Ecos de las Mercedes: escrituras entre la locura y la razón

La portada impresa a color, presente en cada número de Ecos de las Mercedes, una publicación realizada a principios del siglo XX por los internos del hospital que hoy es el Borda, muestra el dibujo de un hombre sentado junto a su escritorio. Sostiene en una mano la pluma y mira al frente, como en un instante de interrupción de la escritura. La expresión en su rostro no llega a ser la de alguien que sonríe

S-antigen in a hereditary visual cell disease: immunocytochemical and immunological studies. Invest Ophthalmol Vis Sci.

S-antigen is a photoreceptor-specific and potentially autoantigenic protein. Using light microscopic immunocytochemistry, the localization of S-antigen was studied in the retinas of normal dogs and Irish setters affected with rod-cone dysplasia, a hereditary retinal degeneration characterized by abnormal cGMP metabolism and arrested outer segment differentiation. Normal and affected dogs were also tested for the presence of humoral and cellular immunity to S-antigen. S-antigen was present in both rods and cones during inner and outer segment differentiation, but there was an apparent loss of immunoreactivity in cones as the retina matured. The developmental appearance and localization of S-antigen in affected retinas was similar to that of normals. S-antigen immunoreactivity decreased during the early stages of rod loss (39-57 days), but was still present in photoreceptor somata in the late stages of retinal degeneration. No significant difference was found between normal and affected setters in humoral immunity to S-antigen, indicating that it probably does not stimulate autoimmunity in red 1. Because normal dog lymphocytes failed to respond when sensitized to bovine S-antigen, cellular immunity to S-antigen in this disease cannot be ruled out. Invest Ophthalmol Vis Sc