379 research outputs found
An HLA-G/SPAG9/STAT3 axis promotes brain metastases
- Author
- Aghaei Nikoo
- Bassey-Archibong Blessing Iquo
- Chafe Shawn Christopher
- Hynds Robert Edward
- Kalpana Subapanditha Minomi
- Kieliszek Agata Monika
- Lam Fred
- Lu Yu
- McKenna Dillon
- Mobilio Daniel
- Parmar Arun
- Provias John
- Rajendra Chokshi Chirayu
- Savage Neil
- Singh Mohini
- Singh Sheila Kumari
- Swanton Charles
- Tatari Nazanin
- Tokar Tomas
- Venugopal Chitra
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 13/02/2023
- Field of study
Brain metastases (BM) are the most common brain neoplasm in adults. Current BM therapies still offer limited efficacy and reduced survival outcomes, emphasizing the need for a better understanding of the disease. Herein, we analyzed the transcriptional profile of brain metastasis initiating cells (BMICs) at two distinct stages of the brain metastatic cascade-the "premetastatic" or early stage when they first colonize the brain and the established macrometastatic stage. RNA sequencing was used to obtain the transcriptional profiles of premetastatic and macrometastatic (non-premetastatic) lung, breast, and melanoma BMICs. We identified that lung, breast, and melanoma premetastatic BMICs share a common transcriptomic signature that is distinct from their non-premetastatic counterparts. Importantly, we show that premetastatic BMICs exhibit increased expression of HLA-G, which we further demonstrate functions in an HLA-G/SPAG9/STAT3 axis to promote the establishment of brain metastatic lesions. Our findings suggest that unraveling the molecular landscape of premetastatic BMICs allows for the identification of clinically relevant targets that can possibly inform the development of preventive and/or more efficacious BM therapies
Cell-intrinsic differences between human airway epithelial cells from children and adults
- Author
- Al Yaghchi Chadwan
- Birchall Martin A
- Butler Colin R
- Case Katie-Marie
- Clarke Sarah E
- De Coppi Paolo
- Denais Celine
- Gowers Kate HC
- Gómez-López Sandra
- Hartley Benjamin E
- Hewitt Richard J
- Hyang Lee Dani Do
- Hynds Robert E
- Janes Sam M
- Lazarus Kyren A
- Masonou Tereza
- Maughan Elizabeth F
- Nigro Ersilia
- Orr Jessica C
- O’Callaghan Christopher
- Pearce David R
- Pennycuick Adam
- Sandhu Gurpreet S
- Smith Claire M
- Teixeira Vitor H
- Woodall Maximillian NJ
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Summary
The airway epithelium is a protective barrier that is maintained by the self-renewal and differentiation of basal stem cells. Increasing age is a principle risk factor for chronic lung diseases, but few studies have explored age-related molecular or functional changes in the airway epithelium. We retrieved epithelial biopsies from histologically normal tracheobronchial sites from pediatric and adult donors and compared their cellular composition and gene expression profile (in laser capture-microdissected whole epithelium, fluorescence-activated cell-sorted basal cells and basal cells in cell culture). Histologically, pediatric and adult tracheobronchial epithelium were similar in composition. We observed age-associated changes in RNA sequencing studies, including higher interferon-associated gene expression in pediatric epithelium. In cell culture, pediatric cells had higher colony-formation ability, sustained in vitro growth and out-competed adult cells in a direct competitive proliferation assay. Our results demonstrate cell-intrinsic differences between airway epithelial cells from children and adults in both homeostatic and proliferative states
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
- Author
- Aengus Stewart
- Aiman Alzetani
- Alex Bowman
- Alexandra Rice
- Alexandrov
- Alison Edwards
- Allah Dino Keerio
- Allan Hackshaw
- Amy Kerr
- Amy Smith
- Anand Devaraj
- Andreatta
- Andrew Furness
- Andrew G. Nicholson
- Andrew J. Rowan
- Andrew Rowan
- Andy Georgiou
- Angela Kwayie
- Angela Leek
- Anita Amadi
- Anne Marie Quinn
- Anshuman Chaturved
- Apostolos Nakas
- Asia Ahmed
- Assma Ben Aissa
- Azmina Verjee
- Babikir Ismail
- Babu Naidu
- Ben Phillimore
- Benjamin Johnson
- Brastianos
- Brown
- Campbell
- Campoli
- Caroline Dive
- Carter
- Celia Simeon
- Charles Swanton
- Charles Swanton
- Chiara Proli
- Christian Ottensmeier
- Christophe Dessimoz
- Christopher Abbosh
- Cibulskis
- Crispin Hiley
- Crispin T. Hiley
- Dahmane Oukrif
- David Lawrence
- David Moore
- Davoli
- Dawn Carnell
- Dean Fennell
- del Campo
- Diana Johnson
- Dionysis Papadatos-Pastos
- Dominic G. Rothwell
- Elaine Borg
- Elaine Smith
- Emily Shaw
- Emma Nye
- Eric Lim
- Eustace Fontaine
- Faiza Idries
- Favero
- Fiona Blackhall
- Fiona Morgan
- Francesca Chemi
- Gareth A. Wilson
- Gareth Wilson
- Gary Middleton
- Ged Brady
- Gemma Hector
- Gerald Langman
- Girija Anand
- Greg Elgar
- Ha
- Hanahan
- Hang Xu
- Hardy Remmen
- Harriet Bell
- Harshil Bhayani
- Haydn Adams
- Helen Davies
- Helen Doran
- Helen L. Lowe
- Hema Chavan
- Herbst
- Hicklin
- Hilary Marshall
- Hilgardt Raubenheimer
- Hillaria Mashinga
- Hiraki
- Hollie Bancroft
- Hoof
- Hugo J.W.L. Aerts
- Jacki Goldman
- Jackie Pierce
- Jacqui A. Shaw
- Jamal-Hanjani
- Jane Rogan
- Jason Lester
- Javier Herrero
- Javier Herrero
- Jennifer Hill
- Jeremy George
- Joan Riley
- Joanne Laycock
- Joanne Webb
- John A. Hartley
- John Carlo Ronquillo
- John Conibear
- John Edwards
- John Gosney
- John Le Quesne
- Jonathan Bennett
- Jonathan Bury
- Jonathan Finch
- Jonathan Tugwood
- Joy Miller
- Juliette Novasio
- Julius Asante-Siaw
- Junaid Choudhary
- Justyna Czyzewska-Khan
- Katrina Moore
- Keith Buchan
- Keith Kerr
- Kelvin Lau
- Kendadai Rammohan
- Kim Suvarna
- Koboldt
- Kroopa Joshi
- Lawrence
- Leena Joseph
- Leire Azcarate
- Lesley Gomersall
- Leticia Bosshard-Carter
- Li
- Li
- Lindsay Primrose
- Louise Nelson
- Luke Martinson
- Lyn Ambrose
- Madava Djearaman
- Magali Taylor
- Maggie Wilcox
- Mahendran Chetty
- Mairead MacKenzie
- Maise Al Bakir
- Malgorzata Kornaszewska
- Marco Novelli
- Maria Elena Cufari
- Mariam Jamal-Hanjani
- Marianne Nicolson
- Marie Aranda
- Marta Costa
- Martin
- Martin Forster
- Martin Hayward
- Mary Bellamy
- Mary Falzon
- Matthew Evison
- McGranahan
- McKenna
- Mehta
- Melanie Irvin-sellers
- Michael Shackcloth
- Michael Sheaff
- Mickael Escudero
- Monica Tavares Barbosa
- Morag Hamilton
- Moretta
- Natalie Mensah
- Neal Navani
- Nicholas McGranahan
- Nicholas McGranahan
- Nicolai J. Birkbak
- Nicolai J. Birkbak
- Nicole Gower
- Nielsen
- Nik Matthews
- Nikolaos Panagiotopoulos
- Ott
- Pat Gorman
- Patricia Fisher
- Paul Bishop
- Paul Taylor
- Paulo De Sousa
- Peter Russell
- Peter Schmid
- Peter Van Loo
- Peter Van Loo
- Phil Crosbie
- Phil Harrison
- Pieter Postmus
- Piha-Paul
- Piotr Krysiak
- Rachael Waddington
- Rachel Rosenthal
- Rachel Rosenthal
- Raffaele Califano
- Rajesh Shah
- Ribas
- Richard Attanoos
- Richard Booton
- Richard Kevin Stone
- Richard Mitter
- Ricky Thakrar
- Rimmer
- Rizvi
- Robert E. Hynds
- Rooney
- Rosenthal
- Roth
- Ruheena Mendes
- Sahin
- Sajid Khan
- Sakshi Gulati
- Salma Kadiri
- Sam M. Janes
- Samra Turajlic
- Sara Lock
- Sarah Danson
- Sarah Feeney
- Schumacher
- Sean Smith
- Seema Shafi
- Selvaraju Veeriah
- Selvaraju Veeriah
- Serena Chee
- Sergio Quezada
- Sharmin Begum
- Shen
- Shirley Palmer
- Shukla
- Shyam Kolvekar
- Silviu Buderi
- Simon Jordan
- Simon Trotter
- Siow Ming Lee
- Snyder
- Sofia Graca
- Sophia Ward
- Sophie Green
- Spranger
- Sridhar Rathinam
- Stefan Dentro
- Stuart Horswell
- Stuart Moss
- Sue Matthews
- Szolek
- Tamara Denner
- Tanya Ahmad
- Teresa Light
- Teresa Marafioti
- Thomas B.K. Watkins
- Thomas B.K. Watkins
- Tim Chambers
- Tracey Horey
- Tran
- Tumeh
- Van Allen
- Van Loo
- Veni Ezhil
- Vineet Prakash
- William Monteiro
- Yenting Ngai
- Yien Ning Sophia Wong
- Yoshihama
- Yota Kitsanta
- Yusura Bakar
- Yvonne Summers
- Zaretsky
- Zhao
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human leukocyte antigen (LOHHLA), a computational tool to determine HLA allele-specific copy number from sequencing data. Using LOHHLA, we find that HLA LOH occurs in 40% of non-small-cell lung cancers (NSCLCs) and is associated with a high subclonal neoantigen burden, APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity. The focal nature of HLA LOH alterations, their subclonal frequencies, enrichment in metastatic sites, and occurrence as parallel events suggests that HLA LOH is an immune escape mechanism that is subject to strong microenvironmental selection pressures later in tumor evolution. Characterizing HLA LOH with LOHHLA refines neoantigen prediction and may have implications for our understanding of resistance mechanisms and immunotherapeutic approaches targeting neoantigens. Video Abstract [Figure presented] Development of the bioinformatics tool LOHHLA allows precise measurement of allele-specific HLA copy number, improves the accuracy in neoantigen prediction, and uncovers insights into how immune escape contributes to tumor evolution in non-small-cell lung cancer
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors
- Author
- Abbosh Christopher
- Adams Haydn
- Ahmad Tanya
- Ahmed Asia
- Al Bakir Maise
- Alzetani Aiman
- Amadi Anita
- Ambrose Lyn
- Anand Girija
- Aranda Marie
- Arce Vargas Frederick
- Asante-Siaw Julius
- Attanoos Richard
- Azcarate Leire
- Bakar Yusura
- Bancroft Hollie
- Barbosa Monica Tavares
- Beers Stephen A.
- Begum Sharmin
- Bell Harriet
- Bellamy Mary
- Ben Aissa Assma
- Bennett Jonathan
- Bhayani Harshil
- Biggs Jennifer
- Birkbak Nicolai J.
- Bishop Paul
- Blackhall Fiona
- Booton Richard
- Borg Elaine
- Bosshard-Carter Leticia
- Bowman Alex
- Brady Ged
- Buchan Keith
- Buderi Silviu
- Bury Jonathan
- Califano Raffaele
- Carnell Dawn
- Challacombe Ben
- Chambers Tim
- Chandra Ashish
- Chaturved Anshuman
- Chavan Hema
- Chee Serena
- Chemi Francesca
- Chester Kerry A.
- Chetty Mahendran
- Choudhary Junaid
- Chowdhury Simon
- Conibear John
- Costa Marta
- Crosbie Phil
- Cufari Maria Elena
- Czyzewska-Khan Justyna
- Dahan Rony
- Danson Sarah
- Davies Helen
- De Sousa Paulo
- Denner Tamara
- Devaraj Anand
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Edwards Alison
- Edwards John
- Elgar Greg
- Escudero Mickael
- Evison Matthew
- Ezhil Veni
- Falzon Mary
- Feeney Sarah
- Fennell Dean
- Fernando Archana
- Finch Jonathan
- Fisher Patricia
- Fontaine Eustace
- Forster Martin
- Fotiadis Nicos
- Francis Nicholas
- Franz Dafne
- Furness Andrew J.S.
- George Jeremy
- Georgiou Andrew
- Goh Gerald
- Goldman Jacki
- Gomersall Lesley
- Gore Martin
- Gorman Pat
- Gosney John
- Gower Nicole
- Graca Sofia
- Green Sophie
- Gulati Sakshi
- Hackshaw Allan
- Hamilton Morag
- Harrison Phil
- Hartley John A.
- Hayes Andrew
- Hayward Martin
- Hazell Steve
- Hector Gemma
- Henry Jake Y.
- Herrero Javier
- Hiley Crispin
- Hill Jennifer
- Horey Tracey
- Horswell Stuart
- Hynds Robert E.
- Idries Faiza
- Iles Natasha
- Irvin-sellers Melanie
- Ismail Babikir
- Jamal-Hanjani Mariam
- Janes Sam M.
- Johnson Benjamin
- Johnson Diana
- Jorda Simon
- Joseph Leena
- Joshi Kroopa
- Kadiri Salma
- Keerio Allah Dino
- Kerr Amy
- Kerr Keith
- Khan Sajid
- Kitsanta Yota
- Kolvekar Shyam
- Kornaszewska Malgorzata
- Krysiak Piotr
- Kwayie Angela
- Langman Gerald
- Larkin James
- Lau Kelvin
- Lawrence David
- Laycock Joanne
- Le Quesne John
- Lee Siow Ming
- Leek Angela
- Lesko Marta H.
- Lester Jason
- Light Teresa
- Lim Eric
- Lock Sara
- Lowe Helen L.
- Lynch Joanna
- MacKenzie Mairead
- Marafioti Teresa
- Marshall Hilary
- Martinson Luke
- Mashinga Hillaria
- Matthews Nik
- Matthews Sue
- McGranahan Nicholas
- Mekkaoui Leila
- Mendes Ruheena
- Mensah Natalie
- Middleton Gary
- Miller Joy
- Miranda Rota Enrique
- Mitter Richard
- Monteiro William
- Moore David
- Moore Katrina
- Morgan Fiona
- Moss Stuart
- Murugaesu Nirupa
- Naidu Babu
- Nakas Apostolos
- Navani Neal
- Nelson Louise
- Ngai Yenting
- Nicholson Andrew G.
- Nicol David
- Nicolson Marianne
- Novasio Juliette
- Novelli Marco
- Nye Emma
- O'Brien Tim
- Ottensmeier Christian
- Oukrif Dahmane
- Palmer Shirley
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Peggs Karl S.
- Phillimore Ben
- Pickering Lisa
- Pierce Jackie
- Postmus Pieter
- Prakash Vineet
- Primrose Lindsay
- Proli Chiara
- Pule Martin
- Quezada Sergio A.
- Quinn Anne Marie
- Rammohan Kendadai
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Ravetch Jeffrey V.
- Remmen Hardy
- Rice Alexandra
- Riley Joan
- Rogan Jane
- Ronquillo John Carlo
- Rosenthal Rachel
- Rothwell Dominic G.
- Rowan Andrew
- Rudman Sarah
- Russell Peter
- Schmid Peter
- Shackcloth Michael
- Shafi Seema
- Shah Rajesh
- Shaw Emily
- Shaw Jacqui A.
- Sheaff Michael
- Simeon Celia
- Sledzinska Anna
- Smith Amy
- Smith Elaine
- Smith Myles
- Smith Sean
- Solomon Isabelle
- Soultati Aspasia
- Spain Lavinia
- Spain Lavinia
- Stares Mark
- Stewart Aengus
- Stone Richard Kevin
- Strauss Dirk
- Summers Yvonne
- Suvarna Kim
- Swanton Charles
- Swanton Charles
- Taylor Magali
- Taylor Paul
- Thakrar Ricky
- Trotter Simon
- Tugwood Jonathan
- Turajlic Samra
- Turajlic Samra
- Van Loo Peter
- Veeriah Selvaraju
- Verjee Azmina
- Waddington Rachael
- Ward Sophia
- Watkins Thomas B.K.
- Webb Joanne
- Werner Sunderland Mariana
- Wilcox Maggie
- Wilson Gareth
- Wong Yien Ning Sophia
- Wotherspoon Andrew
- Xu Hang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/04/2017
- Field of study
CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans. While existing anti-CD25 antibodies were observed to deplete Treg cells in the periphery, upregulation of the inhibitory Fc gamma receptor (FcγR) IIb at the tumor site prevented intra-tumoral Treg cell depletion, which may underlie the lack of anti-tumor activity previously observed in pre-clinical models. Use of an anti-CD25 antibody with enhanced binding to activating FcγRs led to effective depletion of tumor-infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors. Combination with anti-programmed cell death protein-1 antibodies promoted complete tumor rejection, demonstrating the relevance of CD25 as a therapeutic target and promising substrate for future combination approaches in immune-oncology
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.
- Author
- Abbosh Christopher
- Abbosh Christopher
- Abbosh Christopher
- Adams Haydn
- Adams Haydn
- Aerts Hugo J. W. L.
- Aerts Hugo JWL
- Ahmad Tanya
- Ahmad Tanya
- Ahmed Asia
- Ahmed Asia
- Aissa Assma Ben
- Akarca Ayse U
- Akarca Ayse U
- Al Bakir Maise
- Al Bakir Maise
- Alzetani Aiman
- Amadi Anita
- Ambrose Lyn
- Anand Girija
- Anand Girija
- Aranda Marie
- Asante-Siaw Julius
- Ashish Chandra
- Attanoos Richard
- Attanoos Richard
- Attard Gert
- Azcarate Leire
- Baijal Shobhit
- Bakar Yusura
- Bakir Maise Al
- Bancroft Hollie
- Bancroft Hollie
- Beck Stephan
- Begum Sharmin
- Bell Harriet
- Bell Harriet
- Bellamy Mary
- Bennett Jonathan
- Bhayani Harshil
- Bi Wenya Linda
- Biankin Andrew
- Biggs Jennifer
- Birkbak Nicolai J
- Birkbak Nicolai J.
- Bishop Paul
- Blackhall Fiona
- Blackhall Fiona
- Blackhall Fiona
- Booton Richard
- Borg Elaine
- Borg Elaine
- Borg Elaine
- Bosshard-Carter Leticia
- Bova Steve
- Bowman Alex
- Brady Ged
- Brandner Sebastian
- Brenton James
- Bridgewater John
- Buchan Keith
- Buderi Silviu
- Bury Jonathan
- Caldas Carlos
- Califano Raffaele
- Campbell Peter
- Carnell Dawn
- Carter Louise
- Chambers Antony
- Chambers Tim
- Chambers Tim
- Chaturved Anshuman
- Chavan Hema
- Chee Serena
- Chemi Francesca
- Chetty Mahendran
- Chetty Mahendran
- Choudhary Junaid
- Chowdhury Simon
- Cluroe Alison
- Cockcroft Peter
- Collard Martin
- Colloby Peter
- Conibear John
- Constantin Tudor
- Constatin Tudor
- Costa Marta
- Crosbie Phil
- Crosbie Phil
- Czyzewska-Khan Justyna
- Czyzewska-Khan Justyna
- Danson Sarah
- Davies Helen
- Davies Helen
- De Sousa Paulo
- Denner Tamara
- Dentro Stefan
- Dessimoz Christophe
- Devaraj Anand
- Dhomen Nathalie
- Dive Caroline
- Dive Caroline
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Edwards Alison
- Edwards John
- Eeles Ros
- Elena Cufari Maria
- Elgar Greg
- Elgar Greg
- Endozo Raymondo
- Enver Tariq
- Escudero Mickael
- Evison Matthew
- Ezhil Veni
- Ezhil Veni
- Falzon Mary
- Falzon Mary
- Falzon Mary
- Farrelly Laura
- Feeney Sarah
- Fennell Dean
- Fennell Dean
- Fennell Dean A.
- Fennessy Fiona M.
- Finch Jonathan
- Fisher Patricia
- Fitzgerald Rebecca
- Flanagan Adreinne
- Fontaine Eustace
- Forster Martin
- Forster Martin D.
- Foster Chris
- Fraioli Francesco
- Fraser Sioban
- Furness Andrew
- Ganguly Apratim
- George Jeremy
- Georgiou Andy
- Gilbertson Richard
- Gishen Faye
- Goh Gerald
- Goldman Jacki
- Gomersall Lesley
- Gomersall Lesley
- Gorman Pat
- Gosney John
- Gower Nicole
- Graca Sofia
- Green Sophie
- GrÖnroos Eva
- GrÖnroos Eva
- Gulati Sakshi
- Hackshaw Allan
- Hackshaw Allan
- Hackshaw Allan
- Hafez Dina
- Hamilton Morag
- Harrison David
- Harrison Phil
- Hartley John A
- Hartley John A
- Hayward Martin
- Hayward Martin
- Hector Gemma
- Herrero Javier
- Herrero Javier
- Hiley Crispin
- Hiley Crispin
- Hill Jennifer
- Hochauser Daniel
- Horey Tracey
- Horswell Stuart
- Hynds Robert E
- Idries Faiza
- Iles Natasha
- Iles Natasha
- Irvin-sellers Melanie
- Irvin-sellers Melanie
- Ismail Babikir
- Ismail Babikir
- Jamal-Hanjani Mariam
- Jamal-Hanjani Mariam
- Jamal-Hanjani Mariam
- Janes Sam M
- Janes Sam M
- Jimenez-Linan Merche
- Johnson Benjamin
- Johnson Diana
- Johnson Diana
- Jordan Simon
- Joseph Leena
- Joseph Leena
- Joshi Kroopa
- Kadiri Salma
- Kadiri Salma
- Kareht Stephanie
- Keerio Allah Dino
- Kerr Amy
- Kerr Amy
- Kerr Keith
- Kerr Keith
- Khan Sajid
- Khan Sajid
- Kirkizlar Eser
- Kitsanta Yota
- Kolvekar Shyam
- Kolvekar Shyam
- Kornaszewska Malgorzata
- Kornaszewska Malgorzata
- Krebs Matt
- Krysiak Piotr
- Kwayie Angela
- Langman Gerald
- Langman Gerald
- Langman Gerald
- Larkin James
- Lau Kelvin
- Lawrence David
- Lawrence David
- Laycock Joanne
- Laycock Joanne
- Le Quesne John
- Le Quesne John
- Lederman Jonathan
- Lee Siow Ming
- Lee Siow Ming
- leek Angela
- Lester Jason
- Lester Jason
- Light Teresa
- Lim Eric
- Lin C. Jimmy
- Lock Sara
- Lock Sara
- Loda Massimo
- Lok Chi-wah
- Lowe Helen L
- Lowe Helen L
- Lynch Joanna
- Lynch Mark
- MacKenzie Mairead
- Marafioti Teresa
- Marafioti Teresa
- Marafioti Teresa
- Marais Richard
- Marie Quinn Anne
- Marshall Hilary
- Martinson Luke
- Martinson Luke
- Martinson Luke
- Mashinga Hillaria
- Matthews Nik
- Matthews Nik
- Matthews Sue
- Maughan Tim
- McDermott Ultan
- McGranahan Nicholas
- McGranahan Nicholas
- McKenzie Mairead
- McNeish Iain
- Mendes Ruheena
- Mensah Natalie
- Middleton Gary
- Middleton Gary
- Middleton Gary
- Miller Joy
- Mitchison Miriam
- Mitter Richard
- Monteiro William
- Moore David
- Moore David
- Moore David A
- Moore Katrina
- Morgan Fiona
- Moss Stuart
- Murugaesu Nirupa
- Naidu Babu
- Naidu Babu
- Naidu Babu
- Naik Ashwini
- Naik Ashwini
- Nakas Apostolos
- Nakas Apostolos
- Navani Neal
- Nelson Louise
- Ngai Yenting
- Ngai Yenting
- Nicholson Andrew G
- Nicolson Marianne
- Nicolson Marianne
- Nonaka Daisuke
- Novasio Juliette
- Novelli Marco
- Novelli Marco
- Nye Emma
- Oien Karin
- Olisemeke Bernard
- Ottensmeier Christian
- Ottensmeier Christian
- Oukrif Dahmane
- Oukrif Dahmane
- Palmer Shirley
- Panagiotopoulos Nikolaos
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Parker Peter
- Phillimore Ben
- Pierce Jackie
- Postmus Pieter
- Prakash Vineet
- Prakash Vineet
- Primrose Lindsay
- Proctor Ian
- Proli Chiara
- Provenzano Elena
- Quesne John Le
- Quezada Sergio
- Quezada Sergio
- Quezada Sergio A
- Quinn Anne Marie
- Quinn Anne Marie
- Rabinowitz Matthew
- Rabinowitz Matthew
- Rammohan Kendadai
- Rathinam Sridhar
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Remmen Hardy
- Remmen Hardy
- Rice Alexandra
- Riley Joan
- Riley Joan
- Riley Joan
- Rogan Jane
- Ronquillo John Carlo
- Rosenthal Rachel
- Rosenthal Rachel
- Rothwell Dominic G
- Rowan Andrew
- Rowan Andrew
- Russell Peter
- Russell Peter
- Salari Raheleh
- Salari Raheleh
- Schmid Peter
- Schwarz Roland F
- Shackcloth Michael
- Shafi Seema
- Shafi Seema
- Shah Rajesh
- Shah Rajesh
- Sharp Abby
- Shaw Emily
- Shaw Jacqui
- Shaw Jacqui A
- Shaw Jacqui A
- Sheaff Michael
- Shiu Kai-Keen
- Simeon Celia
- Sinclair Ron
- Smith Amy
- Smith Elaine
- Smith Sean
- Sottoriva Andrea
- Spicer James
- Sponer Nicole
- Sponer Nicole
- Stares Mark
- Sterling Caroline
- Stewart Aengus
- Stewart Aengus
- Stewart Grant
- Stone Paddy
- Stone Richard Kevin
- Summers Yvonne
- Summers Yvonne
- Summers Yvonne
- Suvarna Kim
- Swanton Charles
- Swanton Charles
- Swanton Charles
- Szallasi Zoltan
- Tanchel Bruce
- Tavare Simon
- Tavares Barbosa Monica
- Taylor Joanne
- Taylor Magali
- Taylor Paul
- Thakrar Ricky
- Thakrar Ricky
- Thomas Anne
- Tomlinson Ian
- Tookman Adrian
- Trevisan Giorgia
- Trotter Simon
- Trotter Simon
- Tugwood Jonathan
- Turajlic Samra
- Turajlic Samra
- Turajlic Samra
- Van Loo Peter
- Van Loo Peter
- Van Loo Peter
- Veeriah Selvaraju
- Veeriah Selvaraju
- Verjee Azmina
- Waddington Rachael
- Walczak Henning
- Walter Harriet
- Ward Sophia
- Ward Sophia
- Watkins Thomas B K
- Watkins Thomas B K
- Watts Colin
- Webb Joanne
- Webb Joanne
- Wilcox Maggie
- Wilcox Maggie
- Wilson Gareth
- Wilson Gareth A.
- Wilson Rodelaine
- Wong Yien Ning Sophia
- Xu Hang
- Zambrana Francisco
- Zimmermann Bernhard
- Zimmermann Bernhard G.
- Publication venue
- Nature
- Publication date
- 01/01/2017
- Field of study
The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies
Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.
- Author
- Abbosh Christopher
- Adams Haydn
- Ahmad Tanya
- Ahmed Asia
- Aitchison Michael
- Al-Bakir Maise
- Alzetani Aiman
- Ambrose Lyn
- Anand Girija
- Arce Vargas Frederick
- Asante-Siaw Julius
- Attanoos Richard
- Azcarate Leire
- Bakar Yusura
- Bancroft Hollie
- Begum Sharmin
- Bell Harriet
- Bellamy Mary
- Ben Aissa Assma
- Bennett Jonathan
- Bhayani Harshil
- Bishop Paul
- Blackhall Fiona
- Blyth Kevin
- Booton Richard
- Borg Elaine
- Bowman Alex
- Brady Ged
- Buchan Keith
- Buderi Silviu
- Bury Jonathan
- Califano Raffaele
- Carlo Ronquillo John
- Carnell Dawn
- Challacombe Ben
- Chambers Tim
- Chandra Ashish
- Chaturvedi Anshuman
- Chavan Hema
- Chee Serena
- Chemie Francesca
- Chetty Mahendran
- Choudhary Junaid
- Chowdhury Simon
- Conibear John
- Costa Marta
- Crosbie Phil
- Czyzewska-Khan Justyna
- Danson Sarah
- Davies Helen
- De Sousa Paulo
- Denner Tamara
- Devaraj Anand
- Dick Craig
- Dive Caroline
- Djearaman Madava
- Doran Helen
- Drake William
- Edwards John
- Elena Cufari Maria
- Elgar Greg
- Ensell Leah
- Escudero Mickael
- Evison Matthew
- Ezhil Veni
- Falzon Mary
- Feeney Sarah
- Fennell Dean
- Fernando Archana
- Finch Jonathan
- Fontaine Eustace
- Forster Martin
- Fotiadis Nicos
- Francis Nicholas
- Frendéus Björn
- Furness Andrew J.S.
- George Jeremy
- George Robert
- Georgiou Andrew
- Ghorani Ehsan
- Goldman Jacki
- Gomersall Lesley
- Gore Martin
- Gorman Pat
- Gosney John
- Gower Nicole
- Green Sophie
- Gulati Sakshi
- Hackshaw Allan
- Hamilton Morag
- Harrington Kevin
- Harrison Phil
- Harrison-Phipps Karen
- Hartley John
- Hayes Andrew
- Hayward Martin
- Hazell Steve
- Henry Jake Y.
- Herrero Javier
- Hiley Crispin
- Hill Jennifer
- Hill Peter
- Horey Tracey
- Horsfield Catherine
- Horswell Stuart
- Hrouda David
- Hynds Robert
- Idries Faiza
- Jamal-Hanjani Mariam
- Janes Sam
- Johnson Benjamin
- Johnson Diana
- Jordan Simon
- Joseph Leena
- Joshi Kroopa
- Juul Birkbak Nicolai
- Kadiri Salma
- Kerr Amy
- Kerr Keith
- Kevin Stone Richard
- Khan Sajid
- Khiroya Reena
- Kirk Alan
- Kitsanta Yota
- Kooiman Gordon
- Kornaszewska Malgorzata
- Krysiak Piotr
- Kwayie Angela
- Langman Gerald
- Larkin James
- Lau Kelvin
- Lawrence David
- Laycock Joanne
- Le Quesne John
- leek Angela
- Lesko Marta H.
- Lester Jason
- Light Teresa
- Lim Eric
- Litchfield Kevin
- Ljungars Anne
- Lock Sara
- Lopez Jose
- Lowe Helen
- Lynch Joanna
- MacKenzie Mairead
- Marafioti Teresa
- Marie Quinn Anne
- Marshall Hilary
- Martinson Luke
- Mashinga Hillaria
- Matthews Sue
- Mayer Eric
- McGranahan Nicholas
- Melcher Alan
- Mendes Ruheena
- Mensah Natalie
- Middleton Gary
- Miller Joy
- Ming Lee Siow
- Mitter Richard
- Monteiro William
- Moore David
- Moore Katrina
- Morgan Fiona
- Moss Stuart
- Mårtensson Linda
- Naidu Babu
- Nakas Apostolos
- Navani Neal
- Nelson Louise
- Ngai Yenting
- Nicholson Andrew
- Nicol David
- Nicolson Marianne
- Novasio Juliette
- Novelli Marco
- Nye Emma
- O'Brien Tim
- O'Connor Kevin
- O'Donnell Marie
- Olsburgh Jonathan
- Ottensmeier Christian
- Oukrif Dahmane
- Palmer Shirley
- Panagiotopoulos Nikolaos
- Papadatos-Pastos Dionysis
- Patrini Davide
- Peggs Karl S.
- Phillimore Ben
- Pickering Lisa
- Pierce Jackie
- Polson Alexander
- Postmus Pieter
- Prakash Vineet
- Primrose Lindsay
- Proli Chiara
- Pule Martin
- Quezada Sergio A.
- Rammohan Kendadai
- Rathinam Sridhar
- Raubenheimer Hilgardt
- Reading James
- Remmen Hardy
- Rice Alexandra
- Riley Joan
- Roddie Claire
- Rogan Jane
- Rosenthal Rachel
- Rothwell Dominic
- Rowan Andrew
- Rudman Sarah
- Ruef Nora
- Russell Peter
- Scarci Marco
- Schmid Peter
- Shackcloth Michael
- Shah Rajesh
- Shaw Emily
- Shaw Jacqui
- Shaw Penny
- Sheaff Michael
- Smith Elaine
- Smith Myles
- Smith Sean
- Solomon Isabelle
- Spain Lavinia
- Stamp Gordon
- Stewart Aengus
- Stewart Grant
- Strauss Dirk
- Summers Yvonne
- Suvarna Kim
- Swanton Charles
- Tavares Barbosa Monica
- Taylor Magali
- Taylor Paul
- Teige Ingrid
- Tran Maxine
- Trotter Simon
- Tugwood Jonathan
- Turajlic Samra
- van Loo Peter
- Varia Mary
- Veeriah Raju
- Verma Hema
- Waddington Rachael
- Ward Sophie
- Watkins Thomas
- Webb Joanne
- Werner Sunderland Mariana
- Wilcox Maggie
- Wilson Gareth
- Wong Yien Ning Sophia
- Wotherspoon Andrew
- Publication venue
- Cancer Cell
- Publication date
- 01/01/2018
- Field of study
With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo, increasing the CD8+ to Treg cell ratio and promoting tumor rejection. Antibodies with improved FcγR binding profiles drove superior anti-tumor responses and survival. In patients with advanced melanoma, response to ipilimumab was associated with the CD16a-V158F high affinity polymorphism. Such activity only appeared relevant in the context of inflamed tumors, explaining the modest response rates observed in the clinical setting. Our data suggest that the activity of anti-CTLA-4 in inflamed tumors may be improved through enhancement of FcγR binding, whereas poorly infiltrated tumors will likely require combination approaches
Physics case for an LHCb Upgrade II - Opportunities in flavour physics, and beyond, in the HL-LHC era
- Author
- Aaij Roel
- Adeva Bernardo
- Adinolfi Marco
- Aidala Christine Angela
- Ajaltouni Ziad
- Akar Simon
- Albicocco Pietro
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Ali Suvayu
- Alkhazov Georgy
- Alvarez Cartelle Paula
- Alves Jr Antonio Augusto
- Amato Sandra
- Amerio Silvia
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andreassi Guido
- Andreotti Mirco
- Andrews Jason
- Appleby Robert
- Archilli Flavio
- Arnau Romeu Joan
- Artamonov Alexander
- Artuso Marina
- Arzymatov Kenenbek
- Aslanides Elie
- Atzeni Michele
- Bachmann Sebastian
- Back John
- Baker Sophie
- Balagura Vladislav
- Baldini Wander
- Baranov Alexander
- Barlow Roger
- Barsuk Sergey
- Barter William
- Baryshnikov Fedor
- Batozskaya Varvara
- Batsukh Baasansuren
- Battista Vincenzo
- Bay Aurelio
- Beddow John
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Bel Lennaert
- Beliy Nikita
- Bellee Violaine
- Belloli Nicoletta
- Belous Konstantin
- Belyaev Ivan
- Ben-Haim Eli
- Bencivenni Giovanni
- Benson Sean
- Beranek Sarah
- Berezhnoy Alexander
- Bernet Roland
- Berninghoff Daniel
- Bertholet Emilie
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bettler Marc-Olivier
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bifani Simone
- Billoir Pierre
- Birnkraut Alex
- Bizzeti Andrea
- Bjørn Mikkel
- Blago Michele Piero
- Blake Thomas
- Blanc Frederic
- Blusk Steven
- Bobulska Dana
- Bocci Valerio
- Boente Garcia Oscar
- Boettcher Thomas
- Bondar Alexander
- Bondar Nikolay
- Borghi Silvia
- Borisyak Maxim
- Borsato Martino
- Bossu Francesco
- Boubdir Meriem
- Bowcock Themistocles
- Bozzi Concezio
- Braun Svende
- Brodski Michael
- Brodzicka Jolanta
- Brossa Gonzalo Arnau
- Brundu Davide
- Buchanan Emma
- Buonaura Annarita
- Burr Christopher
- Bursche Albert
- Buytaert Jan
- Byczynski Wiktor
- Cadeddu Sandro
- Cai Hao
- Calabrese Roberto
- Calladine Ryan
- Calvi Marta
- Calvo Gomez Miriam
- Camboni Alessandro
- Campana Pierluigi
- Campora Perez Daniel Hugo
- Capriotti Lorenzo
- Carbone Angelo
- Carboni Giovanni
- Cardinale Roberta
- Cardini Alessandro
- Carniti Paolo
- Carson Laurence
- Carvalho Akiba Kazuyoshi
- Casse Gianluigi
- Cassina Lorenzo
- Cattaneo Marco
- Cavallero Giovanni
- Cenci Riccardo
- Chamont David
- Chapman Matthew George
- Charles Matthew
- Charpentier Philippe
- Chatzikonstantinidis Georgios
- Chefdeville Maximilien
- Chekalina Viktoriia
- Chen Chen
- Chen Shanzhen
- Chitic Stefan-Gabriel
- Chobanova Veronika
- Chrzaszcz Marcin
- Chubykin Alexsei
- Ciambrone Paolo
- Cid Vidal Xabier
- Ciezarek Gregory
- Clarke Peter
- Clemencic Marco
- Cliff Harry
- Closier Joel
- Coco Victor
- Coelho Joao A B
- Cogan Julien
- Cogneras Eric
- Cojocariu Lucian
- Collins Paula
- Colombo Tommaso
- Comerma-Montells Albert
- Contu Andrea
- Coombs George
- Coquereau Samuel
- Corti Gloria
- Corvo Marco
- Costa Sobral Cayo Mar
- Couturier Benjamin
- Cowan Greig
- Craik Daniel Charles
- Crocombe Andrew
- Cruz Torres Melissa Maria
- Currie Robert
- D'Ambrosio Carmelo
- d'Argent Philippe
- Da Cunha Marinho Franciole
- Da Silva Cesar Luiz
- Dall'Occo Elena
- Dalseno Jeremy
- Danilina Anna
- Davis Adam
- De Aguiar Francisco Oscar
- De Bruyn Kristof
- De Capua Stefano
- De Cian Michel
- De Miranda Jussara
- De Paula Leandro
- De Serio Marilisa
- De Simone Patrizia
- de Vries Jacco
- Dean Cameron Thomas
- Decamp Daniel
- Del Buono Luigi
- Delaney Blaise
- Dembinski Hans Peter
- Demmer Moritz
- Dendek Adam
- Derkach Denis
- Deschamps Olivier
- Desse Fabrice
- Dettori Francesco
- Dey Biplab
- Di Canto Angelo
- Di Nezza Pasquale
- Didenko Sergey
- Dijkstra Hans
- Dordei Francesca
- Dorigo Mirco
- dos Reis Alberto
- Dosil Suárez Alvaro
- Douglas Lauren
- Dovbnya Anatoliy
- Dreimanis Karlis
- Dufour Laurent
- Dujany Giulio
- Durante Paolo
- Durham John Matthew
- Dutta Deepanwita
- Dzhelyadin Rustem
- Dziewiecki Michal
- Dziurda Agnieszka
- Dzyuba Alexey
- Easo Sajan
- Egede Ulrik
- Egorychev Victor
- Eidelman Semen
- Eisenhardt Stephan
- Eitschberger Ulrich
- Ekelhof Robert
- Eklund Lars
- Ely Scott
- Ene Alexandru
- Escher Stephan
- Esen Sevda
- Evans Timothy
- Falabella Antonio
- Farley Nathanael
- Farry Stephen
- Fazzini Davide
- Färber Christian
- Federici Luca
- Fernandez Declara Placido
- Fernandez Gerard
- Fernandez Prieto Antonio
- Ferrari Fabio
- Ferreira Lopes Lino
- Ferreira Rodrigues Fernando
- Ferro-Luzzi Massimiliano
- Féo Mauricio
- Filippov Sergey
- Fini Rosa Anna
- Fiorini Massimiliano
- Firlej Miroslaw
- Fitzpatrick Conor
- Fiutowski Tomasz
- Fleuret Frederic
- Fontana Marianna
- Fontanelli Flavio
- Forty Roger
- Franco Lima Vinicius
- Frank Markus
- Frei Christoph
- Fu Jinlin
- Funk Wolfgang
- Gabriel Emmy
- Gallas Torreira Abraham
- Galli Domenico
- Gallorini Stefano
- Gambetta Silvia
- Gan Yuyue
- Gandelman Miriam
- Gandini Paolo
- Gao Yuanning
- Garcia Martin Luis Miguel
- Garcia Plana Beatriz
- García Pardiñas Julián
- Garra Tico Jordi
- Garrido Lluis
- Gascon David
- Gaspar Clara
- Gavardi Laura
- Gazzoni Giulio
- Gerick David
- Gersabeck Evelina
- Gersabeck Marco
- Gershon Timothy
- Gerstel Dawid
- Ghez Philippe
- Gianì Sebastiana
- Gibson Valerie
- Girard Olivier Göran
- Giubega Lavinia-Helena
- Gizdov Konstantin
- Gligorov Vladimir
- Golubkov Dmitry
- Golutvin Andrey
- Gomes Alvaro
- Gorelov Igor Vladimirovich
- Gotti Claudio
- Govorkova Ekaterina
- Göbel Carla
- Grabowski Jascha Peter
- Graciani Diaz Ricardo
- Granado Cardoso Luis Alberto
- Graugés Eugeni
- Graverini E
- Graziani Giacomo
- Grecu Alexandru
- Greim Roman
- Griffith Peter
- Grillo Lucia
- Gruber Lukas
- Gruberg Cazon Barak Raimond
- Grünberg Oliver
- Gu Chenxi
- Gushchin Evgeny
- Guz Yury
- Gys Thierry
- Hadavizadeh Thomas
- Hadjivasiliou Christos
- Haefeli Guido
- Haen Christophe
- Haines Susan
- Hamilton Brian
- Han Xiaoxue
- Hancock Thomas Henry
- Hansmann-Menzemer Stephanie
- Harnew Neville
- Harnew Samuel
- Harrison Thomas
- Hasse Christoph
- Hatch Mark
- He Jibo
- Hecker Malte
- Heinicke Kevin
- Heister Arno
- Hennessy Karol
- Henry Louis
- Heß Miriam
- Hicheur Adlène
- Hidalgo Charman Raoul
- Hill Donal
- Hilton Martha
- Hopchev Plamen Hristov
- Hu Wenhua
- Huang Wenqian
- Huard Zachary
- Hulsbergen Wouter
- Humair Thibaud
- Hushchyn Mikhail
- Hutchcroft David
- Hynds Daniel
- Ibis Philipp
- Idzik Marek
- Ilten Philip
- Ivshin Kuzma
- Jacobsson Richard
- Jalocha Pawel
- Jans Eddy
- Jawahery Abolhassan
- Jiang Feng
- John Malcolm
- Johnson Daniel
- Jones Christopher
- Joram Christian
- Jost Beat
- Jurik Nathan
- Kandybei Sergii
- Karacson Matthias
- Kariuki James Mwangi
- Karodia Sarah
- Kazeev Nikita
- Kecke Matthieu
- Keizer Floris
- Kelsey Matthew
- Kenzie Matthew
- Ketel Tjeerd
- Khairullin Egor
- Khanji Basem
- Khurewathanakul Chitsanu
- Kim Kyung Eun
- Kirn Thomas
- Klaver Suzanne
- Klimaszewski Konrad
- Klimkovich Tatsiana
- Koliiev Serhii
- Kolpin Michael
- Kopecna Renata
- Koppenburg Patrick
- Kostiuk Igor
- Kotriakhova Sofia
- Kozeiha Mohamad
- Kravchuk Leonid
- Kreps Michal
- Kress Felix Johannes
- Krokovny Pavel
- Krupa Wojciech
- Krzemien Wojciech
- Kucewicz Wojciech
- Kucharczyk Marcin
- Kudryavtsev Vasily
- Kuonen Axel Kevin
- Kvaratskheliya Tengiz
- Lacarrere Daniel
- Lafferty George
- Lai Adriano
- Lancierini Davide
- Lanfranchi Gaia
- Langenbruch Christoph
- Latham Thomas
- Lazzeroni Cristina
- Le Gac Renaud
- Lefèvre Regis
- Leflat Alexander
- Lefrançois Jacques
- Lemaitre Florian
- Leroy Olivier
- Lesiak Tadeusz
- Leverington Blake
- Li Pei-Rong
- Li Tenglin
- Li Zhuoming
- Liang Xixin
- Likhomanenko Tatiana
- Lindner Rolf
- Lionetto Federica
- Lisovskyi Vitalii
- Liu Xuesong
- Loh David
- Loi Angelo
- Longstaff Iain
- Lopes Jose
- Lovell George Holger
- Lucchesi Donatella
- Lucio Martinez Miriam
- Lupato Anna
- Luppi Eleonora
- Lupton Oliver
- Lusiani Alberto
- Lyu Xiao-Rui
- Machefert Frederic
- Maciuc Florin
- Macko Vladimir
- Mackowiak Patrick
- Maddrell-Mander Samuel
- Maev Oleg
- Maguire Kevin
- Maisuzenko Dmitrii
- Majewski Maciej Witold
- Malde Sneha
- Malecki Bartosz
- Malinin Alexander
- Maltsev Timofei
- Manca Giulia
- Mancinelli Giampiero
- Marangotto Daniele
- Maratas Jan
- Marchand Jean François
- Marconi Umberto
- Marin Benito Carla
- Marinangeli Matthieu
- Marino Pietro
- Marks Jörg
- Marshall Phillip John
- Martellotti Giuseppe
- Martin Morgan
- Martinelli Maurizio
- Martinez Santos Diego
- Martinez Vidal Fernando
- Massafferri André
- Materok Marcel
- Matev Rosen
- Mathad Abhijit
- Mathe Zoltan
- Matteuzzi Clara
- Mauri Andrea
- Maurice Emilie
- Maurin Brice
- Mazurov Alexander
- McCann Michael
- McNab Andrew
- McNulty Ronan
- Mead James Vincent
- Meadows Brian
- Meaux Cedric
- Meier Frank
- Meinert Nis
- Melnychuk Dmytro
- Merk Marcel
- Merli Andrea
- Michielin Emanuele
- Milanes Diego Alejandro
- Millard Edward James
- Minard Marie-Noelle
- Minzoni Luca
- Mitzel Dominik Stefan
- Mogini Andrea
- Molina Rodriguez Josue
- Mombächer Titus
- Monroy Igancio Alberto
- Monteil Stephane
- Morandin Mauro
- Morello Gianfranco
- Morello Michael Joseph
- Morgunova Olga
- Moron Jakub
- Morris Adam Benjamin
- Mountain Raymond
- Mödden Antje
- Muheim Franz
- Mulder Mick
- Murphy Colm Harold
- Murray Donal
- Müller Dominik
- Müller Janine
- Müller Katharina
- Müller Vanessa
- Naik Paras
- Nakada Tatsuya
- Nandakumar Raja
- Nandi Anita
- Nanut Tara
- Nasteva Irina
- Needham Matthew
- Neri Nicola
- Neubert Sebastian
- Neufeld Niko
- Neuner Max
- Nguyen Thi Dung
- Nguyen-Mau Chung
- Nieswand Simon
- Niet Ramon
- Nikitin Nikolay
- Nogay Alla
- O'Hanlon Daniel Patrick
- Oblakowska-Mucha Agnieszka
- Obraztsov Vladimir
- Ogilvy Stephen
- Oldeman Rudolf
- Onderwater Gerco
- Ossowska Anna
- Otalora Goicochea Juan Martin
- Owen Patrick
- Oyanguren Maria Aranzazu
- Pais Preema Rennee
- Palano Antimo
- Palutan Matteo
- Panshin Gennady
- Papanestis Antonios
- Pappagallo Marco
- Pappalardo Luciano
- Parker William
- Parkes Christopher
- Passaleva Giovanni
- Pastore Alessandra
- Patel Mitesh
- Patrignani Claudia
- Pearce Alex
- Pellegrino Antonio
- Penso Gianni
- Pepe Altarelli Monica
- Perazzini Stefano
- Pereima Dmitrii
- Perret Pascal
- Pescatore Luca
- Petridis Konstantinos
- Petrolini Alessandro
- Petrov Aleksandr
- Petrucci Stefano
- Petruzzo Marco
- Pietrzyk Boleslaw
- Pietrzyk Guillaume
- Pikies Malgorzata
- Pili Martina
- Pinci Davide
- Pinzino Jacopo
- Pisani Flavio
- Piucci Alessio
- Placinta Vlad-Mihai
- Playfer Stephen
- Plews Jonathan
- Plo Casasus Maximo
- Polci Francesco
- Poli Lener Marco
- Poluektov Anton
- Polukhina Natalia
- Polyakov Ivan
- Polycarpo Erica
- Pomery Gabriela Johanna
- Ponce Sebastien
- Popov Alexander
- Popov Dmitry
- Poslavskii Stanislav
- Potterat Cédric
- Price Eugenia
- Prisciandaro Jessica
- Prouve Claire
- Pugatch Valery
- Puig Navarro Albert
- Pullen Hannah Louise
- Punzi Giovanni
- Qian Wenbin
- Qin Jia-Jia
- Quagliani Renato
- Quintana Boris
- Rachwal Bartlomiej
- Rademacker Jonas
- Rama Matteo
- Ramos Pernas Miguel
- Rangel Murilo
- Ratnikov Fedor
- Raven Gerhard
- Ravonel Salzgeber Melody
- Reboud Meril
- Redi Federico
- Reichert Stefanie
- Reiss Florian
- Remon Alepuz Clara
- Ren Zan
- Renaudin Victor
- Ricciardi Stefania
- Richards Sophie
- Rinnert Kurt
- Robbe Patrick
- Robert Arnaud
- Rodrigues Ana Barbara
- Rodrigues Eduardo
- Rodriguez Lopez Jairo Alexis
- Roehrken Markus
- Rogozhnikov Alexey
- Roiser Stefan
- Rollings Alexandra Paige
- Romanovskiy Vladimir
- Romero Vidal Antonio
- Rotondo Marcello
- Rudolph Matthew Scott
- Ruf Thomas
- Ruiz Vidal Joan
- Saborido Silva Juan Jose
- Sagidova Naylya
- Saitta Biagio
- Salustino Guimaraes Valdir
- Sanchez Gras Cristina
- Sanchez Mayordomo Carlos
- Sanmartin Sedes Brais
- Santacesaria Roberta
- Santamarina Rios Cibran
- Santimaria Marco
- Santovetti Emanuele
- Sarpis Gediminas
- Sarti Alessio
- Satriano Celestina
- Satta Alessia
- Saur Miroslav
- Savrina Darya
- Schael Stefan
- Schellenberg Margarete
- Schiller Manuel
- Schindler Heinrich
- Schmelling Michael
- Schmelzer Timon
- Schmidt Burkhard
- Schneider Olivier
- Schopper Andreas
- Schreiner HF
- Schubiger Maxime
- Schune Marie Helene
- Schwemmer Rainer
- Sciascia Barbara
- Sciubba Adalberto
- Semennikov Alexander
- Sepulveda Eduardo Enrique
- Sergi Antonino
- Serra Nicola
- Serrano Justine
- Sestini Lorenzo
- Seuthe Alex
- Seyfert Paul
- Shapkin Mikhail
- Shcheglov Yury
- Shears Tara
- Shekhtman Lev
- Shevchenko Vladimir
- Shmanin Evgenii
- Siddi Benedetto Gianluca
- Silva Coutinho Rafael
- Silva de Oliveira Luiz Gustavo
- Simi Gabriele
- Simone Saverio
- Skidmore Nicola
- Skwarnicki Tomasz
- Smeaton John Gordon
- Smith Eluned
- Smith Iwan Thomas
- Smith Mark
- Soares Lavra Lais
- Soares Marcelo
- Sokoloff Michael
- Soler Paul
- Souza De Paula Bruno
- Spaan Bernhard
- Spradlin Patrick
- Stagni Federico
- Stahl Marian
- Stahl Sascha
- Stefko Pavol
- Stefkova Slavomira
- Steinkamp Olaf
- Stemmle Simon
- Stenyakin Oleg
- Stepanova Margarita
- Stevens Holger
- Stone Sheldon
- Storaci Barbara
- Stracka Simone
- Stramaglia Maria Elena
- Straticiuc Mihai
- Straumann Ulrich
- Strokov Sergey
- Sun Jiayin
- Sun Liang
- Swientek Krzysztof
- Syropoulos Vasileios
- Szumlak Tomasz
- Szymanski Maciej Pawel
- T'Jampens Stephane
- Tang Zhipeng
- Tayduganov Andrey
- Tekampe Tobias
- Tellarini Giulia
- Teubert Frederic
- Thomas Eric
- Tilley Matthew James
- Tisserand Vincent
- Tolk Siim
- Tomassetti Luca
- Tou Da Yu
- Tourinho Jadallah Aoude Rafael
- Tournefier Edwige
- Traill Murdo
- Tran Minh Tâm
- Trisovic Ana
- Tsaregorodtsev Andrei
- Tully Alison
- Tuning Niels
- Ukleja Artur
- Usachov Andrii
- Ustyuzhanin Andrey
- Uwer Ulrich
- Vacca Claudia
- Vagner Alexander
- Vagnoni Vincenzo
- Valassi Andrea
- Valat Sebastien
- Valenti Giovanni
- van Beuzekom Martinus
- van Herwijnen Eric
- van Tilburg Jeroen
- van Veghel Maarten
- Vazquez Gomez Ricardo
- Vazquez Regueiro Pablo
- Vázquez Sierra Carlos
- Vecchi Stefania
- Velthuis Jaap
- Veltri Michele
- Veneziano Giovanni
- Venkateswaran Aravindhan
- Verlage Tobias Anton
- Vernet Maxime
- Veronesi Michele
- Veronika Naomi
- Vesterinen Mika
- Viana Barbosa Joao Vitor
- Vieira Daniel
- Vieites Diaz Maria
- Viemann Harald
- Vilasis-Cardona Xavier
- Vitkovskiy Arseniy
- Vitti Marcela
- Volkov Vladimir
- Vollhardt Achim
- Voneki Balazs
- Vorobyev Alexey
- Vorobyev Vitaly
- Waldi Roland
- Walsh John
- Wang Jianchun
- Wang Mengzhen
- Wang Yilong
- Wang Zhenzi
- Ward David
- Wark Heather Mckenzie
- Watson Nigel
- Websdale David
- Weiden Andreas
- Weisser Constantin
- Whitehead Mark
- Wicht Jean
- Wilkinson Guy
- Wilkinson Michael
- Williams Ifan
- Williams Mark Richard James
- Williams Mike
- Williams Timothy
- Wilson Fergus
- Wimberley Jack
- Winn Michael Andreas
- Wishahi Julian
- Wislicki Wojciech
- Witek Mariusz
- Wormser Guy
- Wotton Stephen
- Wyllie Kenneth
- Xiao Dong
- Xie Yuehong
- Xu Ao
- Xu Menglin
- Xu Qingnian
- Xu Zehua
- Xu Zhirui
- Yang Zhenwei
- Yang Zishuo
- Yao Yuezhe
- Yeomans Lauren Emma
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Yushchenko Oleg
- Zarebski Kristian Alexander
- Zavertyaev Mikhail
- Zhang Dongliang
- Zhang Liming
- Zhang Wen Chao
- Zhang Yanxi
- Zhelezov Alexey
- Zheng Yangheng
- Zhu Xianglei
- Zhukov Valery
- Zonneveld Jennifer Brigitta
- Zucchelli Stefano
- Publication venue
- Publication date
- 01/01/2018
- Field of study
The LHCb Upgrade II will fully exploit the flavour-physics opportunities of the HL-LHC, and study additional physics topics that take advantage of the forward acceptance of the LHCb spectrometer. The LHCb Upgrade I will begin operation in 2020. Consolidation will occur, and modest enhancements of the Upgrade I detector will be installed, in Long Shutdown 3 of the LHC (2025) and these are discussed here. The main Upgrade II detector will be installed in long shutdown 4 of the LHC (2030) and will build on the strengths of the current LHCb experiment and the Upgrade I. It will operate at a luminosity up to 2×1034
cm−2s−1, ten times that of the Upgrade I detector. New detector components will improve the intrinsic performance of the experiment in certain key areas. An Expression Of Interest proposing Upgrade II was submitted in February 2017. The physics case for the Upgrade II is presented here in more depth. CP-violating phases will be measured with precisions unattainable at any other envisaged facility. The experiment will probe b → sl+l−and b → dl+l− transitions in both muon and electron decays in modes not accessible at Upgrade I. Minimal flavour violation will be tested with a precision measurement of the ratio of B(B0 → μ+μ−)/B(Bs → μ+μ−). Probing charm CP violation at the 10−5 level may result in its long sought discovery. Major advances in hadron spectroscopy will be possible, which will be powerful probes of low energy QCD. Upgrade II potentially will have the highest sensitivity of all the LHC experiments on the Higgs to charm-quark couplings. Generically, the new physics mass scale probed, for fixed couplings, will almost double compared with the pre-HL-LHC era; this extended reach for flavour physics is similar to that which would be achieved by the HE-LHC proposal for the energy frontier
LHCb upgrade software and computing : technical design report
- Author
- Aaij Roel
- Adeva Bernardo
- Adinolfi Marco
- Aidala Christine Angela
- Ajaltouni Ziad
- Akar Simon
- Albicocco Pietro
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Ali Suvayu
- Alkhazov Georgy
- Alvarez Cartelle Paula
- Alves Jr Antonio Augusto
- Amato Sandra
- Amerio Silvia
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andreassi Guido
- Andreotti Mirco
- Andrews Jason
- Appleby Robert
- Archilli Flavio
- Arnau Romeu Joan
- Artamonov Alexander
- Artuso Marina
- Arzymatov Kenenbek
- Aslanides Elie
- Atzeni Michele
- Bachmann Sebastian
- Back John
- Baker Sophie
- Balagura Vladislav
- Baldini Wander
- Baranov Alexander
- Barlow Roger
- Barsuk Sergey
- Barter William
- Baryshnikov Fedor
- Batozskaya Varvara
- Batsukh Baasansuren
- Battista Vincenzo
- Bay Aurelio
- Beddow John
- Bedeschi Franco
- Bediaga Ignacio
- Beiter Andrew
- Bel Lennaert
- Beliy Nikita
- Bellee Violaine
- Belloli Nicoletta
- Belous Konstantin
- Belyaev Ivan
- Ben-Haim Eli
- Bencivenni Giovanni
- Benson Sean
- Beranek Sarah
- Berezhnoy Alexander
- Bernet Roland
- Berninghoff Daniel
- Bertholet Emilie
- Bertolin Alessandro
- Betancourt Christopher
- Betti Federico
- Bettler Marc-Olivier
- Bezshyiko Iaroslava
- Bhasin Srishti
- Bhom Jihyun
- Bifani Simone
- Billoir Pierre
- Birnkraut Alex
- Bizzeti Andrea
- Bjørn Mikkel
- Blago Michele Piero
- Blake Thomas
- Blanc Frederic
- Blusk Steven
- Bobulska Dana
- Bocci Valerio
- Boente Garcia Oscar
- Boettcher Thomas
- Bondar Alexander
- Bondar Nikolay
- Borghi Silvia
- Borisyak Maxim
- Borsato Martino
- Bossu Francesco
- Boubdir Meriem
- Bowcock Themistocles
- Bozzi Concezio
- Braun Svende
- Brodski Michael
- Brodzicka Jolanta
- Brossa Gonzalo Arnau
- Brundu Davide
- Buchanan Emma
- Buonaura Annarita
- Burr Christopher
- Bursche Albert
- Buytaert Jan
- Byczynski Wiktor
- Cadeddu Sandro
- Cai Hao
- Calabrese Roberto
- Calladine Ryan
- Calvi Marta
- Calvo Gomez Miriam
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- Campora Perez Daniel Hugo
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- Cardinale Roberta
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- Carvalho Akiba Kazuyoshi
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- Cattaneo Marco
- Cavallero Giovanni
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- Chamont David
- Chapman Matthew George
- Charles Matthew
- Charpentier Philippe
- Chatzikonstantinidis Georgios
- Chefdeville Maximilien
- Chekalina Viktoriia
- Chen Chen
- Chen Shanzhen
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- Chobanova Veronika
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- Chubykin Alexsei
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- Cid Vidal Xabier
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- Closier Joel
- Coco Victor
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- Cogan Julien
- Cogneras Eric
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- Coquereau Samuel
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- Cruz Torres Melissa Maria
- Currie Robert
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- d'Argent Philippe
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- Dall'Occo Elena
- Dalseno Jeremy
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- Silva de Oliveira Luiz Gustavo
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- Smith Mark
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- Tisserand Vincent
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- van Herwijnen Eric
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- Vazquez Regueiro Pablo
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- Velthuis Jaap
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- Venkateswaran Aravindhan
- Verlage Tobias Anton
- Vernet Maxime
- Veronesi Michele
- Veronika Naomi
- Vesterinen Mika
- Viana Barbosa Joao Vitor
- Vieira Daniel
- Vieites Diaz Maria
- Viemann Harald
- Vilasis-Cardona Xavier
- Vitkovskiy Arseniy
- Vitti Marcela
- Volkov Vladimir
- Vollhardt Achim
- Voneki Balazs
- Vorobyev Alexey
- Vorobyev Vitaly
- Waldi Roland
- Walsh John
- Wang Jianchun
- Wang Mengzhen
- Wang Yilong
- Wang Zhenzi
- Ward David
- Wark Heather Mckenzie
- Watson Nigel
- Websdale David
- Weiden Andreas
- Weisser Constantin
- Whitehead Mark
- Wicht Jean
- Wilkinson Guy
- Wilkinson Michael
- Williams Ifan
- Williams Mark Richard James
- Williams Mike
- Williams Timothy
- Wilson Fergus
- Wimberley Jack
- Winn Michael Andreas
- Wishahi Julian
- Wislicki Wojciech
- Witek Mariusz
- Wormser Guy
- Wotton Stephen
- Wyllie Kenneth
- Xiao Dong
- Xie Yuehong
- Xu Ao
- Xu Menglin
- Xu Qingnian
- Xu Zehua
- Xu Zhirui
- Yang Zhenwei
- Yang Zishuo
- Yao Yuezhe
- Yeomans Lauren Emma
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Yushchenko Oleg
- Zarebski Kristian Alexander
- Zavertyaev Mikhail
- Zhang Dongliang
- Zhang Liming
- Zhang Wen Chao
- Zhang Yanxi
- Zhelezov Alexey
- Zheng Yangheng
- Zhu Xianglei
- Zhukov Valery
- Zonneveld Jennifer Brigitta
- Zucchelli Stefano
- Publication venue
- Publication date
- 01/01/2018
- Field of study
This document reports the Research and Development activities that are carried out in the software and computing domains in view of the upgrade of the LHCb experiment. The implementation of a full software trigger implies major changes in the core software framework, in the event data model, and in the reconstruction algorithms. The increase of the data volumes for both real and simulated datasets requires a corresponding scaling of the distributed computing infrastructure. An implementation plan in both domains is presented, together with a risk assessment analysis
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
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- Aslanidis Cara
- Asomugha Chinwe O.
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- Bemrose Richard
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- Benke J
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- Chung A
- Cinkowsky Michael J.
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- Craig Matthew
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- D\u27Souza Lisa Marie
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- Daum Christopher
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- De Anda Claudia
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- Evans Gareth
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- Footman Simon
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- Fulton Lucinda A.
- Fulton Robert S.
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- Furuhashi Mie
- Förste Silke
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- Georgescu Anca
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- Goodstadt Leo
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- Gordon Catherine
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- Griffith Jeffrey K.
- Griffiths Coline
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- Hamada Junko
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- Hamilton Keelan A.
- Hamilton Matt
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- Hammon Nancy
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- Han Guiqing
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- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
- Harley Joanne
- Harper David
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- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
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- Holden Jane
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- Idlebird Devincent G.
- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
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- Ishizaki Hinako
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- Iwakawa Shinobu
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- Jacintho Mark
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- Jackson Terri
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- Jahn Niels
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- Jia Jia
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- Jones Steven
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- Kay Michael
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- Keenan Stephen
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- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
- Khurama Divya
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- Kohlberg Sara
- Kojima Kazuyasu
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- Kong Yi
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- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
- Kudoh Jun
- Kuehl Jennifer
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- Kulish Larissa
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- Kwan Chinnie
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- Laird Gavin
- Lam Edward
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- Lamble Ralph
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- Lander Eric S.
- Landers Tom
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- Larke Ben
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- Legall Fitzherbert Henderson, III
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- Levan Jaclyn M.
- Leversha Margaret
- Levine Rosie
- Levy Andrew
- Levy Michaël
- Lewis Doreen
- Lewis Ernest K.
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- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Angular analysis of the B-0 -> K*(0) e(+) e(-) decay in the low-q(2) region
- Author
- Aaij Roel
- Adeva Bernardo
- Adinolfi Marco
- Affolder Anthony
- Ajaltouni Ziad
- Akar Simon
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Ali Suvayu
- Alkhazov Georgy
- Alvarez Cartelle Paula
- Alves Jr Antonio Augusto
- Amato Sandra
- Amerio Silvia
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Anderson Jonathan
- Andreassen Rolf
- Andreotti Mirco
- Andrews Jason
- Appleby Robert
- Aquines Gutierrez Osvaldo
- Archilli Flavio
- Artamonov Alexander
- Artuso Marina
- Aslanides Elie
- Auriemma Giulio
- Baalouch Marouen
- Bachmann Sebastian
- Back John
- Badalov Alexey
- Baesso Clarissa
- Baldini Wander
- Barlow Roger
- Barschel Colin
- Barsuk Sergey
- Barter William
- Batozskaya Varvara
- Battista Vincenzo
- Bay Aurelio
- Beaucourt Leo
- Beddow John
- Bedeschi Franco
- Bediaga Ignacio
- Belogurov Sergey
- Belyaev Ivan
- Ben-Haim Eli
- Bencivenni Giovanni
- Benson Sean
- Benton Jack
- Berezhnoy Alexander
- Bernet Roland
- Bertolin Alessandro
- Bettler Marc-Olivier
- Bien Alexander
- Bifani Simone
- Bird Thomas
- Bizzeti Andrea
- Blake Thomas
- Blanc Frédéric
- Blouw Johan
- Blusk Steven
- Bocci Valerio
- Bondar Alexander
- Bondar Nikolay
- Bonivento Walter
- Borghi Silvia
- Borgia Alessandra
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- Bowen Espen Eie
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- Brett David
- Britsch Markward
- Britton Thomas
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- Brook Nicholas
- Bursche Albert
- Buytaert Jan
- Cadeddu Sandro
- Calabrese Roberto
- Calvi Marta
- Calvo Gomez Miriam
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- Campora Perez Daniel
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- Couturier Benjamin
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- Craik Daniel Charles
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- Cruz Torres Melissa Maria
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- Currie Robert
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- Wilkinson Michael
- Williams Matthew
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- Wilschut Hans
- Wilson Fergus
- Wimberley Jack
- Wishahi Julian
- Wislicki Wojciech
- Witek Mariusz
- Wormser Guy
- Wotton Stephen
- Wright Simon
- Wyllie Kenneth
- Xie Yuehong
- Xing Zhou
- Xu Zhirui
- Yang Zhenwei
- Yuan Xuhao
- Yushchenko Oleg
- Zangoli Maria
- Zavertyaev Mikhail
- Zhang Liming
- Zhang Wen Chao
- Zhang Yanxi
- Zhelezov Alexey
- Zhokhov Anatoly
- Zhong Liang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/01/2015
- Field of study
An angular analysis of the B0→K∗0e+e− decay is performed using a data sample, corresponding to an integrated luminosity of 3.0 {\mbox{fb}^{-1}}, collected by the LHCb experiment in pp collisions at centre-of-mass energies of 7 and 8 TeV during 2011 and 2012. For the first time several observables are measured in the dielectron mass squared (q2) interval between 0.002 and 1.120GeV2/c4. The angular observables FL and ATRe which are related to the K∗0 polarisation and to the lepton forward-backward asymmetry, are measured to be FL=0.16±0.06±0.03 and ATRe=0.10±0.18±0.05, where the first uncertainty is statistical and the second systematic. The angular observables AT(2) and ATIm which are sensitive to the photon polarisation in this q2 range, are found to be AT(2)=−0.23±0.23±0.05 and ATIm=0.14±0.22±0.05. The results are consistent with Standard Model predictions.An angular analysis of the B0 → K^{*}^{0} e+ e− decay is performed using a data sample, corresponding to an integrated luminosity of 3.0 fb−1, collected by the LHCb experiment in pp collisions at centre-of-mass energies of 7 and 8 TeV during 2011 and 2012. For the first time several observables are measured in the dielectron mass squared (q2) interval between 0.002 and 1.120 GeV2 /c4. The angular observables FL and ATRe which are related to the K^{*}^{0} polarisation and to the lepton forward-backward asymmetry, are measured to be FL = 0.16 ± 0.06 ± 0.03 and ATRe = 0.10 ± 0.18 ± 0.05, where the first uncertainty is statistical and the second systematic. The angular observables AT(2) and ATIm which are sensitive to the photon polarisation in this q2 range, are found to be AT(2) = − 0.23 ± 0.23 ± 0.05 and ATIm = 0.14 ± 0.22 ± 0.05. The results are consistent with Standard Model predictions.An angular analysis of the B0→K∗0e+e− decay is performed using a data sample, corresponding to an integrated luminosity of 3.0 {\mbox{fb}^{-1}}, collected by the LHCb experiment in pp collisions at centre-of-mass energies of 7 and 8 TeV during 2011 and 2012. For the first time several observables are measured in the dielectron mass squared (q2) interval between 0.002 and 1.120GeV2/c4. The angular observables FL and ATRe which are related to the K∗0 polarisation and to the lepton forward-backward asymmetry, are measured to be FL=0.16±0.06±0.03 and ATRe=0.10±0.18±0.05, where the first uncertainty is statistical and the second systematic. The angular observables AT(2) and ATIm which are sensitive to the photon polarisation in this q2 range, are found to be AT(2)=−0.23±0.23±0.05 and ATIm=0.14±0.22±0.05. The results are consistent with Standard Model predictions
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