COVID-19: OBSERVATIONS ON STANDARD TREATMENT ALGORITHMS

In this article, a retrospective analysis of the medical histories was carried out in order to develop an individualized approach to treating COVID-19. Questions were raised about the advisability of the universal immunosuppressive therapy, the need to prescribe glucocorticosteroids only taking into account the cytokine profile of patients, the relationship of glucocorticosteroid therapy and carbohydrate metabolism disorders, as one of the most common complications of pharmacotherapy COVID-19 in the patients we studied. Unjustified immunosuppression in the stage of active fight against the infectious agent as a factor of chronization of the process and decrease of the body reactivity, as well as neutralization by immunosuppressive therapy of factors of protection of innate non-specific immunity mobilized to fight the causative agent. The importance of taking into account the probability of thrombosis with consideration of coagulogram indices and thrombosis markers (D-dimer, fibrin degradation products) does not exclude the risk of the hemorrhagic complications when prescribing high doses of anticoagulants. Antibacterial therapy for uncomplicated viral infections is neither an etiologic nor a pathogenetic treatment option. In addition, it leads to the emergence of resistant strains of microorganisms as a result of mutational variability and evolutionary adaptations of bacteria, which greatly complicates the choice of an effective antibacterial drug in some cases. Antithrombotic, glucocorticosteroid and antibacterial therapy should be clinically and laboratory justified in each individual case. The article focuses on the safety of prescribing antipodagric agents in the treatment of COVID-19 as anti-inflammatory. The review considers all the above-mentioned aspects of COVID-19 therapy with reference to foreign studies, describes options for the pathophysiological development of infection. We note the need to develop systematic data on coronavirus, changes that the pathogen induces in the body. This will allow the development of innovative and effective therapeutic strategies for the treatment of the new coronavirus infection

A process approach to management of an educational organization

© 2015, Review of European Studies. All right reserved. Directions for an educational organization development meet the requirements of society to the effectiveness and quality of educational activities in high dynamics of external and internal environment. The article examines the potential of the process approach, which considers management as a continuous performance of certain interrelated activities complex and general management functions when developing a quality management system of an educational organization. In the submitted article the components of the educational activities process are defined, which are based on the quality standard of the final product. This article is intended for educators, researchers, heads of educational institutions, employers, customers of educational services, education management organizations employees

Mental states peculiarities of students proclivity for drug addiction

© 2015, Mediterranean Center of Social and Educational Research. All rights reserved. Tendency to drug addiction has an adverse effect on success of socialization and personal and professional students’ formation. There is a risk of proclivity development for addiction, for a disease that can lead to full degradation of the personality. One of the reasons of drug addiction is students’ being unable to manage their mental states. The features of mental students’ conditions of drug addictionproclivity, the features of their dominating states and a relief of mental states were studied in the research in order to learn the statistical analysis of distinction of reliability of average values. So the correlation analysis was carried out. Data were processed by the program of statistical data processing of SPSS 22.0. It is established that expressiveness of all mental states among students with high tendency to drug addiction is weaker, though negative states are expressed more strongly. Tendency to drug addiction among students is caused by stronger expressiveness of the mental states connected with experiences, and by weaker expressiveness of the mental states connected with physiological reactions. The data obtained during research will allow the correcting of the psychology and pedagogical programs directed at level tendency decrease to drug addiction among students taking into account the features of their mental states

Reactions of 5,7-dichloro-4,6-dinitrobenzofuroxane and -furazane with triphenylphosphine

Reactions of 5,7-dichloro-4,6-dinitrobenzofuroxane and 5,7-dichloro-4,6- dinitrobenzofurazane with triphenylphosphine proceed through a nucleophilic aromatic substitution of chlorine and nitro groups in the six-membered ring of the heterocycles. The structure of the phosphorylation products was established from the IR, 31P NMR, and mass spectra and from XRD and elemental analysis. Schemes of the routes of the phosphorylation are discussed. © 2012 Pleiades Publishing, Ltd

Structure of the 70S ribosome from human pathogen Staphylococcus aureus

© 2016 The Author(s).Comparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact translation specificity and its regulation. Although the importance of such features may be less obvious within more closely related organisms, their existence could account for vital yet species-specific mechanisms of translation regulation that would involve stalling, cell survival and antibiotic resistance. Here, we present the first full 70S ribosome structure from Staphylococcus aureus, a Gram-positive pathogenic bacterium, solved by cryo-electron microscopy. Comparative analysis with other known bacterial ribosomes pinpoints several unique features specific to S. aureus around a conserved core, at both the protein and the RNA levels. Our work provides the structural basis for the many studies aiming at understanding translation regulation in S. aureus and for designing drugs against this often multi-resistant pathogen

Doing Gender Online : Digital Spaces for Identity Politics

Peer reviewe

Clinical and radiographic evaluation of optical density of bone tissue in the center of destruction of chronic apical periodontitis

The purpose of the complex examination was to determine the optical density of bone tissue in the periapical region in the focus of destruction in chronic apical periodontitis of masticatory groups of teeth in young people using methods of radiovisiography and dental computed tomography. To determine the parameters of optical density in the destruction center, 50 sighting images and 18 – dental computer tomograms were performed using radio – imaging data. 68 people aged 20 – 30 years, with various forms of chronic apical periodontitis without endodontic intervention in the anamnesis were examined. Based on the results of the study, there is a significant decrease in optical density in the focus of destruction, which indicates a significant decrease in bone density in the periapical region in chronic periodontitis, obtained by radiovisiography and dental computed tomography were reduced by 2 times compared to the norm. These data should be taken into account when monitoring the treatment of chronic apical periodontitis.Целью комплексного обследования явилось определение показателей оптической плотности костной ткани в периапикальной области в очаге деструкции при хроническом апикальном периодонтите жевательных групп зубов у лиц молодого возраста с помощью методов радиовизиографии и дентальной компьютерной томографии. Для определения параметров оптической плотности в очаге деструкции проводили по данным радиовизиографии – 50 прицельных снимков и 18 – дентальных компьютерных томограмм. Обследовано 68 человек в возрасте 20 – 30 лет, с различными формами хронического апикального периодонтита без эндодонтического вмешательством в анамнезе. Исходя из результатов исследования, отмечается значительное снижение оптической плотности в очаге деструкции, что свидетельствуют о значительном снижении костной плотности в периапикальной области при хроническом периодонтите, полученные методами радиовизиографии и дентальной компьютерной томографии были снижены в 2 раза по сравнению с нормой. Эти данные необходимо учитывать при мониторинге лечения хронического апикального периодонтита

Erratum: Structure of the 70S ribosome from human pathogen Staphylococcus aureus (Nucleic Acids Research (2017) DOI: 10.1093/nar/gkw933)

© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.The authors wish to correct their Funding statement as follows: FUNDING. 'Centre National de la Recherche Scientifique' (CNRS) and the 'Agence Nationale de la Recherche' as part of the 'Investissements d'Avenir' program [LabEx: ANR-10-LABX-0036-NETRNA to P.R., Y.H.; ANR-15-CE11-0021-01 to G.Y.]; 'Fondation pour la Recherche Médicale en France' [FDT20140930867 to I.K; 'European Research Council advanced grant' [294312 to M.Y.]; the 'Russian Science Foundation' [Project No. 16-14-10014 to I.K., M.Y.]. Funding for open access charge: Centre National de la Recherche Scientifique (CNRS). In addition, Marat Yusupov is associated with both affiliations1 and 2. The authors apologise to the readers for this error

The Cryo-EM Structure of a Complete 30S Translation Initiation Complex from Escherichia coli

Formation of the 30S initiation complex (30S IC) is an important checkpoint in regulation of gene expression. The selection of mRNA, correct start codon, and the initiator fMet-tRNAfMet requires the presence of three initiation factors (IF1, IF2, IF3) of which IF3 and IF1 control the fidelity of the process, while IF2 recruits fMet-tRNAfMet. Here we present a cryo-EM reconstruction of the complete 30S IC, containing mRNA, fMet-tRNAfMet, IF1, IF2, and IF3. In the 30S IC, IF2 contacts IF1, the 30S subunit shoulder, and the CCA end of fMet-tRNAfMet, which occupies a novel P/I position (P/I1). The N-terminal domain of IF3 contacts the tRNA, whereas the C-terminal domain is bound to the platform of the 30S subunit. Binding of initiation factors and fMet-tRNAfMet induces a rotation of the head relative to the body of the 30S subunit, which is likely to prevail through 50S subunit joining until GTP hydrolysis and dissociation of IF2 take place. The structure provides insights into the mechanism of mRNA selection during translation initiation