Impurity induced resonant state in a pseudogap state of a high temperature superconductor

We predict a resonance impurity state generated by the substitution of one Cu atom with a nonmagnetic atom, such as Zn, in the pseudogap state of a high-T_c superconductor. The precise microscopic origin of the pseudogap is not important for this state to be formed, in particular this resonance will be present even in the absence of superconducting fluctuations in the normal state. In the presence of superconducting fluctuations, we predict the existence of a counterpart impurity peak on a symmetric bias. The nature of impurity resonance is similar to the previously studied resonance in the d-wave superconducting state.Comment: 4 pages, 2 figure

A comparison of clinical pharmacodynamics of different administration schedules of oral topotecan (Hycamtin)

Prolonged exposure to topotecan in in vitro and in vivo experiments has yielded the highest antitumor efficacy. An oral formulation of topotecan with a bioavailability of 32-44% in humans enables convenient prolonged administration. Pharmacokinetic/pharmacodynamic relationships from four Phase I studies with different schedules of administration of oral topotecan in 99 adult patients with malignant solid tumors refractory to standard forms of chemotherapy were compared. Topotecan was administered as follows: (a) once daily (o.d.) for 5 days every 21 days (29 patients); (b) o.d. for 10 days every 21 days (19 patients); (c) twice daily (b.i.d.) for 10 days every 21 days (20 patients); and (d) b.i.d. for 21 days every 28 days (31 patients). Pharmacokinetic analysis was performed in 55 patients using a validated high-performance liquid chromatographic assay and noncompartmental pharmacokinetic me

Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation

The current status of electric dipole moments of diamagnetic atoms which involves the synergy between atomic experiments and three different theoretical areas -- particle, nuclear and atomic is reviewed. Various models of particle physics that predict CP violation, which is necessary for the existence of such electric dipole moments, are presented. These include the standard model of particle physics and various extensions of it. Effective hadron level combined charge conjugation (C) and parity (P) symmetry violating interactions are derived taking into consideration different ways in which a nucleon interacts with other nucleons as well as with electrons. Nuclear structure calculations of the CP-odd nuclear Schiff moment are discussed using the shell model and other theoretical approaches. Results of the calculations of atomic electric dipole moments due to the interaction of the nuclear Schiff moment with the electrons and the P and time-reversal (T) symmetry violating tensor-pseudotensor electron-nucleus are elucidated using different relativistic many-body theories. The principles of the measurement of the electric dipole moments of diamagnetic atoms are outlined. Upper limits for the nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained combining the results of atomic experiments and relativistic many-body theories. The coefficients for the different sources of CP violation have been estimated at the elementary particle level for all the diamagnetic atoms of current experimental interest and their implications for physics beyond the standard model is discussed. Possible improvements of the current results of the measurements as well as quantum chromodynamics, nuclear and atomic calculations are suggested.Comment: 46 pages, 19 tables and 16 figures. A review article accepted for EPJ

Prediction of size distribution of crude oil drops in the permeate using a slotted pore membrane

This paper was accepted for publication in the journal Chemical Engineering Research and Design and the definitive published version is available at http://dx.doi.org/10.1016/j.cherd.2014.02.017Permeate size distribution of various crude oil drops with, and without, oscillating the membrane has been predicted using the 'Linear Fit' approach. Drops pass through the membrane due to drag force created by the flow of fluid around the drops. Static force is the force responsible for the rejection of drops through the membrane and is directly proportional to the interfacial tension between dispersed and continuous phases. Without applied shear, 100% cut-off of drops though the membrane is assumed when the drag force and the static force balances each other. With the applied shear, 100% cut-off of drops through the membrane is when drops moves away from the membrane surface due to migration velocities and do not pass the membrane into the permeate. Extrapolating 100% cut-off to the origin of the rejection graphs gives a straight line that is referred as 'Linear Fit' and can be used for predicting rejection below 100% cut-off. Linear fit can be used for predicting drop rejection below 100% cut-off. The portion of oil that would not be rejected by the membrane and would pass through the membrane into the permeate can be calculated using this approach. For a given size of drops in a feed suspension, permeate size distribution can be predicted by multiplying the fraction of oil passing through the membrane and the feed size distribution data. Overall concentration of oil in the permeate can be calculated by knowing size distribution of drops in the permeate, and that provides an idea whether the concentration of oil in the permeate is below the standard set by international regulatory authorities

Shear enhanced microfiltration and rejection of crude oil drops through a slotted pore membrane including migration velocities

This article was published in the Journal of Membrane Science [© Elsevier] and the definitive version is available at: http://www.sciencedirect.com/science/article/pii/S0376738812004991Shear enhanced microfiltration of crude oil/water emulsion is investigated and the effect of an applied shear rate on the rejection of droplets by the membrane is reported. Applying vibration provides shear rate at the membrane surface leading to shear-induced migration and an inertial lift of drops/particles. Both phenomena tend to move the droplets away from the membrane surface. The shear-induced migration and inertial lift increase with increasing of the shear rate. A mathematical model is presented to account for the presence of both phenomena. The developed model is used for theoretical prediction of 100% cut-off of crude oil droplets by the membrane with, and with-out, vibration applied. A satisfactory agreement of the model predictions with experimental data shows that the model can be successfully used for a theoretical prediction of 100% cut-off of droplets by slotted pore membranes. Rejection of droplets increased with applying shear rate: at 8000 s-1 shear rate and 200 l m-2 hr-1 flux rate 3 to 4 μm radius droplets were almost completely rejected reducing 400 ppm of crude in the feed to 7 ppm in the permeate

Analysis of shared heritability in common disorders of the brain

Paroxysmal Cerebral Disorder