70 research outputs found
Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review
Global guidance on environmental life cycle impact assessment indicators: progress and case study
A novel fluorescein-bisphosphonate based diagnostic tool for the detection of hydroxyapatite in both cell and tissue models
Abstract A rapid and efficient method for the detection of hydroxyapatite (HAP) has been developed which shows superiority to existing well-established methods. This fluorescein-bisphosphonate probe is highly selective for HAP over other calcium minerals and is capable of detecting lower levels of calcification in cellular models than either hydrochloric acid-based calcium leaching assays or the Alizarin S stain. The probe has been shown to be effective in both in vitro vascular calcification models and in vitro bone calcification models. Moreover we have demonstrated binding of this probe to vascular calcification in rat aorta and to areas of microcalcification, in human vascular tissue, beyond the resolution of computed tomography in human atherosclerotic plaques. Fluorescein-BP is therefore a highly sensitive and specific imaging probe for the detection of vascular calcification, with the potential to improve not only ex vivo assessments of HAP deposition but also the detection of vascular microcalcification in humans
Development of a finger-prick blood test kit and its usability for participants of health examinations
Effect of Europium Substitution on Thermoelectric Properties of Noble-Metal Silicon Clathrates with Ba<sub>8−</sub><i><sub>x</sub></i>Eu<i><sub>x</sub></i>Cu<i><sub>y</sub></i>Si<sub>46−</sub><i><sub>y</sub></i> Nominal Compositions
Carbon and nitrogen stocks and their mineralization potentials are higher under organic than conventional farming practices in Japanese Andosols
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