Cobalt-catalyzed one-pot three-component coupling route to β-acetamido carbonyl compounds: a general synthetic protocol for γ-lactams

An efficient improved procedure for the synthesis of β-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol. The procedure is also amenable to the synthesis of γ-lactams by a three-component coupling reaction with use of 2-carbomethoxybenzaldehyde. The β-acetamido carbonyl compounds derived from 2-carbomethoxybenzaldehyde are useful intermediates as they can be transformed to the corresponding γ -lactams on treatment with base

Synthesis of a novel cis-proline-derived cyclic type VI β-turn mimic via ring-closing metathesis

A cis-proline derived cyclic mimic of a type VI β-turn is synthesized via a ring-closing metathesis reaction. The solution NMR conformational study indicates that the major conformer of the cyclic peptide adopts a type VIa β-turn in CDCl3 and a type VIb β-turn in DMSO-d6