Arrival directions of cosmic rays of E .4 EeV

The anisotropy of cosmic rays observed by the Utah Fly's Eye detector has been studied. Emphasis has been placed on examining distributions of events in galactic coordinates. No statistically significant departure from isotropy has been observed for energies greater than 0.4 EeV (1 EeV = 10 to the 18th power eV). Results of the standard harmonic analysis in right ascension are also presented

The influence of liver dysfunction on cyclosporine pharmacokinetics -A comparison between 70 per cent hepatectomy and complete bile duct ligation in dogs-

The influence of experimentally induced hepatic dysfunction on the pharmacokinetics of Cyclosporine A (CsA) was determined in dogs. The pharmacokinetics of oral (PO) and intravenous (IV) CsA were studied before and after 70 per cent hepatectomy or complete bile duct ligation (CBDL). Changes in liver function were monitored by serial measurements of serum bilirubin, and by the maximum removal rate (Rmax) and plasma disappearance rate (ICG-K) of indocyanine green (ICG). Concentrations of CsA in whole blood were measured by HPLC. Seventy per cent hepatectomy caused significant liver dysfunction: the ICG-Rmax decreased by 47.7±7.1 per cent (mean±SD) and the ICG-K decreased by 61.3±9.7 per cent during the first week after hepatectomy. At the same time, the systemic clearance (CLs) of IV-CsA decreased by 43.9±8.2 per cent, the area under the concentration curve (AUC) of IV-CsA increased by 35.4±20.8 per cent and the bioavailability of CsA decreased by 26.4±14.8 per cent. CBDL also induced significant liver dysfunction: the ICG-Rmax decreased by 39.1±12.8 per cent and the ICG-K decreased by 65.6±3.6 per cent in the second week after the operation. During the same period, the AUC of PO-CsA decreased by 69.9±10.7 per cent and the bioavailability of CsA also decreased markedly by 73.9±15.6 per cent. These data indicate that hepatic impairment significantly influences the pharmacokinetics of CsA, not only by the changes in intestinal absorption, but also by those in hepatic, metabolism. Dose adjustment is therefore necessary in the presence of hepatic dysfunction in order to maintain an adequate blood concentration of CsA without causing side effects. © 1989 The Japan Surgical Society

Revealing the structure of information flows discriminates similar animal social behaviors

Behavioral correlations stretching over time are an essential but often neglected aspect of interactions among animals. These correlations pose a challenge to current behavioral-analysis methods that lack effective means to analyze complex series of interactions. Here we show that non-invasive information-theoretic tools can be used to reveal communication protocols that guide complex social interactions by measuring simultaneous flows of different types of information between subjects. We demonstrate this approach by showing that the tandem-running behavior of the ant Temnothorax rugatulus and that of the termites Coptotermes formosanus and Reticulitermes speratus are governed by different communication protocols. Our discovery reconciles the diverse ultimate causes of tandem running across these two taxa with their apparently similar signaling mechanisms. We show that bidirectional flow of information is present only in ants and is consistent with the use of acknowledgement signals to regulate the flow of directional information

Functional ENTPD1 Polymorphisms in African Americans With Diabetes and End-Stage Renal Disease

Objective: The vascular ectonucleotidase ENTPD1 protects against renal injury and modulates glucose homeostasis in mouse models. We sought to determine whether human variation in ENTPD1 influences predisposition to diabetes or diabetic nephropathy. Research Design and Methods: We analyzed ENTPD1 single nucleotide polymorphisms (SNPs) in 363 African American control subjects, 380 subjects with type 2 diabetes and end-stage renal disease (DM-ESRD), and 326 subjects with ESRD unrelated to diabetes (non–DM-ESRD). Using human cell lines, we correlated disease-associated ENTPD1 haplotypes with ENTPD1 gene expression. Finally, we studied consequences of ENTPD1 deletion in a mouse model of type 2 diabetes (db/db). Results: A common ENTPD1 two-SNP haplotype was associated with increased risk for DM-ESRD (P = 0.0027), and an uncommon four-SNP haplotype was associated with protection against DM-ESRD (P = 0.004). These haplotypes correlated with ENTPD1 gene expression levels in human cell lines in vitro. Subjects with high ENTPD1-expressing haplotypes were enriched in the DM-ESRD group. By crossing ENTPD1-null mice with db mice, we show that ENTPD1 deletion has prominent effects on metabolic syndrome traits. Specifically, deletion of ENTPD1 lowered glucose levels in control (db/−) mice with one functional leptin receptor and dramatically lowered weights in db/db mice with no functional leptin receptors. Similar effects were seen in aged ENTPD1-null mice with normal leptin receptors. Conclusions: ENTPD1 polymorphisms appear to influence susceptibility to type 2 diabetes and/or diabetic nephropathy in African Americans. Studies in human cell lines and in vivo mouse data support a potential role for ENTPD1 genetic variation in susceptibility to type 2 diabetes

Very High-Energy Gamma-Ray Observations of PSR B1509-58 with the CANGAROO 3.8m Telescope

The gamma-ray pulsar PSR B1509-58 and its surrounding nebulae have been observed with the CANGAROO 3.8m imaging atmospheric Cherenkov telescope. The observations were performed from 1996 to 1998 in Woomera, South Australia, under different instrumental conditions with estimated threshold energies of 4.5 TeV (1996), 1.9 TeV (1997) and 2.5 TeV (1998) at zenith angles of ~30 deg. Although no strong evidence of the gamma-ray emission was found, the lowest energy threshold data of 1997 showed a marginal excess of gamma-ray--like events at the 4.1 sigma significance level. The corresponding gamma-ray flux is calculated to be (2.9 +/- 0.7) * 10^{-12}cm^{-2}s^{-1} above 1.9 TeV. The observations of 1996 and 1998 yielded only upper limits (99.5% confidence level) of 1.9 * 10^{-12}cm^{-2}s^{-1} above 4.5 TeV and 2.0 * 10^{-12}cm^{-2}s^{-1} above 2.5 TeV, respectively. Assuming that the 1997 excess is due to Very High-Energy (VHE) gamma-ray emission from the pulsar nebula, our result, when combined with the X-ray observations, leads to a value of the magnetic field strength ~5 micro G. This is consistent with the equipartition value previously estimated in the X-ray nebula surrounding the pulsar. No significant periodicity at the 150ms pulsar period has been found in any of the three years' data. The flux upper limits set from our observations are one order of magnitude below previously reported detections of pulsed TeV emission.Comment: Accepted to publication in Astrophys. Journal, 25 pages, 2 figure

CANGAROO-III Observation of TeV Gamma Rays from the vicinity of PSR B1 706-44

Observation by the CANGAROO-III stereoscopic system of the Imaging Cherenkov Telescope has detected extended emission of TeV gamma rays in the vicinity of the pulsar PSR B1706$-$44. The strength of the signal observed as gamma-ray-like events varies when we apply different ways of emulating background events. The reason for such uncertainties is argued in relevance to gamma-rays embedded in the "off-source data", that is, unknown sources and diffuse emission in the Galactic plane, namely, the existence of a complex structure of TeV gamma-ray emission around PSR B1706$-$44.Comment: 10 pages, 13 figures, to be published in Ap

"Dark" GRB 080325 in a Dusty Massive Galaxy at z ~ 2

We present optical and near infrared observations of GRB 080325 classified as a "Dark GRB". Near-infrared observations with Subaru/MOIRCS provided a clear detection of afterglow in Ks band, although no optical counterpart was reported. The flux ratio of rest-wavelength optical to X-ray bands of the afterglow indicates that the dust extinction along the line of sight to the afterglow is Av = 2.7 - 10 mag. This large extinction is probably the major reason for optical faintness of GRB 080325. The J - Ks color of the host galaxy, (J - Ks = 1.3 in AB magnitude), is significantly redder than those for typical GRB hosts previously identified. In addition to J and Ks bands, optical images in B, Rc, i', and z' bands with Subaru/Suprime-Cam were obtained at about one year after the burst, and a photometric redshift of the host is estimated to be z_{photo} = 1.9. The host luminosity is comparable to L^{*} at z \sim 2 in contrast to the sub-L^{*} property of typical GRB hosts at lower redshifts. The best-fit stellar population synthesis model for the host shows that a large dust extinction (Av = 0.8 mag) attributes to the red nature of the host and that the host galaxy is massive (M_{*} = 7.0 \times 10^{10} Msun) which is one of the most massive GRB hosts previously identified. By assuming that the mass-metallicity relation for star-forming galaxies at z \sim 2 is applicable for the GRB host, this large stellar mass suggests the high metallicity environment around GRB 080325, consistent with inferred large extinction.Comment: 22 pages, 10 figures, accepted for publication in The Astrophysical Journa