Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice

<p>Abstract</p> <p>Background</p> <p>Caffeic acid (CA) and ellagic acid (EA) are phenolic acids naturally occurring in many plant foods. Cardiac protective effects of these compounds against dyslipidemia, hypercoagulability, oxidative stress and inflammation in diabetic mice were examined.</p> <p>Methods</p> <p>Diabetic mice were divided into three groups (15 mice per group): diabetic mice with normal diet, 2% CA treatment, or 2% EA treatment. One group of non-diabetic mice with normal diet was used for comparison. After 12 weeks supplement, mice were sacrificed, and the variation of biomarkers for hypercoagulability, oxidative stress and inflammation in cardiac tissue of diabetic mice were measured.</p> <p>Results</p> <p>The intake of CA or EA significantly increased cardiac content of these compounds, alleviated body weight loss, elevated plasma insulin and decreased plasma glucose levels in diabetic mice (<it>p </it>< 0.05). These treatments also significantly enhanced plasma antithrombin-III and protein C activities (<it>p </it>< 0.05); and decreased triglyceride content in cardiac tissue and plasma (<it>p </it>< 0.05), in which the hypolipidemic effects of EA were significantly greater than that of CA (<it>p </it>< 0.05). CA or EA significantly lowered cardiac levels of malondialdehyde, reactive oxygen species, interleukin (IL)-beta, IL-6, tumor necrosis factor (TNF)-alpha and monocyte chemoattractant protein (MCP)-1 (<it>p </it>< 0.05); and retained cardiac activity of glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (<it>p </it>< 0.05). These compounds also significantly up-regulated cardiac mRNA expression of GPX1, SOD and catalase; and down-regulated IL-1beta, IL-6, TNF-alpha and MCP-1 mRNA expression in diabetic mice (<it>p </it>< 0.05).</p> <p>Conclusion</p> <p>These results support that CA and EA could provide triglyceride-lowering, anti-coagulatory, anti-oxidative, and anti-inflammatory protection in cardiac tissue of diabetic mice. Thus, the supplement of these agents might be helpful for the prevention or attenuation of diabetic cardiomyopathy.</p

Effects of orthographic consistency and homophone density on Chinese spoken word recognition

Studies of alphabetic language have shown that orthographic knowledge influences phonological processing during spoken word recognition. This study utilized the Event-Related Potentials (ERPs) to differentiate two types of phonology-to-orthography (P-to-O) mapping consistencies in Chinese, namely homophone density and orthographic consistency. The ERP data revealed an orthographic consistency effect in the frontal-centrally distributed N400, and a homophone density effect in central-posteriorly distributed late positive component (LPC). Further source analyses using the standardized low-resolution electromagnetic tomography (sLORETA) demonstrated that the orthographic effect was not only localized in the frontal and temporal-parietal regions for phonological processing, but also in the posterior visual cortex for orthographic processing, while the homophone density effect was found in middle temporal gyrus for lexical-semantic selection, and in the temporal-occipital junction for orthographic processing. These results suggest that orthographic information not only shapes the nature of phonological representations, but may also be activated during on-line spoken word recognition

The feedback consistency effect in Chinese character recognition:evidence from a psycholinguistic norm

Researchers have demonstrated the importance of phonology in literacy acquisition and in visual word recognition. For example, the spelling-to-sound consistency effect has been observed in visual word recognition tasks, in which the naming responses are faster and more accurate for words with the same letters that also have the same pronunciation (e.g. -ean is always pronounced /in/, as in lean, dean, and bean). In addition, some studies have reported a much less intuitive feedback consistency effect when a rime can be spelled in different ways (e.g. /ip/ in heap and deep) in lexical decision tasks. Such findings suggest that, with activation flowing back and forth between orthographic and phonological units during word processing, any inconsistency in the mappings between orthography and phonology should weaken the stability of the feedback loop, and, thus, should delay recognition. However, several studies have failed to show reliable feedback consistency in printed word recognition. One possible reason for this is that the feedback consistency is naturally confounded with many other variables, such as orthographic neighborhood or bigram frequency, as these variables are difficult to tease apart. Furthermore, there are challenges in designing factorial experiments that perfectly balance lexical stimuli on all factors besides feedback consistency. This study aims to examine the feedback consistency effect in reading Chinese characters by using a normative data of 3,423 Chinese phonograms. We collected the lexical decision time from 180 college students. A linear mixed model analysis was used to examine the feedback consistency effect by taking into account additional properties that may be confounded with feedback consistency, including character frequency, number of strokes, phonetic combinability, semantic combinability, semantic ambiguity, phonetic consistency, noun-to-verb ratios, and morphological boundedness. Some typical effects were observed, such as the more frequent and familiar a character, the faster one can decide it is a real character. More importantly, the linear mixed model analysis revealed a significant feedback consistency effect while controlling for other factors, which indicated that the pronunciation of phonograms might accommodate the organization of Chinese orthographic representation. Our study disentangled the feedback consistency from the many other factors, and supports the view that phonological activation would reverberate to orthographic representation in visual word recognition

Exploring Online Repeat Purchase Intentions: The Role of Habit

By focusing on online stores, this study investigates the repeat purchase intention of experienced online buyers. Prior research on online behavior continuance models perceived usefulness, trust, satisfaction, and perceived value as the major determinants of continued adoption or loyalty, overlooking the important role of habit. Building on previous work in other disciplines, we define habit in the context of online shopping as the extent to which buyers tend to shop online automatically because of learning. Using recent work on the continued usage of IS (IS continuance) and repeat purchase, we have developed a model suggesting that repeat purchase intention is not only a consequence of trust and switching cost, but also of habit. In particular, in our research model, we propose that online shopping habit moderate the influence of trust such that its importance in determining repeat purchase intention decreases as the online shopping behavior takes on a more habitual nature. Integrating prior research on habit, IS continuance, and repeat purchase further, we suggest how antecedents of repeat purchase intention relate to drivers of habitualization. Data collected from 462 of Yahoo!Kimo shopping center’s customers provide strong support for the research model. Results indicate that higher level of habit deflated trust’s effect on repeat purchase intention. The data also show that satisfaction and familiarity are key to habit formation and thus relevant in the context of online repeat purchase