A turning point?: water saving technologies in north Gujarat's groundwater socio-ecology

Irrigation systemsWater conservationCrop managementVermicompostingIncomeWomenFarmers

Does prophylactic tranexamic acid reduce blood loss in Indian women following vaginal delivery?

Background: Postpartum hemorrhage (PPH) accounts for 25% to 33% of obstetric deaths every year. Anemia is a cause and consequence of PPH. Despite intense efforts to prevent anemia, many Indian women labour with low hemoglobin levels. Tranexamic acid (TXA), an antifibrinolytic, have been demonstrated to reduce blood loss and transfusion requirements in various surgeries including cesarean section. Objectives were to study the efficacy of TXA in effectively reducing blood loss in Indian women following vaginal delivery.Methods: This randomized, double-blind, placebo-controlled study was conducted on 200 patients scheduled for vaginal delivery. In addition to oxytocin 10 units, group T received TXA 15 mg/kg and group P received normal saline administered over 5 minutes. Estimated blood loss, Hemoglobin deficit, need for additional uterotonics, need for blood transfusion, incidence of PPH and adverse events were noted.Results: The fall in hemoglobin was significantly higher in group P (p<0.00001). Estimated 24 hour blood loss was significantly higher by a mean blood volume of 86.99 ml in group P compared to group T (p<0.00001). The incidence of PPH was lower in group T (2.8% versus 11.3%). There were no significant difference in the need for supplementary uterotonics (9.9% versus 15.5%) and the incidence of blood transfusion (2.8% versus 8.5%). No adverse maternal and fetal outcomes were noted.Conclusions: To reduce blood loss following vaginal delivery, TXA may be safely recommended as standard adjunct to Oxytocin for regular management of third stage of labour, especially in developing countries like India

STUDY OF RADON AND THORON CONCENTRATION IN ENVIRONMENT OF MORADABAD DISTRICT OF UTTAR PRADESH, INDIA

Purpose: A study of indoor radon and thoron has been carried out in the dwelling of Moradabad, Uttar Pradesh, India. Radon is an invisible radioactive gas that occurs naturally in the indoor atmosphere. It comes from the natural breakdown of uranium in soils and rocks. Lung cancer risk depends upon the concentration of radon, thoron and their decay product in the air. Methodology: The measurements of radon and thoron concentration were carried out by using LR-115 type II plastic track detectors (SSNTD Technique).  Findings: In the present study the value of radon concentration from10.5 Bq/m3to 30Bq/m3 with an average19.9Bq/m3and thoron concentration from 5.6 Bq/m3 to 24 Bq/m3 with an average of 14.9 Bq/m3. It is observed that radon and thoron concentration is maximum in winter and minimum during summer. The maximum concentration in winter is essentially influenced by the intense temperature inversion, which occurs in the winter season when the wind velocity is low. The maximum concentration in winter is also the result of decreased ventilation because in this season the houses are closed for a long time and radon/thoron accumulated inside the room and a weak positive correlation was observed between radon and thoron. Social Implications:  There are some difficulties in assessing the exact risks of radon in the home. Most studies have used data from miners who will have had far more exposure to radon than is likely in any building. Originality/ Novelty: This study is done at Moradabad City and Research Lab present in S.S.P. G. College Shajhanapur. Data of radon and thoron concentration has been taken from twin cup radon-thoron Dosimeter and Spark Counter

Rare peritoneal tumour presenting as uterine fibroid

Tumour arising from the uterus in the reproductive age group commonly belongs to benign category, the myoma uterus. Here we present a case report of a 22yr old primiparous mother with uterine metastasis from a rare peritoneal malignancy desmoplastic small round cell tumour who presented as uterine myoma. Desmoplastic small round cell tumour is a rare aggressive neoplasm arising from mesothelial cell, with poor prognosis. This woman presented with excessive bleeding per vaginum in the postpartum period,3months after caesarean section.24weeks  enlarged uterine mass found for which uterine artery embolisation was done in vain, later she was planned to undergo myomectomy. But due to widespread uterine mass, hysterectomy was done which led to the diagnosis of this rare neoplasm

Study of the Densities of Some R4NI - Solutions in Water - Isopropyl Alcohol Solvent Mixtures at 313.15 K by Magnetic Float Densitometerz and Then Study Masson’s Equation from Фv Data

Based on Masson's equation we study the molecular interactions between the compositions of the binary solution mixtures for different (%) compositions of Water– Isopropyl alcohol by adding tetraalkyl ammonium iodide at 313.15K. The densities of the solution mixtures (ρ¬s)have been measured very accurately by using Magnetic float Densitometer. The densitometer works on the electrostatic attraction force developed by the passage of current through a solenoid .using this technique, the densities (d¬0¬) of Water – Isopropyl alcohol solvent and mixtures of some tetra alkyl ammonium iodide, viz. Et4NI, Pr4NI, But¬4NI, Pen4NI at 0, 20, 40, 60, 80, 100% compositions (v/v) have been determined experimentally. The apparent molar volumes have been calculated from density data using Masson's equation and graph plotted between ϕv vs √c . The slopes of curves shows that in low dielectric constant medium (i.e, 20% water, =30.76 and 40% water, ∈=42.74 for all the four tetraalkyl ammonium iodide salts have positive slope. But as the dielectric constant of the solvent medium is increased by adding Water – Isopropyl alcohol, further additions of salts in the solution will start contributing towards the volume so the volume will increase on increasing the salt concentration therefore the plot ϕ¬¬¬v+ vs √c curves will give a positive and negative slope the data have been explained on the basis of dielectric constant of the solvent mixtures and size of the electrolyte ion

Drug utilization study in Cardiology outpatient department at a tertiary care hospital

Background: Cardiovascular diseases are the most frequent cause of morbidity and mortality throughout the world particularly in South Asian population. With advent of newer, highly efficacious heterogeneous drugs and changing treatment guidelines, there’s a need to identify the cardiologist preference and prescribing patterns for rational utilization.Methods: It was an open label, prospective, cross-sectional, descriptive type of study conducted in Cardiology Outpatients at a Tertiary care hospital, Navi Mumbai. The study included 100 patients suffering from cardiovascular diseases attending cardiology outpatient department from October 2016 to March 2017. Informed consent was obtained and the currently prescribed drug details were recorded from prescription. The data was analysed for WHO core prescribing indicators and different types of drugs prescribed.Results: The average number of drug products prescribed was 3.4. Most commonly prescribed drugs were Antiplatelets (23%) followed by Statins (19.71%), β blockers (16%), Nitrates (11.70%), Angiotensin converting enzyme inhibitors (8.03%), Calcium channel blockers (5.50%), Angiotensin receptor blockers (4.70%), Diuretics (2.55%), Anticoagulant (1.83%), α+β blocker (1.46%), Cardiac glycosides ((1.09%), Potassium sparing diuretic and central sympatholytics. Majority of drugs were prescribed as single drugs (79.88%) while 20.11% as fixed dose combination (FDC). The combination of Telmisartan + Hydrochlorthiazide was the commonest prescribed FDC. Majority drugs were prescribed from NEDL 2015, but documented low generic prescribing.Conclusions: Antiplatelet and Statins dominated the prescribing pattern with high prescribing trend from national essential drug list, but showed scope for improvement in encouraging the cardiologist to prescribe by generic name