The Ginzburg-Landau Theory of Type II superconductors in magnetic field

Thermodynamics of type II superconductors in electromagnetic field based on the Ginzburg - Landau theory is presented. The Abrikosov flux lattice solution is derived using an expansion in a parameter characterizing the "distance" to the superconductor - normal phase transition line. The expansion allows a systematic improvement of the solution. The phase diagram of the vortex matter in magnetic field is determined in detail. In the presence of significant thermal fluctuations on the mesoscopic scale (for example in high $T_{c}$ materials) the vortex crystal melts into a vortex liquid. A quantitative theory of thermal fluctuations using the lowest Landau level approximation is given. It allows to determine the melting line and discontinuities at melt, as well as important characteristics of the vortex liquid state. In the presence of quenched disorder (pinning) the vortex matter acquires certain "glassy" properties. The irreversibility line and static properties of the vortex glass state are studied using the "replica" method. Most of the analytical methods are introduced and presented in some detail. Various quantitative and qualitative features are compared to experiments in type II superconductors, although the use of a rather universal Ginzburg - Landau theory is not restricted to superconductivity and can be applied with certain adjustments to other physical systems, for example rotating Bose - Einstein condensate.Comment: 60 pages, 15 figures, accepted for publication in Review of Modern Physic

Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization

Ciliopathies are a large group of clinically and genetically heterogeneous disorders caused by defects in primary cilia. Here we identified mutations in TRAF3IP1 (TNF Receptor-Associated Factor Interacting Protein 1) in eight patients from five families with nephronophthisis (NPH) and retinal degeneration, two of the most common manifestations of ciliopathies. TRAF3IP1 encodes IFT54, a subunit of the IFT-B complex required for ciliogenesis. The identified mutations result in mild ciliary defects in patients but also reveal an unexpected role of IFT54 as a negative regulator of microtubule stability via MAP4 (microtubule-associated protein 4). Microtubule defects are associated with altered epithelialization/polarity in renal cells and with pronephric cysts and microphthalmia in zebrafish embryos. Our findings highlight the regulation of cytoplasmic microtubule dynamics as a role of the IFT54 protein beyond the cilium, contributing to the development of NPH-related ciliopathies

Sleep and immune function

Sleep and the circadian system exert a strong regulatory influence on immune functions. Investigations of the normal sleep–wake cycle showed that immune parameters like numbers of undifferentiated naïve T cells and the production of pro-inflammatory cytokines exhibit peaks during early nocturnal sleep whereas circulating numbers of immune cells with immediate effector functions, like cytotoxic natural killer cells, as well as anti-inflammatory cytokine activity peak during daytime wakefulness. Although it is difficult to entirely dissect the influence of sleep from that of the circadian rhythm, comparisons of the effects of nocturnal sleep with those of 24-h periods of wakefulness suggest that sleep facilitates the extravasation of T cells and their possible redistribution to lymph nodes. Moreover, such studies revealed a selectively enhancing influence of sleep on cytokines promoting the interaction between antigen presenting cells and T helper cells, like interleukin-12. Sleep on the night after experimental vaccinations against hepatitis A produced a strong and persistent increase in the number of antigen-specific Th cells and antibody titres. Together these findings indicate a specific role of sleep in the formation of immunological memory. This role appears to be associated in particular with the stage of slow wave sleep and the accompanying pro-inflammatory endocrine milieu that is hallmarked by high growth hormone and prolactin levels and low cortisol and catecholamine concentrations