Choroid plexus tumours

Choroid plexus tumours are rare epithelial brain tumours and limited information is available regarding their biology and the best treatment. A meta-analysis was done to determine prognostic factors and the influence of various treatment modalities. A thorough review of the medical literature (1966–1998) revealed 566 well-documented choroid plexus tumours. These were entered into a database, which was analysed to determine prognostic factors and treatment modalities. Most patients with a supratentorial tumour were children, while the most common sites in adults were the fourth ventricle and the cerebellar pontine angle. Cerebellar pontine angle tumours were more frequently benign. Histology was the most important prognostic factor, as one, five, and 10-year projected survival rates were 90, 81, and 77% in choroid plexus-papilloma (n=353) compared to only 71, 41, and 35% in choroid plexus-carcinoma respectively (P<0.0005). Surgery was prognostically relevant for both choroid plexus-papilloma (P=0.0005) and choroid plexus-carcinoma (P=0.0001). Radiotherapy was associated with significantly better survival in choroid plexus-carcinomas. Eight of 22 documented choroid plexus-carcinomas responded to chemotherapy. Relapse after primary treatment was a poor prognostic factor in choroid plexus-carcinoma patients but not in choroid plexus-papilloma patients. Treatment of choroid plexus tumours should start with radical surgical resection. This should be followed by adjuvant treatment in case of choroid plexus-carcinoma, and a ‘wait and see’ approach in choroid plexus-papilloma

State of the climate in 2018

In 2018, the dominant greenhouse gases released into Earth’s atmosphere—carbon dioxide, methane, and nitrous oxide—continued their increase. The annual global average carbon dioxide concentration at Earth’s surface was 407.4 ± 0.1 ppm, the highest in the modern instrumental record and in ice core records dating back 800 000 years. Combined, greenhouse gases and several halogenated gases contribute just over 3 W m−2 to radiative forcing and represent a nearly 43% increase since 1990. Carbon dioxide is responsible for about 65% of this radiative forcing. With a weak La Niña in early 2018 transitioning to a weak El Niño by the year’s end, the global surface (land and ocean) temperature was the fourth highest on record, with only 2015 through 2017 being warmer. Several European countries reported record high annual temperatures. There were also more high, and fewer low, temperature extremes than in nearly all of the 68-year extremes record. Madagascar recorded a record daily temperature of 40.5°C in Morondava in March, while South Korea set its record high of 41.0°C in August in Hongcheon. Nawabshah, Pakistan, recorded its highest temperature of 50.2°C, which may be a new daily world record for April. Globally, the annual lower troposphere temperature was third to seventh highest, depending on the dataset analyzed. The lower stratospheric temperature was approximately fifth lowest. The 2018 Arctic land surface temperature was 1.2°C above the 1981–2010 average, tying for third highest in the 118-year record, following 2016 and 2017. June’s Arctic snow cover extent was almost half of what it was 35 years ago. Across Greenland, however, regional summer temperatures were generally below or near average. Additionally, a satellite survey of 47 glaciers in Greenland indicated a net increase in area for the first time since records began in 1999. Increasing permafrost temperatures were reported at most observation sites in the Arctic, with the overall increase of 0.1°–0.2°C between 2017 and 2018 being comparable to the highest rate of warming ever observed in the region. On 17 March, Arctic sea ice extent marked the second smallest annual maximum in the 38-year record, larger than only 2017. The minimum extent in 2018 was reached on 19 September and again on 23 September, tying 2008 and 2010 for the sixth lowest extent on record. The 23 September date tied 1997 as the latest sea ice minimum date on record. First-year ice now dominates the ice cover, comprising 77% of the March 2018 ice pack compared to 55% during the 1980s. Because thinner, younger ice is more vulnerable to melting out in summer, this shift in sea ice age has contributed to the decreasing trend in minimum ice extent. Regionally, Bering Sea ice extent was at record lows for almost the entire 2017/18 ice season. For the Antarctic continent as a whole, 2018 was warmer than average. On the highest points of the Antarctic Plateau, the automatic weather station Relay (74°S) broke or tied six monthly temperature records throughout the year, with August breaking its record by nearly 8°C. However, cool conditions in the western Bellingshausen Sea and Amundsen Sea sector contributed to a low melt season overall for 2017/18. High SSTs contributed to low summer sea ice extent in the Ross and Weddell Seas in 2018, underpinning the second lowest Antarctic summer minimum sea ice extent on record. Despite conducive conditions for its formation, the ozone hole at its maximum extent in September was near the 2000–18 mean, likely due to an ongoing slow decline in stratospheric chlorine monoxide concentration. Across the oceans, globally averaged SST decreased slightly since the record El Niño year of 2016 but was still far above the climatological mean. On average, SST is increasing at a rate of 0.10° ± 0.01°C decade−1 since 1950. The warming appeared largest in the tropical Indian Ocean and smallest in the North Pacific. The deeper ocean continues to warm year after year. For the seventh consecutive year, global annual mean sea level became the highest in the 26-year record, rising to 81 mm above the 1993 average. As anticipated in a warming climate, the hydrological cycle over the ocean is accelerating: dry regions are becoming drier and wet regions rainier. Closer to the equator, 95 named tropical storms were observed during 2018, well above the 1981–2010 average of 82. Eleven tropical cyclones reached Saffir–Simpson scale Category 5 intensity. North Atlantic Major Hurricane Michael’s landfall intensity of 140 kt was the fourth strongest for any continental U.S. hurricane landfall in the 168-year record. Michael caused more than 30 fatalities and $25 billion (U.S. dollars) in damages. In the western North Pacific, Super Typhoon Mangkhut led to 160 fatalities and$6 billion (U.S. dollars) in damages across the Philippines, Hong Kong, Macau, mainland China, Guam, and the Northern Mariana Islands. Tropical Storm Son-Tinh was responsible for 170 fatalities in Vietnam and Laos. Nearly all the islands of Micronesia experienced at least moderate impacts from various tropical cyclones. Across land, many areas around the globe received copious precipitation, notable at different time scales. Rodrigues and Réunion Island near southern Africa each reported their third wettest year on record. In Hawaii, 1262 mm precipitation at Waipā Gardens (Kauai) on 14–15 April set a new U.S. record for 24-h precipitation. In Brazil, the city of Belo Horizonte received nearly 75 mm of rain in just 20 minutes, nearly half its monthly average. Globally, fire activity during 2018 was the lowest since the start of the record in 1997, with a combined burned area of about 500 million hectares. This reinforced the long-term downward trend in fire emissions driven by changes in land use in frequently burning savannas. However, wildfires burned 3.5 million hectares across the United States, well above the 2000–10 average of 2.7 million hectares. Combined, U.S. wildfire damages for the 2017 and 2018 wildfire seasons exceeded $40 billion (U.S. dollars)

Estudio exploratorio para la evaluación de la memoria semántica multimodal en niños colombianos

Semantic memory (SM) is a type of long-term memory associated with the storage of general information about the world. Here we assessed the characteristics of the SM battery, developed by Catricalà et al. (2013), in a sample of Colombian children. This battery was originally conceived to evaluate adults, and features six subtests that assess SM in different modalities, using a common set of 48 stimuli in both living and nonliving categories. The design of the current study is of a cross-sectional and exploratory type. The sample was composed of 111 children, 57 boys (51%) and 54 girls (49%), who were 6 (n = 68) and 7 (n = 43) years old and had no intellectual disability. Robust linear regression models and correlation networks were used. We found an effect of age on general intelligence after correcting for gender, and no differences on the six subtest scores after corrections for gender and age were performed. Furthermore, age was found to be positively associated with the naming of colored photographs (β = .75, p = .039), naming in response to an oral description (β = 1.81, p = .039), picture sorting at four levels (β = 7.22, p = .029), and sentence verification (β = 26.66, p = .01). In addition, there were differences between the results obtained in adults in the original study and in the children of our study. This exploratory study supports the feasibility of the Spanish translation of the Catricalà et al. (2013) battery to assess SM in children with a nonclinical condition. Future studies are needed to evaluate the psychometric properties of this SM battery, and to corroborate and expand our findings in a larger sample of control children, and in children with some degree of intellectual disability or suffering of some neurodegenerative or psychiatric conditions.La memoria semántica (SM) es un tipo de memoria a largo plazo asociada con el almacenamiento de información general sobre el mundo. Aquí evaluamos las características de la batería SM, desarrollada por Catricalà et al. (2013), en una muestra de niños colombianos. Esta batería fue concebida originalmente para evaluar adultos, y presenta seis subpruebas que evalúan SM en diferentes modalidades, utilizando un conjunto común de 48 estímulos en las categorías de vida y no vida. El diseño del presente estudio es de tipo transversal y exploratorio. La muestra estaba compuesta por 111 niños, 57 niños (51%) y 54 niñas (49%), que tenían 6 (n = 68) y 7 (n = 43) años y no tenían discapacidad intelectual. Se utilizaron modelos de regresión lineal robustos y redes de correlación. Encontramos un efecto de la edad en la inteligencia general después de corregir por género, y no hubo diferencias en las seis puntuaciones de la subprueba después de realizar correcciones por género y edad. Además, se encontró que la edad se asociaba positivamente con el nombramiento de fotografías en color (β = .75, p = .039), nombrando en respuesta a una descripción oral (β = 1.81, p = .039), clasificación de imágenes en cuatro niveles (β = 7.22, p = .029) y verificación de oraciones (β = 26.66, p = .01). Además, hubo diferencias entre los resultados obtenidos en adultos en el estudio original y en los niños de nuestro estudio. Este estudio exploratorio respalda la viabilidad de la traducción al español de Catricalà et al. (2013) batería para evaluar SM en niños con una condición no clínica. Se necesitan estudios futuros para evaluar las propiedades psicométricas de esta batería SM, y para corroborar y expandir nuestros hallazgos en una muestra más grande de niños control, y en niños con algún grado de discapacidad intelectual o que padecen algunas condiciones neurodegenerativas o psiquiátricas

Lake water temperature modeling in an era of climate change: data sources, models, and future prospects

Lake thermal dynamics have been considerably impacted by climate change, with potential adverse effects on aquatic ecosystems. To better understand the potential impacts of future climate change on lake thermal dynamics and related processes, the use of mathematical models is essential. In this study, we provide a comprehensive review of lake water temperature modeling. We begin by discussing the physical concepts that regulate thermal dynamics in lakes, which serve as a primer for the description of process-based models. We then provide an overview of different sources of observational water temperature data, including in situ monitoring and satellite Earth observations, used in the field of lake water temperature modeling. We classify and review the various lake water temperature models available, and then discuss model performance, including commonly used performance metrics and optimization methods. Finally, we analyze emerging modeling approaches, including forecasting, digital twins, combining process-based modeling with deep learning, evaluating structural model differences through ensemble modeling, adapted water management, and coupling of climate and lake models. This review is aimed at a diverse group of professionals working in the fields of limnology and hydrology, including ecologists, biologists, physicists, engineers, and remote sensing researchers from the private and public sectors who are interested in understanding lake water temperature modeling and its potential applications

[Dataset] Lake water temperature modelling in an era of climate change: data sources, models, and future directions

&lt;p&gt;This repository contains the raw and processed data used to produce Figure 7 in &quot;Lake water temperature modelling in an era of climate change: data sources, models, and future directions&quot; - Reviews of Geophysics, by Piccolroaz et al. (2024).&lt;/p&gt