Sleep-wake misperception. A comprehensive analysis of a large sleep lab cohort

OBJECTIVES Sleep-wake misperception has mainly been reported in insomnia patients. Conversely, the present study aimed to assess the prevalence and correlates of sleep-wake misperception in a large cohort of patients with various sleep-wake disorders, all diagnosed along the third version of the International Classification of Sleep Disorders. METHODS We retrospectively included 2738 patients examined by polysomnography, who in addition estimated upon awakening their total sleep time, sleep onset latency and Wake after sleep onset (WASO). We computed subjective-objective mismatch by the formula (subjective - objective value)/objective value ×100; negative and positive values indicated under- and overestimation, respectively. RESULTS In the entire sample, the magnitude of under- and overestimation of total sleep time was similar, but varied significantly between diagnostic groups, with insomnia and insufficient sleep syndrome showing the most pronounced underestimation and REM parasomnia and circadian rhythm disorders showing the most pronounced overestimation of total sleep time. In all diagnostic categories, a majority tended to overestimate their sleep onset latency and to underestimate the amount of WASO. Younger age was independently correlated with underestimation of total sleep time and WASO, and with overestimation of sleep onset latency. Overestimation of sleep onset latency independently correlated to an increased latency to N3 sleep stage on polysomnography. CONCLUSIONS While sleep-wake misperception is highly prevalent in all sleep-wake disorders, significant differences exist in magnitude of under- and overestimation between distinct diagnostic groups

Poa denudata Steud.

Península QuetrihuépublishedVersio

Hexabromocyclododecane and hexachlorocyclohexane: How lessons learnt have led to improved regulation

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2014 Taylor & Francis.The use of chemicals by society has many benefits but contamination of the environment is an unintended consequence. One example is the organochlorine compound hexachlorocyclohexane (HCH). During the 1980s, when HCH was banned in many countries, the brominated flame retardant, hexabromocyclododecane (HBCD), found increasing use. The persistent, bioaccumulative, and toxic characteristics of HBCD are, 30 years later, likely to warrant global action on production and use under the Stockholm Convention on persistent organic pollutants. Historical lessons have taught us that we need to control the use of chemicals and programs are in place worldwide in an attempt to do so.Tertiary Education Trust Fund, Nigeri

Adesmia horrida Gillies ex Hook. & Arn.

Valle del Río BonetepublishedVersio

Epidemiology of Schistosoma mansoni infection in Ituri Province, north-eastern Democratic Republic of the Congo

BACKGROUND: Schistosomiasis, caused by Schistosoma mansoni, is of great significance to public health in sub-Saharan Africa. In the Democratic Republic of Congo (DRC), information on the burden of S. mansoni infection is scarce, which hinders the implementation of adequate control measures. We assessed the geographical distribution of S. mansoni infection across Ituri province in north-eastern DRC and determined the prevailing risk factors. METHODS/PRINCIPAL FINDINGS: Two province-wide, community-based studies were conducted. In 2016, a geographical distribution study was carried out in 46 randomly selected villages across Ituri. In 2017, an in-depth study was conducted in 12 purposively-selected villages, across the province. Households were randomly selected, and members were enrolled. In 2016, one stool sample was collected per participant, while in 2017, several samples were collected per participant. S. mansoni eggs were detected using the Kato-Katz technique. In 2017, a point-of-care circulating cathodic S. mansoni antigen (POC-CCA) urine test was the second used diagnostic approach. Household and individual questionnaires were used to collect data on demographic, socioeconomic, environmental, behavioural and knowledge risk factors. Of the 2,131 participants in 2016, 40.0% were positive of S. mansoni infection. Infection prevalence in the villages ranged from 0 to 90.2%. Of the 707 participants in 2017, 73.1% were tested positive for S. mansoni. Prevalence ranged from 52.8 to 95.0% across the health districts visited. Infection prevalence increased from north to south and from west to east. Exposure to the waters of Lake Albert and the villages' altitude above sea level were associated with the distribution. Infection prevalence and intensity peaked in the age groups between 10 and 29 years. Preschool children were highly infected (62.3%). Key risk factors were poor housing structure (odds ratio [OR] 2.1, 95% 95% confidence interval [CI] 1.02-4.35), close proximity to water bodies (OR 1.72, 95% CI 1.1-2.49), long-term residence in a community (OR 1.41, 95% CI 1.11-1.79), lack of latrine in the household (OR 2.00, 95% CI 1.11-3.60), and swimming (OR 2.53, 95% CI 1.20-5.32) and washing (OR 1.75, 95% CI 1.10-2.78) in local water bodies. CONCLUSIONS/SIGNIFICANCE: Our results show that S. mansoni is highly endemic and a major health concern in Ituri province, DRC. Infection prevalence and intensity, and the prevailing socioeconomic, environmental, and behavioural risk factors in Ituri reflect intense exposure and alarming transmission rates. A robust plan of action is urgently needed in the province

Portulaca tingoensis D. Legrand var. andina (D. Legrand) D. Legrand

Valle del Río BonetepublishedVersio

Adesmia trijuga Gillies ex Hook. & Arn.

Valle del Río Bonete, entre Yegua Quemada y Junes GrandespublishedVersio

Euphorbia ruiz-lealii Subils

Valle del Río BonetepublishedVersio

Cistanthe minuscula (Añon) Peralta

Valle del Río BonetepublishedVersio

Periodic harmonic functions on lattices and points count in positive characteristic

This survey addresses pluri-periodic harmonic functions on lattices with values in a positive characteristic field. We mention, as a motivation, the game "Lights Out" following the work of Sutner, Goldwasser-Klostermeyer-Ware, Barua-Ramakrishnan-Sarkar, Hunzikel-Machiavello-Park e.a.; see also 2 previous author's preprints for a more detailed account. Our approach explores harmonic analysis and algebraic geometry over a positive characteristic field. The Fourier transform allows us to interpret pluri-periods of harmonic functions on lattices as torsion multi-orders of points on the corresponding affine algebraic variety.Comment: These are notes on 13p. based on a talk presented during the meeting "Analysis on Graphs and Fractals", the Cardiff University, 29 May-2 June 2007 (a sattelite meeting of the programme "Analysis on Graphs and its Applications" at the Isaac Newton Institute from 8 January to 29 June 2007