4 research outputs found
Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19
- Author
- Aasiyah Rashan
- Abby Hurd
- Abdou Gai
- Abdulrahman Al-Fares
- Abhijit Duggal
- Abigail Beane
- Abubacarr Jagne
- Adam Ali
- Adam Hall
- Adam Nowinski
- Adrian Ceccato
- Adrian Streinu-Cercel
- Adrian Tey
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agamemnon Bakakos
- Agnès Meybeck
- Agnès Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ailbhe Cullen
- Ailbhe Hayes
- Aine McCarthy
- Aine McElroy
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Albert Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Notari
- Alex Browne
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexander Zoufaly
- Alexandra Bedossa
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Alexis F Turgeon
- Ali Ait Hssain
- Ali Hachemi
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Alina Kalicinska
- Aline-Marie Florence
- Alison M Meynert
- Alistair D Nichol
- Aliya Mohammed Alameen
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- Am Udara Lakshan Attanyake
- Amal Abrous
- Amanda Corley
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amar Bhatt
- Ami Stuart
- Amiel A Dror
- Amirul Asyraf
- Amna Faheem
- Amy Lester-Grant
- Amy Stone
- Ana Catarino
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Marques
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Benteson Nygaard
- Anders Tveita
- Andra-Maris Post
- Andre Real
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell'Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Dagens
- Andrew Hershey
- Andrew Letizia
- Andrew Udy
- Andrey Svistunov
- André Cabie
- André Dias
- André Roberto
- Andriy Bal
- Andy Law
- Angel Asensio
- Angel Sanchez-Miralles
- Angela Alberti
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anjellica Chen
- Ankana Satya
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anna Roca
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne Opavsky
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B Docherty
- Annmarie O Callaghan
- Ansley Hamer
- Anthony L Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Anton Prinssen
- Antoni Torres
- Antonia Ho
- Antonia Ricchiuto
- Antonio Arcadipane
- Antonio Lalueza
- Antonio Loforte
- Antonio Pesenti
- António Mesquita
- Anuraj Shankar
- Aoife Driscoll
- Aoife Kelly
- Aquiles Rodrigo Henriquez-Trujillo
- Arabella Fahy
- Ardiyan Apriyana
- Argin G
- Arianne Joy Corpuz
- Arie Zainul Fatoni
- Arjen M Dondorp
- Arnaud Scherpereel
- Arne Søraas
- Arsène Kpangon
- Arthur Garan
- Ary Serpa Neto
- Asad Usman
- Asfia Sultana
- Asgar Rishu
- Asma Moin
- Astarini Hidayah
- Atie Suwarti
- Atif Siddiqui
- Audrey Dubot-Pérès
- Aurelius Bonfasius
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Aurore Bousquet
- Axelle Braconnier
- Ayodhia Pitaloka
- B P Sanka Ruwan Sri Darshana
- Bailey Cassandra
- Bailey Williams
- Bairbre McNicholas
- Bakary K Dibba
- Bambang Pujo Semedi
- Bato Hammarström
- Beathe Kiland Granerud
- Beatrice Alex
- Beatriz Amorim Beltrão
- Behzad Nadjm
- Ben Morton
- Benedict Sim Lim Heng
- Benigno Ferreira
- Benjamin Bach
- Benjamin Lefèvre
- Benjamin Smood
- Benjamine Sarton
- Benoit Visseaux
- Benoît Roze
- Benoît Thill
- Bernard Cholley
- Bernardo Ferreira
- Bernhard Roessler
- Bertrand Dussol
- Bénédicte Lefebvre
- Bianca DeBenedictis
- Biing Horng Lee
- Birgitte Stiksrud
- Blake Mergler
- Blandine Rammaert
- Bouchra Loufti
- Bountoy Sibounheuang
- Brenda Molloy
- Brenda Reeve
- Brian Marsh
- Brigid Flynn
- Brigitte Elharrar
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bruno Sarmento Banheiro
- Bryan Whelan
- Burrell Aidan J C
- Caitriona Cody
- Calvin Wong
- Cameron J Fairfield
- Camile Bouisse
- Camille Couffignal
- Camirand-Lemyre Félix
- Caren Friedrich
- Carine Roy
- Carla Eira
- Carlos Alexandre Antunes de Brito
- Carlos Cañada Illana
- Carlos Lumbreras Bermejo
- Carlos M Luna
- Carlos Pimentel
- Carmen Infante Dominguez
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- Caroline Mudara
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- Catarina Silva
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- Catherine Chirouze
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- Tirupakuzhi Vijayaraghavan Bharath Kumar
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- Víctor Quirós González
- Vladislav Mihnovit
- Volkan Korten
- Wai Ching Sin
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Finlayson
- William Greenhalf
- Wilna Oosthuyzen
- Wils Evert-Jan
- Wim Dieperink
- Wing Yiu Ng
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yanay Gorelik
- Yaseen Arabi
- Yash Doshi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zeno Bisoffi
- Zhang Duan Tham
- Zul Amali Che Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Importance: Research diversity and representativeness are paramount in building trust, generating valid biomedical knowledge, and possibly in implementing clinical guidelines. Objectives: To compare variations over time and across World Health Organization (WHO) geographic regions of corticosteroid use for treatment of severe COVID-19; secondary objectives were to evaluate the association between the timing of publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (June 2020) and the WHO guidelines for corticosteroids (September 2020) and the temporal trends observed in corticosteroid use by region and to describe the geographic distribution of the recruitment in clinical trials that informed the WHO recommendation. Design, setting, and participants: This prospective cohort study of 434 851 patients was conducted between January 31, 2020, and September 2, 2022, in 63 countries worldwide. The data were collected under the auspices of the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC)-WHO Clinical Characterisation Protocol for Severe Emerging Infections. Analyses were restricted to patients hospitalized for severe COVID-19 (a subset of the ISARIC data set). Exposure: Corticosteroid use as reported to the ISARIC-WHO Clinical Characterisation Protocol for Severe Emerging Infections. Main outcomes and measures: Number and percentage of patients hospitalized with severe COVID-19 who received corticosteroids by time period and by WHO geographic region. Results: Among 434 851 patients with confirmed severe or critical COVID-19 for whom receipt of corticosteroids could be ascertained (median [IQR] age, 61.0 [48.0-74.0] years; 53.0% male), 174 307 (40.1%) received corticosteroids during the study period. Of the participants in clinical trials that informed the guideline, 91.6% were recruited from the United Kingdom. In all regions, corticosteroid use for severe COVID-19 increased, but this increase corresponded to the timing of the RECOVERY trial (time-interruption coefficient 1.0 [95% CI, 0.9-1.2]) and WHO guideline (time-interruption coefficient 1.9 [95% CI, 1.7-2.0]) publications only in Europe. At the end of the study period, corticosteroid use for treatment of severe COVID-19 was highest in the Americas (5421 of 6095 [88.9%]; 95% CI, 87.7-90.2) and lowest in Africa (31 588 of 185 191 [17.1%]; 95% CI, 16.8-17.3). Conclusions and relevance: The results of this cohort study showed that implementation of the guidelines for use of corticosteroids in the treatment of severe COVID-19 varied geographically. Uptake of corticosteroid treatment was lower in regions with limited clinical trial involvement. Improving research diversity and representativeness may facilitate timely knowledge uptake and guideline implementation
Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
- Author
- Abbas Syed Ali
- Abdalasalam Sabriya
- Abdalhadi Alaa Abdalfattah
- Abdalla Fadlalla Asgad Osman
- Abdalla Naana Reyam
- Abdalla Walaa
- Abdalrheem Almthani Hamza
- Abdalsalam Ashraf
- Abdeewi Saedah
- Abdelgaum Esraa Hassan
- Abdelghafar Yomna Ali
- Abdelhalim Mohamed
- Abdelkabir Mohammed
- Abdelrahman Mohammedahmed Manahil Omer
- Abdelrahman Israa
- Abdelrhman Abdallahrs Asia Atif
- Abdukahil Sheryl Ann
- Abdulbaqi Lamees Adil
- Abdulhamid Salaheddin
- Abdulhamid Widyan
- Abdulkadir Nurul Najmee
- Abdullah Duha Milad
- Abdulwahed Eman
- Abdunabi Rawad
- Abe Ryuzo
- Abebrese Franklina Korkor
- Abel Laurent
- Abodina Ahmed Mohammed
- Abrous Amal
- Absil Lara
- Abu Salem Talat Ahmed
- Abusalama Abdurraouf
- Abuzaid Tareg Abdallah
- Acharya Subhash
- Acker Andrew
- Adam Elisabeth
- Adem Safia
- Ademnou Manuella
- Adewhajah Francisca
- Adrião Diana
- Ads Alaa Mohamed
- Adusei Amos Amoako
- Afum-Adjei Awuah Anthony
- Agbogbatey Melvin
- Ahmed Khalil Reham Abdelhamid
- Ahmed Mohamed Abdelaziz Ali Mostafa
- Ahmed Aya Mustafa
- Ahmed Musaab Mohammed
- Ahmed Shakeel
- Ainscough Kate
- Airlangga Eka
- Aisa Tharwat
- Aisha Ali
- Aisha Bugila
- Akimoto Takako
- Akmal Ernita
- Akwani Chika
- Al Ageel Saleh
- Al Qasim Eman
- Al-Aquily Mohammed
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Al-Saba'a Yousef
- Alajeeli Ahmed
- Alali Ahmed
- Alalqam Razi
- Alameen Aliya Mohammed
- Alaraji Zainab Ahmed
- Alaraji Zinah A.
- Albakry Khalid
- Albatni Safa
- Alberti Angela
- Aldabbourosama Osama
- Aldhalia Amer
- Aldoukali Abdulkarim
- Alegesan Senthilkumar
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alflite Asil
- Alfoudri Huda
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhouri Ahmad Nabil
- Alhouri Hasan
- Ali Mohammed Abdelmalek Awad
- Ali Adam
- Ali Imran
- Ali Syed Muneeb
- Alidjnou Kazali Enagnon
- Aljadi Mahmoud
- Aljamal Sarah
- Alkahlout Mohammed
- Alkaseek Akram
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Almasri Lana
- Almjersah Abdulrahman
- Alqandouz Raja Ahmed
- Alrfaea Walaa
- Alrifaee Moayad
- Alsaadi Rawan
- Alshareea Entisar
- Alshenawy Eslam
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Alyasiri Mohammed Saleh
- Amaral Maria
- Amer Amro Essam
- Amira Nur
- Amuasi John
- Andini Roberto
- Andrejak Claire
- Angheben Andrea
- Angoulvant François
- Ankrah Sophia
- Ansari Muhammad Imran
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Antunes de Brito Carlos Alexandre
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Argin G.
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Ascofare Oumou Maiga
- Asensio Angel
- Ashley Elizabeth A.
- Ashraf Muhammad
- Ashraf Muhammad Sheharyar
- Asiedu-Bekoe Franklin
- Asif Namra
- Asim Mohammad
- Assi Grace
- Assie Jean Baptiste
- Asyraf Amirul
- Atangana Fouda
- Atia Ahmed
- Atif Minahel
- Atikah Ahmad Ridzuan Siti Nurul
- Atique Anika
- Atlowly Moad
- Attanyake AM Udara Lakshan
- Auchabie Johann
- Aumaitre Hugues
- Auvet Adrien
- Axelsen Eyvind W.
- Ayad Ared
- Ayadi Kamaluddin Muhammad Aisar
- Azemar Laurène
- Azizeldin Mohammed
- Azoulay Cecile
- Babatunde Hakeem
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie John Kenneth
- Baird J Kevin
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bakeer Hibah Bileid
- Bakri Ashraf
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Bandoh Irene
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S.
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrigoto Cleide
- Bartoli Marie
- Baruch Joaquin
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Batool AbdAlkarim
- Battaglini Denise
- Bauer Jules
- Bautista Rincon Diego Fernando
- Beane Abigail
- Bedossa Alexandra
- Bedu-Addo Ama Kwakyewaa
- Bee Ker Hong
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Ben Ashur Abir
- Benech Nicolas
- Benjiman Lionel Eric
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Berdeweel Lamis
- Bergeaud Delphine
- Bergin Hazel
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianchi Isabella
- Bianco Claudia
- Bichoka Sandra
- Bidin Farah Nadiah
- Bin Kamarudin Mohd Nazlin
- Binnawara Muhannud
- Binti Mohd Yakop Siti Rohani
- Binti Zaidan Nor Zaila
- Bisoffi Zeno
- Biston Patrick
- Bitker Laurent
- Bittaye Mustapha
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
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- Bolanga Ariel
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- Bolze Pierre-Adrien
- Bompart François
- Bonifasius Aurelius
- Bonney Joe
- Borges Diogo
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- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Boudoin Herwin Nanda
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Bountthasavong Latsaniphone
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O.
- Broadley Tessa
- Brotherton Helen
- Browne Alex
- Brozzi Nicolas
- Brunvoll Sonja Hjellegjerde
- Brusse-Keizer Marjolein
- Bryda Petra
- Buchtele Nina
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- Buonsenso Danilo
- Burhan Erlina
- Buri Donald
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Bævre-Jensen Roar
- Cabie André
- Cabral Susana
- Cabrita Joana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Camões João
- Campana Valentine
- Campbell Paul
- Campisi Josie
- Canepa Cecilia
- Cantero Mireia
- Caoili Janice
- Caraux-Paz Pauline
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Cárcel Sheila
- Ceccato Adrian
- Ceesay Masaneh
- Cely Lina Morales
- Cerkovnik Shelby
- Cervantes-Gonzalez Minerva
- Cevik Muge
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Charpentier Charlotte
- Chas Julie
- Chaudry Muhammad Mobin
- Chávez Iñiguez Jonathan Samuel
- Che Kamaruddin Zul Amali
- Chen Anjellica
- Chen Yih-Sharng
- Chenard Léo
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chidambaram Suresh Kumar
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
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- da Silva Filipe Ana
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- Fowler Robert A.
- Fraher Marianne
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- França Rafael Freitas de Oliveira
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- Freire Marcela Vieira
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- Hamers Raph L.
- Hamidfar Rebecca
- Hammarström Bato
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- Houltham Stuart
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- Ibáñez-Prada Elsa D.
- Ibrahim Fatima
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- Khoo Denisa
- Khoo Ryan
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- Kindgen-Milles Detlef
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- Klenerman Paul
- Klont Rob
- Knight Stephen R.
- Kobbe Robin
- Kodippily Chamira
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- Lachatre Marie
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- Laffey John G.
- Lafhej Nadhem
- Lagrange Marie
- Laine Fabrice
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- Leeming Gary
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- Lim Heng Benedict Sim
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- Lolong Navy
- Loon Leong Chee
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- Lopez-Colon Dalia
- Loschner Anthony L.
- Loubet Paul
- Loufti Bouchra
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- Loy Jia Shyi
- Lucet Jean Christophe
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- Lungu Olguta
- Lunn Miles
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- Maillet Mylène
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- Majeed Nimisha Abdul
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- Martinot Martin
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- McConnochie Rachael
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- McDonald Sarah E.
- McElroy Aine
- McElwee Samuel
- McEvoy Natalie
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- McLean Kenneth A.
- McNally Paul
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- Merckx Antoine
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- Merson Laura
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- Meyer Dan
- Meynert Alison M.
- Meysonnier Vanina
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- Mohammed Nassima Si
- Mohammedelhassan Omer Abdullah
- Mohan Shetty Dr. Rajesh
- Moharam S. A.
- Mohd Noordin Nurul Amani
- Mohd Thabit Alif Adlan
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- Moore Shona C.
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- Müller Karl Erik
- Myrodia Dimitra Melia
- Nabil Hasan Mohammad Ali
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- Nelder Matthew
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- Neto Raul
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- Nghi Anthony
- Nguyen Duc
- Niba Nerissa
- Nichol Alistair D.
- Nitayavardhana Prompak
- Nonas Stephanie
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- Notari Alessandra
- Noursadeghi Mahdad
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- Nurnaningsih Nurnaningsih
- Nusantara Dwi Utomo
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- Oh Tak-Hyuk
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- Ohshimo Shinichiro
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- Olliaro Piero L.
- Ondobo Pierre
- Ong David S. Y.
- Ong Jee Yan
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- Opavsky Anne
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- Orakzai Saijad
- Orozco-Chamorro Claudia Milena
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- Othman Eman
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- Owusu Micheal
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- Patterson Lisa
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- Paul Christelle
- Paul Mical
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- Paxton William A.
- Payen Jean-François
- Peake Sandra L.
- Peariasamy Kalaiarasu
- Peek Giles J.
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
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- Peltan Ithan D.
- Pereira Rui
- Perez Daniel
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- Pettersen Frank Olav
- Peytavin Gilles
- Philippy Fred
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- Png Hon Shen
- Poissy Julien
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- Ponscarme Diane
- Porto Diego Bastos
- Post Andra-Maris
- Postma Douwe F.
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- Pritchard Mark G.
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- Ryckaert Steffi
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- Thakur Anand
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- Thomson Emma C.
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- Tierney Paul
- Tieroshyn Vadim
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- Tirupakuzhi Vijayaraghavan Bharath Kumar
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- Turgeon Alexis F.
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- Uyeki Timothy M.
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- Vongsouvath Manivanh
- Vonkeman Harald
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Walsh Laura
- Wang Chih-Hsien
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- Wei Jia
- Wei Jia
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- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Bailey
- Williams Patricia J.
- Williams Virginie
- Wils Evert-Jan
- Wils Evert-Jan
- Wittman Jessica
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Yew Sing
- Wright Natalie
- Xian Lim Saio
- Xynogalas Ioannis
- Yamazaki Masaki
- Yang Toh Jordan Zhien
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yiaye Touxiong
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zabert Gustavo E.
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Publication date
- 30/05/2024
- Field of study
Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods: This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results: Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83-0.93]). Conclusion: Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders