WFPC2 Observations of Massive and Compact Young Star Clusters in M31

We present color magnitude diagrams of four blue massive and compact star clusters in M31: G38, G44, G94, and G293. The diagrams of the four clusters reveal a well-populated upper main sequence and various numbers of supergiants. The U-B and B-V colors of the upper main sequence stars are used to determine reddening estimates of the different lines of sight in the M31 disk. Reddening values range from E(B-V) = 0.20 +/- 0.10 to 0.31 +/- 0.11. We statistically remove field stars on the basis of completeness, magnitude and color. Isochrone fits to the field-subtracted, reddening-corrected diagrams yield age estimates ranging from 63 +/- 15 Myr to 160 +/- 60 Myr. Implications for the recent evolution of the disk near NGC 206 are discussed.Comment: 17 pages, Latex, ApJ, in Pres

Eosinophil and T Cell Markers Predict Functional Decline in COPD Patients

BACKGROUND. The major marker utilized to monitor COPD patients is forced expiratory volume in one second (FEV1). However, asingle measurement of FEV1 cannot reliably predict subsequent decline. Recent studies indicate that T lymphocytes and eosinophils are important determinants of disease stability in COPD. We therefore measured cytokine levels in the lung lavage fluid and plasma of COPD patients in order to determine if the levels of T cell or eosinophil related cytokines were predictive of the future course of the disease. METHODS. Baseline lung lavage and plasma samples were collected from COPD subjects with moderately severe airway obstruction and emphysematous changes on chest CT. The study participants were former smokers who had not had a disease exacerbation within the past six months or used steroids within the past two months. Those subjects who demonstrated stable disease over the following six months (ΔFEV1 % predicted = 4.7 ± 7.2; N = 34) were retrospectively compared with study participants who experienced a rapid decline in lung function (ΔFEV1 % predicted = -16.0 ± 6.0; N = 16) during the same time period and with normal controls (N = 11). Plasma and lung lavage cytokines were measured from clinical samples using the Luminex multiplex kit which enabled the simultaneous measurement of several T cell and eosinophil related cytokines. RESULTS AND DISCUSSION. Stable COPD participants had significantly higher plasma IL-2 levels compared to participants with rapidly progressive COPD (p = 0.04). In contrast, plasma eotaxin-1 levels were significantly lower in stable COPD subjects compared to normal controls (p < 0.03). In addition, lung lavage eotaxin-1 levels were significantly higher in rapidly progressive COPD participants compared to both normal controls (p < 0.02) and stable COPD participants (p < 0.05). CONCLUSION. These findings indicate that IL-2 and eotaxin-1 levels may be important markers of disease stability in advanced emphysema patients. Prospective studies will need to confirm whether measuring IL-2 or eotaxin-1 can identify patients at risk for rapid disease progression.National Heart, Lung, and Blood Institute (NO1-HR-96140, NO1-HR-96141-001, NO1-HR-96144, NO1-HR-96143; NO1-HR-96145; NO1-HR-96142, R01HL086936-03); The Flight Attendant Medical Research Institute; the Jo-Ann F. LeBuhn Center for Chest Diseas

Grassmannians Gr(N-1,N+1), closed differential N-1 forms and N-dimensional integrable systems

Integrable flows on the Grassmannians Gr(N-1,N+1) are defined by the requirement of closedness of the differential N-1 forms $\Omega_{N-1}$ of rank N-1 naturally associated with Gr(N-1,N+1). Gauge-invariant parts of these flows, given by the systems of the N-1 quasi-linear differential equations, describe coisotropic deformations of (N-1)-dimensional linear subspaces. For the class of solutions which are Laurent polynomials in one variable these systems coincide with N-dimensional integrable systems such as Liouville equation (N=2), dispersionless Kadomtsev-Petviashvili equation (N=3), dispersionless Toda equation (N=3), Plebanski second heavenly equation (N=4) and others. Gauge invariant part of the forms $\Omega_{N-1}$ provides us with the compact form of the corresponding hierarchies. Dual quasi-linear systems associated with the projectively dual Grassmannians Gr(2,N+1) are defined via the requirement of the closedness of the dual forms $\Omega_{N-1}^{\star}$. It is shown that at N=3 the self-dual quasi-linear system, which is associated with the harmonic (closed and co-closed) form $\Omega_{2}$, coincides with the Maxwell equations for orthogonal electric and magnetic fields.Comment: 26 pages, references adde

First Results from Fermi GBM Earth Occultation Monitoring: Observations of Soft Gamma-Ray Sources Above 100 keV

The NaI and BGO detectors on the Gamma-ray Burst Monitor (GBM) on Fermi are now being used for long-term monitoring of the hard X-ray/low energy gamma-ray sky. Using the Earth occultation technique as demonstrated previously by the BATSE instrument on the Compton Gamma-Ray Observatory, GBM can be used to produce multiband light curves and spectra for known sources and transient outbursts in the 8 keV to 1 MeV energy range with its NaI detectors and up to 40 MeV with its BGO detectors. Over 85% of the sky is viewed every orbit, and the precession of the Fermi orbit allows the entire sky to be viewed every ~26 days with sensitivity exceeding that of BATSE at energies below ~25 keV and above ~1.5 MeV. We briefly describe the technique and present preliminary results using the NaI detectors after the first two years of observations at energies above 100 keV. Eight sources are detected with a significance greater than 7 sigma: the Crab, Cyg X-1, SWIFT J1753.5-0127, 1E 1740-29, Cen A, GRS 1915+105, and the transient sources XTE J1752-223 and GX 339-4. Two of the sources, the Crab and Cyg X-1, have also been detected above 300 keV.Comment: 13 pages, 9 figures, submitted to Ap

Star Cluster Formation and Disruption Time-Scales -- I. An empirical determination of the disruption time of star clusters in four galaxies

We present a new method to derive the cluster disruption time in selected regions of galaxies from the mass or age distribution of magnitude-limited cluster samples. If the disruption time of clusters in a region of a galaxy depends on their initial mass as t_4 x (M_cluster/10^4 M_sun)^gamma and if the cluster formation rate is constant, then the mass and age distributions of the observed clusters will each show two powerlaw relations. The values of t_4 and gamma can be derived from these relations. We used this method to derive the cluster disruption time in specific regions in four galaxies: the inner region of M51, a region of M33, the SMC and the solar neighbourhood. The values of gamma are the same in the four galaxies within the uncertainty and the mean value is gamma= 0.62 +- 0.06. However the disruption time t_4 of a cluster of 10^4 M_sun is very different in the different galaxies. The clusters in the SMC have the longest disruption time, t_4 = 8 Gyr, and the clusters at 1 to 3 kpc from the nucleus of M51 have the shortest disruption time of t_4 = 0.04 Gyr. The disruption time of clusters 1 to 5 kpc from the nucleus of M33 is t_4 = 0.13 Gyr and for clusters within 1 kpc from the Sun we find t_4 = 1.0 Gyr.Comment: 18 pages, 18 figures. Accepted for publication by Monthly Notice

Nonequilibrium dynamics of a simple stochastic model

We investigate the low-temperature dynamics of a simple stochastic model, introduced recently in the context of the physics of glasses. The slowest characteristic time at equilibrium diverges exponentially at low temperature. On smaller time scales, the nonequilibrium dynamics of the system exhibits an aging regime. We present an analytical study of the scaling behaviour of the mean energy, of its local correlation and response functions, and of the associated fluctuation-dissipation ratio throughout the regime of low temperature and long times. This analysis includes the aging regime, the convergence to equilibrium, and the crossover behaviour between them.Comment: 36 pages, plain tex, 7 figures, to be published by Journal of Physics

Three years of Fermi GBM Earth Occultation Monitoring: Observations of Hard X-ray/Soft Gamma-Ray Sources

The Gamma ray Burst Monitor (GBM) on board Fermi has been providing continuous data to the astronomical community since 2008 August 12. In this paper we present the results of the analysis of the first three years of these continuous data using the Earth occultation technique to monitor a catalog of 209 sources. From this catalog, we detect 99 sources, including 40 low-mass X-ray binary/neutron star systems, 31 high-mass X-ray binary neutron star systems, 12 black hole binaries, 12 active galaxies, 2 other sources, plus the Crab Nebula, and the Sun. Nine of these sources are detected in the 100-300 keV band, including seven black-hole binaries, the active galaxy Cen A, and the Crab. The Crab and Cyg X-1 are also detected in the 300-500 keV band. GBM provides complementary data to other sky-monitors below 100 keV and is the only all-sky monitor above 100 keV. Up-to-date light curves for all of the catalog sources can be found at http://heastro.phys.lsu.edu/gbm/.Comment: 24 pages, 12 figures, accepted for publication in ApJ

Fluctuation-Dissipation theorems and entropy production in relaxational systems

We show that for stochastic dynamical systems out of equilibrium the violation of the fluctuation-dissipation equality is bounded by a function of the entropy production. The result applies to a much wider situation than `near equilibrium', comprising diffusion as well as glasses and other macroscopic systems far from equilibrium. For aging systems this bounds the age-frequency regimes in which the susceptibilities satisfy FDT in terms of the rate of decay of the H-function, a question intimately related to the reading of a thermometer placed in contact with the system.Comment: 4 pages, RevTex; formula and reference added plus various minor changes in the tex