Parallelization of Reconstructability Analysis Algorithms.

Bush Jones published a series of papers providing sequential algorithms that are key to reconstructability analysis. These algorithms include the determination of unbiased reconstructions and a greedy algorithm for a generalization of the reconstruction problem. The implementation of these sequential algorithms provide scientists and mathematicians with the means of utilizing reconstructability analysis in systems modeling. The algorithms, however, are so computationally intensive that the system is limited to a very small set of variables. Many papers have been written applying reconstructability analysis and maximum entropy methods to various disciplines. Reconstructability analysis has the potential of dramatically impacting the scientific community, but the sequential algorithms leave the utilization of reconstructability analysis infeasible. The author has parallelized the reconstructability analysis algorithms developed by Jones, thereby, bridging the gap between theoretical application and feasible implementation. Since the goal of parallelization of these reconstructability analysis algorithms is to make them feasible to as many researchers as possible, a specific architecture is not assumed. It is assumed that the architecture employed is a multiple data architecture. That is, the architectural design needed for the implementation of these algorithms must have memory local to each processing element (PE). The parallel algorithms developed and presented here do not address the problems of communications between processors of particular architectures. These algorithms assume a reconfigurable bus system which is a bus system whose configuration can be dynamically altered thus allowing broadcasting and long-distance communications to be completed in constant time. It is noted that processor arrays with such reconfigurable bus systems have been designed. Frequently, parallel algorithms do not address the situation in which the number of values on which to operate is larger than the number of processors. However, since the purpose of the parallelization of these reconstructability analysis algorithms is to make them feasible for large structure systems, the parallelization given does address the situation in which the number of values on which to operate is larger than the number of processors available. Therefore, implementation of the algorithms involves simply incorporating the communication protocols between processors for the particular architecture employed

Making metals in East Africa and beyond: archaeometallurgy in Azania, 1966-2015

Over the course of the last 50 years, the field of archaeometallurgy has grown dramatically, becoming firmly established within the realm of archaeological science. The archaeology and ethnography of African metallurgy has made a major contribution to this field, providing valuable information on the impressive range of raw materials and techniques that past metal producers and metalworkers used, as well as providing important insights into the socio-cultural settings that these technologies operated within. This paper summarises the role that Azania played in communicating some of this research, and charts the development of African archaeometallurgy through Azania’s pages

Generation and manipulation of magnetic droplets

This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the Italian Union of Thermofluid dynamics, the Process Intensification Network, HEXAG - the Heat Exchange Action Group and the Institute of Mathematics and its Applications.The continuous flow generation and downstream manipulation of magnetic droplets inside a microfluidic device was investigated. Magnetic droplets were generated from aqueous ferrofluids in organic oil phase using T-junction and flow-focusing geometries in glass microfluidic devices. Due to the hydrophilic nature of glass surfaces, it was necessary to apply a hydrophobic coating in the form fluorocarbons. The size of the magnetic droplets and distance between them were controlled by adjusting the relative flow velocities of ferrofluid and oil carrier liquid. Two modes of droplet manipulation were investigated by placing small permanent magnets in the vicinity of the microfluidic channels: (i) droplet deflection across a flow chamber which could be used for sorting of droplets based on the magnetic field applied and (ii) droplet splitting at a branching junction resulting in two daughter droplets of high and low magnetite content.This study is funded by The University of Kuwait

Human chorionic gonadotropin isoforms in the diagnosis of ectopic pregnancy

This paper has set the scene for re-defining clinical chemistry data for the diagnosis of ectopic pregnancy. Indeed it has proved some assumptions on hCG levels to be false. Professor Iles was/is the principal investigator on these studies

Determination of the glycoforms of human chorionic gonadotropin b-core fragment by matrix-assisted laser desoption/ionisation time of flight mass spectrometry

Background: Metabolism of human chorionic gonadotropin (hCG) in the serum and kidney yields the terminal urinary product hCG ß-core fragment (hCGßcf), comprising two disulfide-linked peptides (ß6-ß40 and ß55-ß92) of which one (ß6-ß40) retains truncated N-linked sugars. Hyperglycosylated hCGßcf may indicate choriocarcinoma or Down syndrome, but the glycosylation profile of hCGßcf has not been thoroughly evaluated. Methods: hCGßcf, purified from pregnancy urine, was reduced by "on-target" dithiothreitol (DTT) reduction and analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The mass ([M+H]+) of the primary sequence of the glycosylated peptide ß6-ß40 was subtracted from the m/z values of the discrete peaks observed to give the masses of the carbohydrate moieties. Carbohydrate structure was predicted by sequentially subtracting the masses of the monosaccharide residues corresponding to N-linked carbohydrates of the hCG ß-subunit reported in the literature. Results: Mass spectra of hCGßcf revealed a broad triple peak at m/z 8700–11300. After reduction, the triple peak was replaced by a discrete set of peaks between m/z 4156 and 6354. A peak at m/z 4156.8 corresponded to the nonglycosylated peptide (ß55-ß92). The remaining nine peaks indicated that urinary hCGßcf comprises a set of glycoforms smaller and larger than the trimannosyl core. Conclusions: hCGßcf comprises a wider set of glycoforms than reported previously. Peaks of highest mass indicate evidence of hyperglycosylated carbohydrate moieties. The data support previous reports that hCGßcf oligosaccharides lack sialic acid and galactose residues. No indication was found of a ß6-ß40 peptide that was entirely devoid of carbohydrate

The 2021 NICE guidelines for assessment and management of chronic pain: A cross-sectional study mapping against a sample of 1,000* in the community

Objectives To characterise the prevailing pharmacological and non-pharmacological pain management strategies among adults with chronic pain, comparing these against the newly published NICE guidelines NG-193, and examine these pre-NG-193 pain management strategies in relation to pain severity, pain interference, sleep quality and mental health outcomes. Design This study was conducted using a cross-sectional online survey study design. Setting This study was conducted on a community-dwelling cohort. Participants Adults aged 18+, living in the UK, with diagnosis of chronic pain by a health care professional. Main outcome measures Primary outcomes were characterisation of the pain management strategies utilised. Secondary outcomes were related to pain severity, pain interference, sleep quality, depression and anxiety via validated self-report measures. Results Several strategies were employed by respondents to manage their chronic pain condition including physical therapy, exercise, psychological therapy and pharmacological therapy. The data also indicated a high level of joint-care planning among patients and their clinicians. Some group differences were found in relation to pain, sleep and mental health outcomes. Conclusion This study set a comparative starting baseline to which the efficacy of the NG-193 may be compared in future years. There is evidence that NICE recommendations are being followed for the management of chronic primary pain conditions; however, pharmacological use of opioid drugs is still reported by 47%. Despite the confirmed evidence in this study of small efficacy of chronic pain by pharmacological agent, the reduction in the use of pain relief medications be it over the counter medications or prescription opioids, as recommended by NG-193, may be slow to be adopted. The data suggest that more care provision is needed to meet the recommendations around pharmacological management and review