110 research outputs found
The Lick AGN Monitoring Project 2011: Spectroscopic Campaign and Emission-Line Light Curves
In the Spring of 2011 we carried out a 2.5 month reverberation mapping
campaign using the 3 m Shane telescope at Lick Observatory, monitoring 15
low-redshift Seyfert 1 galaxies. This paper describes the observations,
reductions and measurements, and data products from the spectroscopic campaign.
The reduced spectra were fitted with a multicomponent model in order to isolate
the contributions of various continuum and emission-line components. We present
light curves of broad emission lines and the AGN continuum, and measurements of
the broad H-beta line widths in mean and root-mean square (rms) spectra. For
the most highly variable AGNs we also measured broad H-beta line widths and
velocity centroids from the nightly spectra. In four AGNs exhibiting the
highest variability amplitudes, we detect anticorrelations between broad H-beta
width and luminosity, demonstrating that the broad-line region "breathes" on
short timescales of days to weeks in response to continuum variations. We also
find that broad H-beta velocity centroids can undergo substantial changes in
response to continuum variations; in NGC 4593 the broad H-beta velocity shifted
by ~250 km/s over a one-month duration. This reverberation-induced velocity
shift effect is likely to contribute a significant source of confusion noise to
binary black hole searches that use multi-epoch quasar spectroscopy to detect
binary orbital motion. We also present results from simulations that examine
biases that can occur in measurement of broad-line widths from rms spectra due
to the contributions of continuum variations and photon-counting noise.Comment: 33 pages, 28 figures, accepted for publication in ApJ Supplement
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The Lick AGN Monitoring Project 2011: Reverberation Mapping of Markarian 50
The Lick AGN Monitoring Project 2011 observing campaign was carried out over
the course of 11 weeks in Spring 2011. Here we present the first results from
this program, a measurement of the broad-line reverberation lag in the Seyfert
1 galaxy Mrk 50. Combining our data with supplemental observations obtained
prior to the start of the main observing campaign, our dataset covers a total
duration of 4.5 months. During this time, Mrk 50 was highly variable,
exhibiting a maximum variability amplitude of a factor of 4 in the U-band
continuum and a factor of 2 in the H-beta line. Using standard
cross-correlation techniques, we find that H-beta and H-gamma lag the V-band
continuum by tau_cen = 10.64(-0.93,+0.82) and 8.43(-1.28,+1.30) days,
respectively, while the lag of He II 4686 is unresolved. The H-beta line
exhibits a symmetric velocity-resolved reverberation signature with shorter
lags in the high-velocity wings than in the line core, consistent with an
origin in a broad-line region dominated by orbital motion rather than infall or
outflow. Assuming a virial normalization factor of f=5.25, the virial estimate
of the black hole mass is (3.2+-0.5)*10^7 solar masses. These observations
demonstrate that Mrk 50 is among the most promising nearby active galaxies for
detailed investigations of broad-line region structure and dynamics.Comment: Accepted for publication in ApJ Letters. 6 pages, 4 figure
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Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease
Objective: To determine the motor phenotype of LRRK2 G2019S mutation carriers. LRRK2 mutation carriers were previously reported to manifest the tremor dominant motor phenotype, which has been associated with slower motor progression and less cognitive impairment compared with the postural instability and gait difficulty (PIGD) phenotype. Design: Cross-sectional observational study. Setting: Thirteen movement disorders centers. Participants: Nine hundred twenty-five early-onset Parkinson disease cases defined as age at onset younger than 51 years. Main Outcome Measures: LRRK2 mutation status and Parkinson disease motor phenotype: tremor dominant or PIGD. Demographic information, family history of Parkinson disease, and the Unified Parkinson's Disease Rating Scale score were collected on all participants. DNA samples were genotyped for LRRK2 mutations (G2019S, I2020T, R1441C, and Y1699C). Logistic regression was used to examine associations of G2019S mutation status with motor phenotype adjusting for disease duration, Ashkenazi Jewish ancestry, levodopa dose, and family history of Parkinson disease. Results: Thirty-four cases (3.7%) (14 previously reported) were G2019S carriers. No other mutations were found. Carriers were more likely to be Ashkenazi Jewish (55.9% vs 11.9%; P < .001) but did not significantly differ in any other demographic or disease characteristics. Carriers had a lower tremor score (P = .03) and were more likely to have a PIGD phenotype (92.3% vs 58.9%; P = .003). The association of the G2019S mutation with PIGD phenotype remained after controlling for disease duration and Ashkenazi Jewish ancestry (odds ratio, 17.7; P < .001). Conclusion: Early-onset Parkinson disease G2019S LRRK2 carriers are more likely to manifest the PIGD phenotype, which may have implications for disease course
Photosynthetic electron flow affects H2O2 signaling by inactivation of catalase in Chlamydomonas reinhardtii
A specific signaling role for H2O2 in Chlamydomonas reinhardtii was demonstrated by the definition of a promoter that specifically responded to this ROS. Expression of a nuclear-encoded reporter gene driven by this promoter was shown to depend not only on the level of exogenously added H2O2 but also on light. In the dark, the induction of the reporter gene by H2O2 was much lower than in the light. This lower induction was correlated with an accelerated disappearance of H2O2 from the culture medium in the dark. Due to a light-induced reduction in catalase activity, H2O2 levels in the light remained higher. Photosynthetic electron transport mediated the light-controlled down-regulation of the catalase activity since it was prevented by 3-(3′4′-dichlorophenyl)-1,1-dimethylurea (DCMU), an inhibitor of photosystem II. In the presence of light and DCMU, expression of the reporter gene was low while the addition of aminotriazole, a catalase inhibitor, led to a higher induction of the reporter gene by H2O2 in the dark. The role of photosynthetic electron transport and thioredoxin in this regulation was investigated by using mutants deficient in photosynthetic electron flow and by studying the correlation between NADP-malate dehydrogenase and catalase activities. It is proposed that, contrary to expectations, a controlled down-regulation of catalase activity occurs upon a shift of cells from dark to light. This down-regulation apparently is necessary to maintain a certain level of H2O2 required to activate H2O2-dependent signaling pathways
A systematic review of task- shifting for HIV treatment and care in Africa
BACKGROUND: Shortages of human resources for health (HRH) have severely hampered the rollout of antiretroviral therapy (ART) in sub-Saharan Africa. Current rollout models are hospital- and physician-intensive. Task shifting, or delegating tasks performed by physicians to staff with lower-level qualifications, is considered a means of expanding rollout in resource-poor or HRH-limited settings. METHODS: We conducted a systematic literature review. Medline, the Cochrane library, the Social Science Citation Index, and the South African National Health Research Database were searched with the following terms: task shift*, balance of care, non-physician clinicians, substitute health care worker, community care givers, primary healthcare teams, cadres, and nurs* HIV. We mined bibliographies and corresponded with authors for further results. Grey literature was searched online, and conference proceedings searched for abstracts. RESULTS: We found 2960 articles, of which 84 were included in the core review. 51 reported outcomes, including research from 10 countries in sub-Saharan Africa. The most common intervention studied was the delegation of tasks (especially initiating and monitoring HAART) from doctors to nurses and other non-physician clinicians. Five studies showed increased access to HAART through expanded clinical capacity; two concluded task shifting is cost effective; 9 showed staff equal or better quality of care; studies on non-physician clinician agreement with physician decisions was mixed, with the majority showing good agreement. CONCLUSIONS: Task shifting is an effective strategy for addressing shortages of HRH in HIV treatment and care. Task shifting offers high-quality, cost-effective care to more patients than a physician-centered model. The main challenges to implementation include adequate and sustainable training, support and pay for staff in new roles, the integration of new members into healthcare teams, and the compliance of regulatory bodies. Task shifting should be considered for careful implementation where HRH shortages threaten rollout programmes
Creating Indigenous Discourse: History, Power, and Imperialism in Academia, Palestinian Case
This article examines the impossibilities of implementing decolonizing research for indigenous scholars. In addition, it articulates the relationship between a decolonizing research approach and the historical and current forms of academic imperialism; a prototype of the Palestinian legacy is presented. The author argues that the current indigenous discourse is a remnant of oppression. The existing indigenous discourse is not due to the original quest but instead, it is in response to oppression. Also, the author explains the struggles of some indigenous scholars in complying with the reporting and ownership of knowledge that is required by Cartesian principles.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
The Nature of QSO Host Galaxies: Bonafide Ellipticals or Recent Mergers?
NRC publication: Ye
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