Spin Relaxation in Graphene with self-assembled Cobalt Porphyrin Molecules

In graphene spintronics, interaction of localized magnetic moments with the electron spins paves a new way to explore the underlying spin relaxation mechanism. A self-assembled layer of organic cobalt-porphyrin (CoPP) molecules on graphene provides a desired platform for such studies via the magnetic moments of porphyrin-bound cobalt atoms. In this work a study of spin transport properties of graphene spin-valve devices functionalized with such CoPP molecules as a function of temperature via non-local spin-valve and Hanle spin precession measurements is reported. For the functionalized (molecular) devices, we observe a slight decrease in the spin relaxation time ({\tau}s), which could be an indication of enhanced spin-flip scattering of the electron spins in graphene in the presence of the molecular magnetic moments. The effect of the molecular layer is masked for low quality samples (low mobility), possibly due to dominance of Elliot-Yafet (EY) type spin relaxation mechanisms

Phase transition and selection in a four-species cyclic Lotka-Volterra model

We study a four species ecological system with cyclic dominance whose individuals are distributed on a square lattice. Randomly chosen individuals migrate to one of the neighboring sites if it is empty or invade this site if occupied by their prey. The cyclic dominance maintains the coexistence of all the four species if the concentration of vacant sites is lower than a threshold value. Above the treshold, a symmetry breaking ordering occurs via growing domains containing only two neutral species inside. These two neutral species can protect each other from the external invaders (predators) and extend their common territory. According to our Monte Carlo simulations the observed phase transition is equivalent to those found in spreading models with two equivalent absorbing states although the present model has continuous sets of absorbing states with different portions of the two neutral species. The selection mechanism yielding symmetric phases is related to the domain growth process whith wide boundaries where the four species coexist.Comment: 4 pages, 5 figure

Past and present: raw material identification approaches at Umhlatuzana rockshelter, South Africa

NWOVidi 276-60-004Human Origin

An e-VLBI image of SN1987A from Australian radio telescopes and the JIVE correlator

We present an image of the expanding shell of the remnant associated with supernova1987A at the highest resolution to date at radio wavelengths, 85 milliarcseconds, using the e-VLBI technique, from 2007 October. This is comparable to the angular resolution obtainedwith the Hubble Space Telescope and is approximately 3 times higher than has been possiblewith the Australia Telescope Compact Array or 5 times higher than with the Chandra X-rayObservatory. The e-VLBI data at 1.4 GHz show good agreement with the ATCA data at 9GHz, resolving the substructure in the equatorial brightness enhancements of the remnant(allowing for the fact that the e-VLBI observations are sensitive to structure on angular scales<0.4?). We place a 3s upper limit on the time-averaged pulsar emission or a compact pulsarpowerednebula at this frequency of 1 mJy/beam. These observations were made usingtelescopes in Australia, with the data transferred in real-time to the European VLBI Networkcorrelator at the Joint Institute for VLBI in Europe, in The Netherlands, via high-speednetworks, as part of the EXPReS project, demonstrating the feasibility of a real-time global e-VLBI network at 512 Mbps per antenna

Idarucizumab for Dabigatran Reversal - Full Cohort Analysis.

BACKGROUND: Idarucizumab, a monoclonal antibody fragment, was developed to reverse the anticoagulant effect of dabigatran. METHODS: We performed a multicenter, prospective, open-label study to determine whether 5 g of intravenous idarucizumab would be able to reverse the anticoagulant effect of dabigatran in patients who had uncontrolled bleeding (group A) or were about to undergo an urgent procedure (group B). The primary end point was the maximum percentage reversal of the anticoagulant effect of dabigatran within 4 hours after the administration of idarucizumab, on the basis of the diluted thrombin time or ecarin clotting time. Secondary end points included the restoration of hemostasis and safety measures. RESULTS: A total of 503 patients were enrolled: 301 in group A, and 202 in group B. The median maximum percentage reversal of dabigatran was 100% (95% confidence interval, 100 to 100), on the basis of either the diluted thrombin time or the ecarin clotting time. In group A, 137 patients (45.5%) presented with gastrointestinal bleeding and 98 (32.6%) presented with intracranial hemorrhage; among the patients who could be assessed, the median time to the cessation of bleeding was 2.5 hours. In group B, the median time to the initiation of the intended procedure was 1.6 hours; periprocedural hemostasis was assessed as normal in 93.4% of the patients, mildly abnormal in 5.1%, and moderately abnormal in 1.5%. At 90 days, thrombotic events had occurred in 6.3% of the patients in group A and in 7.4% in group B, and the mortality rate was 18.8% and 18.9%, respectively. There were no serious adverse safety signals. CONCLUSIONS: In emergency situations, idarucizumab rapidly, durably, and safely reversed the anticoagulant effect of dabigatran. (Funded by Boehringer Ingelheim; RE-VERSE AD ClinicalTrials.gov number, NCT02104947 .)

Coordinated analysis of age, sex, and education effects on change in MMSE scores

Objectives. We describe and compare the expected performance trajectories of older adults on the Mini-Mental Status Examination (MMSE) across six independent studies from four countries in the context of a collaborative network of longitudinal studies of aging. A coordinated analysis approach is used to compare patterns of change conditional on sample composition differences related to age, sex, and education. Such coordination accelerates evaluation of particular hypotheses. In particular, we focus on the effect of educational attainment on cognitive decline.Method. Regular and Tobit mixed models were fit to MMSE scores from each study separately. The effects of age, sex, and education were examined based on more than one centering point.Results. Findings were relatively consistent across studies. On average, MMSE scores were lower for older individuals and declined over time. Education predicted MMSE score, but, with two exceptions, was not associated with decline in MMSE over time.Conclusion. A straightforward association between educational attainment and rate of cognitive decline was not supported. Thoughtful consideration is needed when synthesizing evidence across studies, as methodologies adopted and sample characteristics, such as educational attainment, invariably differ. © 2012 The Author

Designing disorder

This is the author accepted manuscript. The final version is available from Springer Nature via the DOI in this recordMetasurfaces can in principle provide a versatile platform for optical functionalities, but in practice designing and fabricating them to specifications can be difficult. Now, the realization of metasurfaces with engineered disorder allows for versatile optical components that combine the best features of periodic and random systems

Bacterial flagellar motors and osmoelectric molecular rotation by an axially transmembrane well and turnstile mechanism

AbstractBacterial ion-driven flagellar motors are the smallest known rotatory mechanical devices, natural or artificial, their overall diameter being only about 25 nm or one millionth of an inch. They are unique in the fields of biology and engineering. This paper develops a possible osmoelectric or local electrokinetic mechanism of molecular rotatory motion in bilayer membranes, which may help to explain how bacterial flagellar motors work, and may incidentally encourage new developments in the bioenergetics and biomechanics of enzyme, osmoenzyme and porter action

Making the invisible stratigraphy visible: a grid-based, multi-proxy geoarchaeological study of Umhlatuzana rockshelter, South Africa

Umhlatuzana rockshelter is an archaeological site with an occupational record covering the Middle Stone Age, Later Stone Age, and Iron Age. The presence of both Middle and Later Stone Age assemblages makes Umhlatuzana the ideal location for the study of the MSA-LSA transition (20-40 ka) in southern Africa. This transitional period is characterized by important modifications in stone tool technology, from prepared core technology to a toolkit based on microlith production. These changes are argued to have occurred in response to changes in climate and environment leading up to the Last Glacial Maximum. The deposits bearing the transitional assemblages at Umhlatuzana rockshelter appear homogeneous with no visible stratigraphic boundaries. This study integrates geoarchaeological techniques in order to explore fine-resolution geochemical differentiations of the sediments that are macroscopically invisible, and that will provide insight into (post-)depositional processes over time. Samples were systematically retrieved from the western profile of the site following a grid-based sampling strategy and analyzed for pH, elemental composition (XRF), and Magnetic Susceptibility. Additionally, the results were integrated with preliminary micromorphological observations. Our study reveals a steady, gradual change in the geochemistry of the deposits throughout the Pleistocene, related to a combination of environmental change and occupation intensity. We suggest that the part of the sequence reported to bear Middle to Later Stone Age transitional industries is characterized by wetter environmental conditions compared to the underlying deposits. Additionally, we support results from previous studies that excluded large scale post-depositional movement of the sedimentary sequence. Our study offers a successful multi-proxy approach to systematically sample and study archaeological deposits at the macro and micro scale, integrating a variety of geoarchaeological techniques. The approach provides insight into the depositional and post-depositional history of the site, and allows for questions of stratigraphic integrity, anthropogenic input, preservation, and environmental change to be addressed.Thrombosis and Hemostasi