Dyes adsorption from aqueous solutions by Chitosan

In this study the ability of chitosan to remove acid, basic, reactive and direct dyestuffs by adsorption was studied. The effect of several factors influencing dye adsorption such as dye concentration, grain size, pH and temperature were investigated. Desorption of dyes at different pH was also examined. It was shown that the adsorption capacities of chitosan were comparatively high for acid and direct dyes and that the adsorption was controlled by the acidity of the solution. The kinetics of adsorption were found to be of pseudo second order. Batch isotherm studies showed that adsorption of dyes from aqueous solution by chitosan was described by the Langmuir equation

Intermolecular interaction and solid state characterization of abietic acid/chitosan solid dispersions possessing antimicrobial and antioxidant properties

The aim of this work was to prepare and characterize solid dispersions of abietic acid (AB) and chitosan (CS) to investigate how formulation of the mixture may help in the battle against microbial colonization in different areas, such as the biomedical field or the food industry. Solid dispersions were characterized by differential scanning calorimetry, infrared spectroscopy, Raman spectroscopy, polarized optical microscopy, zeta potential and size analysis. The data showed that the dispersion/solvent evaporation method formed solid dispersions in which abietic acid was molecularly dispersed in the carrier. A synergistic effect between the two components in terms of antioxidant and antimicrobial properties was found, especially in the formulations obtained with 1/1 AB/CS molar ratio. Interestingly, the aggregation state (amorphous/crystalline) of AB seemed to affect the antimicrobial activity of the formulation, suggesting increased bioactivity when the drug was in the amorphous state. These findings, together with the demonstrated biocompatibility of the formulations, seem to open promising perspectives for a successful application of the developed AB/CS formulations in the biomedical field or in the food industry

Treatment responses to antiangiogenetic therapy and chemotherapy in nonsecreting paraganglioma (PGL4) of urinary bladder with SDHB mutation: a case report

Paraganglioma (PGL) is a rare neuroendocrine tumor. Currently, the malignancy is defined as the presence of metastatic spread at presentation or during follow-up. Several gene mutations are listed in the pathogenesis of PGL, among which succinate dehydrogenase (SDHX), particularly the SDHB isoform, is the main gene involved in malignancy. A 55-year-old male without evidence of catecholamine secretion had surgery for PGL of the urinary bladder. After 1 year, he showed a relapse of disease and demonstrated malignant PGL without evidence of catecholamine secretion with a germline heterozygous mutation of succinate dehydrogenase B (SDHB). After failure of a second surgery for relapse, he started medical treatment with sunitinib daily but discontinued due to serious side effects. Cyclophosphamide, vincristine, and dacarbazine (CVD) chemotherapeutic regimen stopped the disease progression for 7 months. Conclusion: Malignant PGL is a very rare tumor, and SDHB mutations must be always considered in molecular diagnosis because they represent a critical event in the progression of the oncological disease. Currently, there are few therapeutic protocols, and it is often difficult, as this case demonstrates, to decide on a treatment option according to a reasoned set of choices. Abbreviations: CVD = cyclophosphamide, vincristine and dacarbazine, HIF-1a = hypoxia inducible factor 1 alpha, PGL = paraganglioma, SDH = succinate dehydrogenase, VEGF = vasoendothelial growth factor

Learning to Generate Unambiguous Spatial Referring Expressions for Real-World Environments

Referring to objects in a natural and unambiguous manner is crucial for effective human-robot interaction. Previous research on learning-based referring expressions has focused primarily on comprehension tasks, while generating referring expressions is still mostly limited to rule-based methods. In this work, we propose a two-stage approach that relies on deep learning for estimating spatial relations to describe an object naturally and unambiguously with a referring expression. We compare our method to the state of the art algorithm in ambiguous environments (e.g., environments that include very similar objects with similar relationships). We show that our method generates referring expressions that people find to be more accurate ($\sim$30% better) and would prefer to use ($\sim$32% more often).Comment: International Conference on Intelligent Robots and Systems (IROS 2019), Demo 1: Finding the described object (https://youtu.be/BE6-F6chW0w), Demo 2: Referring to the pointed object (https://youtu.be/nmmv6JUpy8M), Supplementary Video (https://youtu.be/sFjBa_MHS98

Construção das redes de atenção à saúde

Módulo 5 da Capacitação de Profissionais dos Núcleos de Apoio à Saúde da Família (NASF) do Mato Grosso do Sul. A proposição da construção de Redes de Atenção à Saúde (RAS) vem para organizar conjuntos de serviços vinculados entre si por uma missão única, por objetivos comuns e por uma ação cooperativa e interdependente, que permitam ofertar uma atenção contínua e integral à determinada população. Este conteúdo trabalha a definição, os componentes e a estruturação das RAS, porém cabe aqui uma importante reflexão sobre "Qual o lugar do NASF na construção e operacionalização das RAS?