16 research outputs found
The IASLC Early Lung Imaging Confederation (ELIC) Open-Source Deep Learning and Quantitative Measurement Initiative.
BackgroundWith global adoption of CT lung cancer screening, there is increasing interest to use artificial intelligence (AI) deep learning methods to improve the clinical management process. To enable AI research using an open source, cloud-based, globally distributed, screening CT imaging dataset and computational environment that are compliant with the most stringent international privacy regulations that also protects the intellectual properties of researchers, the International Association of the Study of Lung Cancer (IASLC) sponsored development of the Early Lung Imaging Confederation (ELIC) resource in 2018. The objective of this report is to describe the updated capabilities of ELIC and illustrate how this resource can be utilized for clinically relevant AI research.MethodsIn this second Phase of the initiative, metadata and screening CT scans from two time points were collected from 100 screening participants in seven countries. An automated deep learning AI lung segmentation algorithm, automated quantitative emphysema metrics, and a quantitative lung nodule volume measurement algorithm were run on these scans.ResultsA total of 1,394 CTs were collected from 697 participants. The LAV950 quantitative emphysema metric was found to be potentially useful in distinguishing lung cancer from benign cases using a combined slice thickness ≥ 2.5 mm. Lung nodule volume change measurements had better sensitivity and specificity for classifying malignant from benign lung nodules when applied to solid lung nodules from high quality CT scans.ConclusionThese initial experiments demonstrated that ELIC can support deep learning AI and quantitative imaging analyses on diverse and globally distributed cloud-based datasets
Efficacia e tollerabilità della doppia terapia antiaggregante piastrinica con Indobufene e Clopidogrel in pazienti con SCA e allergia documentata all’aspirina, sottoposti a PTCA ed impianto di stent
Influenza degli inibitori di pompa protonica sull’attività antiaggregante del clopidogrel in pazienti con SCA trattati con PTCA ed impianto di stent coronarico
AUMENTO DEI LIVELLI SIERICI DI ANTICORPI ANTI-TRANSGLUTAMINASI TISSUTALE E SVILUPPO DI RIMODELLAMENTO VENTRICOLARE SINISTRO NEL POST-INFARTO
Correlazione tra i livelli sierici di anticorpi anti-transglutaminasi tissutale e sviluppo di rimodellamento ventricolare sinistro nel post-infarto
Inibitori di pompa protonica e resistenza al clopidogrel in pazienti con sindrome coronarica acuta trattati con PTCA ed impianto di stent
Clinical and biochemical improvement following HSCT in a patient with MNGIE: 1-year follow-up
Fatores associados à tosse seca, tosse produtiva e tosse noturna em adultos jovens na Nigéria Factors associated with nocturnal, productive and dry cough in the young adult population of Nigeria
OBJETIVO: Determinar os fatores associados Ă tosse seca, tosse produtiva e tosse noturna entre jovens adultos na NigĂ©ria. MÉTODOS: Foram avaliados 498 indivĂduos com 20-44 anos de idade em Ilorin, NigĂ©ria, utilizando-se o questionário European Community Respiratory Health Survey (ECRHS), administrado por entrevistadores treinados. RESULTADOS: A tosse noturna apresentou associações com asma (OR = 10,87; p < 0,01), alergia nasal (OR = 6,33; p < 0,01), tabagismo (OR = 3,10; p < 0,01), trabalho manual e trabalho nĂŁo manual especializados (OR = 2,86 e 2,10, respectivamente; p < 0,01 para ambos) e gĂŞnero feminino (OR = 1,33; p = 0,17). A tosse produtiva apresentou associações com trabalho manual e trabalho nĂŁo manual especializados (OR = 3,82 e 3,03, respectivamente; p < 0,01 para ambos), tabagismo (OR = 3,10; p < 0,01), asma (OR = 3,27; p < 0,01) e alergia nasal (OR = 5,81; p < 0,01). A tosse seca apresentou associações com asma (OR =5,18; p < 0,01) obesidade (OR =1,88; p = 0,19), tabagismo (OR = 1,77; p = 1,44), alergia nasal (OR = 1,45; p = 0,26) e gĂŞnero feminino (OR =1,36; p = 0,33). A idade, o gĂŞnero, o tipo de residĂŞncia e a obesidade nĂŁo se associaram significativamente a nenhum tipo de tosse (p > 0,05). CONCLUSĂ•ES: A prevenção precoce e o tratamento de condições associadas Ă tosse, assim como a modificação de fatores sociais comumente associados Ă tosse, sĂŁo necessários a fim de reduzir a morbidade respiratĂłria.<br>OBJECTIVE: The aim of this study was to determine the factors associated with nocturnal, productive and dry cough among young adults in Nigeria. METHODS: We evaluated 498 subjects, 20-44 years of age, in Ilorin, Nigeria, using the European Community Respiratory Health Survey (ECRHS) questionnaire, administered by trained interviewers. RESULTS: Nocturnal cough was associated with asthma (OR = 10.87; p < 0.01), nasal allergy (OR = 6.33; p < 0.01), smoking (OR = 3.10; p < 0.01), skilled manual and non-manual work (OR = 2.86 and 2.10, respectively; p < 0.01 for both) and female gender (OR = 1.33; p = 0.17). Productive cough was associated with skilled manual and non-manual work (OR = 3.82 and 3.03, respectively; p < 0.01 for both), smoking (OR = 3.10; p < 0.01), asthma (OR = 3.27; p < 0.01) and nasal allergy (OR = 5.81; p < 0.01). Dry cough was associated with asthma (OR =5.18; p < 0.01) obesity (OR =1.88; p = 0.19), smoking (OR = 1.77; p = 1.44), nasal allergy (OR = 1.45; p = 0.26) and female gender (OR =1.36; p = 0.33). Age, gender, type of residence and obesity were not significantly associated with any type of cough (p > 0.05). CONCLUSIONS: Early prevention and treatment of conditions associated with cough, as well as the modification of social factors commonly associated with cough, are needed in order to reduce respiratory morbidity