The secret lives of the amir sisters : Your family know everything about you. But do they really know who you are

Novel tentang satu keluarga dalam kehidupan300 hlm; 23,3 x 15,3 c

The secret lives of the amir sisters : Your family know everything about you. But do they really know who you are

Novel tentang satu keluarga dalam kehidupan300 hlm; 23,3 x 15,3 c

Concomitant medications and immune checkpoint inhibitor therapy for cancer: causation or association?

The majority of cancer patients assume concomitant medications for the treatment of cancer-related symptoms or co-morbidities. As immune checkpoint inhibitors expand in the treatment of a widening range of malignancies, drug–drug interactions have become an area of increasing interest due to the potential for some concomitant medications to exert immune-modulatory effects and influence outcomes from immunotherapy. Here, we review the evidence supporting this association across selected drug classes including antibiotics, proton pump inhibitors, metformin, and opioids

Concomitant medications and immune checkpoint inhibitor therapy for cancer: causation or association?

The majority of cancer patients assume concomitant medications for the treatment of cancer-related symptoms or co-morbidities. As immune checkpoint inhibitors expand in the treatment of a widening range of malignancies, drug–drug interactions have become an area of increasing interest due to the potential for some concomitant medications to exert immune-modulatory effects and influence outcomes from immunotherapy. Here, we review the evidence supporting this association across selected drug classes including antibiotics, proton pump inhibitors, metformin, and opioids

Exploring Human Health Benefits from Marine Biomedical Research with Fishes

Marine organisms, particularly fishes, harbor a treasure trove of bioactive compounds with immense potential for human health applications. In this review, we delve into the diverse array of bioactive molecules derived from marine fishes and their implications for biomedical research. We explore the therapeutic properties of fish-derived compounds, including antimicrobial peptides, omega-3 fatty acids, collagen, and bioactive peptides, among others andthe mechanisms of action and preclinical studies supporting the use of these compounds in various human health conditions, such as cardiovascular disease, cancer, inflammatory disorders, and neurodegenerative diseases. Additionally, we highlight the importance of sustainable sourcing and ethical considerations in marine biomedical research. Overall, this review underscores the significance of marine fishes as a source of novel therapeutic agents and the promising avenues they offer for advancing human health

The Genus <i>Xanthagaricus</i>: An Updated Global Species Distribution and Phylogeny with the Description of Two New Species from Oman

Xanthagaricus is a saprotrophic mushroom genus with small-sized basidiomata in the family Agaricaceae (Agaricales). Prior to this study, 26 species belonging to this genus have been described and published. In this study, we reported Xanthagaricus for the first time from Oman with the description of two new species. Basidiomata of the new species Xanthagaricus appendiculatus and X. omanicus were collected during the monsoon rains of summer in 2018 in the southern coastal region of Oman. Species descriptions are based on morphological and molecular characterization. Phylogenetic analyses based on internal transcribed spacer region (ITS1-5.8S-ITS2 = ITS) of the nuclear ribosomal DNA clustered the new species in the Xanthagaricus clade with strong statistical support. The new species Xanthagaricusappendiculatus can be distinguished from other species by its purplish pileus with umbonate disc and X. omanicus with the largest pileus (70–90 mm diameter) among the known species of the genus. A detailed description, photographs, line drawings, and a phylogenetic tree showing the position of both new species are provided. A dichotomous key to the known taxa of Xanthagaricus is proposed. Morphological comparisons of new species with known Xanthagaricus taxa are provided. Our observations highlight the diversity of Xanthagaricus and other lepiotaceous mushrooms in southern Oman and further document the need for additional systematic focus on the region’s fungi

Micropsalliota ventricocystidiata Al-Sadi & S. Hussain 2022, sp. nov.

Micropsalliota ventricocystidiata Al-Sadi & S. Hussain, sp. nov. (Figs. 3, 4) MycoBank no: MB842602 Diagnosis: Micropsalliota ventricocystidiata can be distinguished from other species by its: medium-sized basidiomata with hemispheric pileus, covered with reddish-brown squamules, basidiospores amygdaliform to oblong, measuring 7.5–8.5 × 4.5–5.0 µm, with ventricose cheilocystidia. Etymology: The specific epithet “ ventricocystidiata ” refers to the ventricose shape of the cheilocystidia of the new species. Type: Oman, Dhofar, Gogob, 17°18′28.9″ N and 54°06′27.6″ E under the trees of Anogeissus dhofarica, 2 Sept 2018, N. Al Dhanki, S. Al Salami, M. Al Jahwari and I. Al Sabahi, GOB-002 (holotype SQUH-GOB002; GenBank accession: ITS = OM 397374, 28 S = OM 630413). Description:Pileus 30–55 mm diam, at young stage ovoid to parabolic, as the pileus opened becoming hemispheric, at mature stage convex to plano-convex; surface finely squamulose, squamules more or less triangular or granular, slightly erect, concentrated at the center, sparse towards the margin, light reddish-brown (2.5YR 5/4–2.5YR 6/4) to moderate reddish-brown (7.5R 3/4–7.5R 3/6) on a white background; margins slightly scalloped. Lamellae free, crowded (25–30 per centimeter), ventricose, reddish-gray (7.5YR 6/2), with 1–5 series of lamellulae, becoming lightbrown (5YR 6/4) with age. Stipe 40–70 × 7–10 mm, central, equal, hollow, surface granulose, granules white, sparce above the annulus, more concentrated below the annulus, on a white background; annulus single layered, membranous, ascendant, white, smooth on both surfaces. Context white, unchanged on handling. KOH reaction reddish-brown on pileus. Odor and taste not recorded. Basidiospores [60/2/2] (7.0)7.5–8.5(9.0) × (4.0)4.5–5.0(5.5) µm, on average 8.2 × 4.8 µm, Q = 1.6–1.86, av. Q = 1.7, ellipsoid to amygdaliform with acute apex in side view, oblong to sub-cylindrical in frontal view, smooth, brownish in 5% KOH, germ-pore absent. Basidia 20–26 × 8–9.5 µm, clavate, hyaline, smooth, 4-spored. Cheilocystidia 36–46 × 9.5–16 µm, mostly ventricose, rarely sub-cylindrical, abundant, smooth, hyaline. Pleurocystidia absent. Pileus covering is a cutis with septate hyphae, 10–15 µm diam, rarely branched, terminal cells 51–67 × 10–12 µm with acute apex, pale brownish in KOH. Clamp connections absent. ......continued on the next page Habitat and distribution: Scattered in small groups, saprotrophic, on humus rich soil with dead leaves and wood under the trees of Anogeissus dhofarica. So far only known from southern Oman. Additional specimens examined: Oman, Dhofar, Attir, on a shady place with plenty of liverworts, 5 Sept 2018, N. Al Dhanki, S. Al Salami, M. Al Jahwari and I. Al Sabahi, ATR-004 (SQUH-ATR004; GenBank accession: ITS = OM 397373, 28 S = OM 630414). Notes: The new species Micropsalliota ventricocystidiata is characterized by a medium-sized basidiomata with hemispheric to plano-convex pileus, covered with reddish-brown squamules; basidiospores amygdaliform with obtuse apex in side view, oblong in face view, measuring 7.5–8.5 × 4.5–5.0 µm and the cheilocystidia mostly ventricose, rarely more or less subcylindrical. ML phylogenetic analyses revealed that the closely related species of M. ventricocystidiata are: M. suthepensis, M. megaspora, M. repanda and M. sp. (SDJ 2021-8-9) an undescribed species from China. Micropsalliota suthepensis, described from Thailand, differs from M. ventricocystidiata by (i) its smaller pileus (10–20 mm diam) with violet squamules (ii) smaller spores (5–6 × 3–3.5 µm) that are somewhat similar in shape and have apical thickening, and (iii) cheilocystidia clavate with non-capitate apex (Zhao et al. 2010). Micropsalliota megaspora, also described from Thailand, differs in its small sized basidiomata, smaller spores (5.2–6.5 × 3.4–4 µm) and pyriform shaped cheilocystidia (Zhao et al. 2010). Micropsalliota repanda, originally described from Togo, differs from the new species by its pinkish pileal fibrils with clavate cheilocystidia (Heinemann 1980). Morphological comparison of the new species with regards to other species of Micropsalliota are further sorted in detail in Table 2. Morphologically, the new species M. ventricocystidiata is similar to M. digitatocystis R.L. Zhao, J.X. Li & M.Q. He (2021: 171), a recently described species from China (Li et al. 2021). Both species share the reddish-brown pileal squamules. On the basis of basidiospores morphology, both species can be differentiated. Basidiospores in M. digitatocystis are mostly ellipsoid to amygdaliform and comparatively smaller (5.8–7.4 × 4–4.6 µm; Li et al. 2021). In M. ventricocystidiata, basidiospores are amygdaliform with obtuse apex to sub cylindrical or oblong and larger (7.5–8.5 × 4.5–5.0 µm). In M. digitatocystis cheilocystidia are cylindrical to subclavate, subcapitate to capitate, measuring 37.4–52 × 9–16.4 µm. On the other hand, cheilocystidia in M. ventricocystidiata are mostly ventricose, rarely subcylindrical.Published as part of Al-Kharousi, Moza, Hussain, Shah, Al-Muharabi, Marwa A., Al-Maqbali, Dua'A, Al-Shabibi, Zahra, Al-Balushi, Abdullah H., Al-Yahya'Ei, Mohamed N., Saady, Nadiya Al, Velazhahan, Rethinasamy & Al-Sadi, Abdullah M., 2022, Notes on the genus Micropsalliota (Agaricales, Basidiomycota) and the description of a new species from Southern Oman, pp. 113-126 in Phytotaxa 543 (2) on pages 119-123, DOI: 10.11646/phytotaxa.543.2.2, http://zenodo.org/record/645074

Differential Expression of Oman’s Wild Lavender, Lavandula subnuda for Chemical Composition towards Medicinal and Aromatic Application

Plants have been used directly or indirectly as medicines for over 5000 years as a source of antibiotics, antineoplastics, analgesics, and cardio-protective, among others. Approximately 70–90% of the population in developing countries continue to use ancient medicines based on plant extracts for treatment. Recently, the isolation and identification of biologically active compounds and molecules from nature have led to the discovery of new therapeutics, prompting the improvement of the health and pharmaceutical sectors. Phytochemicals revolve around the pharmaceutical industry's research and development (R&D) sector as a source of new molecules leading to the development of new novel drugs. Given the above, the present investigation addresses the differential nature of wild lavender (Lavandula subnuda Benth) plants of diverse locations in Oman with respect to their chemical composition of the essential oil in addition to morphological characters and chlorophyll contents of leaves to explore the possibility of isolating its prime chemical compounds on a commercial scale in perfumery industry. There are no previous studies so far who have reported on essential oil recovery and chemical composition exclusively in respect of Lavandula subnuda. Composite samples of ten randomly selected plants were collected from wadi habitats of four diversified locations. Edaphic features of managed sites were recorded, and their soil chemical contents were determined following instructions using S1 Titan/Tracer 5/CTX equipment of Bruker developed based on energy dispersive X-ray fluorescence (EDXRF). Morphological traits were measured using a ruler, and chlorophyll contents were recorded using the atLEAF CHL Plus chlorophyll meter as atLEAF values. The essential oil was extracted using ETHO X's advanced microwave extraction system and analyzed for chemical compounds using GC-MS analysis on Shimadzu GC-2010 Plus gas chromatograph. The experimental data were analyzed statistically, wherever required, by applying basic statistics of the EXCEL -16 version. The results indicated that in general, the Lavandula subnuda plants of locations of high altitudes had higher expressivity in all the morphological traits and chlorophyll contents than those of low altitudes. The essential oil recovery, however, was found to be higher from the plant samples of lower altitudes (0.70 to 0.79% (w/w)) than from those of higher mountains/ altitudes (0.15 to 0.18% (w/w)). The pattern of values of commonly occurring chemical contents of essential oils was different. Each essential oil's top ten chemical compounds contributed about 80% of the total in four locations. Of the ten top chemical compounds, eight compounds, namely D-Germacrene (42.67%) from Wadi Al-Khod, Estragole (32%) and Linalool (23.89%) from Wadi Halban), trans-Borneol (23.46%) and 4-Terpineol (18.73%) from Wadi Najd Al-Waqba and Kessane (18.60%), beta-cis-Caryophyllene (13.68%) and beta-Elemene (10.618%) from Wadi Al-Hayul, were found highest in quantity and had huge potential for further application. It is concluded that there exists a higher possibility of adapting Good Agriculture Practice (GAP) to produce the highest herbage yield of vegetative parts of Lavandula subnuda plants based on morphological features under wild conditions to extract these compounds on a commercial scale in both the pharmaceutical and perfumery industries.Keywords: Morphology, Chlorophyll, Chemical compounds, Differential Expression, Lavandula subnuda,, Lamiacea