Industry convergence in rural tourism development: a China-featured term or a new initiative?

Industry convergence is a popular term that has been widely referenced in the context of rural tourism development in China. All levels of government (local, regional, national) in China have repeatedly addressed the significance of industry convergence in their tourism plans and related policies. Despite its popularity, limited studies at present have explored this concept in-depth. Using Huai’an as a case, this study applied a path analysis and reported the industry convergence process in a destination. The findings of this study can provide both theoretical and practical implications that are useful for tourism planners and policy makers

Fault Injection based Failure Analysis of three CentOS-like Operating Systems

The reliability of operating system (OS) has always been a major concern in the academia and industry. This paper studies how to perform OS failure analysis by fault injection based on the fault mode library. Firstly, we use the fault mode generation method based on Linux abstract hierarchy structure analysis to systematically define the Linux-like fault modes, construct a Linux fault mode library and develop a fault injection tool based on the fault mode library (FIFML). Then, fault injection experiments are carried out on three commercial Linux distributions, CentOS, Anolis OS and openEuler, to identify their reliability problems and give improvement suggestions. We also use the virtual file systems of these three OSs as experimental objects, to perform fault injection at levels of Light and Normal, measure the performance of 13 common file operations before and after fault injection.Comment: 9 pages, 8 figure

GraphLLM: Boosting Graph Reasoning Ability of Large Language Model

The advancement of Large Language Models (LLMs) has remarkably pushed the boundaries towards artificial general intelligence (AGI), with their exceptional ability on understanding diverse types of information, including but not limited to images and audio. Despite this progress, a critical gap remains in empowering LLMs to proficiently understand and reason on graph data. Recent studies underscore LLMs' underwhelming performance on fundamental graph reasoning tasks. In this paper, we endeavor to unearth the obstacles that impede LLMs in graph reasoning, pinpointing the common practice of converting graphs into natural language descriptions (Graph2Text) as a fundamental bottleneck. To overcome this impediment, we introduce GraphLLM, a pioneering end-to-end approach that synergistically integrates graph learning models with LLMs. This synergy equips LLMs with the ability to proficiently interpret and reason on graph data, harnessing the superior expressive power of graph learning models. Our empirical evaluations across four fundamental graph reasoning tasks validate the effectiveness of GraphLLM. The results exhibit a substantial average accuracy enhancement of 54.44%, alongside a noteworthy context reduction of 96.45% across various graph reasoning tasks

Exposure to Polycyclic Aromatic Hydrocarbons, Plasma Cytokines, and Heart Rate Variability

Epidemiological studies have suggested associations between polycyclic aromatic hydrocarbons (PAHs) and heart rate variability (HRV). However, the roles of plasma cytokines in these associations are limited. In discovery stage of this study, we used Human Cytokine Antibody Arrays to examine differences in the concentrations of 280 plasma cytokines between 8 coke-oven workers and 16 community residents. We identified 19 cytokines with significant different expression (fold change ≥2 or ≤−2, and q-value 16% BDNF decreases. Additionally, OH-PAHs were positively associated with activated leukocyte cell adhesion molecule (ALCAM) and C-reactive protein (CRP) (p 20% increases in CRP. We also found significant associations between these cytokines and HRV (p 8% decreases in HRV. Our results indicated PAH exposure was associated with plasma cytokines, and higher cytokines were associated with decreased HRV, but additional human and potential mechanistic studies are needed

Geological Characteristics of Deep Shale Gas and Their Effects on Shale Fracability in the Wufeng-Longmaxi Formations of the Southern Sichuan Basin, China

The deep shale gas reservoirs of the Wufeng-Longmaxi Formations in the southern Sichuan Basin have strong heterogeneity and complex geological characteristics, resulting in a poor fracturing effect and low vertical production. Based on whole-rock X-ray diffraction analysis, scanning electron microscopy, shale gas-bearing experiments, rock mechanical parameter tests and well logging and elemental logging data, the sedimentary environment, and geological characteristics of this deep shale gas are analyzed, and the shale fracability is evaluated. (1) The type of organic matter is affected by factors such as sea level change, hydrodynamics, reducing environmental conditions, algae bioenrichment, and tectonic stability, and the contents of Type I and Type II kerogens in the lowermost reservoir of the Wufeng-Longmaxi Formations are high. (2) The pores between the biogenic siliceous minerals (the framework) and numerous organic pores provide space for the occurrence of shale gas. High-quality reservoirs have a high brittle mineral content, a high Young’s modulus, a low Poisson’s ratio, an appropriate fracturing pressure, a small net stress difference, and a high shale fracability. (3) Multicluster perforation, temporary plugging near the wellbore, and multistage fracturing can be used in the Wufeng Formation-Longmaxi Formation, increasing the near-wellbore hydraulic fracture complexity and improving the hydraulic fracturing effect

Influence of Complex Hydraulic Environments on the Mechanical Properties of Pile-Soil Composite Foundation in the Coastal Soft Soil Area of Zhuhai

Based on a plain concrete pile composite foundation project in the coastal area of Zhuhai, considering the complex hydraulic load environment induced by tidal water-level changes, finite element simulations and parameter calibrations were carried out to determine the physical and mechanical properties of plain concrete pile composite foundation. The hardening soil small (HSS) model, which can be used to simulate the complex mechanical behavior of soft soil under small strain, was selected for modeling analysis. Model parameters were calibrated through resonance column tests, triaxial consolidation drainage loading and unloading shear tests. The complex hydraulic loads were analyzed, including the effects of cyclic tidal action and the sudden rise and fall of the water level induced by strong storm surges on the force, deformation of plain concrete piles, and the mechanical seepage properties of soft soil around piles. The results indicate that: (1) Compared with coastal soft soil in Shanghai, Zhoushan, Tianjin, and other areas, the soft soil in the Zhuhai area has a smaller dynamic shear modulus, cohesion and internal friction angle, and worse engineering properties. (2) The sudden rise of water level leads to a sudden change in the pore pressure of the groundwater, which induces a large deformation of the pile-soil composite foundation. If the foundation on the offshore (dike) side exhibits the most prominent deformation and foundation damage, such as uneven settlement is prone to occur. (3) The offshore side pile is most affected by the hydraulic loads. The deformation of the pile body along the pile body is uneven and the deformation of the upper pile body is relatively large, which may cause fracture damage

Polysaccharide dextran-based conjugate for selective co-delivery of two synergistic drugs docetaxel and docosahexaenoic acid to tumor cells

AbstractMost chemotherapeutic agents are nonspecific distribution and cause systemic toxicities. Polysaccharide-based conjugates are promising strategies to overcome these drawbacks. To this end, two synergistic drugs docetaxel (DTX) and docosahexaenoic acid (DHA) were independently covalently bonded through individual linkers to dextran (100 kDa) to produce a novel dual-drug conjugate dextran–DHA–DTX. The single-drug conjugates dextran–DHA and dextran–DTX were also prepared for comparison. Fluorescent dye Cy7.5-based conjugates dextran–Cy7.5 and dextran–DHA–Cy7.5 were synthesized for cellular uptake study. The dual-drug conjugate dextran–DHA–DTX self-assembled into nanoparticles with the diameter of 102.3 ± 8.3 nm and demonstrated enhanced water solubility and improved pharmacokinetic profiles. Cellular uptake results showed that the dual-drug conjugate entered cells more than the parent DTX by determining the intracellular DTX contents via HPLC/MS analysis and by determining the fluorescent intensity of dextran-Cy7.5 and dextran–DHA–Cy7.5. Importantly, the dual-drug conjugate dextran–DHA–DTX significantly accumulated in tumor tissues and dramatically reduced the DTX concentrations in normal tissues. The dual-drug conjugate completely eradicated all the MCF-7 xenograft tumors without obvious side effects and showed more superior antitumor activity than parent DTX and single-drug conjugate dextran–DTX and dextran–DHA. Both in vitro and in vivo studies showed that DHA enhanced the antitumor activity of dextran–DTX. The polysaccharide dextran-based dual-drug conjugates may represent an effective way to improve the chemotherapeutic agents

Prophylactic cranial irradiation for extensive stage small cell lung cancer: a meta-analysis of randomized controlled trials

BackgroundPrevious studies have demonstrated that prophylactic cranial irradiation (PCI) could reduce the risk of brain metastases and prolong the overall survival (OS) of patients with small cell lung cancer (SCLC). However, it remains controversial whether the efficacy and safety of PCI would be subjected to the different characteristics of patients with extensive stage of SCLC. This meta-analysis aims to evaluate the efficacy and safety of PCI in patients with extensive stage SCLC.MethodsPubMed, Embase, and the Cochrane Library were searched for relevant studies from inception to May, 2021. Hazard ratios (HRs) were used to measure the OS and progression-free survival (PFS), and relative risks (RRs) were employed to calculate the incidence of brain metastases, survival rate, and adverse events. Summary results were pooled using random-effect models.ResultsThere were 1215 articles identified, and 15 trials were included, with a total of 1,623 participants. Patients who received PCI did not result in significantly improved OS [HR=0.87, 95%CI (0.70, 1.08) p=0.417] and PFS [HR=0.81, 95%CI (0.69, 0.95) p=0.001], compared with those who did not receive PCI, while patients who received PCI had a significantly decreased incidence of brain metastases [RR=0.57, 95%CI (0.45, 0.74), p<0.001]. PCI group showed no improvements in 2-year (RR=1.03, p=0.154), 3-year (RR=0.97, p=0.072), 4-year (RR=0.71, p=0.101) and 5-year survival rates (RR=0.32, p=0.307), compared with non-PCI group, whereas the overall RR indicated that PCI was associated with a higher 1-year survival rate [RR=1.46, 95%CI (1.08, 1.97), p=0.013]. In addition, PCI treatment was shown to be associated with increased incidence of adverse events, including fatigue, dermatitis, anorexia, nausea, vomiting, malaise, and cognitive impairment.ConclusionThis meta-analysis suggests that PCI can reduce the incidence of brain metastases in extensive stage SCLC. Although PCI has no significant effect on the OS, it improves 1-year survival in patients with extensive stage SCLC. However, PCI does not significantly affect 2,3,4,5-year survival and may result in a significantly increased risk of adverse events

Electron modulation and morphology engineering jointly accelerate oxygen reaction to enhance Zn-Air battery performance

Combining morphological control engineering and diatomic coupling strategies, heteronuclear Fe-Co bimetals are efficiently intercalated into nitrogen-doped carbon materials with star-like to simultaneously accelerate oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The half-wave potential and kinetic current density of the ORR driven by FeCoNC/SL surpass the commercial Pt/C catalyst. The overpotential of OER is as low as 316 mV (η10), and the mass activity is at least 3.2 and 9.4 times that of mononuclear CoNC/SL and FeNC/SL, respectively. The power density and specific capacity of the Zn-air battery with FeCoNC/SL as air cathode are as high as 224.8 mW cm−2 and 803 mAh g−1, respectively. Morphologically, FeCoNC/SL endows more reactive sites and accelerates the process of oxygen reaction. Density functional theory reveals the active site of the heteronuclear diatomic, and the formation of FeCoN5C configuration can effectively tune the d-band center and electronic structure. The redistribution of electrons provides conditions for fast electron exchange, and the change of the center of the d-band avoids the strong adsorption of intermediate species to simultaneously take into account both ORR and OER and thus achieve high-performance Zn-air batteries

Clinical significance of tumor deposits in gastric cancer after radical gastrectomy: a propensity score matching study

Abstract Objective The value of tumor deposits (TDs) in the prognosis and staging of gastric cancer (GC) is still under debate. This study aims to evaluate the prognostic value of TDs and the best ways to incorporate TDs in the TNM classification of GC. Methods Patients (n = 3460) undergoing curative gastrectomy for GC in the West China Hospital from 2005 to 2017 were retrospectively reviewed and divided into two groups according to the TD status (positive vs. negative). Later, clinicopathological features and overall survival (OS) between the two groups were compared. Thereafter, the associations between the presence of TD and other clinicopathological factors were evaluated through logistic regression. In addition, univariate and multivariate Cox regression were conducted for determining prognostic factors. The possibility of selection bias was reduced through conducting the 1:1 propensity score matching (PSM) analysis. The modified classification systems proposed previously that incorporated TDs into the TNM staging system were assessed. Results There were 10.5% of patients (362/3460) diagnosed with TDs. TDs were significantly related to unfavorable factors such as advanced T stage and N stage and independently associated with poor prognosis. The 5-year OS of patients with TDs was significantly lower than that of patients without TDs (31.0% vs. 60.9%, P < 0.001), whereas higher than that of patients with peritoneal metastasis (31.0% vs. 5.0%, P < 0.001). In patients receiving chemotherapy, the 5-year OS of patients with TDs was also significantly lower than that of patients without TDs (42.0% vs. 50.9%, P = 0.026). Moreover, the system incorporating TDs in the TNM classification as metastatic lymph nodes outperformed others. Conclusions TDs are related to the aggressive characteristics and are an independent prognostic factor for GC. Incorporating TDs in the TNM classification as the metastatic lymph nodes increases the accuracy in predicting prognosis