Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Impact of Relatedness, Uncertainty and Slack on Corporate Entrepreneurship Decisions

Purpose – The purpose of this study is to evaluate the effect of opportunity relatedness and uncertainty on the decision of a corporate entrepreneur to pursue a venturing opportunity. Design/methodology/approach – The study uses a conjoint experimental design to reveal the structure of respondents\u27 decision policies. Data were gathered from 47 useable replies from corporate entrepreneurs and were analyzed with hierarchical linear modeling (HLM). Findings – Results show that product relatedness, market relatedness, perceived certainty about expected outcomes and slack resources all have a positive effect on the willingness of a corporate entrepreneur to pursue a new venture idea. Moreover, slack was found to diminish the positive effect of product relatedness on the likelihood to pursue a venturing opportunity. Practical implications – By providing a better understanding of decision-making schemas of corporate entrepreneurs, the findings of this study help improve the practice of entrepreneurship at the organizational level. In order to make more accurate opportunity assessments, corporate entrepreneurs need to be aware of their cognitive strategies and need to factor in the salient criteria affecting such assessments. Originality/value – This paper adds to the limited understanding of corporate-level decision-making with regard to pursuing venturing opportunities. More specifically, the paper adds new insights regarding how relatedness and uncertainty affect new venture opportunity assessments in the presence (or lack thereof) of slack resources

Effects of modality and filtering on emotional responses in adults with normal hearing

The purpose of this project was two-fold. First, it was to evaluate the contribution of low- and high-frequency information to emotional responses to non-speech sounds in adults with normal hearing. The second purpose was to evaluate the effect of stimulus modality on emotional responses, with particular focus on the effect of disrupted affective processing in the auditory domai

On The Basics of Training for Muscle Size and Strength

We read the article of Buckner et al. (1), hoping to find new insights on resistance training. Unfortunately, the article is a restatement of information contained in previously published reviews from this group. Here are our major concerns

On "The Basics of Training for Muscle Size and Strength".

Letter to the editor