Numerical simulation of rivulet evolution on a circular cylinder in an airflow

On wet and windy days, the inclined cables of cable-stayed bridges may experience a large amplitude oscillation known as Rain-Wind-Induced Vibration (RWIV). It has previously been shown by 'in-situ' and wind-tunnel studies that the formation of rain-water accumulations or 'rivulets' at approximately the separation points of the external aerodynamic flow field and the resulting effect that these rivulets have on this field may be one of the primary mechanisms for RWIV. A numerical method has been developed to undertake simulations of certain aspects of RWIV, in particular, rivulet formation and evolution. Specifically a two-dimensional model for the evolution of a thin film of water on the outer surface of a horizontal circular cylinder subject to the pressure and shear forces that result from the external flow field is presented. Numerical simulations of the resulting evolution equation using a bespoke pseudo-spectral solver capture the formation of two-dimensional rivulets, the geometry, location andgrowth rate of which are all in good agreement with previous studies. Examinations of how the distribution and magnitude of aerodynamic loading and the Reynolds number influence the rivulet temporal evolution are undertaken, theresults of which indicate that while all three affect the temporal evolution, the distribution of the loading has the greatest effect

Numerical simulation of rivulet evolution on a horizontal cable subject to an external aerodynamic field

On wet and windy days, the inclined cables of cable-stayed bridges may experience a large amplitude oscillation known as rain-wind-induced vibration (RWIV). It has previously been shown by in situ and wind-tunnel studies that the formation of rain-water accumulations or ‘rivulets’ at approximately the separation points of the external aerodynamic flow field and the resulting effect that these rivulets have on this field may be one of the primary mechanisms for RWIV. A numerical method has been developed to undertake simulations of certain aspects of RWIV, in particular, rivulet formation and evolution. Specifically a two-dimensional model for the evolution of a thin film of water on the outer surface of a horizontal circular cylinder subject to the pressure and shear forces that result from the external flow field is presented. Numerical simulations of the resulting evolution equation using a bespoke pseudo-spectral solver capture the formation of two-dimensional rivulets, the geometry, location and growth rate of which are all in good agreement with previous studies. Examinations of how the distribution and magnitude of aerodynamic loading and the Reynolds number influence the rivulet temporal evolution are undertaken, the results of which indicate that while all three affect the temporal evolution, the distribution of the loading has the greatest effect

New developments in rain–wind-induced vibrations of cables

On wet and windy days, the inclined cables of cable stayed bridges can experience large amplitude, potentially damaging oscillations known as rain-wind-induced vibration (RWIV). RWIV is believed to be the result of a complicated non-linear interaction between rivulets of rain water that run down the cables and the wind loading on the cables from the unsteady aerodynamics; however, despite a considerable international research effort, the underlying physical mechanism that governs this oscillation is still not satisfactorily understood. An international workshop on RWIV was held in April 2008, hosted at the University of Strathclyde. The main outcomes of this workshop are summarised in the paper. A numerical method to investigate aspects of the RWIV phenomenon has recently been developed by the authors, which couples an unsteady aerodynamic solver to a thin-film model based on lubrication theory for the flow of the rain water to ascertain the motion of the rivulets owing to the unsteady aerodynamic field. This novel numerical technique, which is still in the relatively early stages of development, has already provided useful information on the coupling between the external aerodynamic flow and the rivulet, and a summary of some of the key results to date is presented

Synchronous collaborative information retrieval: techniques and evaluation

Synchronous Collaborative Information Retrieval refers to systems that support multiple users searching together at the same time in order to satisfy a shared information need. To date most SCIR systems have focussed on providing various awareness tools in order to enable collaborating users to coordinate the search task. However, requiring users to both search and coordinate the group activity may prove too demanding. On the other hand without effective coordination policies the group search may not be effective. In this paper we propose and evaluate novel system-mediated techniques for coordinating a group search. These techniques allow for an effective division of labour across the group whereby each group member can explore a subset of the search space.We also propose and evaluate techniques to support automated sharing of knowledge across searchers in SCIR, through novel collaborative and complementary relevance feedback techniques. In order to evaluate these techniques, we propose a framework for SCIR evaluation based on simulations. To populate these simulations we extract data from TREC interactive search logs. This work represent the first simulations of SCIR to date and the first such use of this TREC data

A comparison of short-term and long-term air pollution exposure associations with mortality in two cohorts in Scotland

Air pollution–mortality risk estimates are generally larger at longer-term, compared with short-term, exposure time scales. We compared associations between short-term exposure to black smoke (BS) and mortality with long-term exposure–mortality associations in cohort participants and with short-term exposure–mortality associations in the general population from which the cohorts were selected. We assessed short-to-medium–term exposure–mortality associations in the Renfrew–Paisley and Collaborative cohorts (using nested case–control data sets), and compared them with long-term exposure–mortality associations (using a multilevel spatiotemporal exposure model and survival analyses) and short-to-medium–term exposure–mortality associations in the general population (using time-series analyses). For the Renfrew–Paisley cohort (15,331 participants), BS exposure–mortality associations were observed in nested case–control analyses that accounted for spatial variations in pollution exposure and individual-level risk factors. These cohort-based associations were consistently greater than associations estimated in time-series analyses using a single monitoring site to represent general population exposure {e.g., 1.8% [95% confidence interval (CI): 0.1, 3.4%] vs. 0.2% (95% CI: 0.0, 0.4%) increases in mortality associated with 10-μg/m3 increases in 3-day lag BS, respectively}. Exposure–mortality associations were of larger magnitude for longer exposure periods [e.g., 3.4% (95% CI: –0.7, 7.7%) and 0.9% (95% CI: 0.3, 1.5%) increases in all-cause mortality associated with 10-μg/m3 increases in 31-day BS in case–control and time-series analyses, respectively; and 10% (95% CI: 4, 17%) increase in all-cause mortality associated with a 10-μg/m3 increase in geometic mean BS for 1970–1979, in survival analysis]. After adjusting for individual-level exposure and potential confounders, short-term exposure–mortality associations in cohort participants were of greater magnitude than in comparable general population time-series study analyses. However, short-term exposure–mortality associations were substantially lower than equivalent long-term associations, which is consistent with the possibility of larger, more persistent cumulative effects from long-term exposures

Differentiation of marrow stromal cells into photoreceptors in the rat eye

Retinal degenerations and dystrophies are the major causes of genetically inherited blindness that are characterized by the apoptotic death of the photoreceptor cell layer of the retina. To date, no treatment exists for these diseases and only recently have they been considered as candidates for gene and stem cell therapies. Here we report the ability of adult CD90+ marrow stromal cells (MSCs) to be induced by activin A, taurine, and EGF into cells (20-32%) expressing photoreceptor-specific markers rhodopsin, opsin, and recoverin in vitro. CD90+ cells were either transduced with recombinant adeno-associated virus expressing green fluorescent protein (GFP) or bromodeoxyuridine (BrdU) labeled and then injected into the subretinal space of adult Royal College of Surgeons rats. Fundus photography and angiography showed no adverse effects of CD90+ MSC transplantation. GFP-expressing cells or BrdU-positive cells covered ∼30% of the entire retinal area. By 2 weeks after injection, CD90+ MSCs integrated into the host retina, forming structures similar to the photoreceptor layer and expressed a photoreceptor-specific marker. No teratoma formation was observed in the recipient retina. The subretinally delivered CD90+ MSCs did not stain for proliferating cell nuclear antigen, indicating that they primarily undergo differentiation rather than proliferation. In addition, we established that transplanted cells can attract synaptic vesicles and hence are potentially capable of signal transduction. This study demonstrates for the first time the partial differentiation of adult CD90+ MSCs into photoreceptors in vitro and in vivo. Our results establish a proof of concept for CD90+ MSC differentiation with autologous transplantation, which may provide a promising therapeutic strategy for the treatment of some forms of genetically inherited retinal degenerations

Metric trees of generalized roundness one

Every finite metric tree has generalized roundness strictly greater than one. On the other hand, some countable metric trees have generalized roundness precisely one. The purpose of this paper is to identify some large classes of countable metric trees that have generalized roundness precisely one. At the outset we consider spherically symmetric trees endowed with the usual combinatorial metric (SSTs). Using a simple geometric argument we show how to determine decent upper bounds on the generalized roundness of finite SSTs that depend only on the downward degree sequence of the tree in question. By considering limits it follows that if the downward degree sequence $(d_{0}, d_{1}, d_{2}...)$ of a SST $(T,\rho)$ satisfies $|\{j \, | \, d_{j} > 1 \}| = \aleph_{0}$, then $(T,\rho)$ has generalized roundness one. Included among the trees that satisfy this condition are all complete $n$-ary trees of depth $\infty$ ($n \geq 2$), all $k$-regular trees ($k \geq 3$) and inductive limits of Cantor trees. The remainder of the paper deals with two classes of countable metric trees of generalized roundness one whose members are not, in general, spherically symmetric. The first such class of trees are merely required to spread out at a sufficient rate (with a restriction on the number of leaves) and the second such class of trees resemble infinite combs.Comment: 14 pages, 2 figures, 2 table

Relationship of dietary monounsaturated fatty acids to blood pressure: the international study of macro/micronutrients and blood pressure

Objective: In short-term feeding trials, replacement of other macronutrients with monounsaturated fatty acid reduces blood pressure. However, observational studies have not clearly demonstrated a relationship between monounsaturated fatty acid intake and blood pressure. We report associations of monounsaturated fatty acid intake of individuals with blood pressure in a cross-sectional study. Methods: The International Study of Macro/Micronutrients and Blood Pressure is a cross-sectional epidemiologic study of 4,680 men and women ages 40-59 from 17 population samples in China, Japan, United Kingdom, and United States. Nutrient intake data were based on four in-depth multi-pass 24-hour dietary recalls/person and two timed 24-hour urine collections/person. Blood pressure was measured eight times at four visits. Results: Mean monounsaturated fatty acid intake ranged from 8.1 %kcal (China) to 12.2%kcal (United States). With sequential models to control for possible confounders (dietary, other), linear regression analyses showed significant inverse relationship of total monounsaturated fatty acid intake with diastolic blood pressure for all participants; for 2,238 “non-intervened” individuals, the relationship was stronger. Estimated diastolic blood pressure differences with 2-SD higher monounsaturated fatty acids (5.35 %kcal) were -0.82 mm Hg (P<0.05) for all participants and -1.70 mm Hg (P<0.01) for non-intervened individuals. Inverse associations of dietary total oleic acid (main monounsaturated) with blood pressure in non-intervened individuals were not significant, but those of oleic acid from vegetable sources were stronger and significant (P<0.05). Conclusions: Dietary monounsaturated fatty acid intake, especially oleic acid from vegetable sources, may contribute to prevention and control of adverse blood pressure levels in general populations. Condensed Abstract The associations of monounsaturated fatty acid intake of individuals with blood pressure was investigated in a cross-sectional epidemiologic study of 4,680 men and women ages 40-59 from 17 population samples in China, Japan, United Kingdom, and United States. Linear regression analyses showed significant inverse relationship of total monounsaturated fatty acid intake with diastolic blood pressure. Inverse associations of dietary total oleic acid from vegetable sources with blood pressure in non-intervened individuals were stronger and significant. Dietary monounsaturated fatty acid intake, especially oleic acid from vegetable sources, may contribute to prevention and control of adverse blood pressure levels in general populations