Embolia do líquido amniótico

Trabalho realizado no contexto do estágio de Cuidados Intensivos do Internato Médico ComplementarA ELA é considerada uma emergência obstétrica rara com consequências catastróficas maternas e fetais. A forma de apresentação geralmente consiste num colapso materno súbito, profundo e imprevisível associado a hipoxémia hipotensão e coagulação intravascular disseminada. A sua ocorrência está relacionada com a entrada em circulação materna de componentes do líquido amniótico e células fetais. A terapêutica é primariamente de suporte, sendo críticos o reconhecimento e a abordagem precoces. Porque constitui um síndrome raro, a informação disponível até à data é escassa baseando-se, essencialmente, em “case reports” individuais e séries de autópsia, pelo que muitos aspectos relacionados com a patologia permanecem ainda envoltos em dúvida e controvérsia

Quantum chemical properties used in structure-activity relationship studies

In this work we show that structure-activity relationship studies are of great importance in modern chemistry and biochemistry. In order to obtain a significant correlation, it is crucial that appropriate descriptors be employed. Thus, quantum chemical calculations are an attractive source of new molecular descriptors which can, in principle, express all the electronic and geometric properties of molecules and their interactions with the biological receptor.CNPqCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)FAPES

Longitudinal study of physical fitness levels, BMI and childhood obesity in school context

This work is aimed at knowing the level of physical aptitude and its degree of association, regarding an urban and a rural area, in children from the primary education schools. The sample consisted of six schools from the primary education of the county of Fundão: Santa Teresinha school (a central school), and the schools of Valverde, Fatela, Enxames, Alcaria and Peroviseu (peripheral schools). The sample has been selected in order to have a certain number of pupils from a peripheral area and another one from a central area of the city. The total sample is represented by 161 pupils, 76 are female and 85 are male and they are aged between 6 and 10. 85 come from an urban area and 76 come from a rural area. The analysis of the physical aptitude had as a reference the battery Prudential Fitnessgram (2002). According to the results obtained in the anthropometry, boys and girls from rural areas are heavier and taller than the boys and girls from urban areas. Regarding the BMI and body fat, it is males in rural areas that show a higher number of pupils in the healthy zone. As far as females are concerned, it is the urban area that has more pupils in that zone. It was also noticed that there are a huge percentage of girls from the rural area in the thin zone. In the differentiation between genders, boys have better results in physical aptitude and obesity levels. Regarding the influence of the living area, there are obviously better results in the urban area than in the rural area. Our study reveals that there are significant differences in the physical aptitude tests when they were applied at two different moments. After the analysis and interpretation of the results, we can conclude that boys and girls coming from rural areas are taller and heavier than the ones from urban areas and that they exhibit a lower body mass index. When defining the percentage of subjects classified in the “healthy zone”, the BMI numbers in boys from rural areas that are in the healthy zone are higher than those of boys from urban areas. Regarding girls, the ones from urban areas as well as those from rural areas have almost the same percentage in the healthy zone. Concerning fat, it is males in the rural areas that have more pupils in the healthy zone. As for girls, the ones from the urban areas have better results in the three zones, being the healthy zone that has a higher percentage of girls. In the relationship between the genders, boys have better results in the levels of physical aptitude and obesity. In the relationship between the areas, the urban one shows better results. The existence of two periods of analysis allowed us to notice an improvement in all the tests

Influence of sociological aspects on the level of physical activity in physical education students

Adopting and maintaining an active lifestyle for adolescent students, seems to be impaired and influenced by several factors, among them stand out environmental, psychological and social factors. Thus, the general objectives of this study were submitted to study and understand the extent to which these environmental, social and personal factors help and influence the level of physical activity (PA) by the adolescents in school age. More specifically, we will study: (1) the possible association between level of physical activity, age and gender; (2) consider and determine whether there is an association between socioeconomic variables and physical activity level of the population sample; (3) assess on the possible association between environmental variables and perceived physical activity of the adolescents. The sample consisted of 286 high school students, male gender (n = 125) and female (n = 161) aged between 15 and 18 years of age. As an instrument of study, a questionnaire was used. The main results of this study demonstrate a possible relationship between gender and level of PA, while boys tend to be more active than girls and also an association between socioeconomic variables and level of physical activity

Qualidade pós-colheita de frutos de tomate cv. Andréa tratados com etileno.

Made available in DSpace on 2011-04-09T16:14:41Z (GMT). No. of bitstreams: 1 andreuccettiqualidade.pdf: 244767 bytes, checksum: 15518329a14741122646ceab02568d5a (MD5) Previous issue date: 2007-12-0

Avaliação holística do doente com ferida: boas práticas no serviço de Cirurgia C

Formação dada ao grupo de enfermeiros, no contexto das boas práticas na abordagem do doente com feridaN/

A Framework for Analyzing Fog-Cloud Computing Cooperation Applied to Information Processing of UAVs

Unmanned aerial vehicles (UAVs) are a relatively new technology. Their application can often involve complex and unseen problems. For instance, they can work in a cooperative-based environment under the supervision of a ground station to speed up critical decision-making processes. However, the amount of information exchanged among the aircraft and ground station is limited by high distances, low bandwidth size, restricted processing capability, and energy constraints. These drawbacks restrain large-scale operations such as large area inspections. New distributed state-of-the-art processing architectures, such as fog computing, can improve latency, scalability, and efficiency to meet time constraints via data acquisition, processing, and storage at different levels. Under these amendments, this research work proposes a mathematical model to analyze distribution-based UAVs topologies and a fog-cloud computing framework for large-scale mission and search operations. The tests have successfully predicted latency and other operational constraints, allowing the analysis of fog-computing advantages over traditional cloud-computing architectures.Comment: Volume 2019, Article ID 7497924, 14 page

Decreased Survival in African Patients with Triple Negative Breast Cancer

Abstract Introduction: Triple Negative Breast Carcinomas (TNBC) are more prevalent in younger women especially those with African Ancestry, in whom the disease appears to be more aggressive. Since there are no data on Africans living in continental Europe, we sought to analyse a sample of African women from a European country and determine if, like African Americans, they have more aggressive tumor biology and poorer outcomes. Methods: We performed a retrospective review of TNBC to compare clinical and pathological features and survival between African and non-African patients. All women presented with breast cancer (BC), between 2005 and 2014, to a single general hospital, in Portugal. Results: A total of 144 (9.3% of the whole sample) TNBC patients were identified and amongst these, 17 were African (12%). African patients were not significantly younger than non-African patients (median age of 60 years vs 57.2 years, respectively, p=0.59). Regarding tumor size, nodal status and histologic grade at presentation, these variables were very similar between the two cohorts. Nevertheless, the prevalence of initially metastatic BC was significantly higher among the African population (41.2% vs 11%, p<0,005) and the outcome was worse for these patients (median survival: 62 vs 15 months, p<0.005). Conclusions: Our study demonstrated that African patients more frequently presented with late stage disease and worse survival outcome than the non-African population. These findings may be explained by more aggressive tumor biology.info:eu-repo/semantics/publishedVersio

Two- and Three-Dimensional Quantitative Structure-Activity Relationships Studies on a Series of Liver X Receptor Ligands

Liver X receptor (LXR) is an attractive drug target for the development of novel therapeutic agents for the treatment of dyslipidaemia and cholestasis. In the present work, comparative molecular field analysis (CoMFA) and hologram quantitative structure-activity relationship (HQSAR) studies were conducted on a series of potent LXR ligands. Significant correlation coefficients (CoMFA, r2 = 0.98 and q2 = 0.69; HQSAR, r2 = 0.99 and q2 = 0.85) were obtained, indicating the potential of the models for untested compounds. The models were then used to predict the potency of an external test set, and the predicted values obtained from the 2D and 3D models were in good agreement with the experimental results. The final QSAR models, along with the information obtained from 3D steric and electrostatic contour maps and 2D contribution maps should be useful for the design of novel LXR ligands having improved potency