9 research outputs found
Strategies to inhibit tumour associated integrin receptors: rationale for dual and multi-antagonists
- Author
- Albelda S. M.
- Amirkhosravi A.
- Aumailley M.
- Bandyopadhyay A.
- Barker P. L.
- Batt D. G.
- Bello L.
- Benfatti F.
- Bennett J. S.
- Bianchi-Smiraglia A.
- Bisanz K.
- Bochen A.
- Boys M. L.
- Bretschi M.
- Bretschi M.
- Brooks P. C.
- Buergy D.
- Burbridge M. F.
- Böger C.
- Calderwood D. A.
- Calvete J. J.
- Calvete J. J.
- Carey C. M.
- Chen Q.
- Chico T. J. A.
- Christoforides C.
- Chu F. M.
- Chung K.-H.
- Cohen S. A.
- Cox D.
- Dardik R.
- Davenport R. J.
- Davis F. B.
- De Corte B. L.
- De S.
- Dechantsreiter M. A.
- Dome B.
- Duan X. P.
- Engebraaten O.
- Engleman V. W.
- Erdreich-Epstein A.
- Friedlander M.
- Gasparini G.
- Gentilucci L.
- Gomes N.
- Goodman S. L.
- Goodman S. L.
- Goodman S. L.
- Hailey S.
- Harms J. F.
- Heidenreich A.
- Helen M. Sheldrake
- Henderson N. C.
- Humphries J. D.
- Ishikawa M.
- Ishikawa M.
- Kang I.-C.
- Kerr J. S.
- Kim S.
- Knowles L. M.
- Kubota D.
- Kubota D.
- Kumar C. C.
- Laurence H. Patterson
- Laurens N.
- Letourneau J. J.
- Lin E.
- Liu Y.
- Lonsdorf A. S.
- Lucena S. E.
- Malik G.
- Marelli U. K.
- Marinelli L.
- Marinelli L.
- Marinelli L.
- Martin P. L.
- Martin S.
- Mas-Moruno C.
- Mas-Moruno C.
- Matsuno H.
- Maubant S.
- Max R.
- McCabe N. P.
- Meerovitch K.
- Menendez J. A.
- Minea R.
- Minea R. O.
- Mitjans F.
- Morjen M.
- Mullamitha S. A.
- Naber H. P.
- Nabors L. B.
- Nadrah K.
- Nagae M.
- Oleksowicz L.
- Osterkamp F.
- O’Day S.
- O’Day S. J.
- Palumbo J. S.
- Parvani J. G.
- Pecheur I.
- Peishoff C. E.
- Perron-Sierra F.
- Pfaff M.
- Pontes-JĂşnior J.
- Reinmuth N.
- Reynolds A. R.
- Romanov V. I.
- Ross F. P.
- Scarborough R. M.
- Scarborough R. M.
- Scaringi C.
- Schaffner F.
- Schittenhelm J.
- Schittenhelm J.
- Schmieder A. H.
- Schneider J. G.
- Shannon K. E.
- Sheldrake H. M.
- Shih C.-H.
- Simon K. O.
- Sloan E. K.
- Smallheer J. M.
- Sowmya G.
- Stachurska A.
- Steri V.
- Stragies R.
- Sung V.
- Swenson S.
- Sánchez E. E.
- The IMPACT-II Investigators.
- Timar J.
- Tolomelli A.
- Topol E. J.
- Trabocchi A.
- Trikha M.
- Trikha M.
- Trikha M.
- Trikha M.
- van den Hoogen C.
- van der Flier A.
- van der Horst G.
- van der Horst G.
- Vermorken J. B.
- Vogetseder A.
- Wan A. M.
- Wu Y. J.
- Xiao T.
- Zhang W.
- Zhao F.
- Zhao Y.
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- 26/02/2014
- Field of study
YesThe integrins are a family of 24 heterodimeric transmembrane cell surface receptors. Involvement in cell attachment to the extracellular matrix, motility, and proliferation identifies integrins as therapeutic targets in cancer and associated conditions; thrombosis, angiogenesis and osteoporosis. The most reported strategy for drug development is synthesis of an agent that is highly selective for a single integrin receptor. However, the ability of cancer cells to change their integrin repertoire in response to drug treatment renders this approach vulnerable to the development of resistance and paradoxical promotion of tumor growth. Here, we review progress towards development of antagonists targeting two or more members of the RGD-binding integrins, notably αvβ3, αvβ5, αvβ6, αvβ8, α5β1, and αIIbβ3, as anticancer therapeutics
New antiplatelet drugs
- Author
- Ariyoshi
- Balsano
- Balsano
- Balsano
- Bar
- Bellinger
- Bellucci
- Berkowitz
- Bousser
- Burch
- CAPRIE Stenering Committee
- Catella-Lawson
- Charo
- Coller
- Coller
- Coller
- Coller
- Coller
- Coller
- Dardik
- De Clerck
- De Cree
- DeWitt
- DeWitt
- Diener
- Faulds
- Fiddler
- Fiessinger
- FitzGerald
- FitzGerald
- Folts
- Fujimura
- Funk
- Gapinski
- Gent
- Gold
- Golino
- Gryglewski
- Hass
- Hattori
- Henriksson
- Heras
- Herbert
- Hoet
- Kiernan
- Kleiman
- Klein
- Klimt
- Knudtson
- Lefkovits
- Lievre
- Limet
- Mallet
- Matsuno
- Moake
- Mueller
- Nong
- O'Connor
- Ohman
- Page
- Palareti
- Patrignani
- Peng
- Pengo
- Pogliani
- Pytela
- Radomski
- Radomski
- Roth
- Roth
- Roth
- Rothrock
- Sakata
- Samama
- Schafer
- Schrör
- Schrör
- Schulman
- Schömig
- Serruys
- Serruys
- Shapiro
- Sims
- Solomon
- Splawinska
- Su
- Takishita
- Tcheng
- Tcheng
- Thaulow
- The EPIC Investigators
- The EPILOG Investigators
- The IMPACT-II Investigators
- The Ridogrel Versus Aspirin Patency Trial (RAPT)
- Theroux
- Théroux
- Topol
- Tranchesi
- Vane
- Verheugt
- Vermylen
- Weiner
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Secondary Arterial Reconstructions
- Author
- A Breda van
- A Carter
- A Collaboration
- A Collaboration
- A Lundell
- A Miller
- A Neufang
- A Schanzer
- AD Whittemore
- AF Aburahma
- AJ Avino
- AJ Geraghty
- AP Hingorani
- AW Clowes
- AW Clowes
- AW Clowes
- B Arfvidsson
- B Girolami
- B Kelly
- B Satiani
- B Sussman
- BL Ferris
- BL Johnson
- C Gonsalves
- C Randon
- C Stettler
- C Wixon
- CAPRIE Steering Committee
- CN Tinder
- D Hasenstab
- D Rosenthal
- D Rosenthal
- D Rosenthal
- DE Szilagyi
- DF Bandyk
- DF Bandyk
- DF Bandyk
- DG Hackam
- DH Olojugba
- DI Axel
- DM Ihnat
- DT Baril
- E Ascer
- EC Lipsitz
- EG Nabel
- EJ Marcaccio
- EM Rzucidlo
- F Spinelli
- FJ Veith
- FJ Veith
- G Kretschmer
- G Tepe
- GJ Landry
- GL Knatterud
- GV Shrikhande
- H Dardik
- HF Simosa
- HR Watson
- II Dardik
- J Wöhrle
- JB Towne
- JC Paramo
- JJ Gilbertson
- JJF Belch
- JL Mills
- JL Mills
- JL Mills
- JL Mills
- JM Seeger
- JR Hoch
- K Kasirajan
- K Ouriel
- K Ouriel
- K Visser
- KP Donas
- KR Wengerter
- M Aberg
- M Aberg
- M Belkin
- M Bosiers
- M Söderström
- MD Dake
- MJ Eagleton
- MJ Eagleton
- MJ Tangelder
- ML Marin
- MM Idu
- N Troisi
- NA Shoenfeld
- P Alonso-Coello
- P Dunlop
- P Moody
- PA Schneider
- PJ Rossi
- R Garvin
- R Mofidi
- R Mofidi
- R Vikram
- RB Rutherford
- RB Rutherford
- RL Dalman
- RS Brumberg
- RT Hagino
- RT Lancaster
- S Renwick
- SA Berceli
- SE Bergentz
- SG Katz
- STILE Investigators
- TA Abbruzzese
- TC Collins
- TM Bergamini
- TP Sarac
- VK Stark
- W Tian
- WC Johnson
- WJ Gasper
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Fibronectin and Other Cell Interactive Glycoproteins
- Author
- A Komoriya
- A Woods
- AP Mould
- APN Skubitz
- AR Kornblihtt
- AS Asch
- B Lyons-Giordano
- B Sjoberg
- BC Zhu
- BR Tomasini
- C Wolff
- CA Pearson
- CD Laherty
- CS Izzard
- D Heinegárd
- D Jenne
- D Jenne
- D Reiman
- DB Donoviel
- DC Dean
- DD Hunter
- DD Roberts
- DE Hall
- DF Mosher
- DF Mosher
- DM Pesciotta-Peters
- DR Friedlander
- DS Grant
- DW Barnes
- E Dejana
- EJ Mackie
- EV Prochownik
- F Grinnell
- F Oyama
- FJ Fogerty
- FS Jones
- G Fox
- G Panayotou
- GR Martin
- H Hirano
- HC Taylor
- HK Kleinman
- HP Erickson
- II Singer
- II Singer
- J Enenstein
- J Graf.
- J Lahav
- J Lawler
- J Lawler
- J Lawler
- J Musial
- J Spring
- J Varani
- J-C Boucaut
- JA Donald Mc
- JA Donald Mc
- JB Carthy Mc
- JB Carthy Mc
- JC Loftus
- JE Murphy-Ullrich
- JF Riou
- JL Guan
- JW Lash
- K Beck
- K Burridge
- K Dahlbäck
- K Ehrig
- K Kouzi-Koliakos
- K Kubota
- K Mann
- K Olden
- K Tashiro
- KC Ingham
- KC Ingham
- KM Yamada
- KM Yamada
- KR Gehlsen
- KS O’Shea
- KT Preissner
- L Dillner
- LK Thompson
- LY Sakai
- M Aumailley
- M Aumailley
- M Baron
- M Hayashi
- M Izumi
- M Moos
- M Obara
- M Sasaki
- M Yamagata
- MA Bourdon
- MD Bale
- MD Pierschbacher
- MD Pierschbacher
- ME Durkin
- MH Ginsberg
- MJ Benecky
- MJ Humphries
- MJ Humphries
- MJ Humphries
- MM Lotz
- MW Long
- NV Ketis
- P Knox
- P Liesi
- P Vischer
- PD Yurchenco
- PJ Keown-Longo Mc
- PR Kaesberg
- R Chiquet-Ehrismann
- R Chiquet-Ehrismann
- R Dardik
- R Deutzmann
- R Ehrismann
- R Keynes
- R Timpl
- RA Fava
- RA Majack
- RJ Owens
- RL Silverstein
- RO Hynes
- RP Hershberger
- RP Mecham
- RP Penttinen
- RS Patel
- S Chakravarti
- S Dufour
- S Dufour
- S Hoffman
- S Hoffman
- S Spiegel
- S Suzuki
- SE D’Souza
- SK Akiyama
- SK Akiyama
- T Darribére
- T Kanemoto
- T Vartio
- T Yatohgo
- TF Lane
- VA Lightner
- WA Frazier
- Y Nojima
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1991
- Field of study
Secondary Arterial Reconstruction
- Author
- A Breda van
- A Carter
- A Collaboration
- A Collaboration
- A Lundell
- A Miller
- A Neufang
- A Schanzer
- AD Whittemore
- AF Aburahma
- AJ Avino
- AJ Geraghty
- AP Hingorani
- AW Clowes
- AW Clowes
- AW Clowes
- B Arfvidsson
- B Girolami
- B Kelly
- B Satiani
- B Sussman
- BL Ferris
- BL Johnson
- C Gonsalves
- C Randon
- C Stettler
- C Wixon
- CAPRIE Steering Committee
- CN Tinder
- D Hasenstab
- D Rosenthal
- D Rosenthal
- D Rosenthal
- DE Szilagyi
- DF Bandyk
- DF Bandyk
- DF Bandyk
- DG Hackam
- DH Olojugba
- DI Axel
- DM Ihnat
- DT Baril
- E Ascer
- EC Lipsitz
- EG Nabel
- EJ Marcaccio
- EM Rzucidlo
- F Spinelli
- FJ Veith
- FJ Veith
- G Kretschmer
- G Tepe
- GJ Landry
- GL Knatterud
- GV Shrikhande
- H Dardik
- HF Simosa
- HR Watson
- II Dardik
- J Wöhrle
- JB Towne
- JC Paramo
- JJ Gilbertson
- JJF Belch
- JL Mills
- JL Mills
- JL Mills
- JL Mills
- JM Seeger
- JR Hoch
- K Kasirajan
- K Ouriel
- K Ouriel
- K Visser
- KP Donas
- KR Wengerter
- M Aberg
- M Aberg
- M Belkin
- M Bosiers
- M Söderström
- MD Dake
- MJ Eagleton
- MJ Eagleton
- MJ Tangelder
- ML Marin
- MM Idu
- N Troisi
- NA Shoenfeld
- P Alonso-Coello
- P Dunlop
- P Moody
- PA Schneider
- PJ Rossi
- R Garvin
- R Mofidi
- R Mofidi
- R Vikram
- RB Rutherford
- RB Rutherford
- RL Dalman
- RS Brumberg
- RT Hagino
- RT Lancaster
- S Renwick
- SA Berceli
- SE Bergentz
- SG Katz
- STILE Investigators
- TA Abbruzzese
- TC Collins
- TM Bergamini
- TP Sarac
- VK Stark
- W Tian
- WC Johnson
- WJ Gasper
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Secondary Arterial Reconstruction
- Author
- A Breda van
- A Carter
- A Collaboration
- A Collaboration
- A Lundell
- A Miller
- A Neufang
- A Schanzer
- AD Whittemore
- AF Aburahma
- AJ Avino
- AJ Geraghty
- AP Hingorani
- AW Clowes
- AW Clowes
- AW Clowes
- B Arfvidsson
- B Girolami
- B Kelly
- B Satiani
- B Sussman
- BL Ferris
- BL Johnson
- C Gonsalves
- C Randon
- C Stettler
- C Wixon
- CAPRIE Steering Committee
- CN Tinder
- D Hasenstab
- D Rosenthal
- D Rosenthal
- D Rosenthal
- DE Szilagyi
- DF Bandyk
- DF Bandyk
- DF Bandyk
- DG Hackam
- DH Olojugba
- DI Axel
- DM Ihnat
- DT Baril
- E Ascer
- EC Lipsitz
- EG Nabel
- EJ Marcaccio
- EM Rzucidlo
- F Spinelli
- FJ Veith
- FJ Veith
- G Kretschmer
- G Tepe
- GJ Landry
- GL Knatterud
- GV Shrikhande
- H Dardik
- HF Simosa
- HR Watson
- II Dardik
- J Wöhrle
- JB Towne
- JC Paramo
- JJ Gilbertson
- JJF Belch
- JL Mills
- JL Mills
- JL Mills
- JL Mills
- JM Seeger
- JR Hoch
- K Kasirajan
- K Ouriel
- K Ouriel
- K Visser
- KP Donas
- KR Wengerter
- M Aberg
- M Aberg
- M Belkin
- M Bosiers
- M Söderström
- MD Dake
- MJ Eagleton
- MJ Eagleton
- MJ Tangelder
- ML Marin
- MM Idu
- N Troisi
- NA Shoenfeld
- P Alonso-Coello
- P Dunlop
- P Moody
- PA Schneider
- PJ Rossi
- R Garvin
- R Mofidi
- R Mofidi
- R Vikram
- RB Rutherford
- RB Rutherford
- RL Dalman
- RS Brumberg
- RT Hagino
- RT Lancaster
- S Renwick
- SA Berceli
- SE Bergentz
- SG Katz
- STILE Investigators
- TA Abbruzzese
- TC Collins
- TM Bergamini
- TP Sarac
- VK Stark
- W Tian
- WC Johnson
- WJ Gasper
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Die Möglichkeiten der chirurgischen Behandlung zerebraler Mangeldurchblutung bei Veränderungen im Bereich der extrakraniellen Hirngefäßabschnitte
- Author
- A. D. Sousa Pereira
- A. G. Sharf
- A. Gund
- A. Isfort
- A. Martelli
- A. May
- A. MĂĽller
- A. P. Maphgittot
- A. R. Cordell
- B. S. Oppenhiemer
- Bank
- Bland
- C. G. Rob
- C. G. Rob
- C. G. Rob
- C. G. Rob
- C. Henschen
- C. Kulenkampff
- Ch. Rob
- Ch. Spunda
- Craddock
- D. B. Matloff
- D. Denney-Brown
- D. Yashon
- Dohrn
- E. Moniz
- F. A. Wood
- F. Martorell
- F. Martorell
- F. Penzoldt
- F. Volhard
- G. Ghersone
- G. Heberer
- G. Markos
- G. W. P. Pickering
- Grage
- H. B. Wheeler
- H. Bettelheim
- H. C. Johnson
- H. Chiari
- H. Dardik
- H. Denck
- H. Denck
- H. H. G. Eastcott
- H. Hager
- H. Hager
- H. Hager
- H. Heidrich
- H. Herrschaft
- H. J. Morius
- H. J. Movins II.
- H. Reisner
- H. Siedek
- I. Lengsfeld
- I. Natali
- Imparato
- J. Cailar Du
- J. Duquesnel
- J. F. Toole
- J. J. Garamella
- J. J. Garamella
- J. J. Garamella
- J. Kugler
- J. M. Dennery
- J. Pietri
- J. Quandt
- J. R. Hunt
- J. S. Elkington
- J. Vedrinne
- J. Vollmar
- J. Vollmar
- J. W. D. Bull
- K. I. Nakao
- K. Jellinger
- Kellogg
- Kianouri
- L. Contorni
- L. L. Gonzalez
- Levowitz
- M. Ambler
- M. E. Bakey De
- M. E. Bakey De
- M. Fisher
- M. Reivich
- M. Takayasu
- M. Yasagil
- O. Sjoquist
- P. O. Yates
- P. Tala
- R. D. Adams
- R. H. Rutledfe
- R. Houdart
- R. Leriche
- R. P. Honf
- R. P. Honf
- R. Raskind
- R. Schmutzler
- R. W. Hollenhorst
- Rainer
- Thompson
- V. I. Lerman
- W. F. Barker
- W. H. Broadbent
- W. M. Lougheed
- W. P. Chung
- W. S. Moore
- W. S. Moore
- W. Umbach
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years.
- Author
- Abbott GT
- Abul-Khoudoud O
- Acher C
- Adelman M
- Adiseshiah M
- Ady N
- Allaire E
- Allende B
- Allore H
- Antonelli M
- Arora S
- Aruny J
- Ashe L
- Ashleigh R
- Ashley S
- Ashour MY
- Auguste M
- Aukett M
- Aulivola B
- Azadegan R
- Baas AF
- Baas AF
- Back M
- Bader M
- Badra A
- Bahmani DD
- Bak AAA
- Baker S
- Balm R
- Balm R
- Balm R
- Balm R
- Bandyk D
- Baque J
- Baraniewski HM
- Barbe E
- Barke RA
- Barral X
- Barshes N
- Bartoli J-M
- Batson N
- Batt M
- Baum R
- Bayne J
- Beach V
- Beard JD
- Beard JD
- Bechara C
- Beckwith D
- Becquemin J-P
- Becquemin J-P
- Becquemin J-P
- Becquemin J-P
- Becquemin J-P
- Behdad M
- Belhomme D
- Bell J
- Bell PRF
- Belli AM
- Bender MHM
- Berceli SA
- Beregi JP
- Bergeron P
- Bhola MA
- Bianchi C
- Bishop V
- Blackwell C
- Blair PHB
- Blankensteijn JD
- Blankensteijn JD
- Blankensteijn JD
- Blankensteijn JD
- Blankensteijn JD
- Blankensteijn JD
- Bleuet F
- Blin V
- Blundell J
- Boardley D
- Boekema N
- Boissier C
- Boomsma JHB
- Borie H
- Borrelly P
- Boudjema N
- Bouillanne P-J
- Boyes S
- Bradbury AW
- Braesco J
- Braganza M
- Braithwaite B
- Branchereau A
- Brenot R
- Briand O
- Brillu C
- Brock S
- Brookes JAS
- Brown KR
- Brown LC
- Brown LC
- Brown O
- Bruijninckx CMA
- Bryce J
- Burdick TS
- Bush RL
- Buskens E
- Busman A
- Busuttil SJ
- Buth J
- Buth J
- Buth J
- Buth J
- Buxton MJ
- Byrne D
- C D
- Cagiannos C
- Cambria RA
- Campbell WB
- Cannady E
- Cardon A
- Cardon J-M
- Carmichael M
- Caropolo LJ
- Carr SC
- Cayne N
- Cercueil JP
- Cerveira JJ
- Chacko JKY
- Chaillou P
- Chaix D
- Chalmers NC
- Chance T
- Chand P
- Chatellier G
- Chevalier P
- Chew D
- Cheysson E
- Chong K
- Cikrit D
- Clason AE
- Clavier E
- Cleary P
- Cole L
- Coleman J
- Coles EC
- Collins MA
- Colombier D
- Combes M
- Coogan SM
- Corson JD
- Cosgrove C
- Costargent A
- Cousins C
- Cullen JJ
- Cunin P
- Curran G
- Cushing C
- Cuypers PWM
- Cuypers PWM
- D'Alicourt A
- d'Audiffret AC
- Dalman R
- Dardik A
- Darrieux H
- David V
- Davies JN
- Davis E
- Day NN
- de Bruin JL
- de Haan M
- de Mol van Otterloo JCA
- de Mol BAJM
- de Rooij TPW
- de Smet AAEA
- de Vries C
- Dean MRE
- Demon A
- Dennison T
- Desgranges P
- DeSpiegelaere H
- Destrieux L
- Deux J-F
- Devine C
- DeVirgillio C
- Dewhirst N
- Dogas G
- Dolbeau G
- Dosluoglu HH
- Downes M
- Doyle T
- Duddy M
- Dunlap B
- Durant L
- Duvaldestin P
- Dwyer SS
- Ebaugh J
- Edwards J
- Edwards PR
- Edwards R
- Eidt JF
- Eiseman M
- El Sayed H
- Ellis K
- Ellis PK
- Endo M
- Enon B
- Enouf D
- Epstein D
- Errington B
- Escalante AM
- Eschberger K
- Estes M
- Ettles DF
- Evans M
- EVAR-1 DREAM, OVER and ACE Trialists
- Fabiani JN
- Fairman R
- Farrell H
- Farrell W
- Favier C
- Favre J-P
- Favre JP
- Feldman R
- Fiessinger J-N
- Fisher C
- Fishwick NG
- Forbes BA
- Foster M
- Fox AD
- Framberg S
- Freischlag JA
- Fujitani R
- Fulford P
- Gagne P
- Gahtan V
- Gaines PA
- Garance P
- Garcia O
- Garnham A
- Garrett HE
- Gelabert HA
- Gibbs SJ
- Giglia JS
- Glickerman DG
- Goff JM
- Golden MA
- Gordon IL
- Goubault F
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- Zellner S
- Zeman M
- Zhou W
- Zickler RW
- Publication venue
- Br J Surg
- Publication date
- 26/09/2016
- Field of study
BACKGROUND: The erosion of the early mortality advantage of elective endovascular aneurysm repair (EVAR) compared with open repair of abdominal aortic aneurysm remains without a satisfactory explanation. METHODS: An individual-patient data meta-analysis of four multicentre randomized trials of EVAR versus open repair was conducted to a prespecified analysis plan, reporting on mortality, aneurysm-related mortality and reintervention. RESULTS: The analysis included 2783 patients, with 14 245 person-years of follow-up (median 5·5 years). Early (0-6 months after randomization) mortality was lower in the EVAR groups (46 of 1393 versus 73 of 1390 deaths; pooled hazard ratio 0·61, 95 per cent c.i. 0·42 to 0·89; P = 0·010), primarily because 30-day operative mortality was lower in the EVAR groups (16 deaths versus 40 for open repair; pooled odds ratio 0·40, 95 per cent c.i. 0·22 to 0·74). Later (within 3 years) the survival curves converged, remaining converged to 8 years. Beyond 3 years, aneurysm-related mortality was significantly higher in the EVAR groups (19 deaths versus 3 for open repair; pooled hazard ratio 5·16, 1·49 to 17·89; P = 0·010). Patients with moderate renal dysfunction or previous coronary artery disease had no early survival advantage under EVAR. Those with peripheral artery disease had lower mortality under open repair (39 deaths versus 62 for EVAR; P = 0·022) in the period from 6 months to 4 years after randomization. CONCLUSION: The early survival advantage in the EVAR group, and its subsequent erosion, were confirmed. Over 5 years, patients of marginal fitness had no early survival advantage from EVAR compared with open repair. Aneurysm-related mortality and patients with low ankle : brachial pressure index contributed to the erosion of the early survival advantage for the EVAR group. Trial registration numbers: EVAR-1, ISRCTN55703451; DREAM (Dutch Randomized Endovascular Aneurysm Management), NCT00421330; ACE (Anévrysme de l'aorte abdominale, Chirurgie versus Endoprothèse), NCT00224718; OVER (Open Versus Endovascular Repair Trial for Abdominal Aortic Aneurysms), NCT00094575
Cardiovascular Activity
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- U Zimmermann
- U Zimmermann
- UB Kaupp
- UM Parkkisenniemi
- UM Steckelings
- UM Steckelings
- UT RĂĽegg
- V Boswell-Smith
- V Brechler
- V Breu
- V Calderone
- V Camarda
- V Camarda
- V Camarda
- V Flockerzi
- V Gross
- V Gross
- V Jaffe
- V Joukov
- V Kecskemeti
- V Kirkin
- V Macri
- V Mutafova-Yambolieva
- V Nigro
- V Piercy
- V Piercy
- V Ramkumar
- V Sauzeau
- V St
- V Zwieten
- VA IurlaroM
- VA IurlaroM
- Van de Water A Verheyen J, Xhonneux R, Reneman RS
- VB Fiedler
- VC Middlefell
- VC Swamy
- VEO Valli
- VG Varsos
- VJ Dzau
- VJ Ferrans
- VJ Lotti
- VO Nikolaev
- VS Bishop
- VY Reddy
- W Bernauer
- W Chao
- W Feldberg
- W Feldberg
- W Fischli
- W Grossman
- W Hsueh
- W Häuser
- W Isola
- W Kobinger
- W Liedtke
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Linz
- W Martin
- W Meesmann
- W Meesmann
- W Penz
- W Pettinger
- W Schallek
- W Schaper
- W Schaper
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Schoner
- W Song
- W Spinelli
- W Sun
- W Tornatzky
- W Vine
- W Vleeming
- W Wienen
- WA Catterall
- WA Catterall
- WA Catterall
- WA Catterall
- WA Mann
- WA Pulsinelli
- WB Stam
- WC Bowman
- WC Bowman
- WC Ko
- WD Heiss
- WE Jacobus
- WF Lubbe
- WG Anderson
- WH Beinfield
- WH Gilst van
- WH Gilst van
- WH Gilst van
- WH Zhu
- Wienen W Hauel N, van Meel JCA, Narr B, Ries U, Entzeroth M (1993) Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277. Br J Pharmacol 110:245–252 Wong PC, Quan ML, Saye JAM, Bernard R, Crain EJ Jr, Nc- Call DE, Watson CA, Zaspel AM, Smith RD, Wexler RR, Timmermans PBMWM, Chiu AT
- WJ ChicagoCrumb Jr
- WJ Chiou
- WJ Greenlee
- WJ Greenlee
- WJ Linz
- WJ Rossowski
- WJ Rossowski
- WJ Thompson
- WK Samson
- WL Miller
- WL Rosenberg
- WLF WolffMR
- WM Vogel
- WN Tapp
- WP Schilling
- WR Huckle
- WR Tracey
- WT Chiu
- WW Brooks
- X Cheng
- X Joseph
- X Li
- X Monnet
- X Su
- X Xin
- X Xin
- X Xu
- X Zhang
- XH Gu
- XM Yang
- XP Yang
- XY Lu
- XZ Xu
- XZ Xu
- Y Aoki
- Y Bi
- Y Blaauw
- Y Blaauw
- Y Coulouarn
- Y Deng
- Y Dumont
- Y Funahashi
- Y Guo
- Y Guo
- Y Hamma-Kourbali
- Y Hashimoto
- Y Hayashi
- Y Huang
- Y Huang
- Y Ishida
- Y Ishiyama
- Y Isumi
- Y Kambayashi
- Y Kamisaki
- Y Katano
- Y Lebedinsky
- Y Magata
- Y Maruyama
- Y Meur Le
- Y Murakawa
- Y Naka
- Y Nishimura
- Y Nozawa
- Y Nozawa
- Y Nozawa
- Y Nozawa
- Y Ogawa
- Y Pommier
- Y Qiu
- Y Saishin
- Y Salomon
- Y Shibouta
- Y Suzuki
- Y Takai
- Y Takano
- Y Takata
- Y Takuwa
- Y Tamura
- Y Trolese-Mongheal
- Y Trolese-Mongheal
- Y Urade
- Y Urade
- Y Urade
- Y Wan
- Y Wan
- Y Yamori
- Y Yamori
- Y Yang
- Y Yonezawa
- Y Yonezawa
- Y Yu
- Y-C Tong
- Y-J Cao
- Y-P Tang
- YC Cheng
- YC Cheng
- YC Cheng
- YC Cheng
- YC Cheng
- YC Cheng
- YH Chan
- YH Liu
- YH Liu
- YH Liu
- YJ Liu
- YL Lai
- YL Lai
- YL Li
- YM Lin
- YM McDonaldKM
- YM Pinto
- YP Vedernikov
- YP Vedernikov
- YP Wu
- YS YildirimMK
- YT Sia
- YX Wang
- YX Wang
- YX Wang
- Z Liu
- Z Shan
- Z Szilvássy
- Z Vogel
- Z Wang
- Z Wang
- Z Yang
- Z Yang
- Z Yao
- ZA Damanhouri
- ZI Terashita
- ZM Chu
- ZS Ercan
- ZS Ercan
- ZS Herman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2007
- Field of study