Controlled Data Sharing for Collaborative Predictive Blacklisting

Although sharing data across organizations is often advocated as a promising way to enhance cybersecurity, collaborative initiatives are rarely put into practice owing to confidentiality, trust, and liability challenges. In this paper, we investigate whether collaborative threat mitigation can be realized via a controlled data sharing approach, whereby organizations make informed decisions as to whether or not, and how much, to share. Using appropriate cryptographic tools, entities can estimate the benefits of collaboration and agree on what to share in a privacy-preserving way, without having to disclose their datasets. We focus on collaborative predictive blacklisting, i.e., forecasting attack sources based on one's logs and those contributed by other organizations. We study the impact of different sharing strategies by experimenting on a real-world dataset of two billion suspicious IP addresses collected from Dshield over two months. We find that controlled data sharing yields up to 105% accuracy improvement on average, while also reducing the false positive rate.Comment: A preliminary version of this paper appears in DIMVA 2015. This is the full version. arXiv admin note: substantial text overlap with arXiv:1403.212

Открытый доступ: обсуждение. Новая модель публикации и обнародования как вариант открытого доступа

The article of mosaic structure comprises the materials of the panel discussion “Collaboration & community. The transition to open access” held by Copyright Clearance Center (USA) within the framework London Book Fair in April, 2018. These materials (arguments presented by four discussion participants, experts in scholarly publishing: a publisher of Cambridge University Press, Cambridge University librarian, expert of Royal Society of Chemistry, and Executive Director of Knowledge Unlatched, a crowdfunding platform), and the introduction speech by Christopher Kenneally, discussion moderator, were published on the discussion date and distributed to the participants. By courtesy of Christopher Kenneally and Alastair Horn in charge of the Academic Bulletin where the prematerials were first published, we are including the original English-language text, the translation and the author’s summary and arguments on expanding publication formats, e. g. outspreading of panel sessions at conferences. The article is aimed at two goals: to introduce readers to several issues of the open access system voiced at the discussion panel, and to analyze in detail the methods of audience communication (the technologies based on open access principles). The selection of materials, permission for translation into Russian (and the translation) as well as the permission for reprinting the original are accomplished by Andrey I. Zemskov, RNPLS&T leading researcher, who attended the discussion panel. He is also the author of the summary review on the new publication and public exposure model as an open access version.Эта статья, имеющая сложную – «мозаичную» – структуру, содержит материалы семинара «Сотрудничество и сообщество. Переход к открытому доступу», проведенного на Лондонской книжной ярмарке в апреле 2018 г. американской компанией по доставке информации Copyright Clearance Center. Эти материалы (рассуждения четырех участников семинара – специалистов в сфере научных публикаций: издателя из Cambridge University Press, библиотекаря того же университета, представителя научного общества Royal Society of Chemistry и исполнительного директора платформы по сбору средств методом краудфандинга Knowledge Unlatched), а также вступительное слово модератора семинара Кристофера Киннелли (Christopher Kenneally) были опубликованы в день проведения этого мероприятия, их получили его участники. С любезного разрешения К. Киннелли и Аластара Хорна (Alastair Horn), ответственного за выпуск этого Академического бюллетеня, в котором размещены подготовительные материалы, мы публикуем оригинальный англоязычный текст и его перевод. Эта публикация преследует две цели: ознакомить читателей с проблемами развития системы открытого доступа, озвученными в ходе работы пленарной сессии; представить детальный разбор используемых методов работы с аудиторией (все технологии опираются на принципы открытого доступа). Отбор материала, работу по получению разрешений на русскоязычный перевод (и сам перевод) и на повторное использование оригинального материала (разрешение на перепечатку) выполнил А. И. Земсков, ведущий научный сотрудник ГПНТБ России, принявший участие в этом семинаре; он – автор заключительных обобщающих замечаний о новой модели публикации и обнародования как варианте открытого доступа

The determinants of vulnerability to currency crises: country-specific factors versus regional factors

We investigate the determinants of exchange market pressures (EMP) for some new EU member states at both the national and regional levels, where macroeconomic and financial variables are considered as potential sources. The regional common factors are extracted from these variables by using dynamic factor analysis. The linear empirical analysis, in general, highlights the importance of country-specific factors to defend themselves against vulnerability in their external sectors. Yet, given a significant impact of the common component in credit on EMP, a contagion effect is apparent through the conduit of credit market integration across these countries under investigation

Constraints on the lake volume required for hydro-fracture through ice sheets

Author Posting. © American Geophysical Union, 2009. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 36 (2009): L10501, doi:10.1029/2008GL036765.Water-filled cracks are an effective mechanism to drive hydro-fractures through thick ice sheets. Crack geometry is therefore critical in assessing whether a supraglacial lake contains a sufficient volume of water to keep a crack water-filled until it reaches the bed. In this study, we investigate fracture propagation using a linear elastic fracture mechanics model to calculate the dimensions of water-filled cracks beneath supraglacial lakes. We find that the cross-sectional area of water-filled cracks increases non-linearly with ice sheet thickness. Using these results, we place volumetric constraints on the amount of water necessary to drive cracks through ∼1 km of sub-freezing ice. For ice sheet regions under little tension, lakes larger than 0.25–0.80 km in diameter contain sufficient water to rapidly drive hydro-fractures through 1–1.5 km of subfreezing ice. This represents ∼98% of the meltwater volume held in supraglacial lakes in the central western margin of the Greenland Ice Sheet.Support for this research was provided by NSF and NASA (through ARC-0520077, ARC- 0531345, and ARC-520382) and by the Joint Initiative Awards Fund from the Andrew Mellon Foundation, and the WHOI Ocean and Climate Change Institute and Clark Arctic Research Initiative

Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a serious public health issue associated with high fat, high sugar diets. However, the molecular mechanisms mediating NAFLD pathogenesis are only partially understood. Here we adopt an iterative multi-scale, systems biology approach coupled to in vitro experimentation to investigate the roles of sugar and fat metabolism in NAFLD pathogenesis. The use of fructose as a sweetening agent is controversial; to explore this, we developed a predictive model of human monosaccharide transport, signalling and metabolism. The resulting quantitative model comprising a kinetic model describing monosaccharide transport and insulin signalling integrated with a hepatocyte-specific genome-scale metabolic network (GSMN). Differential kinetics for the utilisation of glucose and fructose were predicted, but the resultant triacylglycerol production was predicted to be similar for monosaccharides; these predictions were verified by in vitro data. The role of physiological adaptation to lipid overload was explored through the comprehensive reconstruction of the peroxisome proliferator activated receptor alpha (PPARα) regulome integrated with a hepatocyte-specific GSMN. The resulting qualitative model reproduced metabolic responses to increased fatty acid levels and mimicked lipid loading in vitro. The model predicted that activation of PPARα by lipids produces a biphasic response, which initially exacerbates steatosis. Our data support the evidence that it is the quantity of sugar rather than the type that is critical in driving the steatotic response. Furthermore, we predict PPARα-mediated adaptations to hepatic lipid overload, shedding light on potential challenges for the use of PPARα agonists to treat NAFLD

Collaborative International Research in Clinical and Longitudinal Experience Study in NMOSD

OBJECTIVE: To develop a resource of systematically collected, longitudinal clinical data and biospecimens for assisting in the investigation into neuromyelitis optica spectrum disorder (NMOSD) epidemiology, pathogenesis, and treatment. METHODS: To illustrate its research-enabling purpose, epidemiologic patterns and disease phenotypes were assessed among enrolled subjects, including age at disease onset, annualized relapse rate (ARR), and time between the first and second attacks. RESULTS: As of December 2017, the Collaborative International Research in Clinical and Longitudinal Experience Study (CIRCLES) had enrolled more than 1,000 participants, of whom 77.5% of the NMOSD cases and 71.7% of the controls continue in active follow-up. Consanguineous relatives of patients with NMOSD represented 43.6% of the control cohort. Of the 599 active cases with complete data, 84% were female, and 76% were anti-AQP4 seropositive. The majority were white/Caucasian (52.6%), whereas blacks/African Americans accounted for 23.5%, Hispanics/Latinos 12.4%, and Asians accounted for 9.0%. The median age at disease onset was 38.4 years, with a median ARR of 0.5. Seropositive cases were older at disease onset, more likely to be black/African American or Hispanic/Latino, and more likely to be female. CONCLUSION: Collectively, the CIRCLES experience to date demonstrates this study to be a useful and readily accessible resource to facilitate accelerating solutions for patients with NMOSD

Verification of model simulated mass balance, flow fields and tabular calving events of the Antarctic ice sheet against remotely sensed observations

The Antarctic ice sheet (AIS) has the greatestpotential for global sea level rise. This study simulates AISice creeping, sliding, tabular calving, and estimates the totalmass balances, using a recently developed, advanced icedynamics model, known as SEGMENT-Ice. SEGMENTIceis written in a spherical Earth coordinate system.Because the AIS contains the South Pole, a projectiontransfer is performed to displace the pole outside of thesimulation domain. The AIS also has complex ice-watergranularmaterial-bedrock configurations, requiringsophisticated lateral and basal boundary conditions.Because of the prevalence of ice shelves, a ‘girder yield’type calving scheme is activated. The simulations of presentsurface ice flow velocities compare favorably with InSARmeasurements, for various ice-water-bedrock configurations.The estimated ice mass loss rate during 2003–2009agrees with GRACE measurements and provides morespatial details not represented by the latter. The modelestimated calving frequencies of the peripheral ice shelvesfrom 1996 (roughly when the 5-km digital elevation andthickness data for the shelves were collected) to 2009compare well with archived scatterometer images. SEGMENT-Ice’s unique, non-local systematic calving schemeis found to be relevant for tabular calving. However, theexact timing of calving and of iceberg sizes cannot besimulated accurately at present. A projection of the futuremass change of the AIS is made, with SEGMENT-Iceforced by atmospheric conditions from three differentcoupled general circulation models. The entire AIS is estimatedto be losing mass steadily at a rate of*120 km3/a atpresent and this rate possibly may double by year 2100

Attempt to produce element 120 in the 244 Pu + 58 Fe reaction

An experiment aimed at the synthesis of isotopes of element 120 has been performed using the 244 Pu( 58 Fe,xn) 302−x 120 reaction. No decay chains consistent with fusion-evaporation reaction products were observed during an irradiation with a beam dose of 7.1 × 10 18 330-MeV 58 Fe projectiles. The sensitivity of the experiment corresponds to a cross section of 0.4 pb for the detection of one decay

Synthesis of the isotopes of elements 118 and 116 in the 249Cf and 245Cm+48Ca fusion reactions

The decay properties of {sup 290}116 and {sup 291}116, and the dependence of their production cross sections on the excitation energies of the compound nucleus, {sup 293}116, have been measured in the {sup 245}Cm({sup 48}Ca,xn){sup 293-x}116 reaction. These isotopes of element 116 are the decay daughters of element 118 isotopes, which are produced via the {sup 249}Cf+{sup 48}Ca reaction. They performed the element 118 experiment at two projectile energies, corresponding to {sup 297}118 compound nucleus excitation energies of E* = 29.2 {+-} 2.5 and 34.4 {+-} 2.3 MeV. During an irradiation with a total beam dose of 4.1 x 10{sup 19} {sup 48}Ca projectiles, three similar decay chains consisting of two or three consecutive {alpha} decays and terminated by a spontaneous fission (SF) with high total kinetic energy of about 230 MeV were observed. The three decay chains originated from the even-even isotope {sup 294}118 (E{sub {alpha}} = 11.65 {+-} 0.06 MeV, T{sub {alpha}} = 0.89{sub -0.31}{sup +1.07} ms) produced in the 3n-evaporation channel of the {sup 249}Cf+{sup 48}Ca reaction with a maximum cross section of 0.5{sub -0.3}{sup +1.6} pb

Indication for a volatile element 114

Recently, the chemical investigation of element 112 revealed a highly volatile, noble metallic behaviour, as expected for the last group 12 member of the periodic table. The observed volatility and chemical inertness were ascribed to the growing influence of relativistic effects on the chemical properties of the heaviest elements with increasing nuclear charge. Here, we report for the first time on gas phase chemical experiments aiming at a determination of element 114 properties. This element was investigated using its isotopes 287-114 and 288-114 produced in the nuclear fusion reactions of 48Ca with 242Pu and 244Pu, respectively. Identification of three atoms of element 114 in thermochromatography experiments and their deposition pattern on a gold surface indicates that this element is at least as volatile as simultaneously investigated elements Hg, At, and element 112. This behaviour is rather unexpected for a typical metal of group 14