13,687 research outputs found
Protein folding in hydrophobic-polar lattice model: a flexible ant colony optimization approach
This paper proposes a flexible ant colony (FAC) algorithm for solving protein folding problems based on the hydrophobic-polar square lattice model. Collaborations of novel pheromone and heuristic strategies in the proposed algorithm make it more effective in predicting structures of proteins compared with other state-of-the-art algorithms
Nonequilibrium Phase Transitions of Vortex Matter in Three-Dimensional Layered Superconductors
Large-scale simulations on three-dimensional (3D) frustrated anisotropic XY
model have been performed to study the nonequilibrium phase transitions of
vortex matter in weak random pinning potential in layered superconductors. The
first-order phase transition from the moving Bragg glass to the moving smectic
is clarified, based on thermodynamic quantities. A washboard noise is observed
in the moving Bragg glass in 3D simulations for the first time. It is found
that the activation of the vortex loops play the dominant role in the dynamical
melting at high drive.Comment: 3 pages,5 figure
A system for learning statistical motion patterns
Analysis of motion patterns is an effective approach for anomaly detection and behavior prediction. Current approaches for the analysis of motion patterns depend on known scenes, where objects move in predefined ways. It is highly desirable to automatically construct object motion patterns which reflect the knowledge of the scene. In this paper, we present a system for automatically learning motion patterns for anomaly detection and behavior prediction based on a proposed algorithm for robustly tracking multiple objects. In the tracking algorithm, foreground pixels are clustered using a fast accurate fuzzy k-means algorithm. Growing and prediction of the cluster centroids of foreground pixels ensure that each cluster centroid is associated with a moving object in the scene. In the algorithm for learning motion patterns, trajectories are clustered hierarchically using spatial and temporal information and then each motion pattern is represented with a chain of Gaussian distributions. Based on the learned statistical motion patterns, statistical methods are used to detect anomalies and predict behaviors. Our system is tested using image sequences acquired, respectively, from a crowded real traffic scene and a model traffic scene. Experimental results show the robustness of the tracking algorithm, the efficiency of the algorithm for learning motion patterns, and the encouraging performance of algorithms for anomaly detection and behavior prediction
A system for learning statistical motion patterns
Analysis of motion patterns is an effective approach for anomaly detection and behavior prediction. Current approaches for the analysis of motion patterns depend on known scenes, where objects move in predefined ways. It is highly desirable to automatically construct object motion patterns which reflect the knowledge of the scene. In this paper, we present a system for automatically learning motion patterns for anomaly detection and behavior prediction based on a proposed algorithm for robustly tracking multiple objects. In the tracking algorithm, foreground pixels are clustered using a fast accurate fuzzy k-means algorithm. Growing and prediction of the cluster centroids of foreground pixels ensure that each cluster centroid is associated with a moving object in the scene. In the algorithm for learning motion patterns, trajectories are clustered hierarchically using spatial and temporal information and then each motion pattern is represented with a chain of Gaussian distributions. Based on the learned statistical motion patterns, statistical methods are used to detect anomalies and predict behaviors. Our system is tested using image sequences acquired, respectively, from a crowded real traffic scene and a model traffic scene. Experimental results show the robustness of the tracking algorithm, the efficiency of the algorithm for learning motion patterns, and the encouraging performance of algorithms for anomaly detection and behavior prediction
Exact solution of gyration radius of individual's trajectory for a simplified human mobility model
Gyration radius of individual's trajectory plays a key role in quantifying
human mobility patterns. Of particular interests, empirical analyses suggest
that the growth of gyration radius is slow versus time except the very early
stage and may eventually arrive to a steady value. However, up to now, the
underlying mechanism leading to such a possibly steady value has not been well
understood. In this Letter, we propose a simplified human mobility model to
simulate individual's daily travel with three sequential activities: commuting
to workplace, going to do leisure activities and returning home. With the
assumption that individual has constant travel speed and inferior limit of time
at home and work, we prove that the daily moving area of an individual is an
ellipse, and finally get an exact solution of the gyration radius. The
analytical solution well captures the empirical observation reported in [M. C.
Gonz`alez et al., Nature, 453 (2008) 779]. We also find that, in spite of the
heterogeneous displacement distribution in the population level, individuals in
our model have characteristic displacements, indicating a completely different
mechanism to the one proposed by Song et al. [Nat. Phys. 6 (2010) 818].Comment: 4 pages, 4 figure
Ultrafast fluorescent decay induced by metal-mediated dipole-dipole interaction in two-dimensional molecular aggregates
Two-dimensional molecular aggregate (2DMA), a thin sheet of strongly
interacting dipole molecules self-assembled at close distance on an ordered
lattice, is a fascinating fluorescent material. It is distinctively different
from the single or colloidal dye molecules or quantum dots in most previous
research. In this paper, we verify for the first time that when a 2DMA is
placed at a nanometric distance from a metallic substrate, the strong and
coherent interaction between the dipoles inside the 2DMA dominates its
fluorescent decay at picosecond timescale. Our streak-camera lifetime
measurement and interacting lattice-dipole calculation reveal that the
metal-mediated dipole-dipole interaction shortens the fluorescent lifetime to
about one half and increases the energy dissipation rate by ten times than
expected from the noninteracting single-dipole picture. Our finding can enrich
our understanding of nanoscale energy transfer in molecular excitonic systems
and may designate a new direction for developing fast and efficient
optoelectronic devices.Comment: 9 pages, 6 figure
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HSV-2 Infection of Human Genital Epithelial Cells Upregulates TLR9 Expression Through the SP1/JNK Signaling Pathway
It is known that herpes simplex virus type 2 (HSV-2) triggers the activation of Toll-like receptor (TLR) 9 signaling pathway and the consequent production of antiviral cytokines in dendritic cells. However, the impact of HSV-2 infection on TLR9 expression and signaling in genital epithelial cells, the primary HSV-2 targets, has yet to be determined. In the current study, by using both human genital epithelial cell lines and primary genital epithelial cells as models, we found that HSV-2 infection enhances TLR9 expression at both mRNA and protein levels. Such enhancement is virus replication-dependent and CpG-independent, while the HSV-2-mediated upregulation of TLR9 does not activate TLR9 signaling pathway. Mechanistically, a SP1 binding site on TLR9 promoter appears to be essential for HSV-2-induced TLR9 transactivation. Upon HSV-2 infection, SP1 translocates from the cytoplasm to the nucleus, and consequently binds to TLR9 promoter. By using specific inhibitors, the JNK signaling pathway is shown to be involved in the HSV-2-induced TLR9 transactivation, while HSV-2 infection increases the phosphorylation but not the total level of JNK. In agreement, antagonism of JNK signaling pathway inhibits the HSV-2-induced SP1 nuclear translocation. Taken together, our study demonstrates that HSV-2 infection of human genital epithelial cells promotes TLR9 expression through SP1/JNK signaling pathway. Findings in this study provide insights into HSV-2-host interactions and potential targets for immune intervention
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