KRAS G12C阻害薬耐性の大腸癌に対する有効な併用療法の開発

京都大学新制・課程博士博士(医学)甲第24804号医博第4996号新制||医||1067(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 武藤 学, 教授 藤田 恭之, 教授 川口 義弥学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

トルコ、アナトリア高原、トゥズ湖とコンヤ盆地における過去２４，０００年間の湖水位変動と扇状地の形成

Alluvial fans developed and lake levels fluctuated several times according to the climatic changes during the last 24,000 years. Alluvial fans developed in Lake Tuz in the cold, pluvial periods of increasing discharge during the Holocene around 5000 yr BP. and after 3500 yr BP. Lake expansion occurred at 23 ka., 18-20 ka., 14-15 ka., and 11ka. over the last 24,000 years in the Konya Basin. These expansions, shown by the raised lake terraces and beach ridges, were mainly due to cold and pluvial climatic changes. The lake level rose in the colder climate during marine oxygen isotope stage 2 and the Younger Dryas period. The lake level reached its highest level of 1013 to 1014 m during the last Glacial maximum before 18 ka

Intra-articular osteoid osteoma of the calcaneus: a case report and review

AbstractOsteoid osteoma of the calcaneus is rare and frequently misdiagnosed as arthritis because of similar symptoms. In addition, radiographic findings may be nonspecific, and magnetic resonance imaging (MRI) may show a bone marrow edema and changes in adjacent soft tissue. A 19-year-old man presented with a 6-month history of persistent pain and swelling in the left hind foot; diagnostic computed tomography and MRI analyses revealed lesions suggesting an intra-articular osteoid osteoma of the calcaneus. Initial MRI did not show specific findings. On operation, the tumor was removed by curettage; pathologic findings demonstrated woven bone trabeculae surrounded by connective tissue, confirming the diagnosis. To the best of our knowledge, MRI scans in all cases of calcaneal osteoid osteoma reported till 3 months after the injury exhibited a nidus. We believe that calcaneal osteoid osteoma should be considered as a differential diagnosis in patients undergoing MRI 3 months after symptom presentation; early computed tomography is critical in diagnosis

Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice.

UnlabelledPeritoneal disseminated cancer is highly treatment resistant. We here report the efficacy of intraperitoneal (i.p.) administration of tumor-targeting Salmonella typhimurium A1-R in a nude mouse model of disseminated human ovarian cancer. The mouse model was established by intraperitoneal injection of the human ovarian cancer cell line SKOV3-GFP. Seven days after implantation, mice were treated with S. typhimurium A1-R via intravenous (i.v.) or i.p. administration at the same dose, 5 × 10(7) CFU, once per week. Both i.v. and i.p. treatments effected prolonged survival compared with the untreated control group (P=0.025 and P<0.001, respectively). However, i.p. treatment was less toxic than i.v.TreatmentTumor-specific targeting of S. typhimurium A1-R was confirmed with bacterial culture from tumors and various organs and tumor or organ colony formation after i.v. or i.p. injection. Selective tumor targeting was most effective with i.p. administration. The results of the present study show S. typhimurium A1-R has promising clinical potential for disseminated ovarian cancer, especially via i.p. administration

Salvage surgery with a tumor prosthesis for femoral condylar nonunion at the very advanced age of 90 years

We report an unusual case of multifragmentary condylar femoral nonunion with severe synovitis and bone loss in a 90-year-old woman. Initially, conservative treatment of the condylar femoral fracture was indicated because the fracture was severely comminuted and the patient was very advanced in age. The fracture failed to heal. Salvage surgery with a total knee tumor endoprosthetic replacement was performed. Four years postoperatively, the patient was walking without knee pain using a walker. We believe that the present results justify the use of a megaprosthesis in the treatment of benign conditions even in very elderly patients. © 2012