Towards a Data Sharing Culture: Recommendations for Leadership from Academic Health Centers

Rebecca Crowley and colleagues propose that academic health centers can and should lead the transition towards a culture of biomedical data sharing

Evidence supporting somatic assembly of the DNA segments (minigenes), coding for the framework, and complementarity-determining segments of immunoglobulin variable regions.J. Exp. Med

The variable regions 1 (V-regions) 2 of immunoglobulin light (VL) and heavy (VH) chains can be considered to be made up of four framework (FR) separated by three complementarity-determining (hypervariable [1-3, cf. 4]) regions or segments (CDR). This is supported by x-ray crystallographic studies (5-8). In the light chains, FR1