LD-plot of the region of interest in PCLO.

<p>The SNPs with the lowest P-values, rs2715147 and rs2715148 are in high LD with eachother and with rs2522833. This supports the hypothesis that either rs2522833 or a SNP in high LD with it is the most likely causal variant in this cohort.</p

Base pairs and percentage of region covered on the Sequence Capture arrays.

<p>Base pairs and percentage of region covered on the Sequence Capture arrays.</p

Haplotypes constructed using PLINK and their respective P-values.

<p>Haplotypes constructed using PLINK and their respective P-values.</p

The number of SNPs used for the epistasis analysis.

<p>The number of SNPs used for the epistasis analysis.</p

The LD-structure of <i>PCLO</i>.

<p>The LD-structure of <i>PCLO</i> shown in an r²-plot created in Haploview. The plot shows the LD-block in which the SNPs with the lowest P-values were found. Non-synonymous coding SNP rs2522833, rs2715147 and rs2715148 are in high r² with each other.</p

Linear fit for the Z-scores and correlation (√r²) between markers and rs2715147.

<p>The linear fit with Z-scores versus r relative to rs2715147, for 77 markers in <i>PCLO</i>.</p

Selected genes, their function and the number of tag SNPs required to reach 100% coverage at m.a.f.>0.1 and r2>0.8.

<p>Selected genes, their function and the number of tag SNPs required to reach 100% coverage at m.a.f.>0.1 and r2>0.8.</p

The haplotypes with the lowest P-values, per gene.

<p>The haplotypes with the lowest P-values, per gene.</p

Coverage calculated for each gene at r²>0.8 m.a.f.>0.1 before and after fine mapping.

<p>Coverage calculated for each gene at r²>0.8 m.a.f.>0.1 before and after fine mapping.</p