70 research outputs found

    For academic publishing to be trans-inclusive, authors must be allowed to retroactively change their names

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    Many trans researchers change their name to match their gender identity. However, there is currently no clear, simple or standardised way for publications to be updated to reflect this. As a result, many trans authors are caught between losing their publication record and involuntarily being outed. Lilian Hunt explains the existing name change policies and outlines experiences of trans researchers of the current system. She calls on publishers to adopt processes that will allow authors to retroactively change their name and highlights the good practice that the coalition, EDIS- Equality, Diversity and Inclusion in Science- has spearheaded

    Non-equilibrium thermodynamic analysis of double diffusive, nanofluid forced convection in microreactors with radiation effects

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    This paper presents a theoretical investigation of the second law performance of double diffusive forced convection in microreactors with the inclusion of nanofluid and radiation effects. The investigated microreactors consist of a single microchannel, fully filled by a porous medium. The transport of heat and mass are analysed by including the thick walls and a first order, catalytic chemical reaction on the internal surfaces of the microchannel. Two sets of thermal boundary conditions are considered on the external surfaces of the microchannel; (1) constant temperature and (2) constant heat flux boundary condition on the lower wall and convective boundary condition on the upper wall. The local thermal non-equilibrium approach is taken to thermally analyse the porous section of the system. The mass dispersion equation is coupled with the transport of heat in the nanofluid flow through consideration of Soret effect. The problem is analytically solved and illustrations of the temperature fields, Nusselt number, total entropy generation rate and performance evaluation criterion (PEC) are provided. It is shown that the radiation effect tends to modify the thermal behaviour within the porous section of the system. The radiation parameter also reduces the overall temperature of the system. It is further demonstrated that, expectedly, the nanoparticles reduce the temperature of the system and increase the Nusselt number. The total entropy generation rate and consequently PEC shows a strong relation with radiation parameter and volumetric concentration of nanoparticles

    sQueeze: Accelerated Quantum Pulse Schedules

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    Quantum devices in the Noisy Intermediate-Scale Quantum (NISQ) era are limited by high error rates and short decoherence times. Typically, compiler optimisations have provided solutions at the gate level. Alternatively, we exploit the finest level of quantum control and introduce a set of pulse level quantum compiler optimisations: sQueeze. Instead of relying on existing calibration that may be inaccurate, we provide a method for the live calibration of two new parameterised basis gates Rx(θ)R_{x}(\theta) and Rzx(θ)R_{zx}(\theta) using an external server. We validate our techniques using the IBM quantum devices and the OpenPulse control interface over more than 8 billion shots. The Rx(θ)R_{x}(\theta) gates are on average 52.7% more accurate than their current native Qiskit decompositions, while Rzx(θ)R_{zx}(\theta) are 22.6% more accurate on average. These more accurate pulses also provide up to a 4.1×\times speed-up for single-qubit operations and 3.1×\times speed-up for two-qubit gates. Then sQueeze demonstrates up to a 39.6% improvement in the fidelity of quantum benchmark algorithms compared to conventional approaches

    Two-dimensional heat and mass transfer and thermodynamic analyses of porous microreactors with Soret and thermal radiation effects: An analytical approach

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    Transport of heat and mass and the thermodynamics of porous microreactors with thermal diffusion and radiation effects are investigated analytically. The examined configuration includes an axisymmetric, thick-wall microchannel with an iso-flux thermal boundary condition imposed on the external surfaces. The microchannel is filled with porous materials and accommodates a zeroth order homogenous chemical reaction. Internal radiative heat transfer is modelled in addition to heat convection and conduction, while the local thermal non-equilibrium approach is taken within the porous section of the system. The transport of species is coupled with that of heat via the inclusion of thermodiffusion or Soret effect. Two-dimensional heat and mass transfer differential equations are solved analytically. The results are subsequently used to predict the thermodynamic irreversibilities inside the reactor and a thorough analysis of local and total entropy generation rates is performed. Also, the changes in Nusselt number, calculated on the internal walls of the microreactor, versus various parameters are reported. It is shown that the radiation effects can impact the temperature of the solid phase of the porous medium and lead to alteration of Nusselt number. It is further observed that the transfer of mass is the main source of irreversibility in the system. The findings are of particular use for the design and analysis of the microreactors with homogenous chemical reactions and can be also used for the validation of computational models

    Quantifying decision-making in dynamic, continuously evolving environments

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    During perceptual decision-making tasks, centroparietal electroencephalographic (EEG) potentials report an evidence accumulation-to-bound process that is time locked to trial onset. However, decisions in real-world environments are rarely confined to discrete trials; they instead unfold continuously, with accumulation of time-varying evidence being recency-weighted towards its immediate past. The neural mechanisms supporting recency-weighted continuous decision-making remain unclear. Here, we use a novel continuous task design to study how the centroparietal positivity (CPP) adapts to different environments that place different constraints on evidence accumulation. We show that adaptations in evidence weighting to these different environments are reflected in changes in the CPP. The CPP becomes more sensitive to fluctuations in sensory evidence when large shifts in evidence are less frequent, and the potential is primarily sensitive to fluctuations in decision-relevant (not decision-irrelevant) sensory input. A complementary triphasic component over occipito-parietal cortex encodes the sum of recently accumulated sensory evidence, and its magnitude covaries with parameters describing how different individuals integrate sensory evidence over time. A computational model based on leaky evidence accumulation suggests that these findings can be accounted for by a shift in decision threshold between different environments, which is also reflected in the magnitude of pre-decision EEG activity. Our findings reveal how adaptations in EEG responses reflect flexibility in evidence accumulation to the statistics of dynamic sensory environments

    Ethnicity, popular democratic movements and labour in Malaysia

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    This article uses framing theory to examine how activists and trade unions have framed labour’s political agenda in Malaysia. A polity grounded in ethnicity continues to hinder the formation of cross-ethnic collective worker identities and labour politics. However, inclusive popular democratising movements have strengthened in recent years, providing a favourable context for greater emphasis on non-ethnic political action by trade unions. The latter have shifted in this direction, adopting elements of the popular movement’s ‘human rights’ internationalism. Thus, the democratic movement’s frame has influenced that of the trade unions, with implications for framing theory

    Science forum : sex differences and sex bias in human circadian and sleep physiology research

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    Growing evidence shows that sex differences impact many facets of human biology. Here we review and discuss the impact of sex on human circadian and sleep physiology, and we uncover a data gap in the field investigating the non-visual effects of light in humans. A virtual workshop on the biomedical implications of sex differences in sleep and circadian physiology then led to the following imperatives for future research: (1) design research to be inclusive and accessible, (2) implement recruitment strategies that lead to a sex-balanced sample, (3) use data visualization to grasp the effect of sex, (4) implement statistical analyses that include sex as a factor and/or perform group analyses by sex, where possible, (5) make participant-level data open and available to facilitate future meta-analytic efforts

    MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria

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    MPV17 is a mitochondrial inner membrane protein whose dysfunction causes mitochondrial DNA abnormalities and disease by an unknown mechanism. Perturbations of deoxynucleoside triphosphate (dNTP) pools are a recognized cause of mitochondrial genomic instability; therefore, we determined DNA copy number and dNTP levels in mitochondria of two models of MPV17 deficiency. In Mpv17 ablated mice, liver mitochondria showed substantial decreases in the levels of dGTP and dTTP and severe mitochondrial DNA depletion, whereas the dNTP pool was not significantly altered in kidney and brain mitochondria that had near normal levels of DNA. The shortage of mitochondrial dNTPs in Mpv17-/- liver slows the DNA replication in the organelle, as evidenced by the elevated level of replication intermediates. Quiescent fibroblasts of MPV17-mutant patients recapitulate key features of the primary affected tissue of the Mpv17-/- mice, displaying virtual absence of the protein, decreased dNTP levels and mitochondrial DNA depletion. Notably, the mitochondrial DNA loss in the patients’ quiescent fibroblasts was prevented and rescued by deoxynucleoside supplementation. Thus, our study establishes dNTP insufficiency in the mitochondria as the cause of mitochondrial DNA depletion in MPV17 deficiency, and identifies deoxynucleoside supplementation as a potential therapeutic strategy for MPV17-related disease. Moreover, changes in the expression of factors involved in mitochondrial deoxynucleotide homeostasis indicate a remodeling of nucleotide metabolism in MPV17 disease models, which suggests mitochondria lacking functional MPV17 have a restricted purine mitochondrial salvage pathway
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