2 research outputs found
Ecological non-linear state space model selection via adaptive particle Markov chain Monte Carlo (AdPMCMC)
We develop a novel advanced Particle Markov chain Monte Carlo algorithm that
is capable of sampling from the posterior distribution of non-linear state
space models for both the unobserved latent states and the unknown model
parameters. We apply this novel methodology to five population growth models,
including models with strong and weak Allee effects, and test if it can
efficiently sample from the complex likelihood surface that is often associated
with these models. Utilising real and also synthetically generated data sets we
examine the extent to which observation noise and process error may frustrate
efforts to choose between these models. Our novel algorithm involves an
Adaptive Metropolis proposal combined with an SIR Particle MCMC algorithm
(AdPMCMC). We show that the AdPMCMC algorithm samples complex, high-dimensional
spaces efficiently, and is therefore superior to standard Gibbs or Metropolis
Hastings algorithms that are known to converge very slowly when applied to the
non-linear state space ecological models considered in this paper.
Additionally, we show how the AdPMCMC algorithm can be used to recursively
estimate the Bayesian Cram\'er-Rao Lower Bound of Tichavsk\'y (1998). We derive
expressions for these Cram\'er-Rao Bounds and estimate them for the models
considered. Our results demonstrate a number of important features of common
population growth models, most notably their multi-modal posterior surfaces and
dependence between the static and dynamic parameters. We conclude by sampling
from the posterior distribution of each of the models, and use Bayes factors to
highlight how observation noise significantly diminishes our ability to select
among some of the models, particularly those that are designed to reproduce an
Allee effect
Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus
We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri NRRL181 and Aspergillus clavatus NRRL1. Comparative genomic analysis of A1163 with the recently sequenced A. fumigatus isolate Af293 has identified core, variable and up to 2% unique genes in each genome. While the core genes are 99.8% identical at the nucleotide level, identity for variable genes can be as low 40%. The most divergent loci appear to contain heterokaryon incompatibility (het) genes associated with fungal programmed cell death such as developmental regulator rosA. Cross-species comparison has revealed that 8.5%, 13.5% and 12.6%, respectively, of A. fumigatus, N. fischeri and A. clavatus genes are species-specific. These genes are significantly smaller in size than core genes, contain fewer exons and exhibit a subtelomeric bias. Most of them cluster together in 13 chromosomal islands, which are enriched for pseudogenes, transposons and other repetitive elements. At least 20% of A. fumigatus-specific genes appear to be functional and involved in carbohydrate and chitin catabolism, transport, detoxification, secondary metabolism and other functions that may facilitate the adaptation to heterogeneous environments such as soil or a mammalian host. Contrary to what was suggested previously, their origin cannot be attributed to horizontal gene transfer (HGT), but instead is likely to involve duplication, diversification and differential gene loss (DDL). The role of duplication in the origin of lineage-specific genes is further underlined by the discovery of genomic islands that seem to function as designated “gene dumps” and, perhaps, simultaneously, as “gene factories”