X-ray absorption studies of copper (II) mixed ligand complexes with benzimidazole as one of the ligands

168-172X-ray absorption near edge structure (XANES) measurements have been made on the K-edge of copper in some of its biologically important complexes involving benzimidazole (BzImH) and other inorganic anionic ligands (X), viz; [Cu(BzImH)4X2] and [Cu(BzIm)2],where X= Cl, Br, 1/2SO4, ClO4, NO3, and BzIm = benzimidazolato anion. Various X-ray absorption parameters in the near edge region, such as., chemical shift, i.e., shift of K-edge of copper in complex with respect to K-edge of copper metal, energy position of the principal absorption maximum and edge-width have been estimated. All the complexes have been found to have copper in oxidation state +2. The shape of the K-edge has been found to show splitting of the K-edge into two components, i.e., K1 and K2 in all of these complexes. This feature suggests elongated octahedral and distorted tetrahedral geometries for the complexes which have also been proposed from the earlier studies. Further, the values of the chemical shift suggest the relative ionic character of the complexes in the following sequence: Cu(BzImH)4Br2 4Cl2< Cu(BzImH)4SO4 4(ClO4)2 4(NO3)2. The edge-widths of the K-edge also support this relative ionic character

Terpenoids-LXXI: constituents of Indian black dammar resin

Some of the components of the Indian black dammar resin obtained from the tree Canarium strictum Roxb., have been isolated mainly by employing solvent partition and column chromatography. The petroleum ether extract of the methanol-soluble portion contains (+) junenol (III), a new monoethynoid sesquiterpene ketone canarone(IV), a liquid sesquiterpene alcohol epi-khusinol (V), α-amyrin(Ia), β-amyrin(IIa), β-amyrin acetate, ψ-taraxasterol (VIa), its related newly isolated diol ψ-epitaraxastane diol (VIIIa) and the new ketol (VII), along with another new triterpene diol very closely resembling, 11-β-hydroxy-α-amyrin (IXa). Petroleum ether extract of the methanol insoluble portion was found to contain α-amyrin, β-amyrin and 11-keto-α-amyrin (Xa)

Analysis of photographically recorded EXAFS spectra using theoretical model

308-314The EXAFS data obtained by employing laboratory set-ups using X-ray films as detectors, has been analyzed qualitatively and empirically to yield information about molecular structure and average bond length. Such photographic data has been analyzed by Fourier transforming and fitting with theoretical standards using the available software packages in the present paper. The results obtained have been compared with those obtained from another laboratory set-up employing rotating anode X-ray tube with scintillation detector and also with the results obtained from synchrotron EXAFS set-ups using ionization chambers and CCD as detectors. By taking two examples, one of the Cu metal foil spectra, in which EXAFS oscillations are strong and another of the copper complex, viz., Cu(en)2(ONO2)2 [en = ethylenediamine] spectra, in which EXAFS oscillations are weak, it has been shown that the commonly available laboratory EXAFS set-ups employing photographic method of registration can also be used for easy and quick determination of the local structures at least for the first two coordination shells

Terpenoids-LXXXVI: structure of epi-Ψ-taraxastanonol and epi-Ψ-taraxastanediol

Two new pentacyclic triterpenes of the taraxastane group have beenisolated from Canarium strictum Roxb. One is a ketol and the other a diol. Chemical evidence, IR, UV, NMR spectra and their mass spectral disintegration patterns show that they are represented by the structures I and IIa. They have been named as epi-Ψ-taraxastanonol and epi-Ψ taraxastane diol respectively

Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: a study of the International Myeloma Working Group.

For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-body computed tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P<0.0001). Of 66 patients with SMM based on CSS, 12 (22.2%) had osteolytic lesions on WBCT. In comparison, WBCT failed to detect some bone destructions in the appendicular skeleton possibly due to limitations of the field of view. Presence of lytic bone lesions in WBCT was of borderline prognostic significance (P=0.051) for SMM patients, with a median time to progression of 38 versus 82 months for those without bone destructions. In conclusion, WBCT identifies significantly more sites of bone destruction than CSS. More than 20% of patients with SMM according to CSS have in fact active MM detectable with WBCT. On the basis of this and other studies, WBCT (either computed tomography (CT) alone or as part of a positron emission tomography-CT protocol) should be considered the current standard for the detection of osteolytic lesions in MM

Whole-body computed tomography versus conventional skeletal survey in patients with multiple myeloma: A study of the International Myeloma Working Group

For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-body computed tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P&lt;0.0001). Of 66 patients with SMM based on CSS, 12 (22.2%) had osteolytic lesions on WBCT. In comparison, WBCT failed to detect some bone destructions in the appendicular skeleton possibly due to limitations of the field of view. Presence of lytic bone lesions in WBCT was of borderline prognostic significance (P=0.051) for SMM patients, with a median time to progression of 38 versus 82 months for those without bone destructions. In conclusion, WBCT identifies significantly more sites of bone destruction than CSS. More than 20% of patients with SMM according to CSS have in fact active MM detectable with WBCT. On the basis of this and other studies, WBCT (either computed tomography (CT) alone or as part of a positron emission tomography-CT protocol) should be considered the current standard for the detection of osteolytic lesions in MM. © 2017 The Author(s)