868 research outputs found
Edge overload breakdown in evolving networks
We investigate growing networks based on Barabasi and Albert's algorithm for
generating scale-free networks, but with edges sensitive to overload breakdown.
the load is defined through edge betweenness centrality. We focus on the
situation where the average number of connections per vertex is, as the number
of vertices, linearly increasing in time. After an initial stage of growth, the
network undergoes avalanching breakdowns to a fragmented state from which it
never recovers. This breakdown is much less violent if the growth is by random
rather than preferential attachment (as defines the Barabasi and Albert model).
We briefly discuss the case where the average number of connections per vertex
is constant. In this case no breakdown avalanches occur. Implications to the
growth of real-world communication networks are discussed.Comment: To appear in Phys. Rev.
Multi-component lattice-Boltzmann model with interparticle interaction
A previously proposed [X. Shan and H. Chen, Phys. Rev. E {\bf 47}, 1815,
(1993)] lattice Boltzmann model for simulating fluids with multiple components
and interparticle forces is described in detail. Macroscopic equations
governing the motion of each component are derived by using Chapman-Enskog
method. The mutual diffusivity in a binary mixture is calculated analytically
and confirmed by numerical simulation. The diffusivity is generally a function
of the concentrations of the two components but independent of the fluid
velocity so that the diffusion is Galilean invariant. The analytically
calculated shear kinematic viscosity of this model is also confirmed
numerically.Comment: 18 pages, compressed and uuencoded postscript fil
Comparing Recent Organizing Templates for Test Content between ACS Exams in General Chemistry and AP Chemistry
Two different versions of “big ideas” rooted content maps have recently been published for general chemistry. As embodied in the content outline from the College Board, one of these maps is designed to guide curriculum development and testing for advanced placement (AP) chemistry. The Anchoring Concepts Content Map for general chemistry from the ACS Exams Institute is a component of a larger content map for the four-year undergraduate curriculum. This article compares the structure and content in these two maps to provide perspective on the current nature of the general chemistry curriculum. This contribution is part of a special issue on teaching introductory chemistry in the context of the AP chemistry course redesign
Photoinduced 3D orientational order in side chain liquid crystalline azopolymers
We apply experimental technique based on the combination of methods dealing
with principal refractive indices and absorption coefficients to study the
photoinduced 3D orientational order in the films of liquid crystalline (LC)
azopolymers. The technique is used to identify 3D orientational configurations
of trans azobenzene chromophores and to characterize the degree of ordering in
terms of order parameters. We study two types of LC azopolymers which form
structures with preferred in-plane and out-of-plane alignment of
azochromophores, correspondingly. Using irradiation with the polarized light of
two different wavelengths we find that the kinetics of photoinduced anisotropy
can be dominated by either photo-reorientation or photoselection mechanisms
depending on the wavelength. We formulate the phenomenological model describing
the kinetics of photoinduced anisotropy in terms of the isomer concentrations
and the order parameter tensor. We present the numerical results for absorption
coefficients that are found to be in good agreement with the experimental data.
The model is also used to interpret the effect of changing the mechanism with
the wavelength of the pumping light.Comment: uses revtex4 28 pages, 10 figure
Diffusion in a multi-component Lattice Boltzmann Equation model
Diffusion phenomena in a multiple component lattice Boltzmann Equation (LBE)
model are discussed in detail. The mass fluxes associated with different
mechanical driving forces are obtained using a Chapman-Enskog analysis. This
model is found to have correct diffusion behavior and the multiple diffusion
coefficients are obtained analytically. The analytical results are further
confirmed by numerical simulations in a few solvable limiting cases. The LBE
model is established as a useful computational tool for the simulation of mass
transfer in fluid systems with external forces.Comment: To appear in Aug 1 issue of PR
Growing Scale-Free Networks with Tunable Clustering
We extend the standard scale-free network model to include a ``triad
formation step''. We analyze the geometric properties of networks generated by
this algorithm both analytically and by numerical calculations, and find that
our model possesses the same characteristics as the standard scale-free
networks like the power-law degree distribution and the small average geodesic
length, but with the high-clustering at the same time. In our model, the
clustering coefficient is also shown to be tunable simply by changing a control
parameter - the average number of triad formation trials per time step.Comment: Accepted for publication in Phys. Rev.
Controlled dendrimersome nanoreactor system for localised hypochlorite-induced killing of bacteria
Antibiotic resistance is a serious global health problem necessitating new bactericidal approaches such as nanomedicines. Dendrimersomes (DSs) have recently become a valuable alternative nanocarrier to polymersomes and liposomes due to their molecular definition and synthetic versatility. Despite this, their biomedical application is still in its infancy. Inspired by the localized antimicrobial function of neutrophil phagosomes and the versatility of DSs, a simple three-component DS-based nanoreactor with broad-spectrum bactericidal activity is presented. This was achieved by encapsulation of glucose oxidase (GOX) and myeloperoxidase (MPO) within DSs (GOX-MPO-DSs), self-assembled from an amphiphilic Janus dendrimer, that possesses a semipermeable membrane. By external addition of glucose to GOX-MPO-DS, the production of hypochlorite (−OCl), a highly potent antimicrobial, by the enzymatic cascade was demonstrated. This cascade nanoreactor yielded a potent bactericidal effect against two important multidrug resistant pathogens, Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa), not observed for H2O2 producing nanoreactors, GOX-DS. The production of highly reactive species such as –OCl represents a harsh bactericidal approach that could also be cytotoxic to mammalian cells. This necessitates the development of strategies for activating –OCl production in a localized manner in response to a bacterial stimulus. One option of locally releasing sufficient amounts of substrate using a bacterial trigger (released toxins) was demonstrated with lipidic glucose-loaded giant unilamellar vesicles (GUVs), envisioning, e.g., implant surface modification with nanoreactors and GUVs for localized production of bactericidal agents in the presence of bacterial growth
Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides
The therapeutic and research potentials of oligonucleotides (ONs) have been hampered in part by their inability to effectively escape endosomal compartments to reach their cytosolic and nuclear targets. Splice-switching ONs (SSOs) can be used with endosomolytic small molecule compounds to increase functional delivery. So far, development of these compounds has been hindered by a lack of high-resolution methods that can correlate SSO trafficking with SSO activity. Here we present in-depth characterization of two novel endosomolytic compounds by using a combination of microscopic and functional assays with high spatiotemporal resolution. This system allows the visualization of SSO trafficking, evaluation of endosomal membrane rupture, and quantitates SSO functional activity on a protein level in the presence of endosomolytic compounds. We confirm that the leakage of SSO into the cytosol occurs in parallel with the physical engorgement of LAMP1-positive late endosomes and lysosomes. We conclude that the new compounds interfere with SSO trafficking to the LAMP1-positive endosomal compartments while inducing endosomal membrane rupture and concurrent ON escape into the cytosol. The efficacy of these compounds advocates their use as novel, potent, and quick-acting transfection reagents for antisense ONs
Maintaining and improving the control and safety systems for the Electromagnetic Calorimeter of the CMS experiment
This paper presents the current architecture of the control and safety systems designed and implemented for the Electromagnetic Calorimeter (ECAL) of the Compact Muon Solenoid (CMS) experiment at the Large Hadron Collider (LHC). An evaluation of system performance during all CMS physics data taking periods is reported, with emphasis on how software and hardware solutions are used to overcome limitations, whilst maintaining and improving reliability and robustness. The outcomes of the CMS ECAL Detector Control System (DCS) Software Analysis Project were a fundamental step towards the integration of all control system applications and the consequent piece-by-piece software improvements allowed a smooth transition to the latest revision of the system. The ongoing task of keeping the system in-line with new hardware technologies and software platforms specified by the CMS DCS Group is discussed. The structure of the comprehensive support service with detailed incident logging is presented in addition to a complete test setup for reproducing failures and for testing solutions prior to deployment into production. A correlation between the acquired experience, the development of new software tools and a reduction in the DCS support load is highlighted.International Conference on Computing in High Energy and Nuclear Physics (CHEP), May 21-25, 2012, New York Univ, New York, N
- …