1,050 research outputs found
A Superspace Formulation of The BV Action for Higher Derivative Theories
We first analyze the anti-BRST and double BRST structures of a certain higher
derivative theory that has been known to possess BRST symmetry associated with
its higher derivative structure. We discuss the invariance of this theory under
shift symmetry in the Batalin Vilkovisky (BV) formalism. We show that the
action for this theory can be written in a manifestly extended BRST invariant
manner in superspace formalism using one Grassmann coordinate.
It can also be written in a manifestly extended BRST invariant manner and
on-shell manifestly extended anti-BRST invariant manner in superspace formalism
using two Grassmann coordinates.Comment: accepted for publication in EPJ
Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function
Oxidative DNA damage induces changes in the neuronal cell cycle and activates a DNA damage response to promote repair, but these processes may be altered under a chronic oxidative environment, leading to the accumulation of unrepaired DNA damage and continued activation of a DNA damage response. Failure to repair DNA damage can lead to apoptosis or senescence, which is characterized by a permanent cell-cycle arrest. Increased oxidative stress and accumulation of oxidative DNA damage are features of brain ageing and neurodegeneration but the effects of persistent DNA damage in neurons are not well-characterized. We developed a model of persistent oxidative DNA damage in immortalized post-mitotic neurons in vitro by exposing them to a sub-lethal concentration of hydrogen peroxide following a âdouble stressâ protocol, and performed a detailed characterization of the neuronal transcriptome using microarray analysis. Persistent DNA damage significantly altered the expression of genes involved in cell cycle regulation, DNA damage response and repair mechanisms, and mitochondrial function, suggesting an active DDR response to replication stress and alterations in mitochondrial electron transport chain. qPCR and functional validation experiments confirmed hyperactivation of mitochondrial Complex I in response to persistent DNA damage. These changes in response to persistent oxidative DNA damage may lead to further oxidative stress, contributing to neuronal dysfunction and ultimately neurodegeneration
Mapping our Universe in 3D with MITEoR
Mapping our universe in 3D by imaging the redshifted 21 cm line from neutral
hydrogen has the potential to overtake the cosmic microwave background as our
most powerful cosmological probe, because it can map a much larger volume of
our Universe, shedding new light on the epoch of reionization, inflation, dark
matter, dark energy, and neutrino masses. We report on MITEoR, a pathfinder
low-frequency radio interferometer whose goal is to test technologies that
greatly reduce the cost of such 3D mapping for a given sensitivity. MITEoR
accomplishes this by using massive baseline redundancy both to enable automated
precision calibration and to cut the correlator cost scaling from N^2 to NlogN,
where N is the number of antennas. The success of MITEoR with its 64
dual-polarization elements bodes well for the more ambitious HERA project,
which would incorporate many identical or similar technologies using an order
of magnitude more antennas, each with dramatically larger collecting area.Comment: To be published in proceedings of 2013 IEEE International Symposium
on Phased Array Systems & Technolog
GJ 1252 b: A 1.2 R\u3csub\u3eâ\u3c/sub\u3e Planet Transiting An M3 Dwarf At 20.4 pc
We report the discovery of GJ 1252 b, a planet with a radius of 1.193 ± 0.074 Râ and an orbital period of 0.52 days around an M3-type star (0.381 ± 0.019 Mâ, 0.391 ± 0.020 Râ) located 20.385 ± 0.019 pc away. We use Transiting Exoplanet Survey Satellite (TESS) data, ground-based photometry and spectroscopy, Gaia astrometry, and high angular resolution imaging to show that the transit signal seen in the TESS data must originate from a transiting planet. We do so by ruling out all false-positive scenarios that attempt to explain the transit signal as originating from an eclipsing stellar binary. Precise Doppler monitoring also leads to a tentative mass measurement of 2.09 ± 0.56 Mâ. The host star proximity, brightness (V = 12.19 mag, K = 7.92 mag), low stellar activity, and the system\u27s short orbital period make this planet an attractive target for detailed characterization, including precise mass measurement, looking for other objects in the system, and planet atmosphere characterization
The 2HWC HAWC Observatory Gamma Ray Catalog
We present the first catalog of TeV gamma-ray sources realized with the
recently completed High Altitude Water Cherenkov Observatory (HAWC). It is the
most sensitive wide field-of-view TeV telescope currently in operation, with a
1-year survey sensitivity of ~5-10% of the flux of the Crab Nebula. With an
instantaneous field of view >1.5 sr and >90% duty cycle, it continuously
surveys and monitors the sky for gamma ray energies between hundreds GeV and
tens of TeV.
HAWC is located in Mexico at a latitude of 19 degree North and was completed
in March 2015. Here, we present the 2HWC catalog, which is the result of the
first source search realized with the complete HAWC detector. Realized with 507
days of data and represents the most sensitive TeV survey to date for such a
large fraction of the sky. A total of 39 sources were detected, with an
expected contamination of 0.5 due to background fluctuation. Out of these
sources, 16 are more than one degree away from any previously reported TeV
source. The source list, including the position measurement, spectrum
measurement, and uncertainties, is reported. Seven of the detected sources may
be associated with pulsar wind nebulae, two with supernova remnants, two with
blazars, and the remaining 23 have no firm identification yet.Comment: Submitted 2017/02/09 to the Astrophysical Journa
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