Theoretical Framework on the Role of Knowledge Management for Students on Academic Performance

Knowledge management is a developing sector that has received lots of consideration and support from the community which is industrial. Knowledge management is a young academic field which has not been built up a systematized and unified framework. This paper reviews the role of knowledge management for students on academic performance by using the structural equation modeling. Through applying knowledge management in the study process can help students to gain better results. As a result, it can be expected to shed light on the relative importance of knowledge management on students’ academic performance. Keywords: Knowledge management, Academic performance, digital economy DOI: 10.7176/IKM/11-2-05 Publication date:March 31st 202

Using metagenomics tool to evaluate the enrichment efficiency of methanogens in marine sediment in Truong Sa archipelage, Khanh Hoa province, Vietnam

Methanogens (archaea bacteria that produce methan) play an important role in the anaerobic digestion of organic waste, however, in marine environment, the low density of methanogens makes anaerobic digestion very slow. In this study, we used methagenomics tool to evaluate the enrichment efficiency of methanogens communities in marine sediments as a basis for building a anaerobic microbial formulation to treat organic waste in marine environment. The results of determination of methanogen density by MPN method have shown that methanogen has been accumulated with higher density (up to 3.2.107 MNP/ml) through 2 times of enrichment in artificial seawater with CH3COONa 10 mM substrate. In addition, metagenomics data have also shown a decrease in the number of archaea species through each enrichment, indicating that methanogenic species have gradually dominated the microbial community. This is the first study on using metagnenomics tools to evaluate the enrichment of methanogens in marine sediment samples in Truong Sa archipelago, Vietnam. Metagenomics data help provide more reliable evidence in microbial studies, especially in obligate anaerobes such as methanogens

Chumnguh Thleum: Understanding Liver Illness and Hepatitis B Among Cambodian Immigrants

Cambodian immigrants are over 25 times more likely to have evidence of chronic hepatitis B infection than the general US population. Carriers of HBV are over 100 times more likely to develop liver cancer than non-carriers. Liver cancer incidence is the second leading cancer for Cambodian men and the sixth for Cambodian women. Despite this, this underserved population has received very little attention from health disparities researchers. Culturally and linguistically appropriate interventions are necessary to increase hepatitis B knowledge, serologic testing, and vaccination among Cambodian Americans. Eight group interviews were held with Cambodian American men (48) and women (49). Focus group discussion revealed unanticipated information about sociocultural influences on participants’ understanding about hepatitis B transmission, disease course, and prevention and treatment informed by humoral theories underlying Khmer medicine, by biomedicine, and by migration experiences. Our findings reveal the value of qualitative exploration to providing cultural context to biomedical information—a formula for effective health promotion and practice

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population. Methods AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Eligible patients were adults (aged ≥18 years) with a clinical diagnosis of acute stroke in the previous 2–15 days, brain imaging consistent with ischaemic or haemorrhagic stroke, and a persisting neurological deficit that produced a modified Rankin Scale (mRS) score of 1 or more. Patients were randomly assigned 1:1 via a web-based system using a minimisation algorithm to once daily, oral fluoxetine 20 mg capsules or matching placebo for 6 months. Patients, carers, investigators, and outcome assessors were masked to the treatment allocation. The primary outcome was functional status, measured by the mRS, at 6 months. The primary analysis was an ordinal logistic regression of the mRS at 6 months, adjusted for minimisation variables. Primary and safety analyses were done according to the patient's treatment allocation. The trial is registered with the Australian New Zealand Clinical Trials Registry, ACTRN12611000774921. Findings Between Jan 11, 2013, and June 30, 2019, 1280 patients were recruited in Australia (n=532), New Zealand (n=42), and Vietnam (n=706), of whom 642 were randomly assigned to fluoxetine and 638 were randomly assigned to placebo. Mean duration of trial treatment was 167 days (SD 48·1). At 6 months, mRS data were available in 624 (97%) patients in the fluoxetine group and 632 (99%) in the placebo group. The distribution of mRS categories was similar in the fluoxetine and placebo groups (adjusted common odds ratio 0·94, 95% CI 0·76–1·15; p=0·53). Compared with patients in the placebo group, patients in the fluoxetine group had more falls (20 [3%] vs seven [1%]; p=0·018), bone fractures (19 [3%] vs six [1%]; p=0·014), and epileptic seizures (ten [2%] vs two [<1%]; p=0·038) at 6 months. Interpretation Oral fluoxetine 20 mg daily for 6 months after acute stroke did not improve functional outcome and increased the risk of falls, bone fractures, and epileptic seizures. These results do not support the use of fluoxetine to improve functional outcome after stroke

Digital literacy, online security behaviors and E-payment intention

E-payment is a key component of e-commerce, facilitating improved user efficiency and fostering the intent to use e-commerce in the digital realm and the international integration arena. This study investigates the joint impact of digital literacy on two similar but fundamentally different activities which are security control behavior and e-payment continuance intention. This research contributes to the growing field of literature in two ways. First, the study examines Digital Literacy, which distinguishes three broad dimensions - Tech Familiarity, Policy understanding, Awareness of institutional surveillance, and its association with Security control Behaviors and E-payment continuance intention. Second, the study tests the mediator effect of Security control Behaviors on the relationship between Digital Literacy and E-payment Intention. The data were collected by using both offline and online survey methods across the national scope, employing a quota sampling approach to encompass a wide range of consumer demographics. Structural equation modeling with the sample of Vietnamese respondents was applied to test the influence of digital literacy on customers’ security control behavior and intention to use e-payments. The results endorse that 1) digital literacy has an important impact on online security behavior; 2) digital literacy bridges a strong direct association with e-payment continuance Intention and indirect through online security behavior. This study suggests several theoretical and practical implications from the findings, as well as limitations and future directions

Phase I Clinical Trial Using Autologous Ex Vivo Expanded NK Cells and Cytotoxic T Lymphocytes for Cancer Treatment in Vietnam

(1) Background: Immune cell therapy recently attracted enormous attention among scientists as a cancer treatment, but, so far, it has been poorly studied and applied in Vietnam. The aim of this study was to assess the safety of autologous immune cell therapy for treating lung, liver, and colon cancers&mdash;three prevalent cancers in Vietnam. (2) Method: This was an open-label, single-group clinical trial that included 10 patients with confirmed diagnosis of colon, liver, or lung cancer, conducted between March 2016 and December 2017. (3) Results: After 20&ndash;21 days of culture, the average number of cytotoxic T lymphocytes (CTLs) increased 488.5-fold and the average cell viability was 96.3%. The average number of natural killer cells (NKs) increased 542.5-fold, with an average viability of 95%. Most patients exhibited improved quality of life, with the majority of patients presenting a score of 1 to 2 in the Eastern Cooperative Oncology Group (ECOG) performance status (ECOG/PS) scale, a decrease in symptoms on fatigue scales, and an increase in the mean survival time to 18.7 months at the end of the study. (4) Conclusion: This method of immune cell expansion met the requirements for clinical applications in cancer treatment and demonstrated the safety of this therapy for the cancer patients in Vietnam

Chronic Pain and Associated Factors Related to Depression among Older Patients in Hanoi, Vietnam

The interaction of chronic pain and depression among older people has been studied for many years. This study aimed to investigate the frequency of chronic pain and depression among older patients and correlated factors. A cross-sectional study was conducted in 921 older patients at the National Geriatric Hospital from November 2019 to March 2020. We used the Charlson Comorbidity Index (CCI) to assess the comorbid condition, a numerical rating scale (NRS) to examine pain severity, and Geriatric Depression Scale—15 items (GDS-15) to measure depression among participants. A chi-square test and Tobit regression were used to analyze the relationships. A total of 921 older patients participated in the study. The proportion of depression accounted for 55.8%. The mean Charlson score and number of diseases were 1.2 and 4.7, respectively. A positive correlation was found between comorbidity and chronic pain and depression. Moreover, socio-demographic variables such as occupation, education, and income were associated with pain and depressive symptoms. This study highlights the issue of mental health in older people with chronic pain. The results indicate the necessity of frequent depression screening, pain management, and social activity programs for older people to enhance their health

Optimization of Microwave-Assisted Extraction Process of Callicarpa candicans (Burm. f.) Hochr Essential Oil and Its Inhibitory Properties against Some Bacteria and Cancer Cell Lines

Callicarpa candicans (Burm. f.) Hochr. (Callicarpa cana L.) is a medicinal plant that is distributed mainly in the tropics and subtropics of Asia and finds a wide range of uses in traditional medicine. In this study, we attempted and optimized the microwave-assisted hydro-distillation (MAHD) process to obtain essential oil from the leaves of C. candicans. In addition, the obtained oil was analyzed for volatile composition by gas chromatography&ndash;mass spectrometry (GC-MS) and assayed for bioactivity against several bacteria and cancer cell lines. To optimize the extraction process, response surface methodology (RSM) in combination with central composite design (CCD) was adopted. Experimental design and optimization were carried out with respect to three experimental factors including the ratio of water to raw material, extraction time, and microwave power. The optimal extraction conditions were obtained as follows: water to raw material ratio of 6/1 (v/w), extraction time 42 min, and microwave power 440 W. Composition determination of the obtained C. candicans essential oil indicated the presence of predominant components including caryophyllene &lt;b-&gt; (10.45%), cadinene &lt;d-&gt; (10.28%), gurjunene &lt;a-&gt; (8.95%), muurolene &lt;g-&gt; (8.92%), selinene &lt;a-&gt; (7.06%), selinene &lt;b-&gt; (5.59%), and copaene &lt;a-&gt; (5.40%). In comparison with the essential oils obtained via traditional hydro-distillation method, the essential oil extracted by MAHD exhibited superior anti-proliferative activity on all tested cancer cell lines. Current results imply that the MAHD is capable of recovering biologically-active natural products of greater quantity than that recovered by the conventional distillation