SERUM AND URINE LEUCINE RICH ALPHA-2-GLYCOPROTEIN-1 IS ASSOCIATED WITH KIDNEY TRANSPLANT INJURY AND FAILURE

Affiliations are different in Web of Science publication and original journal publication. Here are given the affiliations provided in Nephrology Dialysis Transplantation publication because they are more accurate.publishersversionPeer reviewe

Leucine-Rich Alpha-2-Glycoprotein (LRG-1) as a Potential Kidney Injury Marker in Kidney Transplant Recipients

Publisher Copyright: © Ann Transplant, 2022;.Background: Material/Methods: Results: Conclusions: Kidney transplantation is the treatment of choice for most patients with end-stage renal disease. To improve patient and transplant survival, non-invasive diagnostic methods for different pathologies are important. Leucine-rich alpha-2-glycoprotein (LRG-1) is an innovative biomarker that is elevated in cases of angiogenesis, inflammation, and kidney injury. However, there are limited data about the diagnostic role of LRG-1 in kidney transplant recipients. The aim of this study was to evaluate the association between serum LRG-1, urine LRG-1, and kidney transplant function and injury. We enrolled 35 kidney transplant recipients in the study. LRG-1 in the serum and urine was detected using ELISA. We evaluated the correlation of serum and urine LRG-1 with traditional serum and urine kidney injury markers. A higher level of serum LRG-1 correlates with a higher level of urine LRG-1. Serum LRG-1 has a positive correlation with transplant age, serum urea, serum creatinine, serum cystatin C, proteinuria, and fractional excretion of sodium (FENa) and a negative correlation with hemoglobin and estimated glomerular filtration rate (eGFR). Urine LRG-1 has a positive correlation with serum cystatin C, proteinuria, and urine neutrophil gelatinase-as-sociated lipocalin (NGAL). Higher levels of serum and urine LRG-1 are associated with kidney transplant injury and functional deterioration. Thus, LRG-1 might be also as a biomarker for tubular dysfunction in patients after kidney transplantation.publishersversionPeer reviewe

The Importance of Early Diagnosis and Intervention in Chronic Kidney Disease: Calls-to-Action from Nephrologists Based Mainly in Central/Eastern Europe

Background: Chronic kidney disease (CKD) has a global prevalence of 9.1–13.4%. Comorbidities are abundant and may cause and affect CKD. Cardiovascular disease strongly correlates with CKD, increasing the burden of both diseases. Summary: As a group of 15 clinical nephrologists primarily practicing in 12 Central/Eastern European countries, as well as Israel and Kazakhstan, herein we review the significant unmet needs for patients with CKD and recommend several key calls-to-action. Early diagnosis and treatment are imperative to ensure optimal outcomes for patients with CKD, with the potential to greatly reduce both morbidity and mortality. Lack of awareness of CKD, substandard indicators of kidney function, suboptimal screening rates, and geographical disparities in reimbursement often hamper access to effective care. Key Messages: Our key calls-to-action to address these unmet needs, thus improving the standard of care for patients with CKD, are the following: increase disease awareness, such as through education; encourage provision of financial support for patients; develop screening algorithms; revisit primary care physician referral practices; and create epidemiological databases that rectify the paucity of data on early-stage disease. By focusing attention on early detection, diagnosis, and treatment of high-risk and early-stage CKD populations, we aim to reduce the burdens, progression, and mortality of CKD

High-Risk Human Papillomavirus Infection in Latvian Male Kidney Transplant Recipients

Publisher Copyright: © 2016 by Maksims Cistjakovs.Kidney transplant recipients have higher incidence of human papillomavirus (HPV)-related malignancies, but studies on the natural history of HPV infection are insufficient, especially regarding in male recipients. The aim of this study was to evaluate the course of high-risk HPV (HR-HPV) infection after kidney allograft transplantation in male recipients: to estimate frequency and activity of HR-HPV infection under immune system suppression. Twenty male renal recipients (age 20-68) were enrolled in this investigation and examined in dynamics. Peripheral EDTA-blood samples and urine samples were collected from each patient 2 weeks, 6 months and 12 months after transplantation. Polymerase chain reaction (PCR) with consensus primers was used for initial detection of high range HPV types, a commercial qPCR kit for detection of HR-HPV load in urine samples and ELISA for detection of serum IgG class antibodies to HR-HPV L1-capsid protein. Overall, combining molecular (HR-HPV genomic sequences detected by real-time PCR) and serological studies (IgG class antibodies to HR-HPV L1-capsids' protein), high frequency of HRHPV infection among male kidney transplant recipients (9/20; 45%) was showed. However, the majority of HR-HPV positive recipients (7/9; 78%) showed signs of infection clearance. It means that, despite the applied immune suppressive therapy, the host's immune system is capable of dealing with HR-HPV infection up to the 12th month after transplantation. However, the sample size should be increased to enable through statistical analysis before final conclusions are made.publishersversionPeer reviewe

Polyoma BK Virus Infection in Renal Transplant Recipients. Doctoral Thesis

Promocijas darbs veikts: Rīgas Stradiņa Universitātē, Paula Stradiņa Klīniskās universitātes slimnīcas Latvijas Transplantācijas centrā sadarbojoties ar slimnīcas citoloģijas laboratoriju, Patoloģijas institūtu un Rīgas Stradiņa Universitātes Augusta Kirhenšteina Mikrobioloģijas un virusoloģijas institūta onkovirusoloģijas nodaļu. Aizstāvēšana: Rīgas Stradiņa Universitātes Internās medicīnas Promocijas padomes sēdē 2011.gada 13. jūnijā plkst.15:00, Rīgas Stradiņa Universitātē, Dzirciema ielā 16, Rīgā.Darbs veikts ar Eiropas Sociālā Fonda līdzfinansētā projekta „Atbalsts doktorantiem studiju programmas apguvei un zinātniskā grāda ieguvei Rīgas Stradiņa universitātē” Nr. 2009/ 0147/ 1DP/ 1.1.2.1.2/ 09/ IPIA/ VIAA/ 009 atbalst

Polyoma BK Virus Infection in Renal Transplant Recipients. Summary of the Doctoral Thesis

Promocijas darbs veikts: Rīgas Stradiņa Universitātē, Paula Stradiņa Klīniskās universitātes slimnīcas Latvijas Transplantācijas centrā sadarbojoties ar slimnīcas citoloģijas laboratoriju, Patoloģijas institūtu un Rīgas Stradiņa Universitātes Augusta Kirhenšteina Mikrobioloģijas un virusoloģijas institūta onkovirusoloģijas nodaļu. Aizstāvēšana: Rīgas Stradiņa Universitātes Internās medicīnas Promocijas padomes sēdē 2011.gada 13. jūnijā plkst.15:00, Rīgas Stradiņa Universitātē, Dzirciema ielā 16, Rīgā.Darbs izpildīts ar ESF projekta „Atbalsts doktorantiem studiju programmas apguvei un zinātniskā grāda ieguvei Rīgas Stradiņa universitātē” Nr. 2009/ 0147/ 1DP/ 1.1.2.1.2/ 09/ IPIA/ VIAA/ 009 atbalst

Poliomas BK vīrusa infekcija pacientiem ar nieres transplantātu. Promocijas darba kopsavilkums

The dissertation was performed in: Riga Stradins University, Transplantation center of Latvia of P. Stradins Clinical University Hospital in cooperation with the Cytology Laboratory, Institute of Pathology and Department of Oncovirology of August Kirchenstein Institute of Microbiology and Virology in Riga Stradins University. Defence: at the meeting of Riga Stradins University Doctoral Board in internal medicine disciplines on 13th of June, 2011, at 15.00, Riga Stradins University, 16 Dzirciema str., Riga.The work was supported by ESF Project “Support to doctor’s studies and acquiring an academic degree in Riga Stradins University” No. 2009/ 0147/ 1DP/ 1.1.2.1.2/ 09/ IPIA/ VIAA/ 00

The importance of early diagnosis and intervention in chronic kidney disease: calls-to-action from nephrologists based mainly in Central/Eastern Europe /

Background: Chronic kidney disease (CKD) has a global prevalence of 9.1?13.4%. Comorbidities are abundant and may cause and affect CKD. Cardiovascular disease strongly correlates with CKD, increasing the burden of both diseases. Summary: As a group of 15 clinical nephrologists primarily practicing in 12 Central/Eastern European countries, as well as Israel and Kazakhstan, herein we review the significant unmet needs for patients with CKD and recommend several key calls-to-action. Early diagnosis and treatment are imperative to ensure optimal outcomes for patients with CKD, with the potential to greatly reduce both morbidity and mortality. Lack of awareness of CKD, substandard indicators of kidney function, suboptimal screening rates, and geographical disparities in reimbursement often hamper access to effective care. Key Messages: Our key calls-to-action to address these unmet needs, thus improving the standard of care for patients with CKD, are the following: increase disease awareness, such as through education; encourage provision of financial support for patients; develop screening algorithms; revisit primary care physician referral practices; and create epidemiological databases that rectify the paucity of data on early-stage disease. By focusing attention on early detection, diagnosis, and treatment of highrisk and early-stage CKD populations, we aim to reduce the burdens, progression, and mortality of CKD. ? 2024 The Author(s). Published by S. Karger AG, Basel