Turbulent mixing of two-layer stratified fluid

Author Posting. © American Institute of Physics, 2007. This is the author's version of the work. It is posted here by permission of American Institute of Physics for personal use, not for redistribution. The definitive version was published in Physics of Fluids 19 (2007): 125104, doi:10.1063/1.2821913.A two-layer salt-stratified tank of water was mixed by turbulence generated by many excursions of a horizontally moving vertical rod. The objective is to observe the timedependent response of the mean density field for ranges of Richardson number Ri>0.9 and Reynolds Number Re>600. As the density profile of the fluid gradually evolves from a single step to a mixed state over a wide range of time, there is almost perfect collapse of all the profiles to one universal profile as a function of a similarity variable. Although the turbulent diffusion is not constant, the value in the limit of small stratification has similar magnitude to values found by others

200-Gb/s Polarization Multiplexed Doubly Differential QPSK Signal Transmission over 80-km SSMF Using Tandem SSB without Optical Amplification

We propose 200-Gb/s polarization multiplexed tandem SSB DDQPSK with intradyne detection for 80-km SSMF transmission. Without optical amplification, dispersion compensation or carrier recovery, the simulated receiver sensitivity for 80-km transmission was below -25.5 dBm (at 7% HDFEC threshold)

Amplifier-free 200-Gb/s tandem SSB doubly differential QPSK signal transmission over 80-km SSMF with simplified receiver-side DSP

We numerically demonstrate 80-km standard single-mode fiber transmission without optical amplification, dispersion compensation or carrier recovery using 200-Gb/s tandem single sideband modulated doubly differential QPSK. Simulation results show that doubly differential encoding enables practically constant system performance for frequency offsets within ± 2.3 GHz and allows a linewidth tolerance of 2.5 × 10−3 at 1-dB receiver sensitivity penalty. Employing 2.9-MHz linewidth lasers, the receiver sensitivity penalty at 7% HD-FEC threshold for 80-km transmission is less than 0.2 dB. By adding a 12-symbol decision feedback in the 2nd differential operation of doubly differential decoding, the receiver sensitivity is improved by 3.7 dB

Evaluation of 100G DP-QPSK long-haul transmission performance using second order co-pumped Raman laser based amplification

We present, for the first time, a detailed investigation of the impact of second order co-propagating Raman pumping on long-haul 100G WDM DP-QPSK coherent transmission of up to 7082 km using Raman fibre laser based configurations. Signal power and noise distributions along the fibre for each pumping scheme were characterised both numerically and experimentally. Based on these pumping schemes, the Q factor penalties versus co-pump power ratios were experimentally measured and quantified. A significant Q factor penalty of up to 4.15 dB was observed after 1666 km using symmetric bidirectional pumping, compared with counter-pumping only. Our results show that whilst using co-pumping minimises the intra-cavity signal power variation and amplification noise, the Q factor penalty with co-pumping was too great for any advantage to be seen. The relative intensity noise (RIN) characteristics of the induced fibre laser and the output signal, and the intra-cavity RF spectra of the fibre laser are also presented. We attribute the Q factor degradation to RIN induced penalty due to RIN being transferred from the first order fibre laser and second order co-pump to the signal. More importantly, there were two different fibre lasing regimes contributing to the amplification. It was random distributed feedback lasing when using counter-pumping only and conventional Fabry-Perot cavity lasing when using all bidirectional pumping schemes. This also results in significantly different performances due to different laser cavity lengths for these two classes of laser

Demonstration of nonlinear inverse synthesis transmission over transoceanic distances

Nonlinear Fourier transform (NFT) and eigenvalue communication with the use of nonlinear signal spectrum (both discrete and continuous), have been recently discussed as promising transmission methods to combat fiber nonlinearity impairments. In this paper, for the first time, we demonstrate the generation, detection and transmission performance over transoceanic distances of 10 Gbaud and nonlinear inverse synthesis (NIS) based signal (4 Gb/s line rate), in which the transmitted information is encoded directly onto the continuous part of the signal nonlinear spectrum. By applying effective digital signal processing techniques, a reach of 7344 km was achieved with a bit-error-rate (BER) (2.1×10-2) below the 20% FEC threshold. This represents an improvement by a factor of ~12 in data capacity x distance product compared with other previously demonstrated NFT-based systems, showing a significant advance in the active research area of NFT-based communication systems

Transmission comparison of ultra-long Raman fibre laser based amplification with first and dual order Raman amplification using 10×118 Gbit/s DP-QPSK

Experimental investigations of 10×118 Gbit/s DP-QPSK WDM transmission using three types of distributed Raman amplification techniques are presented. Novel ultra-long Raman fibre laser based amplification with second order counter-propagated pumping is compared with conventional first order and dual order counter-pumped Raman amplification. We demonstrate that URFL based amplification can extend the transmission reach up to a distance of 7520 km in comparison with 5010 km and 6180 km using first order and dual order Raman amplification respectively

Study of Mill Island ice core (East Antarctica): A sensitive site for high resolution ocean climate signals?

第2回極域科学シンポジウム　氷床コアセッション 11月16日（水） 国立極地研究所 2階大会議

Linear and Nonlinear Noise Characterisation of Dual Stage Broadband Discrete Raman Amplifiers

We characterise the linear and nonlinear noise of dual stage broadband discrete Raman amplifiers (DRAs) based on conventional Raman gain fibres. Also, we propose an optimised dual stage DRA setup that lowers the impact of nonlinear noise (generated in the amplifier) on the performance of a transmission link (with 100-km amplifier spacing). We numerically analyse the design of a backward pumped cascaded dual stage 100-nm DRA with high gain (∼20 dB) and high saturated output power (>23 dBm). We show that the noise figure (NF) of the dual stage DRA is mainly dominated by the first stage irrespective of the type of gain fibre chosen in the second stage, and we also demonstrate that optimising the length and the type of Raman gain fibre can have significant impact on the size of inter/intrasignal nonlinearities generated. Here, we report a theoretical model to calculate the nonlinear noise power generated in transmission spans with dual stage DRAs considering piecewise signal power evolution through the Raman gain fibres. The predicted signal-to-noise ratio (SNR) performances are calculated from the combined contributions from NF and nonlinear product power obtained using the proposed analytical model for transmission systems deployed with 100-km transmission span compensated by different dual stage DRAs. Finally, an optimised IDF 6 km-SMF 10 km dual stage configuration has been identified using the theoretical model, which allows maximum SNR of 14.6 dB at 1000 km for 1 THz Nyquist wavelength division multiplexed signal and maximum transmission reach of 3400 km at optimum launch power assuming 8.5 dB HD-FEC limit of the Nyquist PM-QPSK signal

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model.

Inhibitors of BRAFV600E kinase are currently under investigations in preclinical and clinical studies involving BRAFV600E glioma. Studies demonstrated clinical response to such individualized therapy in the majority of patients whereas in some patients tumors continue to grow despite treatment. To study resistance mechanisms, which include feedback activation of mitogen-activated protein kinase (MAPK) signaling in melanoma, we developed a luciferase-modified cell line (2341luc) from a BrafV600E mutant and Cdkn2a- deficient murine high-grade glioma, and analyzed its molecular responses to BRAFV600E- and MAPK kinase (MEK)-targeted inhibition. Immunocompetent, syngeneic FVB/N mice with intracranial grafts of 2341luc were tested for effects of BRAFV600E and MEK inhibitor treatments, with bioluminescence imaging up to 14-days after start of treatment and survival analysis as primary indicators of inhibitor activity. Intracranial injected tumor cells consistently generated high-grade glioma-like tumors in syngeneic mice. Intraperitoneal daily delivery of BRAFV600E inhibitor dabrafenib only transiently suppressed MAPK signaling, and rather increased Akt signaling and failed to extend survival for mice with intracranial 2341luc tumor. MEK inhibitor trametinib delivered by oral gavage daily suppressed MAPK pathway more effectively and had a more durable anti-growth effect than dabrafenib as well as a significant survival benefit. Compared with either agent alone, combined BRAFV600E and MEK inhibitor treatment was more effective in reducing tumor growth and extending animal subject survival, as corresponding to sustained MAPK pathway inhibition. Results derived from the 2341luc engraftment model application have clinical implications for the management of BRAFV600E glioma