Experimental determination of the roughness functions of marine coatings

The aim of this paper is to determine the roughness functions of different marine coatings, including two novel FOUL-X-SPEL paints and two existing commercial coatings, and two control surfaces, using the overall method of Granville (1987). An extensive series of towing tests of flat plates coated with different antifouling coatings was carried out at the Kelvin Hydrodynamics Laboratory (KHL) of the University of Strathclyde. The tests were designed to examine the as applied drag performances of FOUL-X-SPEL paints and compare them with two existing reference paints and two control surfaces. The surface roughness amplitude parameters of all of the test surfaces were measured using a hull roughness analyser. In total over 150 runs were carried out, including a series of repeat tests designed to quantify the uncertainty in the results. The drag coefficients and roughness function values of each surface were evaluated along with the uncertainty limits

The outcome of 41 Late-Diagnosed Turkish GA-1 Patients: A Candidate for the Turkish NBS

Background: Glutaric aciduria type 1(GA-1) is an inherited cerebral organic aciduria. Untreated patients with GA-1 have a risk of acute encephalopathic crises during the first 6 years of life. In so far as GA-1 desperately does not exist in Turkish newborn screening (NBS) program, most patients in our study were late-diagnosed. / Method: This study included 41 patients diagnosed with acylcarnitine profile, urinary organic acids, mutation analyses in the symptomatic period. We presented with clinical, neuroradiological, and molecular data of our 41 patients. / Results: The mean age at diagnosis was 14.8 13.9 (15 days to 72 months) and, high blood glutaconic acid, glutarylcarnitine and urinary glutaric acid (GA) levels in 41 patients were revealed. Seventeen different mutations in the glutaryl-CoA dehydrogenase gene were identified, five of which were novel. The patients, most of whom were late-diagnosed, had a poor neurological outcome. Treatment strategies made a little improvement in dystonia and the frequency of encephalopathic attacks. / Conclusion: All GA-1 patients in our study were severely affected since they were latediagnosed, while others show that GA-1 is a treatable metabolic disorder if it is diagnosed with NBS. This study provides an essential perspective of the severe impact on GA-1 patients unless it is diagnosed with NBS. We immediately advocate GA-1 to be included in the Turkish NBS

The influence of nonlinearities on the symmetric hydrodynamic response of a 10,000 TEU Container ship

The prediction of wave-induced motions and loads is of great importance for the design of marine structures. Linear potential flow hydrodynamic models are already used in different parts of the ship design development and appraisal process. However, the industry demands for design innovation and the possibilities offered by modern technology imply the need to also understand the modelling assumptions and associated influences of nonlinear hydrodynamic actions on ship response. At first instance, this paper presents the taxonomy of different Fluid Structure Interaction (FSI) methods that may be used for the assessment of ship motions and loads. Consequently, it documents in a practical way the effects of weakly nonlinear hydrodynamics on the symmetric wave-induced responses for a 10,000TEU Container ship. It is shown that the weakly nonlinear FSI models may be useful for the prediction of symmetric wave-induced loads and responses of such ship not only in way of amidships but also at the extremities of the hull. It is concluded that validation of hydrodynamic radiation and diffraction forces and their respective influence on ship response should be especially considered for those cases where the variations of the hull wetted surface in time may be noticeable

Global wave loads on a damaged ship

A computational tool was applied based on a two dimensional linear method to predict the hydrodynamic loads for damaged ships. Experimental tests on a ship model have also been carried out to predict the hydrodynamic loads in various design conditions. The results of the theoretical method and experimental tests are compared to validate the theoretical method. The extreme wave induced loads have been calculated by short term prediction. For the loads in intact condition, the prediction with duration of 20 years at sea state 5 is used, while for loads in damaged conditions the prediction in 96 hours exposure time at sea 3 is used. The maximum values of the most probable extreme amplitudes of dynamic wave induced loads in damaged conditions are much less than those in intact condition because of the reduced time. An opening could change the distribution of not only stillwater bending moment but also wave-induced bending moment. It is observed that although some cross sections are not structurally damaged, the total loads acting on these cross sections after damage may be increased dramatically compared to the original design load in intact condition

The effect of spacing on the vortex-induced vibrations of two tandem flexible cylinders

Vortex-induced vibrations (VIV) of two flexible cylinders arranged in tandem are studied using a two-way fluidstructure interaction (FSI) method with different spacing ratios (Sx/D) at Reynolds number Re = 500 using a twoway fluid-structure interaction (FSI) method. The main objective of this study is to investigate the effect of spacing on the hydrodynamic interactions and the VIV responses of these cylinders. The responses of the two flexible cylinders are found to be similar to the classical VIV responses at small Sx/D. Once Sx/D is large enough for the vortices to become detached from the upstream cylinder, the response of the upstream cylinder is similar to the typical VIV response whereas the downstream cylinder undergoes wake-induced vibration (WIV). The characteristics of the response of the downstream cylinder in the present study are similar to those of the first two response regimes classified by previous researchers. The third regime is not observed for the flexible downstream cylinder with both ends fixed. The two changes in the phase relation between the cross-flow displacements of the two tandem flexible cylinders are discovered to be linked with the initial-upper branch transition and the upperlower branch transition, respectively. The correlation lengths of the two flexible cylinders decrease significantly in the transition range between the upper and lower branches. Three modes of vortex shedding (2S, P + S and 2P) have been identified in the present study. The upper-branch 2P mode is found to be associated with largeamplitude vibration of the upstream cylinder and the P + S mode is observed to be related to large-amplitude vibration of the downstream cylinder for Sx/D = 3.5 and 5. On the other hand, the lower-branch 2P mode leads to small-amplitude vibration of the downstream cylinder in the post-lock-in range at Sx/D = 2.5. The relative phase shifts of the sectional lift coefficients on different spanwise cross sections can be attributed to the variation of the vortex shedding flow along the flexible cylinders, and these phase shifts result in poor phasing between the forces and the displacements which is related to the decrease of the correlation lengths

Posterior reversible encephalopathy syndrome in a child with cyclical vomiting and hypertension: a case report

<p>Abstract</p> <p>Introduction</p> <p>Posterior reversible encephalopathy syndrome is characterized by headache, nausea and vomiting, seizures and visual disturbances. It has certain characteristic radiological features, which allow diagnosis in the appropriate clinical setting and enable appropriate clinical therapy to be instituted.</p> <p>Case presentation</p> <p>A 10-year-old Caucasian girl who was hospitalized due to recurrent vomiting was diagnosed as having posterior reversible encephalopathy syndrome after an initial diagnosis of cyclical vomiting and hypertension was made.</p> <p>Conclusion</p> <p>Posterior reversible encephalopathy syndrome is a rare disorder in children. Early recognition of characteristic radiological features is key to the diagnosis as clinical symptoms may be non-specific or mimic other neurological illnesses. To the best of our knowledge this is the first case to report an association between posterior reversible encephalopathy syndrome, cyclical vomiting and hypertension. Furthermore, in this case, the resolution of the abnormalities found on magnetic resonance imaging over time did not appear to equate with clinical recovery.</p

Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome

Defective primary ciliogenesis or cilium stability forms the basis of human ciliopathies, including Joubert syndrome (JS), with defective cerebellar vermis development. We performed a high-content genome wide siRNA screen to identify genes regulating ciliogenesis as candidates for JS. We analyzed results with a supervised learning approach, using SYSCILIA gold standard, Cildb3.0, a centriole siRNA screen and the GTex project, identifying 591 likely candidates. Intersection of this data with whole exome results from 145 individuals with unexplained JS identified six families with predominantly compound heterozygous mutations in KIAA0586. A c.428del base deletion in 0.1% of the general population was found in trans with a second mutation in an additional set of 9 of 163 unexplained JS patients. KIAA0586 is an orthologue of chick Talpid3, required for ciliogenesis and sonic hedgehog signaling. Our results uncover a relatively high frequency cause for JS and contribute a list of candidates for future gene discoveries in ciliopathies