Les artistes suisses à Paris

Liste complète des récompenses accordées par le jury international aux artistes suisses du groupe des beaux-arts (peinture et dessin)

Estudio de la coordinación de las protecciones por métodos computarizados aplicados al centro comercial mall del sur

En la actualidad muchas de las empresas e industrias cuentan con sistemas eléctricos antiguos que no están sujetos a una coordinación de sus protecciones eléctricas o en su defecto cuentan con coordinaciones fuera de rangos establecidos y como producto de esto se tiene desde perdidas del fluido eléctrico innecesarias hasta incendios por fallas eléctricas no despejadas correctamente. El presente trabajo de investigación trata sobre la coordinación de las protecciones eléctricas en un sistema industrial tipo Centro Comercial (Mall del Sur). Lo cual nos garantizará una alta confiabilidad en los sistemas eléctricos de distribución, el estudio consiste en la coordinación de las protecciones desde el punto de interconexión en las redes de media tensión a 13.8KV hasta las barras de carga a 480 y 220V. A nivel de 13.8KV las protecciones principales se realizan mediante relés SEL 551 y G.E 735, mientras que aguas abajo al mismo nivel de tensión se realiza la protección de los alimentadores mediante Seccionadores-Fusibles trifásicos (los fusibles utilizados son de marca INAEL), finalmente se tiene las barras a 480 y 220V las mismas que son protegidas con Breakers Cutler Hammer. La coordinación es realizada a base de curvas de fusibles, breakers y reles principales mostrando gráficamente los resultados deseados al final del estudio.ESPO

"Double eyes” sign of congenital bilateral dacryocystoceles

Dacryocystocele is caused by nasolacrimal duct obstruction and results in cystic dilatation of the proximal part of the nasolacrimal duct, which is located inferomedial to the orbit, leading to fluid accumulation. It is important to consider that persistent congenital bilateral dacryocystoceles may cause neonatal nasal obstruction resulting in respiratory difficulty, and large dacryocystoceles may require surgical drainage. Ultrasonography demonstrates that congenital bilateral dacryocystoceles and normal eyeballs prenatally resemble two pairs of cystic "lesions” of different sizes. We herein present a case of prenatally diagnosed isolated congenital bilateral dacryocystoceles and propose the new name of "double eyes” sign for this rare condition to create an impact on medical students and resident

Isolated gestational proteinuria preceding the diagnosis of preeclampsia : an observational study

Introduction. Some pregnant women develop significant proteinuria in the absence of hypertension. However, clinical significance of isolated gestational proteinuria (IGP) is not well understood. This study aimed to determine the prevalence of IGP in singleton pregnancies and the proportion of women with IGP who subsequently developed preeclampsia (IGP-PE) among all PE cases. Material and methods. This was an observational study of 6819 women with singleton pregnancies at 12 centers, including 938 women with at least once determination of protein-to-creatinine ratio (P/Cr). Significant proteinuria in pregnancy (SPIP) was defined as P/Cr (mg/mg) level >0.27. IGP was defined as SPIP in the absence of hypertension. Gestational hypertension (GH) preceding preeclampsia (GH-PE) was defined as preeclampsia (PE) in which GH preceded SPIP. Simultaneous PE (S-PE) was defined as PE in which both SPIP and hypertension occurred simultaneously. Results. IGP and PE were diagnosed in 130 (1.9%) and 158 (2.3%) of 6819 women, respectively. Of 130 women with IGP, 32 (25%) progressed to PE and accounted for 20% of all women with PE. Hence, women with IGP had a relative risk of 13.1 (95% CI; 9.2-18.5) for developing PE compared with those without IGP [25% (32/130) vs. 1.9% (126/6689)]. At diagnosis of SPIP, P/Cr levels already exceeded 1.0 more often in women with S-PE than in those with IGP-PE [67% (33/49) vs. 44% (14/32), respectively, p = 0.031]. Conclusions. IGP is a risk factor for PE, and IGP-PE accounts for a considerable proportion (20%) of all PE

Design side by side

The starting point for most of what is written here is people with disabilities. Situations of great difficulty need to be highly prioritized, for their own sake and also because that which first appears to be “special” sooner or later comes to benefit s

L’Ange du foyer : regards féminins sur les Indiennes au XIXe siècle

Cette étude analyse, à travers deux romans, comment les Françaises ont vu les Indiennes depuis le XIXe siècle jusqu’au XXIe siècle et comment cette vision était utilisée pour encourager les femmes françaises à se libérer de la domination masculine.  Il s’agit une recherche exploratoire et comparée entreprise pour analyser non seulement la condition de la femme en France à travers les siècles, mais aussi celle en Inde aux mêmes époques. Nena-Sahib ou l’insurrection des Indes, écrit en 1857 par Clémence Robert, et Dans la ville d’or et d’argent, rédigé par Kénizé Mourad en 2010, sont les deux romans qui présentent, implicitement ou explicitement, les différences dans la condition féminine des deux pays, voire des deux continents.  À travers l’analyse de ces deux romans, en évoquant la théorie de Simone de Beauvoir et celle de Elaine Showalter, nous avons pu observer une célébration de la transcendance de la femme subalterne colonisée par rapport à l'immanence du colonisateur blanc. Mots-clefs : Awadh. Britanniques. Insurrection. Hazrat Mahal. Nana Sahib.  Angels in the house : feminine writings on 19th century Indian Women Abstract : This study analyses, through two novels, how the French women saw the Indian women from the 19th century to the 21st century and how this vision was used to encourage French women to free themselves from male domination. It is a explorative and comparative research undertaken to analyse not only the condition of women in France through the centuries but also that of India during the same period. Nena-Sahib ou l’insurrection des Indes written in 1857 by Clemence Robert and Dans la ville d’or et d’argent by Kénizé Mourad in 2010 are the two novels that present, either implicitly or explicitly, the difference in the conditions of women in the two countries, or even two continents. To analyse these two novels, we, by evoking the theory of Simone de Beauvoir and that of Elaine Showalter, are able to osberve the celebration of the transcendence of the colonised subaltern woman vis-à-vis the immanence of the white coloniser. Keywords : Awadh. Britains. Insurrection. Hazrat Mahal. Nana Sahib.  O anjo do lar : olhares femininos sobre as Indianas no século XIX Resumo :Este estudo analisa, através de dois romances, como as Francesas têm visto as Indianas desde o século XIX até o século XXI e como essa visão era usada para encorajar as mulheres francesas a se libertarem da dominação masculina. Trata-se de uma pesquisa exploratória e comparativa realizada para analisar não só a condição feminina na França ao longo dos séculos, mas também a da Índia nas mesmas épocas. Nena-Sahib ou l’insurrection des Indes, escrito em 1857 por Clémence Robert, e Dans la ville d’or et d’argent, escrito por Kenizé Mourad em 2010, são os dois romances que apresentam, implícita ou explicitamente, as diferenças no status feminino dos dois países, ou de ambos os continentes. Através da análise desses dois romances, evocando a teoria de Simone de Beauvoir e a de Elaine Showalter, pudemos observar uma celebração da transcendência da mulher subalterna colonizada em relação à imanência do colonizador branco. Palavras-chave : Awadh. Britânicos. Insurreição. Hazrat Mahal. Nana Sahib.  El ángel del hogar : miradas femeninas sobre las Indias en el siglo XIX Resumen :Este estudio analiza, a través de dos novelas, como las francesas han visto a las Indias desde el siglo XIX hasta el siglo XXI y cómo esa visión era usada para alentar a las mujeres francesas a liberarse de la dominación masculina. Se trata de una investigación exploratoria y comparativa realizada para analizar no sólo la condición femenina en Francia a lo largo de los siglos, sino también la de la India en las mismas épocas. Nena-Sahib ou l’insurrection des Indes, escrita em 1857 por Clémence Robert, y Dans la ville d’or et d’argent, escrito por Kenizé Mourad en 2010, son las dos novelas que presentan, implícita o explícitamente, las diferencias en el estatus femenino de los dos países, o de ambos continentes. A través del análisis de estas dos novelas, evocando la teoría de Simone de Beauvoir y la de Elaine Showalter, pudimos observar una celebración de la trascendencia de la mujer subalterna colonizada en relación a la inmanencia del colonizador blanco. Palabras-clave : Awadh. Británicos. Insurrección. Hazrat Mahal. Nana Sahib.

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Intracellular Ca2+ Imbalance Critically Contributes to Paraptosis

Paraptosis is a type of programmed cell death that is characterized by dilation of the endoplasmic reticulum (ER) and/or mitochondria. Since paraptosis is morphologically and biochemically different from apoptosis, understanding its regulatory mechanisms may provide a novel therapeutic strategy in malignant cancer cells that have proven resistant to conventional pro-apoptotic treatments. Relatively little is known about the molecular basis of paraptosis, but perturbations of cellular proteostasis and ion homeostasis appear to critically contribute to the process. Ca2+ transport has been shown to be important in the paraptosis induced by several natural products, metal complexes, and co-treatment with proteasome inhibitors and certain Ca2+-modulating agents. In particular, the Ca2+-mediated communication between the ER and mitochondria plays a crucial role in paraptosis. Mitochondrial Ca2+ overload from the intracellular Ca2+-flux system located at the ER-mitochondrial axis can induce mitochondrial dilation during paraptosis, while the accumulation of misfolded proteins within the ER lumen is believed to exert an osmotic force and draw water from the cytoplasm to distend the ER lumen. In this process, Ca2+ release from the ER also critically contributes to aggravating ER stress and ER dilation. This review focuses on the role of Ca2+ transport in paraptosis by summarizing the recent findings related to the actions of Ca2+-modulating paraptosis-inducing agents and discussing the potential cancer therapeutic strategies that may effectively induce paraptosis via Ca2+ signaling

La bibliothèque de Johann Philipp von Wessenberg-Ampringen : un don fondateur de l’identité européenne de la BNU

Portrait gravé de Johann Philipp von Wessenberg-Ampringen dans la biographie que lui a consacré Alfred von Arneth en 1898 (Johann Freiherr von Wessenberg: ein österreichischer Staatsmann des neunzehnten Jahrhunderts, Wien, W. Braumüller ; coll. BNU) Cliché Jean-Pierre Rosenkranz Avant-propos Comment éclairer la personnalité de celui qui se cache derrière la collection de livres ? Dans le cas du baron Johann Philipp von Wessenberg, il est particulièrement important de tenir compte de la situa..