New Pharmacological Agents to Aid Smoking Cessation and Tobacco Harm Reduction: What has been Investigated and What is in the Pipeline?

A wide range of support is available to help smokers to quit and aid attempts at harm reduction, including three first-line smoking cessation medications: nicotine replacement therapy, varenicline and bupropion. Despite the efficacy of these, there is a continual need to diversify the range of medications so that the needs of tobacco users are met. This paper compares the first-line smoking cessation medications to: 1) two variants of these existing products: new galenic formulations of varenicline and novel nicotine delivery devices; and 2) twenty-four alternative products: cytisine (novel outside of central and eastern Europe), nortriptyline, other tricyclic antidepressants, electronic cigarettes, clonidine (an anxiolytic), other anxiolytics (e.g. buspirone), selective 5-hydroxytryptamine (5-HT) reuptake inhibitors, supplements (e.g. St John’s wort), silver acetate, nicobrevin, modafinil, venlafaxine, monoamine oxidase inhibitors (MAOI), opioid antagonist, nicotinic acetylcholine receptors (nAChR) antagonists, glucose tablets, selective cannabinoid type 1 receptor antagonists, nicotine vaccines, drugs that affect gamma-aminobutyric acid (GABA) transmission, drugs that affect N-methyl-D-aspartate receptors (NMDA), dopamine agonists (e.g. levodopa), pioglitazone (Actos; OMS405), noradrenaline reuptake inhibitors, and the weight management drug lorcaserin. Six criteria are used: relative efficacy, relative safety, relative cost, relative use (overall impact of effective medication use), relative scope (ability to serve new groups of patients), and relative ease of use (ESCUSE). Many of these products are in the early stages of clinical trials, however, cytisine looks most promising in having established efficacy and safety and being of low cost. Electronic cigarettes have become very popular, appear to be efficacious and are safer than smoking, but issues of continued dependence and possible harms need to be considered

Mass and Free Energy of Lovelock Black Holes

An explicit formula for the ADM mass of an asymptotically AdS black hole in a generic Lovelock gravity theory is presented, identical in form to that in Einstein gravity, but multiplied by a function of the Lovelock coupling constants and the AdS curvature radius. A Gauss\u27 law type formula relates the mass, which is an integral at infinity, to an expression depending instead on the horizon radius. This and other thermodynamic quantities, such as the free energy, are then analyzed in the limits of small and large horizon radius, yielding results that are independent of the detailed choice of Lovelock couplings. In even dimensions, the temperature diverges in both limits, implying the existence of a minimum temperature for black holes. The negative free energy of sufficiently large black holes implies the existence of a Hawking-Page transition. In odd dimensions the temperature still diverges for large black holes, which again have negative free energy. However, the temperature vanishes as the horizon radius tends to zero and sufficiently small black holes have positive specific heat

Targeted Grazing: Applying the Research to the Land

The discipline of range science is in part based on the observation that vegetation on rangelands changes in response to livestock grazing. For much of the history of range science, livestock grazing was considered to affect range plants and ecological condition negatively. Thus range plants were classified as increasers, decreasers, or invaders as a function of their response to grazing. The concept that grazing can be used to restore degraded rangelands is relatively new. It requires a paradigm shift for most people from grazing animals reaping the benefits of the land to the land reaping the benefits of the grazing animals. Using livestock to accomplish vegetation management goals is referred to as targeted grazing. Targeted grazing is defined as the application of a particular kind of grazing animal at a specified season, duration, and intensity to accomplish specific vegetation management goals. It is the last half of this definition that differentiates targeted grazing from traditional grazing. The focus is on the vegetation and the subsequent outcomes and changes in composition or structure, rather than the performance of the grazing animal. Where the potential for targeted grazing to create positive change on the landscape has been clearly demonstrated through research and the experiences of practitioners, it still struggles to gain recognition as a viable vegetation management option. The recently published handbook Targeted Grazing: A Natural Approach to Vegetation Management and Landscape Enhancement was organized and written largely by range scientists to provide the scientific basis for targeted grazing. However, it did not provide much information on the practical and daily management decisions required by contract graziers and land managers. While the scientific basis for targeted grazing provides the foundation for understanding and improving this technology, as with all grazing management it is the daily operations and decisions that determine its success. The diversity of situations to which this tool can be applied necessitates the exchange of real-life experiences to promote learning among practitioners and to inform land managers of the successful programs and potential pitfalls to avoid....The Rangelands archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform March 202