IZQUIERDA ARMADA Y GÉNERO EN EL RÍO DE LA PLATA DURANTE LOS 60 Y 70: UN ESTADO DE LA CUESTIÓN

Este artículo propone una revisión y síntesis crítica de la producción historiográfica sobre las izquierdas armadas de los sesenta y setenta en el Río de la Plata desde una perspectiva de historia del género, la familia y la sexualidad en relación a lo político. El foco está puesto en la manera en que los procesos de modernización sociocultural de la familia y la sexualidad interpelaron al campo de las izquierdas, produciendo ambivalencias y disputas que entrelazaron lo personal y lo político. La primera sección del artículo aborda las concepciones y prácticas en torno a la sexualidad y la familia a mediados de siglo. La segunda parte analiza algunos de los trabajos más relevantes acerca de las izquierdas armadas en Argentina y Uruguay. El artículo pone de relieve la creciente complejidad en los abordajes y marcos teóricos utilizados, y traza el mapa de una agenda de investigación en ciernes

D2.6 Compiled proceedings of Annual Conferences

This document collects the proceedings of the 3 Annual Conferences and the Final Conference as organised under SHERPA. It brings together the main contributions from interventions and keynote speeches during these conferences, as well as from the interactive sessions

La incorporación de la voz del alumnado en el desarrollo de una estructura curricular modular. La experiencia del grado de educación social en la UPV-EHU

Con el objetivo de acercar las prácticas universitarias al discurso de democratización educativa, este artículo recoge la experiencia de la incorporación de la voz del alumnado en el desarrollo de la estructura modular del Grado de Educación Social de la UPV-EHU. Centrándonos en un análisis del efecto de la incorporación de la voz del alumnado en las estructuras organizativas, en diferentes contextos, en su propio aprendizaje y en el cambio de las prácticas docentes, hemos intentado desvelar el sentido otorgado a la participación del alumnado en la vida formativa y universitaria, detectar los claroscuros que se visualizan a su acción como sujeto y analizar el efecto producido en su aprendizaje.With the aim of bringing university practices to address educational democratization, this article describes the experiences of incorporating student voice in the development of the modular structure of Social Education degree from the UPV-EHU. Focusing on an analysis of the effect of the incorporation of student voice in organizational structures, in different contexts, in their own learning and changing teaching practices, we tried to reveal the meaning given to student participation in the life training and university detect shades that are displayed to its action as a subject and analyze the effect on their learning

Use of Placental MSCs and their exosomes as theragnostic agents for cancer treatment and diagnostic.

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Epidemiological, clinical and economic burden of alopecia areata in Spain: a real-world retrospective study. The PETALO study

Background: Alopecia areata (AA) is a chronic autoimmune disease that causes non-scarring hair loss. Data are lacking on the epidemiology and clinical and economic burden of AA in Spain. Objectives: To estimate the prevalence and incidence of AA in Spain and describe sociodemographic and clinical characteristics, treatment patterns, healthcare resource utilization (HCRU) and associated costs. Materials & Methods: This was an observational, retrospective, descriptive study based on the Health Improvement Network (THIN (R)) database (Cegedim Health Data, Spain). Patients with ICD9-Code 704.01 for AA, registered between 2014 and 2021, were identified. Prevalence (%) and incidence rates per 1,000 patient-years (IR) of AA were calculated and clinical characteristics, treatment characteristics and HCRU/costs were assessed. Results: A total of 5,488 patients with AA were identified. The point prevalence of AA in 2021 was 0.44 (95% confidence interval [CI]: 0.43-0.45) overall, 0.48 (0.47-0.49) in adults, and 0.23 (0.21-0.26) in children <= 12 years. The 2021 IR for AA in adults was 0.55 (0.51-0.60). Of 3,351 adults with AA, 53.4% were female, mean (standard deviation [SD]) age was 43.1 (14.7) years, and 41.6% experienced comorbidities. Among adults, 2.7% used systemic treatment (0.5% immunosuppressants, 2.5% oral corticosteroids, 0.3% both). Laboratory tests and health care professional visits were the principal drivers of cost, which was 821.2 (1065.6)/patient in the first year after diagnosis. Conclusion: The epidemiology of AA in Spain is comparable with that reported for other countries, being more prevalent among adults. There is a significant burden of comorbidities and cost for patients, with limited use of systemic treatments, suggesting an unmet treatment need in this population

Preparación del claustro de Educación Física para impartir la asignatura en función del modelo del profesional en la Carrera de Medicina

Introduction: in all generations of syllabuses, Physical Education has been decontextualized from the majors; as a tendency, a traditional approach is maintained as based on the teaching of sports and centered on the development of sports and physical skills, on forming values and habits of systematically practicing physical and sports activities as a means to improve health, but which is poorly related with the professional profiles of each graduate. Objective: to design a professional self-improvement program for Physical Education I professors in the Medicine major of Pinar del Río University of Medical Sciences, in order to contribute with the integration of contents taking into account the professional model. Material and method: a pedagogical kind study supported on dialectic-materialist method was carried out, because of its capacity to integrate qualitative and quantitative features, which allowed determining empirical, theoretical and statistical methods. Observation and surveys were included into the first group. Historical-logical, systemic-structural and documentary review into de second group which allowed collecting information about the faculty training regarding the research problem. Results: the faculty has an inadequate didactical preparation when teaching the subject of Physical Education I, regarding integration of contents, which may contribute to the profile of the coming health professional’s profile. We determined the needs overcoming these. Conclusions: from the results obtained, a postgraduate degree or diploma will be proposed to improve the preparation of the Physical Education faculty, being able to link the subject with the profile of the Medicine major graduate.Introducción: en todas las generaciones de planes de estudios, la Educación Física ha estado descontextualizada de las carreras; como tendencia se mantiene un enfoque tradicional basado en la enseñanza del deporte y centrado en el desarrollo de habilidades deportivas y capacidades físicas, en la formación de valores y hábitos de práctica sistemática de actividades físico-deportivas como medios para el mejoramiento de la salud, pero poco se relaciona directamente con el perfil de salida de cada egresado. Objetivo: diseñar un programa de superación profesional para los docentes de la asignatura Educación Física I de la Carrera de Medicina de la Universidad de Ciencias Médicas de Pinar del Río que contribuya a la integración de los contenidos en función del modelo del profesional. Material y método: se realizó un estudio de corte pedagógico sustentado en el método dialéctico materialista, por su capacidad de integrar lo cualitativo y cuantitativo, permitió determinar los métodos del nivel empírico, teórico y los estadísticos. Dentro del primer grupo la observación y las encuestas, en el segundo grupo el histórico lógico, sistémico estructural, y la revisión documental, que permitió recoger información acerca de la preparación de los docentes en cuanto al problema de investigación. Resultados: los docentes poseen una insuficiente preparación didáctica a la hora de impartir la asignatura de Educación Física I para la integración de los contenidos, que tribute al perfil de formación del futuro profesional de la salud. Se determinaron las necesidades de superación de estos. Conclusiones: a partir de los resultados obtenidos se propondrá un posgrado o diplomado para elevar la preparación del claustro de Educación Física, logrando vincular la asignatura con el perfil del egresado de la carrera de Medicina

ICTs as a tool in the teaching of history: Proposals to approach the Middle Ages

El presente trabajo pretende reflexionar sobre los desafíos que la sociedad atravesada por las tecnologías le presenta a las prácticas educativas. Para esto nos introduciremos en el contexto uruguayo y en el Plan CEIBAL específicamente, como ejemplo de una política educativa que busca acompasar la educación con la realidad actual. Como futuros docentes de Historia, nos interesa profundizar en la educación en y con las tecnologías como alternativa didáctica para superar las dificultades pedagógicas que se plantean a partir de los obstáculos historiográficos que presenta la Edad Media.This paper intends to reflect upon the challenges that society, crossed by technologies, presents to educational practices. For this purpose, we immerse ourselves in the Uruguayan context, particularly in «Plan CEIBAL», as an example of an educational policy that seeks to encompass education with today’s reality. As future History teachers, we find it interesting to go deeper into education in and with technologies as a methodological alternative to overcome the pedagogical difficulties that arise from the historiographical obstacles presented by the Middle Ages.Dossier: Las nuevas tecnologías en la enseñanza de la historia: contexto, crítica y balance provisorioFacultad de Humanidades y Ciencias de la Educació

Human placenta-derived mesenchymal stem cells stimulate neuronal regeneration by promoting axon growth and restoring neuronal activity

In the last decades, mesenchymal stem cells (MSCs) have become the cornerstone of cellular therapy due to their unique characteristics. Specifically human placenta-derived mesenchymal stem cells (hPMSCs) are highlighted for their unique features, including ease to isolate, non-invasive techniques for large scale cell production, significant immunomodulatory capacity, and a high ability to migrate to injuries. Researchers are exploring innovative techniques to overcome the low regenerative capacity of Central Nervous System (CNS) neurons, with one promising avenue being the development of tailored mesenchymal stem cell therapies capable of promoting neural repair and recovery. In this context, we have evaluated hPMSCs as candidates for CNS lesion regeneration using a skillful co-culture model system. Indeed, we have demonstrated the hPMSCs ability to stimulate damaged rat-retina neurons regeneration by promoting axon growth and restoring neuronal activity both under normoxia and hypoxia conditions. With our model we have obtained neuronal regeneration values of 10%–14% and axonal length per neuron rates of 19-26, μm/neuron. To assess whether the regenerative capabilities of hPMSCs are contact-dependent effects or it is mediated through paracrine mechanisms, we carried out transwell co-culture and conditioned medium experiments confirming the role of secreted factors in axonal regeneration. It was found that hPMSCs produce brain derived, neurotrophic factor (BDNF), nerve-growth factor (NGF) and Neurotrophin-3 (NT-3), involved in the process of neuronal regeneration and restoration of the physiological activity of neurons. In effect, we confirmed the success of our treatment using the patch clamp technique to study ionic currents in individual isolated living cells demonstrating that in our model the regenerated neurons are electrophysiologically active, firing action potentials. The outcomes of our neuronal regeneration studies, combined with the axon-regenerating capabilities exhibited by mesenchymal stem cells derived from the placenta, present a hopeful outlook for the potential therapeutic application of hPMSCs in the treatment of neurological disorders.post-print2885 K

The AtCathB3 gene, encoding a cathepsin B-like protease, is expressed during germination of Arabidopsis thaliana and transcriptionally repressed by the basic leucine zipper protein GBF1

© The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/ ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.Protein hydrolysis plays an important role during seed germination and post-germination seedling establishment. In Arabidopsis thaliana, cathepsin B-like proteases are encoded by a gene family of three members, but only the AtCathB3 gene is highly induced upon seed germination and at the early post-germination stage. Seeds of a homozygous T-DNA insertion mutant in the AtCathB3 gene have, besides a reduced cathepsin B activity, a slower germination than the wild type. To explore the transcriptional regulation of this gene, we used a combined phylogenetic shadowing approach together with a yeast one-hybrid screening of an arrayed library of approximately 1200 transcription factor open reading frames from Arabidopsis thaliana. We identified a conserved CathB3-element in the promoters of orthologous CathB3 genes within the Brassicaceae species analysed, and, as its DNA-interacting protein, the G-Box Binding Factor1 (GBF1). Transient overexpression of GBF1 together with a PAtCathB3::uidA (β-glucuronidase) construct in tobacco plants revealed a negative effect of GBF1 on expression driven by the AtCathB3 promoter. In stable P35S::GBF1 lines, not only was the expression of the AtCathB3 gene drastically reduced, but a significant slower germination was also observed. In the homozygous knockout mutant for the GBF1 gene, the opposite effect was found. These data indicate that GBF1 is a transcriptional repressor of the AtCathB3 gene and affects the germination kinetics of Arabidopsis thaliana seeds. As AtCathB3 is also expressed during post-germination in the cotyledons, a role for the AtCathB3-like protease in reserve mobilization is also inferred.Peer reviewe