KMT-2016-BLG-1836Lb: A Super-Jovian Planet from a High-cadence Microlensing Field

We report the discovery of a super-Jovian planet in the microlensing event KMT-2016-BLG-1836, which was found by the Korea Microlensing Telescope Network (KMTNet) high-cadence observations (Γ ~ 4 hr^⁻¹). The planet–host mass ratio q ~ 0.004. A Bayesian analysis indicates that the planetary system is composed of a super-Jovian M_(planet) = 2.2^(+1.9)_(-1.1)M_J planet orbiting an M or K dwarf, M_(host) = 0.49^(+0.38)_(-0.25) M_⊙, at a distance of D_L = 7.1^(+0.8)_(-2.4) kpc. The projected planet–host separation is 3.5^(+1.1)_(-0.9) au, implying that the planet is located beyond the snow line of the host star. Future high-resolution images can potentially strongly constrain the lens brightness and thus the mass and distance of the planetary system. Without considering detailed detection efficiency, selection, or publication biases, we find a potential mass-ratio desert at −3.7 ≾ log q ≾ −3.0 for the 31 published KMTNet planets

KMT-2016-BLG-1836Lb: A Super-Jovian Planet from a High-cadence Microlensing Field

We report the discovery of a super-Jovian planet in the microlensing event KMT-2016-BLG-1836, which was found by the Korea Microlensing Telescope Network (KMTNet) high-cadence observations (Γ ~ 4 hr^⁻¹). The planet–host mass ratio q ~ 0.004. A Bayesian analysis indicates that the planetary system is composed of a super-Jovian M_(planet) = 2.2^(+1.9)_(-1.1)M_J planet orbiting an M or K dwarf, M_(host) = 0.49^(+0.38)_(-0.25) M_⊙, at a distance of D_L = 7.1^(+0.8)_(-2.4) kpc. The projected planet–host separation is 3.5^(+1.1)_(-0.9) au, implying that the planet is located beyond the snow line of the host star. Future high-resolution images can potentially strongly constrain the lens brightness and thus the mass and distance of the planetary system. Without considering detailed detection efficiency, selection, or publication biases, we find a potential mass-ratio desert at −3.7 ≾ log q ≾ −3.0 for the 31 published KMTNet planets

The Shortcomings and Improvement Strategies of Public Physical Education Courses in Chinese Universities

With the development of China’s higher education, China’s university education has developed rapidly and the number of students enrolled has been increasing. At present, the number of college students in China has exceeded 24 million, showing a prosperous scene. However, with the rapid development of college education, the participation rate of college students in sports is generally low, and the college physical education courses set up to promote college students’ sports have not played their due role. This study analyzes the shortcomings of current college physical education and proposes that college physical education in China should change the current situation of outdated teaching concepts, unreasonable teaching evaluation system, insufficient teaching content, and cultivate college students’ interest in sports and lifelong sports

Game and Intrinsic Motivation: Basketball Teaching for Pupil

The cultivation of pupils’ sports interests is related to the formation of pupils’ sports habits and their physical health in the future. At present, the physical condition of primary and secondary school students in China is not optimistic. Basketball, as a part of school sports, is widely carried out in schools in China. Scientific organization of basketball teaching in primary schools can better improve the physical quality of pupils and cultivate their interest in basketball. Pupils are still in the stage of physical and mental development, and their bones, muscles and nervous system are not well developed, their attention is easy to be distracted, and they can not carry out large amount of exercise, so they should focus on motivational exercise and basic teaching. As a means of teaching, games can improve pupils’ interest in the practice and stimulate their intrinsic motivation to participate in basketball, which should be appropriately increased in teaching

Epigenetics in ovarian cancer: premise, properties, and perspectives.

Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality. Therefore, it is both urgent and important to identify biomarkers facilitating early identification and novel agents preventing recurrence. Accumulating evidence demonstrates that epigenetic aberrations (particularly histone modifications) are crucial in tumor initiation and development. Histone acetylation and methylation are respectively regulated by acetyltransferases-deacetylases and methyltransferases-demethylases, both of which are implicated in ovarian cancer pathogenesis. In this review, we summarize the most recent discoveries pertaining to ovarian cancer development arising from the imbalance of histone acetylation and methylation, and provide insight into novel therapeutic interventions for the treatment of ovarian carcinoma

Reducing toxicity and increasing efficiency: aconitine with liquiritin and glycyrrhetinic acid regulate calcium regulatory proteins in rat myocardial cell

Background: Compatibility of Radix Aconiti Carmichaeli and Liquorice is known to treat heart diseases such as heart failure and cardiac arrhythmias. This work answers the question that whether the active components (Aconitine, Liquiritin and Glycyrrhetinic Acid) of Radix Aconiti Carmichaeli and Liquorice could result in regulating intracellular calcium homeostasis and calcium cycling, and thereby verifies the therapeutic material basis.Materials and Methods: The myocardial cells were divided into twelve groups randomly as control group, Aconitine group, nine different dose groups that orthogonal combined with Aconitine, Liquiritin and Glycyrrhetinic Acid, and Verapamil group. The myocardial cellular survival rate and morphology were assessed. The expression of calcium regulation protein(RyR2、NCX1、DHPR-a1) in the myocardial cell by Western-blotting.Results: The results exhibited that Aconitine (120 uM) significantly damaged on myocardial cell, decreased the survival rate and expression of Na+/Ca2+ exchangers (NCX1) and dihydropteridine reducta-α1 (DHPR-a1), and increased the expression of ryanodine receptor type2 (RyR2) obviously. The compatibility groups (Aconitine, Liquiritin and Glycyrrhetinic Acid) all could against the damage on the myocardial cell by Aconitine at different levels.Conclusion: Aconitine with Liquiritin and Glycyrrhetinic Acid may regulate the expression of calcium-regulated proteins to protect myocardial cells from damage.Keywords: Aconitine, Liquiritin, Glycyrrhetinic Acid, myocardial cell, calcium regulator

Multiple-Clade H5N1 Influenza Split Vaccine Elicits Broad Cross Protection against Lethal Influenza Virus Challenge in Mice by Intranasal Vaccination

Background: The increase in recent outbreaks and unpredictable changes of highly pathogenic avian influenza (HPAI) H5N1 in birds and humans highlights the urgent need to develop a cross-protective H5N1 vaccine. We here report our development of a multiple-clade H5N1 influenza vaccine tested for immunogenicity and efficacy to confer cross-protection in an animal model. Methodology/Principal Findings: Mice received two doses of influenza split vaccine with oil-in-water emulsion adjuvant SP01 by intranasal administration separated by two weeks. Single vaccines (3 mg HA per dose) included rg-A/Vietnam/1203/ 2004(Clade 1), rg-A/Indonesia/05/2005(Clade 2.1), and rg-A/Anhui/1/2005(Clade 2.3.4). The trivalent vaccine contained 1 mg HA per dose of each single vaccine. Importantly, complete cross-protection was observed in mice immunized using trivalent vaccine with oil-in-water emulsion adjuvant SP01 that was subsequently challenged with the lethal A/OT/SZ/097/03 influenza strain (Clade 0), whereas only the survival rate was up to 60 % in single A/Anhui/1/2005 vaccine group. Conclusion/Significance: Our findings demonstrated that the multiple-clade H5N1 influenza vaccine was able to elicit a cross-protective immune response to heterologous HPAI H5N1 virus, thus giving rise to a broadly cross-reactive vaccine to potential prevention use ahead of the strain-specific pandemic influenza vaccine in the event of an HPAI H5N1 influenza outbreak. Also, the multiple-clade adjuvanted vaccine could be useful in allowing timely initiation of vaccination agains

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2.

There is an urgent need for animal models to study SARS-CoV-2 pathogenicity. Here, we generate and characterize a novel mouse-adapted SARS-CoV-2 strain, MASCp36, that causes severe respiratory symptoms, and mortality. Our model exhibits age- and gender-related mortality akin to severe COVID-19. Deep sequencing identified three amino acid substitutions, N501Y, Q493H, and K417N, at the receptor binding domain (RBD) of MASCp36, during in vivo passaging. All three RBD mutations significantly enhance binding affinity to its endogenous receptor, ACE2. Cryo-electron microscopy analysis of human ACE2 (hACE2), or mouse ACE2 (mACE2), in complex with the RBD of MASCp36, at 3.1 to 3.7 Å resolution, reveals the molecular basis for the receptor-binding switch. N501Y and Q493H enhance the binding affinity to hACE2, whereas triple mutations at N501Y/Q493H/K417N decrease affinity and reduce infectivity of MASCp36. Our study provides a platform for studying SARS-CoV-2 pathogenesis, and unveils the molecular mechanism for its rapid adaptation and evolution

KMT-2022-BLG-2397: Brown Dwarf at the Upper Shore of the Einstein Desert

We measure the Einstein radius of the single-lens microlensing event KMT-2022-BLG-2397 to be theta_E=24.8 +- 3.6 uas, placing it at the upper shore of the Einstein Desert, 9 < theta_E / uas < 25, between free-floating planets (FFPs) and bulge brown dwarfs (BDs). In contrast to the six BD (25 < theta_E < 50) events presented by Gould+22, which all had giant-star source stars, KMT-2022-BLG-2397 has a dwarf-star source, with angular radius theta_* ~ 0.9 uas. This prompts us to study the relative utility of dwarf and giant sources for characterizing FFPs and BDs from finite-source point-lens (FSPL) microlensing events. We find `dwarfs' (including main-sequence stars and subgiants) are likely to yield twice as many theta_E measurements for BDs and a comparable (but more difficult to quantify) improvement for FFPs. We show that neither current nor planned experiments will yield complete mass measurements of isolated bulge BDs, nor will any other planned experiment yield as many theta_E measurements for these objects as KMT. Thus, the currently anticipated 10-year KMT survey will remain the best way to study bulge BDs for several decades to come.Comment: 45 pages, 9 Figures, submitted to AAS Journal

KMT-2021-BLG-1122L: The first microlensing triple stellar system

We systematically inspect the microlensing data acquired by the KMTNet survey during the previous seasons in order to find anomalous lensing events for which the anomalies in the lensing light curves cannot be explained by the usual binary-lens or binary-source interpretations. From the inspection, we find that interpreting the three lensing events OGLE-2018-BLG-0584, KMT-2018-BLG-2119, and KMT-2021-BLG-1122 requires four-body (lens+source) models, in which either both the lens and source are binaries (2L2S event) or the lens is a triple system (3L1S event). Following the analyses of the 2L2S events presented in \citet{Han2023}, here we present the 3L1S analysis of the KMT-2021-BLG-1122. It is found that the lens of the event KMT-2021-BLG-1122 is composed of three masses, in which the projected separations (normalized to the angular Einstein radius) and mass ratios between the lens companions and the primary are $(s_2, q_2)\sim (1.4, 0.53)$ and $(s_3, q_3) \sim (1.6, 0.24)$. By conducting a Bayesian analysis, we estimate that the masses of the individual lens components are $(M_1, M_2, M_3)\sim (0.47\,M_\odot, 0.24\,M_\odot, 0.11\,M_\odot)$. The companions are separated in projection from the primary by $(a_{\perp,2}, a_{\perp,3})\sim (3.5, 4.0)$~AU. The lens of KMT-2018-BLG-2119 is the first triple stellar system detected via microlensing.Comment: 8 pages, 7 figures, 2 table