タンパクシツシゲントシテノクロレラソウタイオヨビトルラコウボニカンスルケンキュウ

京都大学0048新制・課程博士農学博士甲第892号農博第98号新制||農||86(附属図書館)学位論文||S44||N314(農学部図書室)2221UT51-45-B483京都大学大学院農学研究科農芸化学専攻(主査)教授 満田 久輝, 教授 緒方 浩一, 教授 千葉 英雄学位規則第5条第1項該当Kyoto UniversityDA

Estimation of Internal Viscoelasticity by Mechanical Impedance

In evaluating the stiffness of skin surface, internal structures such as bone and muscle often affect the measurements. In the present paper, acoustic random vibration is used to estimated the viscoelasticity of a silicone-gel model. This viscoelasticity, which includes two different stiffness strata, is first estimated using a mechanical impedance spectrum, which describes the relation between the depth and viscoelasticity of internal objects. This method is applied to the depth of a silicone-gel tumor model measured by ultrasound imaging and the viscoelasticity of internal gel can be accurately estimated

Relationship between tissue characterization with 40MHz intravascular ultrasound imaging and 64-slice computed tomography

AbstractBackgroundIdentification of coronary plaque composition is important for selecting the treatment strategy, and 64-slice computed tomography (CT) is a noninvasive method of characterizing atherosclerotic plaques. However, the correlation between plaque characteristics detected by CT and intravascular ultrasound (IVUS) is not clear. A 40MHz IVUS imaging system (iMap-IVUS) has recently been developed to evaluate plaque composition. The aim of this study was to compare iMap-IVUS with 64-slice CT angiography for the characterization of non-calcified coronary plaques.Methods and resultsBoth 64-slice CT angiography and iMap-IVUS were performed in 19 patients (38 plaques). CT values were measured as Hounsfield units (HU) in circular regions of interest (ROI) drawn on the plaques. The iMap-IVUS system analyzed coronary plaques as fibrotic, lipidic, necrotic, or calcified tissue based on the radiofrequency spectrum.A positive correlation was found between CT values and the percentage of fibrotic plaque (r=0.34, p=0.036) or calcified plaque (r=0.40, p=0.011). Conversely, a negative correlation was found between CT values and the percentage of lipidic plaque (r=−0.41, p=0.01), or necrotic plaque (r=−0.41, p=0.01).ConclusionsGood correlations were observed between the characteristics of non-calcified plaque determined by iMap-IVUS and the CT values of plaque detected by 64-slice CT scanning

Dual roles of pearlite microstructure to interfere/facilitate gaseous hydrogen-assisted fatigue crack growth in plain carbon steels

Fatigue crack growth of two carbon steels with different pearlite volume fractions were studied in pressurized gaseous hydrogen environment. Notably, pearlite was found to mitigate hydrogen-assisted fatigue crack acceleration. This positive impact of pearlite was ascribed to ferrite/cementite lamellar aligned perpendicularly to the cracking direction, which functioned as barriers to intermittently arrest the crack propagation. Meanwhile, brittle delamination fracture ensued in the pearlite lamellar lying parallel to the crack-plane increased the crack growth rate and compromised the above positive effect to some extent. The material behavior is rationalized in light of fractographical observations and microstructural analyses of the crack-wake.acceptedVersio

A Pilot Study: The Beneficial Effects of Combined Statin-exercise Therapy on Cognitive Function in Patients with Coronary Artery Disease and Mild Cognitive Decline.

Objective Hypercholesterolemia, a risk factor in cognitive impairment, can be treated with statins. However, cognitive decline associated with "statins" (HMG-CoA reductase inhibitors) is a clinical concern. This pilot study investigated the effects of combining statins and regular exercise on cognitive function in coronary artery disease (CAD) patients with prior mild cognitive decline. Methods We recruited 43 consecutive CAD patients with mild cognitive decline. These patients were treated with a statin and weekly in-hospital aerobic exercise for 5 months. We measured serum lipids, exercise capacity, and cognitive function using the mini mental state examination (MMSE). Results Low-density lipoprotein cholesterol levels were significantly decreased, and maximum exercise capacity (workload) was significantly increased in patients with CAD and mild cognitive decline after treatment compared with before. Combined statin-exercise therapy significantly increased the median (range) MMSE score from 24 (22-25) to 25 (23-27) across the cohort (p<0.01). Changes in body mass index (BMI) were significantly and negatively correlated with changes in the MMSE. After treatment, MMSE scores in the subgroup of patients that showed a decrease in BMI were significantly improved, but not in the BMI-increased subgroup. Furthermore, the patients already on a statin at the beginning of the trial displayed a more significant improvement in MMSE score than statin-naïve patients, implying that exercise might be the beneficial aspect of this intervention as regards cognition. In a multivariate logistic regression analysis adjusted for age >65 years, sex, and presence of diabetes mellitus, a decrease in BMI during statin-exercise therapy was significantly correlated with an increase in the MMSE score (odds ratio: 4.57, 95% confidence interval: 1.05-20.0; p<0.05). Conclusion Statin-exercise therapy may help improve cognitive dysfunction in patients with CAD and pre-existing mild cognitive decline