Polycystic Ovary Syndrome - diagnosis and treatment

Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder, and a major cause of infertility in women. An excessive amount of androgen hormones are produced by polycystic ovaries in PCOS with irregular menstruation and anovulation as result. The most common early symptoms are infertility, hirsutism and acne. Type 2 diabetes mellitus, metabolic syndrome, and possibly cardiovascular disease and endometrial carcinoma are all associated as lifelong implications with the diagnosis of PCOS. Medical treatment of PCOS should be tailored to the woman's symptoms and goals. In broad terms, treatment includes diet regulation, weight loss, oral contraceptives, clomiphene citrate and in vitro fertilization

Analysis of quantum coherence for localized fermionic systems in an accelerated motion

Although quantum coherence is a well known phenomenon in quantum information theory and quantum optics, it has been investigated from the resource theory perspective only recently. Furthermore, quantum coherence has important implications in relativistic quantum information where the degradation of entanglement can be attributed to decoherence. In this paper, we investigate the quantum coherence of Dirac field modes localized in a cavity as observed by two relatively accelerated observers. The acceleration is assigned very small values and its effects are investigated in a perturbative regime. For this purpose, we use parameterized two-qubit pure entangled state and a Werner state. We find that coherence shows a periodic degradation due to accelerated motion. However, this degradation can be balanced by adjusting the durations of uniform and accelerated motion. Moreover, it is found that dynamics of quantum coherence closely resembles that of entanglement under the same settings. This similarity confirms the recent attempts to relate the resource theories of coherence and entanglement in a relativistic regime.publishedVersionUnit Licence Agreemen

Telemedicine in the Era of COVID-19 and Beyond: A new horizon

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ADVANCEMENTS IN MARBURG VIRUS VACCINE DEVELOPMENT: UNRAVELLING RECENT FINDINGS. A NARRATIVE REVIEW.

Marburg Virus Disease (MVD) is a lethal single-stranded RNA virus transmitted by Egyptian rousette bats, causing 12 surges in Sub-Saharan Africa, including a recent outbreak in Tanzania in 2023. With a fatality rate of approximately 90%, no approved vaccines currently exist. Ongoing research explores potential candidates, such as a recombinant vesicular stomatitis virus (VSV)-based vaccine and MVA-BN-Filo, aiming to combat this deadly infection. The objective of this review is to comprehensively examine Marburg virus vaccines, exploring various candidates and their development stages, efficacy in non-human primates and human studies, and challenges faced in the development process. Various vaccines are under development, including Ad26, Ad5, viral vector, and DNA vaccines. Promising candidates like Ad26.Filo and ChAd3-MARV have emerged. Additionally, VLP-based, DNA plasmid and rVSV-based vaccines are discussed, highlighting their effectiveness and challenges in development, such as limited information, gene expression issues, and outbreak control measures. The implications for future research and clinical practice/policy development are significant. Marburg virus vaccine development shows promise in mitigating the threat posed by this deadly pathogen. Despite complex challenges, advancements in vaccine candidates offer hope. Continued research and development may lead to the successful prevention of major Marburg virus outbreaks. Ongoing clinical trials indicate potential breakthroughs in a short period, contributing to public health protection.    

Immunohistochemical Expression of Nkx3.1 in Prostatic Adenocarcinoma and Benign Prostatic Hyperplasia at a Tertiary Care Hospital in Karachi

OBJECTIVES To determine NKX3.1 expression in prostatic adenocarcinoma and benign prostate hyperplasia on Immunohistochemistry at a tertiary care hospital in Karachi. METHODOLOGY 74 prostatic specimens were recruited in this comparative cross-sectional study at the Department of Pathology, Pakistan Navy Station Shifa Hospital, Karachi, from January 2018 to February 2019. Of these, 37 specimens were of prostatic adenocarcinoma, and 37 were benign prostate hyperplasia. All specimens were subjected to immunohistochemical staining with NKX3.1. Statistical analysis was done by using SPSS version 23.0. The association of the extent of NKX3.1 staining between the adenocarcinoma and hyperplasia group was assessed using the Chi-square test x2. RESULTSOf the 37 cases of benign prostatic hyperplasia subjected to NKX3.1 staining, 32 showed positive staining with strong to moderate intensity. No staining was observed in 5 cases. 37 cases of adenocarcinoma prostate stained for NKX3.1 revealed positive staining in 30 cases with strong to moderate intensity. Negative staining was seen in 7 cases. The prostatic adenocarcinoma showed a statistically significant association of NKX3.1 positivity compared to benign prostatic hyperplasia cases. The p-value was found to be 0.03. CONCLUSION NKX3.1 staining was highly specific for prostate epithelium, as it was positive in most cases. This immune marker was useful for distinguishing prostatic origin in the context of metastatic lesions. Adding NKX3.1 protein staining to a panel of features may add value to the diagnosis if applied in the appropriate clinicopathologic context

A High-Performance System Architecture for Medical Imaging

Medical imaging is classified into different modalities such as ultrasound, X-ray, computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), single-photon emission tomography (SPECT), nuclear medicine (NM), mammography, and fluoroscopy. Medical imaging includes various imaging diagnostic and treatment techniques and methods to model the human body, and therefore, performs an essential role to improve the health care of the community. Medical imaging, scans (such as X-Ray, CT, etc.) are essential in a variety of medical health-care environments. With the enhanced health-care management and increase in availability of medical imaging equipment, the number of global imaging-based systems is growing. Effective, safe, and high-quality imaging is essential for the medical decision-making. In this chapter, we proposed a medical imaging-based high-performance hardware architecture and software programming toolkit called high-performance medical imaging system (HPMIS). The HPMIS can perform medical image registration, storage, and processing in hardware with the support of C/C++ function calls. The system is easy to program and gives high performance to different medical imaging applications

Role of TGF-?1 in Urinary Bladder Carcinoma

The present study aimed to evaluate sera TGF- ?1 concentration in patients with urinary bladder carcinoma (UBC). All malignant of them was transitional cell carcinoma (TCC) type , patients with urinary bladder disorders (UBD ) and healthy control , and to study the correlation between sera TGF-?1 levels and tumor stages and grades in UBC patients . A direct ELISA test was used to quantify the seraTGF-?1 concentrations in sera of 58 patients with urinary bladder carcinoma UBC of different grades (G) and stages (T) all malignant of them was transitional cell carcinoma (TCC) type , 15 from patients with UBD and 15 healthy subjects . Sera levels of TGF-?1 were elevated in patients with UBC and UBD compared to healthy (P ? 0.01) .There was no association between tumor stages and serum level of TGF-?1 (P?0.05) . Whereas there was an association between serum levels of TFG-?1 and tumor grades (p ?0.05) . Increased serum level was found in high grades G?2 of patient with UBC

AMC: Advanced Multi-accelerator Controller

The rapid advancement, use of diverse architectural features and introduction of High Level Synthesis (HLS) tools in FPGA technology have enhanced the capacity of data-level parallelism on a chip. A generic FPGA based HLS multi-accelerator system requires a microprocessor (master core) that manages memory and schedules accelerators. In a real environment, such HLS multi-accelerator systems do not give a perfect performance due to memory bandwidth issues. Thus, a system demands a memory manager and a scheduler that improves performance by managing and scheduling the multi-accelerator’s memory access patterns efficiently. In this article, we propose the integration of an intelligent memory system and efficient scheduler in the HLS-based multi-accelerator environment called Advanced Multi-accelerator Controller (AMC). The AMC system is evaluated with memory intensive accelerators, High Performance Computing (HPC) applications and implemented and tested on a Xilinx Virtex-5 ML505 evaluation FPGA board. The performance of the system is compared against the microprocessor-based systems that have been integrated with the operating system. Results show that the AMC based HLS multi-accelerator system achieves 10.4x and 7x of speedup compared to the MicroBlaze and Intel Core based HLS multi-accelerator systems.Peer ReviewedPostprint (author’s final draft

The Contours of New Regional Alignments in South Asia

South Asia is an important but complex region. Its manifold complexity is largely ascribed through historical, economic, political and strategic manifestations. The region has witnessed instability in all the given premises and interactions. The entirety happens to be the fact that the structure of alignments is motivated by security complexes which involve cohesion of foreign powers and regional states. The US, Russia, Iran and China now make out to be contemporary stakeholders in South Asian security equation. Their involvement has been seen as a major reorientation in the regional dynamics in terms of political, economic and security characteristics. The manifold possibilities of re-alignments are what the future of the region will look like. The chance of full-fledged strategic alliance in the face of US-India on the basis of similar political, economic and security interests is on the horizon. As a corollary to this alliance pattern, there is China-Russia-Pakistan alliance which is similar in force but opposite in direction. These two systems are one set of opposition forces to each other, which are also natural in form. Another structure which occurs out of the regional dynamics happens to be of India-Iran-Afghanistan which is a trifecta aiming at Pakistan. On the other hand, Russia-China-Pakistan which could turn into a politically motivated and economically driven alliance and can also cover certain aspects of security. Therefore, due to various changes in order there will stem out various patterns of relationships, which could set the order of the region as one marked by various fluctuating alignment patterns