Cero, Radio Voz e Punto Radio). Esta base de datos de acceso online elaborouse a partires dunha ficha de análise na que se abordan – desde o punto de vista cuantitativo e cualitativo – parámetros como a xerarquización e estrutura informativa, o desglose temático, ámbeto xeográfico (orixe da información), natureza e diversidade de fontes, entre outros. O propósito principal desta investigación, na que se levan analizado máis de 20 mil novas e máis de 30 mil fontes, é obter unha completa radiografía da realidade informativa. Este corpus é susceptible de numerosas aplicacións para a obtención de resultados baseados na complementariedade e interrelacionabilidade, e permite extraer conclusións sobre o tratamento informativo, estético e de linguaxe da información audiovisual en Galicia

Development of a prediction model for short-term remission of patients with Crohn’s disease treated with anti-TNF drugs

Therapy with anti-tumor necrosis factor (TNF) has dramatically changed the natural history of Crohn’s disease (CD). However, these drugs are not without adverse events, and up to 40% of patients could lose efficacy in the long term. We aimed to identify reliable markers of response to anti-TNF drugs in patients with CD. A consecutive cohort of 113 anti-TNF naive patients with CD was stratified according to clinical response as short-term remission (STR) or non-STR (NSTR) at 12 weeks of treatment. We compared the protein expression profiles of plasma samples in a subset of patients from both groups prior to anti-TNF therapy by SWATH proteomics. We identified 18 differentially expressed proteins (p ≤ 0.01, fold change ≥ 2.4) involved in the organization of the cytoskeleton and cell junction, hemostasis/platelet function, carbohydrate metabolism, and immune response as candidate biomarkers of STR. Among them, vinculin was one of the most deregulated proteins (p < 0.001), whose differential expression was confirmed by ELISA (p = 0.054). In the multivariate analysis, plasma vinculin levels along with basal CD Activity Index, corticosteroids induction, and bowel resection were factors predicting NSTR

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio

Iniciativa de pesquisa no ciberespazo lusófono - Rede para a detección de barreiras na circulación de produtos do audiovisual galego

A aplicación das novas tecnoloxías e do concepto “rede virtual” como sustento do proceso investigador, preséntase como piar básico do proxecto Lusofonía: interactividade e interculturalidade do Grupo de Estudos Audiovisuais da USC. Este proxecto, ao abeiro do programa In.ci.te de I+D, pretende localizar, a partir do estudo da recepción de produtos-modelo, as barreiras lingüísticas, culturais ou políticas que frean a circulación de produtos audiovisuais en lingua galega no espazo lusófono. Tanto a formulación inicial como a metodoloxía de traballo e mesmo a obtención de resultados artéllanse de acordo coa aplicación das tecnoloxías da Sociedade da Información ao conxunto do proceso. Créase, pois, unha intranet de xestión específica de xeito que, tanto as relacións dos membros do equipo de investigación, como as destes cos grupos parceiros e cos universos de recepción da pesquisa, conformasen unha rede de intercambio que tivese como marco de desenvolvemento o ciberespazo lusófono

Occurrence of endocrine disrupting compounds in five estuaries of the northwest coast of Spain: Ecological and human health impact

The occurrence and spatial distribution of alkylphenols (4-tert-octylphenol, 4-n-octylphenol, 4-n-nonylphenol, nonylphenol) and bisphenol A were examined in five estuaries along the Northwest coastal area of Spain. As far as we know, no previous works about this topic could be found in the literature. A total of 98 seawater samples were collected during May 2011–July 2012 and analyzed by a highly sensitive DLLME–LC–MS/MS methodology recently developed. Results indicated nonylphenol was the most ubiquitous compound with maximal concentration of 0.337 μg L−1 (Ría de Vigo). The environmental quality standards (EQS) established in Directive 2013/39/EU for 4-tert-octylphenol were slightly exceeded in some sampling points. Fishing harbours, water treatment plant and industrial discharges were supposed as the main sources of contamination. Low and medium ecological risk was determined in all estuaries. Possible endocrine effects on biota and population were estimated in terms of estrogenic activity and daily intake respectively, and no risk was found in any case.En prensa3,206

Occurrence of alkylphenols and bisphenol A in wild mussel samples from the Spanish Atlantic coast and Bay of Biscay

Wild mussels (Mytilus galloprovincialis) were selected as bioindicators of chemical pollution to evaluate the occurrence and spatial distribution of five endocrine disrupting compounds in the Spanish Atlantic coast and Bay of Biscay. A total of 24 samples were collected in May, 2011 and analysed by selective pressurized liquid extraction followed by liquid chromatography tandem mass spectrometry determination. Branched alkylphenols (4-tert-octylphenol and nonylphenol) were determined in more than 90% of the analysed samples whereas the presence of linear alkylphenols (4-n-octylphenol and 4-n-nonylphenol) was scarcely detected (< 12% of the samples). Wastewater treatment plants discharges and nautical, fishing and shipping activities were considered the primary sources of contamination by alkylphenols. Bisphenol A was found in 16% of the analysed samples associated to punctual industrial discharges. A total endocrine disrupting compound (alkylphenols and bisphenol A) average concentration of 604 ng g− 1 dw was calculated and nonylphenol was the main contributor in almost all sampling points.Versión del edito